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Article
Chemistry, Multidisciplinary
Yi Cen et al.
Summary: This study discovered that ivermectin can alleviate tumor hypoxia by inhibiting mitochondrial respiration, enhancing oxygen-dependent photodynamic therapy (PDT). Chlorin e6 and ivermectin were encapsulated into stable Pluronic F127 micelles to synergize their pharmacological behaviors. These micelles passively targeted the drugs into tumors and improved their cellular internalization. Through inducing mitochondrial dysfunction, the micelles reduced oxygen consumption and increased reactive oxygen species production, thereby improving the efficacy of PDT against hypoxic tumors.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biochemistry & Molecular Biology
Ke Zheng et al.
Summary: Recently, the rapid acquisition of bacterial resistance and slow healing of infected wounds have become a threat to human life and health. In this study, a thermosensitive antibacterial platform called ZnPc(COOH)8:PMB@gel was developed using chitosan-based hydrogels and nanocomplexes. The platform showed the potential for simultaneous detection and treatment of Gram-negative bacteria by triggering fluorescence and reactive oxygen species (ROS) when exposed to E. coli bacteria at 37 degrees C. The platform also demonstrated enhanced antibacterial efficacy compared to individual components and facilitated the complete healing of wounds infected with E. coli bacteria.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Physical
Ke Zheng et al.
Summary: In this study, a nanoplatform was constructed by forming metal chelating complexes (FeP) and subsequent adsorption of the photosensitizer ZnPc(COOH)8 mediated by polylysine (PL) on the surface. The nanocomplexes FeP@PL:ZnPc(COOH)8 exhibited the ability of GSH depletion and chemodynamic activity, which synergistically enhanced PDAT efficacy. FeP@PL:ZnPc(COOH)8 possessed excellent antibacterial activity in vivo and in vitro, attributed to increased production of reactive oxygen species (ROS), reduced GSH level in bacteria, improved bacterial uptake, and enhanced destruction of the bacterial outer membrane. Moreover, FeP@PL:ZnPc(COOH)8 exhibited accelerated wound healing efficacy and the ability to recognize bacteria-infected wounds, making it an effective theranostic nanoplatform for bacterial infections.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Rui Wang et al.
Summary: The study successfully developed smart phototheranostic nanomaterials NanoPcM for low-background and tumor-targeted fluorescence imaging, as well as superior immunogenic photodynamic therapy against solid tumors. The combination of NanoPcM-based PDT and alpha PD-I-based immunotherapy efficiently inhibited tumor growth and triggered abscopal effects. This approach shows promise for the future design of nanomaterials in cancer imaging and therapy.
Article
Chemistry, Multidisciplinary
Tianya Liu et al.
Summary: Targeted therapy and immunotherapy have transformed cancer treatment, but face challenges of side effects and limited response. Novel nanoscale infinite coordination polymers offer a feasible strategy for tumor targeting and immune sensitization. MOICP, constructed through a one-pot self-assembled strategy, shows promising results in inhibiting Wnt signaling and enhancing immunotherapy effectiveness in cancer models.
Article
Chemistry, Multidisciplinary
Lina Feng et al.
Summary: A strategy of acceptor planarization and donor rotation was proposed to design type I photosensitizers (PSs) and photothermal reagents for tumor therapy. Experimental results showed that nanoparticles with the most rotors exhibited the highest photothermal conversion efficiency, making them suitable for NIR fluorescence imaging-guided synergistic therapy.
Article
Engineering, Environmental
Fang Ma et al.
Summary: This study successfully developed a size-tunable nanostructure through supramolecular self-assembly strategy to redress the hypoxic tumor microenvironment and enhance tumor immunotherapy. The results showed that this nano medicine significantly increased drug concentration in tumor cells and restored the drug's action, while maintaining a favorable safety profile.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Oncology
Qinghua Wu et al.
Summary: Hypoxia in the tumor microenvironment weakens cytotoxic T cell function and promotes recruitment of regulatory T cells, thereby reducing tumor immunogenicity. Hypoxia-inducible factors (HIFs), especially HIF1A and HIF2A, play important roles in tumor immune escape through various mechanisms. Understanding these mechanisms can lead to the development of targeted therapies for tumor treatment.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Review
Pharmacology & Pharmacy
Shuwen Fu et al.
Summary: Nanoparticulate drug delivery systems (Nano-DDSs) offer a potential solution to the challenges of anticancer drug delivery. However, limitations such as low drug loading, premature drug leakage, and carrier-related toxicity restrict their clinical outcomes and translation. Recently, pure drug nano-assemblies (PDNAs) have gained considerable attention due to their easy and reproducible preparation technique, addressing quality control, scale-up production, and clinical translation. PDNAs, acting as both carriers and cargos, have ultra-high drug loading and hold promise for combination therapies to overcome issues in cancer treatment such as tumor metastasis and drug resistance.
ACTA PHARMACEUTICA SINICA B
(2022)
Review
Pharmacology & Pharmacy
Quan Gao et al.
Summary: This article discusses the synergistic anticancer effects and related mechanisms of combined therapy using chemotherapeutic drugs and natural compounds, aiming to enhance the efficacy of cancer treatment and reduce adverse consequences. In addition, the design and application of nano drug delivery systems for co-delivery of drugs can also improve anticancer efficacy.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Review
Pharmacology & Pharmacy
Rui Sun et al.
Summary: The enhanced permeability and retention (EPR) effect has been considered the basis of tumor-targeted drug delivery, but its heterogeneity and limitations in clinical practice are now being recognized. Researchers are exploring alternative strategies independent of the EPR effect.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Medicine, Research & Experimental
Shixue Yang et al.
Summary: The study demonstrates that targeted inhibitors can effectively disrupt energy metabolism in GBM and inhibit tumor proliferation.
Review
Chemistry, Multidisciplinary
Yilin Wan et al.
Summary: Photodynamic therapy (PDT) is a promising treatment modality due to its high spatiotemporal selectivity, minimal invasiveness, and low systemic toxicity, however, the hypoxic nature of many solid tumors limits its therapeutic effect. Efforts have been made to increase tumor oxygen content and alleviate tumor hypoxia through various strategies developed in the past decade, including delivering exogenous oxygen, generating oxygen in situ, reducing tumor cellular oxygen consumption, regulating the tumor microenvironment, and inhibiting the hypoxia-inducible factor 1 signaling pathway.
ADVANCED MATERIALS
(2021)
Article
Engineering, Biomedical
Li Huang et al.
Summary: Carrier-free nanodrugs, completely formulated with one or more drugs, have shown great potential in cancer therapy by improving pharmacodynamics/pharmacokinetics, reducing toxicity, and increasing drug loading. Utilizing different preparation strategies, these nanodrugs have demonstrated advantages in various therapeutic modalities, which may pave the way for effective treatments in the future.
Article
Nanoscience & Nanotechnology
Ke Zheng et al.
Summary: In this study, β-cyclodextrins were modified by acetonization to improve drug loading capacity for the chemotherapy drug doxorubicin. The modified cyclodextrins self-assembled into nanoparticles with a photosensitizer for antitumor therapy, showing excellent stability and pH-sensitive drug release characteristics. In vivo experiments demonstrated significant tumor targeting and antitumor activity with minimal side effects.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Pharmacology & Pharmacy
Shiming He et al.
Summary: Esophageal cancer is a common and deadly cancer with two histological subtypes - esophageal squamous cell carcinoma and esophageal adenocarcinoma. Available treatment strategies include surgery, chemotherapy, and molecular targeted therapy, with poor prognosis. This review discusses the latest developments in chemotherapy, molecular targeted therapy, and immunotherapy for esophageal cancer.
ACTA PHARMACEUTICA SINICA B
(2021)
Review
Chemistry, Multidisciplinary
Dapeng Chen et al.
Summary: Photodynamic therapy (PDT) has great potential for tumor treatment, with type I PDT showing superiority over type II PDT in treating hypoxic tumors. Recent research focuses on developing highly effective type I photosensitizers and addressing key challenges in clinical translations of these photosensitizers.
Article
Chemistry, Multidisciplinary
Mingle Li et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Review
Pharmacology & Pharmacy
Yixin Sun et al.
ACTA PHARMACEUTICA SINICA B
(2020)
Review
Engineering, Biomedical
Jianming Chen et al.
Editorial Material
Chemistry, Physical
Subehndu Pandit et al.
Review
Pharmacology & Pharmacy
Jun Cao et al.
ADVANCED DRUG DELIVERY REVIEWS
(2020)
Article
Chemistry, Multidisciplinary
Ya-Tong Fan et al.
ADVANCED FUNCTIONAL MATERIALS
(2019)
Review
Chemistry, Inorganic & Nuclear
Xingshu Li et al.
COORDINATION CHEMISTRY REVIEWS
(2019)
Review
Oncology
Thomas M. Ashton et al.
CLINICAL CANCER RESEARCH
(2018)
Article
Multidisciplinary Sciences
Rahul P. Bakshi et al.
NATURE COMMUNICATIONS
(2018)
Article
Biotechnology & Applied Microbiology
Yaxin Zhang et al.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2017)
