☆ 4.6 Article

Association of epistatic effects of MTHFR, ACE, APOB, and APOE gene polymorphisms with the risk of myocardial infarction and unstable angina in Egyptian patients

GENE (2024)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Cardiac & Cardiovascular Systems

Novel lipid biomarkers and associated gene polymorphism in young ST-segment elevation myocardial infarction

Ghazi Muheeb et al.

Summary: The prevalence of coronary artery disease (CAD) is increasing in younger individuals. Lipid biomarkers and their genetic polymorphisms play an important role in the development of CAD. This study explored the role of lipid biomarkers and genetic polymorphisms in young ST-segment elevation myocardial infarction (STEMI) patients. The results showed that lipid biomarkers (Apo A1, Apo B, PON1) and their genetic polymorphisms are associated with the susceptibility for STEMI in young individuals.

INDIAN HEART JOURNAL (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

Biochemical Association of MTHFR C677T Polymorphism with Myocardial Infarction in the Presence of Diabetes Mellitus as a Risk Factor

Tauqeer Hussain Mallhi et al.

Summary: Myocardial infarction (MI) is a cardiovascular disease caused by coronary artery blockage, leading to cardiac muscle death. The etiology of MI involves environmental, occupational, and genetic factors. Previous studies have shown that different variants of the MTHFR gene are responsible for MI by impacting folate and homocysteine metabolism. This study focuses on investigating the genetic polymorphism of MTHFR C677T (rs1801133) and its association with MI in the presence of diabetes mellitus (DM) as a risk factor. The study found that the T/T homozygous genotype of MTHFR C677T (rs1801133) was significantly associated with MI in patients with DM as a risk factor.

METABOLITES (2023)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Association between ACE I/D genetic polymorphism and the severity of coronary artery disease in Vietnamese patients with acute myocardial infarction

Duy Cong Tran et al.

Summary: This study aimed to investigate the association between ACE I/D genotypes and the severity of coronary artery disease in patients with acute myocardial infarction. The study found that the DD genotype of the ACE I/D polymorphism was independently associated with a higher severity of coronary artery disease.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2023)

添加到收藏夹

Article Genetics & Heredity

Association of integrin-beta 2 polymorphism and expression with the risk of rheumatoid arthritis and osteoarthritis in Egyptian patients

Aliaa M. Selim et al.

Summary: This study evaluated the association of ITGB2 rs2070946 single nucleotide polymorphism with the vulnerability to rheumatoid arthritis (RA) and osteoarthritis (OA), as well as its influence on ITGB2 mRNA expression, and the potential of serum ITGB2 expression in the diagnosis of RA and OA. The results showed that serum ITGB2 mRNA expression was upregulated in RA and OA patients, and ITGB2 rs2070946 was associated with an increased risk of both diseases. Serum ITGB2 expression could be a valuable biomarker for the timely diagnosis of RA and OA.

BMC MEDICAL GENOMICS (2023)

添加到收藏夹

Review Genetics & Heredity

Genetic Risk Factors Related to Coronary Artery Disease and Role of Transforming Growth Factor Beta 1 Polymorphisms

Damian Malinowski et al.

Summary: Coronary artery disease (CAD) is a leading cause of mortality worldwide and has a heritable component. Recent research has made progress in uncovering the genetic factors involved, offering potential for prevention, diagnosis, and treatment. Numerous genes related to lipid and carbohydrate metabolism, endothelial and smooth muscle function, coagulation, and the immune system have been identified as playing a role in CAD. Inflammation, mediated in part by TGF beta 1, is important in the development of CAD.

GENES (2023)

添加到收藏夹

Article Medicine, General & Internal

The LDL-C/Apo B predicts coronary atherosclerotic heart disease in non-diabetic patients without high LDL-C

Hae Won Jung et al.

Summary: The association between Apo B, Apo B/A1 ratio, lipoprotein (a), and LDL-C/Apo B ratio with coronary artery disease (CAD) in non-diabetic patients without high LDL-C levels was unclear. A study was conducted on 487 non-diabetic patients with LDL-C < 130.0 mg/dL to evaluate the most strongly associated parameter with CAD. The LDL-C/Apo B ratio was found to be the most predictive parameter for coronary atherosclerosis in non-diabetic patients without high LDL-C levels.

MEDICINE (2023)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Cis-epistasis at the LPA locus and risk of cardiovascular diseases

Lingyao Zeng et al.

Summary: This study attempts to identify non-additive genetic effects associated with CAD, specifically epistatic interactions. A SNP pair located in cis at the LPA locus was found to be jointly associated with risk for CAD, peripheral arterial disease, aortic stenosis, hepatic lipoprotein(a) levels, and Lp(a) serum levels, while individual SNPs displayed no association. Further exploration revealed a strong dependency on a rare variant influencing risk through additive genetic as well as epistatic effects.

CARDIOVASCULAR RESEARCH (2022)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Analysis of 61 SNPs from the CAD specific genomic loci reveals unique set of SNPs as significant markers in the Southern Indian population of Hyderabad

Manjula Gorre et al.

Summary: This study aims to investigate the genetic susceptibility profile of CAD specifically in the Southern Indian population of Hyderabad by studying the pattern of association of SNPs selected from CAD specific genomic loci.

BMC CARDIOVASCULAR DISORDERS (2022)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Meta-analysis of the association between Apolipoprotein E polymorphism and risks of myocardial infarction

Aiyu Shao et al.

Summary: This meta-analysis study found that individuals with APOE epsilon 2 genotype may have a protective effect against myocardial infarction, while individuals with APOE epsilon 4 genotype may have an increased risk of myocardial infarction.

BMC CARDIOVASCULAR DISORDERS (2022)

添加到收藏夹

Review Genetics & Heredity

Methylenetetrahydrofolate Reductase Polymorphism (rs1801133) and the Risk of Hypertension among African Populations: A Narrative Synthesis of Literature

Sihle E. Mabhida et al.

Summary: This review examines the genetic evidence on the association between the MTHFR gene and hypertension risk in African populations, comparing it to global data. The findings suggest a limited amount of literature on the topic in Africa, particularly among the black African population.

GENES (2022)

添加到收藏夹

Article Genetics & Heredity

Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants

Krishna G. Aragam et al.

Summary: This study identified and characterized over 250 risk loci for coronary artery disease (CAD) through a genome-wide association study, shedding light on the potential causal mechanisms for CAD. The research findings revealed the involvement of early developmental processes, cell cycle signaling, and vascular cell migration and proliferation in the pathogenesis of CAD.

NATURE GENETICS (2022)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Clinical utility of polygenic risk scores for coronary artery disease

Derek Klarin et al.

Summary: In recent years, significant progress has been made in the discovery of genes related to the risk of coronary artery disease, and polygenic risk scores are widely used for predicting disease occurrence and guiding clinical treatment. These scores are also used for screening high-risk patients, identifying treatment-beneficial populations, and designing effective clinical trial protocols.

NATURE REVIEWS CARDIOLOGY (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Apolipoprotein B and Cardiovascular Disease: Biomarker and Potential Therapeutic Target

Jennifer Behbodikhah et al.

Summary: Apolipoprotein B plays a crucial role in atherogenic lipoproteins, with two major isoforms: apoB48 and apoB100. ApoB concentration serves as a direct measure of circulating atherogenic lipoproteins, independent of particle cholesterol content, making it a more accurate indicator of cardiovascular risk than total cholesterol or LDL cholesterol.

METABOLITES (2021)

添加到收藏夹

Review Medicine, General & Internal

Genetics of coronary artery disease in the post-GWAS era

Zhifen Chen et al.

Summary: Over the past decade, genome-wide association studies (GWAS) have significantly expanded our understanding of the genetics of coronary artery disease (CAD). These studies have led to unprecedented discoveries in CAD research, from low-frequency variants to polygenic risk, marking a new era in the field.

JOURNAL OF INTERNAL MEDICINE (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

LncRNA GAS5 and miR-137 Polymorphisms and Expression are Associated with Multiple Sclerosis Risk: Mechanistic Insights and Potential Clinical Impact

Mohmoud A. Senousy et al.

ACS CHEMICAL NEUROSCIENCE (2020)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Statistical and Functional Studies Identify Epistasis of Cardiovascular Risk Genomic Variants From Genome-Wide Association Studies

Yabo Li et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2020)

添加到收藏夹

Article Oncology

Association of SNP-SNP Interactions Between RANKL, OPG, CHI3L1, and VDR Genes With Breast Cancer Risk in Egyptian Women

Olfat G. Shaker et al.

CLINICAL BREAST CANCER (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Genetics of Common, Complex Coronary Artery Disease

Kiran Musunuru et al.

CELL (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Association of MTMR3 rs12537 at miR-181a binding site with rheumatoid arthritis and systemic lupus erythematosus risk in Egyptian patients

Mahmoud A. Senousy et al.

SCIENTIFIC REPORTS (2019)

添加到收藏夹

Review Pathology

Apolipoprotein E in lipoprotein metabolism, health and cardiovascular disease

A. David Marais

PATHOLOGY (2019)

添加到收藏夹

Article Hematology

The Effect of ACE I/D Polymorphisms Alone and With Concomitant Risk Factors on Coronary Artery Disease

Ahmed Amara et al.

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS (2018)

添加到收藏夹

Article Genetics & Heredity

Association of genetic variants of hemostatic genes with myocardial infarction in Egyptian patients

Amal Ahmed Abd El-Fattah et al.

GENE (2018)

添加到收藏夹

Review Genetics & Heredity

Genetics of coronary artery disease: discovery, biology and clinical translation

Amit V. Khera et al.

NATURE REVIEWS GENETICS (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Coronary artery disease-associated genetic variants and biomarkers of inflammation

Morten Krogh Christiansen et al.

PLOS ONE (2017)

添加到收藏夹

Article Cell Biology

Evolution of human apolipoprotein E (APOE) isoforms: Gene structure, protein function and interaction with dietary factors

Patricia Huebbe et al.

AGEING RESEARCH REVIEWS (2017)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Apolipoprotein E gene polymorphism and risk of type 2 diabetes and cardiovascular disease

Dalia El-Lebedy et al.

CARDIOVASCULAR DIABETOLOGY (2016)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Genetics of Coronary Artery Disease

Ruth McPherson et al.

CIRCULATION RESEARCH (2016)

添加到收藏夹

Article Genetics & Heredity

LDLR, ApoB and ApoE genes polymorphisms and classical risk factors in premature coronary artery disease

Tarek A. Abd El-Aziz et al.

GENE (2016)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

C667T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene and susceptibility to myocardial infarction: A systematic review and meta-analysis

Shahab Alizadeh et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2016)

添加到收藏夹

Article Medicine, Research & Experimental

Association of C677T MTHFR and G20210A FII prothrombin polymorphisms with susceptibility to myocardial infarction

Wiam Hmimech et al.

BIOMEDICAL REPORTS (2016)

添加到收藏夹

Article Genetics & Heredity

Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: Epidemiology, metabolism and the associated diseases

Siaw-Cheok Liew et al.

EUROPEAN JOURNAL OF MEDICAL GENETICS (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

Association between Apolipoprotein E polymorphism and myocardial infarction risk: A systematic review and meta-analysis

Yi-Lian Wang et al.

FEBS OPEN BIO (2015)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Relation between Apolipoprotein E Gene Polymorphism and Severity of Coronary Artery Disease in Acute Myocardial Infarction

Zulkuf Karahan et al.

CARDIOLOGY RESEARCH AND PRACTICE (2015)

添加到收藏夹

Article Peripheral Vascular Disease

Apolipoprotein B/Apolipoprotein A-I Ratio and Apolipoprotein B: Long-Term Predictors of Myocardial Infarction in Initially Healthy Middle-Aged Men-a 13-Year Follow-Up

Caroline Schmidt et al.

ANGIOLOGY (2014)

添加到收藏夹

Article Biochemistry & Molecular Biology

Association of Genetic Variants of MTHFR, ENPP1, and ADIPOQ with Myocardial Infarction in Egyptian Patients

Olfat Gamil Shaker et al.

CELL BIOCHEMISTRY AND BIOPHYSICS (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Meta-Analysis of Apolipoprotein E Gene Polymorphism and Susceptibility of Myocardial Infarction

Hong Xu et al.

PLOS ONE (2014)

添加到收藏夹

Article Medicine, Research & Experimental

Apo E Gene Polymorphism Affects Development of Type 2 Diabetic Nephropathy in Asian Populations, Especially in East Asians: An Updated Meta-Analysis

Yao-jun Wu

MEDICAL SCIENCE MONITOR (2014)

添加到收藏夹

Article Biochemistry & Molecular Biology

Angiotensin-Converting Enzyme Inhibition and Angiotensin AT1 Receptor Blockade Downregulate Angiotensin-Converting Enzyme Expression and Attenuate Renal Injury in Streptozotocin-Induced Diabetic Rats

Tarek K. Motawi et al.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2013)

添加到收藏夹

Review Public, Environmental & Occupational Health

World Health Organization definition of myocardial infarction: 2008-09 revision

Shanthi Mendis et al.

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2011)

添加到收藏夹

Article Chemistry, Multidisciplinary

Exploring epistatic relationships of NO biosynthesis pathway genes in susceptibility to CHD

Yuan-chao Tu et al.

ACTA PHARMACOLOGICA SINICA (2010)

添加到收藏夹

Article Endocrinology & Metabolism

Diagnosis and Classification of Diabetes Mellitus

DIABETES CARE (2010)

添加到收藏夹

Article Medicine, General & Internal

APOE Genotype, Lipids, and Coronary Heart Disease Risk A Prospective Population Study

Heather Ward et al.

ARCHIVES OF INTERNAL MEDICINE (2009)

添加到收藏夹

Article Peripheral Vascular Disease

Angiotensin-converting enzyme gene insertion/deletion polymorphism in Egyptian patients with myocardial infarction

Ahmad Settin et al.

JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM (2009)

添加到收藏夹

Article Hematology

Four SNPs on chromosome 9p21 in a South Korean population implicate a genetic locus that confers high cross-race risk for development of coronary artery disease

Gong-Qing Shen et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2008)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Glycated apolipoprotein B and myocardial infarction

G. Misciagna et al.

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2007)

添加到收藏夹

Article Hematology

Epistatic and pleiotropic effects of polymorphisms in the fibrinogen and coagulation factor XIII genes on plasma fibrinogen concentration, fibrin gel structure and risk of myocardial infarction

MN Mannila et al.

THROMBOSIS AND HAEMOSTASIS (2006)

添加到收藏夹

Review Genetics & Heredity

Investigating the genetic determinants of cardiovascular disease using candidate genes and meta-analysis of association studies

JP Casas et al.

ANNALS OF HUMAN GENETICS (2006)

添加到收藏夹

Article Medicine, General & Internal

Angiotensin-converting enzyme insertion/deletion genotype, exercise, and physical decline

SB Kritchevsky et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2005)

添加到收藏夹

Article Nutrition & Dietetics

Gene-nutrient interactions and DNA methylation

S Friso et al.

JOURNAL OF NUTRITION (2002)

添加到收藏夹

Article Genetics & Heredity

Heritabilities of apolipoprotein and lipid levels in three countries

M Beekman et al.

TWIN RESEARCH (2002)

添加到收藏夹

Article Peripheral Vascular Disease

ACE D/I polymorphism and incidence of post-PTCA restenosis -: A prospective, angiography-based evaluation

RYL Zee et al.

HYPERTENSION (2001)

添加到收藏夹

Article Hematology

ACE gene polymorphism in cardiovascular disease -: Meta-analyses of small and large studies in whites

B Agerholm-Larsen et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2000)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.