☆ 4.6 Article

The use of polymorphic state modifiers in solid lipid microparticles: The role of structural modifications on drug release performance

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2024)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Pharmacology & Pharmacy

Control of API release with matrix polymorphism in tristearin microspheres

Amanda M. Pluntze et al.

Summary: Glycerides are commonly used as solid matrices in pharmaceutical intermediates and dosage forms. The release of drugs from these matrices is controlled by diffusion-based mechanisms, with chemical and crystal polymorph differences of the lipid matrix influencing the release rates. This study focuses on the impacts of tristearin polymorphism on drug release using model formulations containing crystalline caffeine. The results show that the release rates are influenced by the polymorphic states of tristearin and the conversion routes between them. The findings provide valuable insights for formulators in understanding the impacts of triglyceride polymorphism on drug release rates.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2023)

添加到收藏夹

Article Medicine, Research & Experimental

Phase Behavior of Drug-Lipid-Surfactant Ternary Systems toward Understanding the Annealing-Induced Change

Varun Kushwah et al.

Summary: This study systematically investigated the effect of annealing conditions and Kolliphor P 407 content on the physicochemical and structural properties of solid-lipid formulations. The researchers found that the polymorphic transformation of Compritol was dependent on the Kolliphor P 407 content and identified higher miscibility in certain binary mixtures. The observed higher miscibility of Kolliphor P 407 with specific components was proposed as the trigger for physical separation during melt solidification, with phase separation underlying the formation of a stable beta-polymorphic form of Compritol upon annealing.

MOLECULAR PHARMACEUTICS (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

Impact of Surface Properties of Core Material on the Stability of Hot Melt-Coated Multiparticulate Systems

Sonja Schertel et al.

Summary: The study investigated the interaction between active pharmaceutical ingredients (APIs) and lipid-based coating, as well as their changes during storage. Experimental results on surface properties of APIs, coating composition, water sorption alteration of coated particles, crystal growth of lipids in the coating, and cleavage work necessary to overcome coating adhesion provided insights into addressing drug release instability challenges.

PHARMACEUTICS (2021)

添加到收藏夹

Article Food Science & Technology

Solid lipid microparticles loaded with ascorbic acid: Release kinetic profile during thermal stability

Juliana Domingues dos Santos Carvalho et al.

Summary: This study investigated the stability of solid lipid microparticles loaded with ascorbic acid under thermal cyclization conditions. The results showed that the particles were stable during the 45 days of storage, with controlled release and retention rates ranging from 74.25% to 83.07%. The polymorphic analysis revealed that beta' crystals were predominant in all formulations studied.

JOURNAL OF FOOD PROCESSING AND PRESERVATION (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Impact of polysorbate 65 on tripalmitin crystal growth and release stability of hot melt coated multiparticulate systems

Sonja Schertel et al.

Summary: This study examined the effect of PS 65 concentration on the crystal growth of PPP, with low concentrations promoting crystal growth and resulting in a slow release of HCT, while high concentrations led to phase separation of PPP and PS 65, accelerating the release. The increase in PS 65 reinforced the molecular interaction with HCT, leading to less crystal growth and a slower release from the coating.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Strain and Grain Size Determination of CeO2 and TiO2 Nanoparticles: Comparing Integral Breadth Methods versus Rietveld, μ-Raman, and TEM

Yamerson Canchanya-Huaman et al.

Summary: This study used various methods to analyze X-ray diffractograms of spherical cerium dioxide and titanium dioxide anatase nanoparticles, aiming to evaluate their reliability and limitations. Through integral breadth methods, linear regression analysis, and the Rietveld whole powder pattern decomposition method, accurate crystallite sizes and microstructural parameters were obtained.

NANOMATERIALS (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Liquid Lipids Act as Polymorphic Modifiers of Tristearin-Based Formulations Produced by Melting Technologies

Serena Bertoni et al.

Summary: This study evaluated the impact of different oral-approved liquid lipids on the polymorphism, phase transitions, and structure of solid lipid-based formulations, and their influence on drug release. The addition of liquid lipids was found to promote the transition of tristearin from the alpha-form to the stable beta-form, affecting the crystal structure of tristearin-based formulations and influencing the release behavior of a model hydrophilic drug. Overall, the addition of liquid lipids can be considered an interesting approach to control triglyceride crystallization in the beta-form, enabling the production of stable lipid formulations.

PHARMACEUTICS (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Evolution of the microstructure and the drug release upon annealing the drug loaded lipid-surfactant microspheres

Varun Kushwah et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2020)

添加到收藏夹

Article Medicine, Research & Experimental

Solid Lipid Microparticles for Oral Delivery of Catalase: Focus on the Protein Structural Integrity and Gastric Protection

Serena Bertoni et al.

MOLECULAR PHARMACEUTICS (2020)

添加到收藏夹

Article Biophysics

An investigation into the release behavior of solid lipid microparticles in different simulated gastrointestinal fluids

Beatrice Albertini et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Effect of the Nano Crystal Size on the X-ray Diffraction Patterns of Biogenic Hydroxyapatite from Human, Bovine, and Porcine Bones

Sandra M. Londono-Restrepo et al.

SCIENTIFIC REPORTS (2019)

添加到收藏夹

Article Pharmacology & Pharmacy

Long-term release and stability of pharmaceutical proteins delivered from solid lipid implants

Moritz Vollrath et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2017)

添加到收藏夹

Article Pharmacology & Pharmacy

Microphase separation in solid lipid dosage forms as the cause of drug release instability

Diogo Gomes Lopes et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2017)

添加到收藏夹

Article Pharmacology & Pharmacy

Advanced stable lipid-based formulations for a patient-centric product design

Karin Becker et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2016)

添加到收藏夹

Article Chemistry, Medicinal

Role of Lipid Blooming and Crystallite Size in the Performance of Highly Soluble Drug-Loaded Microcapsules

Diogo G. Lopes et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2015)

添加到收藏夹

Review Food Science & Technology

Nanostructured Fat Crystal Systems

Nuria C. Acevedo et al.

ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 6 (2015)

添加到收藏夹

Article Pharmacology & Pharmacy

Assessment of enzymatic prodrug stability in human, dog and simulated intestinal fluids

A. S. Borde et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2012)

添加到收藏夹

Article Chemistry, Multidisciplinary

Unsaturated Emulsifier-Mediated Modification of the Mechanical Strength and Oil Binding Capacity of a Model Edible Fat Crystallized under Shear

Nuria C. Acevedo et al.

LANGMUIR (2012)

添加到收藏夹

Review Pharmacology & Pharmacy

The Use of Biorelevant Dissolution Media to Forecast the In Vivo Performance of a Drug

Sandra Klein

AAPS JOURNAL (2010)

添加到收藏夹

Article Chemistry, Medicinal

Solid Lipid Microparticles Produced by Spray Congealing: influence of the Atomizer on Microparticle Characteristics and Mathematical Modeling of the Drug Release

Nadia Passerini et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2010)

添加到收藏夹

Article Pharmacology & Pharmacy

Design and in vitro/in vivo evaluation of novel nicorandil extended release matrix tablets based on hydrophilic interpolymer complexes and a hydrophobic waxy polymer

Ghada Ahmed Abdelbary et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2008)

添加到收藏夹

Article Chemistry, Physical

Spontaneous formation of fractal structures on triglyceride surfaces with reference to their super water-repellent properties

Wenjun Fang et al.

JOURNAL OF PHYSICAL CHEMISTRY B (2007)

添加到收藏夹

Article Pharmacology & Pharmacy

Solid lipid microparticles as a sustained release system for pulmonary drug delivery

Severine Jaspart et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2007)

添加到收藏夹

Article Thermodynamics

DSC and high resolution X-ray diffraction coupling

M. Ollivon et al.

JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY (2006)

添加到收藏夹

Article Food Science & Technology

Systematic investigation of lard polymorphism using combined DSC and time-resolved synchrotron X-ray diffraction

D Kalnin et al.

EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY (2005)

添加到收藏夹

Article Chemistry, Medicinal

Role of blooming in determining the storage stability of lipid-based dosage forms

N Khan et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2004)

添加到收藏夹

Article Chemistry, Physical

Effect of degree, type, and position of unsaturation on the pKa of long-chain fatty acids

JR Kanicky et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2002)

添加到收藏夹

Article Chemistry, Multidisciplinary

Structure of β-trimyristin and β-tristearin from high-resolution X-ray powder diffraction data

A van Langevelde et al.

ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE CRYSTAL ENGINEERING AND MATERIALS (2001)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.