期刊
ADVANCED THERAPEUTICS
卷 -, 期 -, 页码 -出版社
WILEY
DOI: 10.1002/adtp.202300330
关键词
drug delivery; nanoparticle; pancreatic cancer; stimuli-responsive; therapeutics
Pancreatic cancer treatment is hindered by the complex tumor microenvironment, but the emergence of stimuli-responsive nanomaterials presents a promising avenue for targeted drug delivery. These nanomaterials can intelligently and selectively respond to external and internal stimuli, promoting drug accumulation and release in pancreatic cancer tissue for enhanced therapeutic efficacy.
Pancreatic cancer is characterized by a high mortality rate and unfavorable prognosis. This is primarily attributed to poor accumulation of therapeutic agents at the target site due to the presence of a highly complex tumor microenvironment surrounding the pancreatic cancer tissue. However, a promising avenue for targeted drug delivery has emerged in the form of stimuli-responsive materials. These advanced nanocarriers, encompassing both external and internal stimuli-responsive nanoparticles, can be formulated to control the release of therapeutic agents precisely in response to specific activation. By harnessing external stimuli such as light, ultrasound, or magnetic fields, as well as intrinsic biological triggers including pH, redox potential, hypoxia, and temperature, these nanomaterials exhibit 'intelligent' and selective responses within complex biological environments. These responsive nanoparticles have been shown to address challenges associated with poor vascularity and thick desmoplastic stromal layers, which are hallmarks of pancreatic cancer, by promoting enhanced drug accumulation and release at the target site relative to conventional therapy. This work explores the design strategies for advanced stimuli-responsive nanomaterials, integrating both internal and external stimuli, with the potential to enhance drug delivery efficacy in pancreatic cancer. It addresses the challenges and prospects in their development and offers insights for future clinical applications. Pancreatic cancer treatment has the potential to be transformed through the adoption of stimuli-responsive materials as therapeutics. Here, it is examined how materials can be designed to respond to external stimuli, such as ultrasound, light, and magnetic fields, and internal factors, including pH changes, redox imbalances, and enzymatic activity, to afford precise control of drug delivery and enhanced therapeutic efficacy.image
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