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Lessons from genomic profiling: towards a molecular-based classification of ovarian Sertoli-Leydig cell tumour

HISTOPATHOLOGY (2023)

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Article Pathology

Well-differentiated Sertoli-Leydig Cell Tumors (SLCTs) Are Not Associated With DICER1 Pathogenic Variants and Represent a Different Tumor Type to Moderately and Poorly Differentiated SLCTs

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Summary: In this study, DICER1 molecular testing was performed on 18 cases of well-differentiated SLCT, and all were found to be DICER1 wild-type. Based on the molecular and morphological observations, it is suggested that well-differentiated SLCT is a distinct and unrelated tumor type in the ovarian sex cord-stromal tumor family, separate from the more common moderately/poorly differentiated and retiform SLCTs.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2023)

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DICER1 and FOXL2 Mutation Status Correlates With Clinicopathologic Features in Ovarian Sertoli-Leydig Cell Tumors

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INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY (2018)

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DICER1 hotspot mutations in ovarian Sertoli-Leydig cell tumors: a potential association with androgenic effects

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HUMAN PATHOLOGY (2017)

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DICER1 Mutations Are Consistently Present in Moderately and Poorly Differentiated Sertoli-Leydig Cell Tumors

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AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2017)

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Agustin F. Fernandez et al.

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NEW ENGLAND JOURNAL OF MEDICINE (2012)

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FOXL2 Is a Sensitive and Specific Marker for Sex Cord-Stromal Tumors of the Ovary

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Kris Ann P. Schultz et al.

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Mutation of FOXL2 in Granulosa-Cell Tumors of the Ovary

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NEW ENGLAND JOURNAL OF MEDICINE (2009)

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