Iridium-catalyzed asymmetric, complete hydrogenation of pyrimidinium salts under batch and flow

A highly enantioselective method for the complete hydrogenation of pyrimidinium salts using Ir/(S,S)-f-Binaphane complex as the catalyst was presented in this study. This approach affords facile access to a range of fully saturated chiral hexahydropyrimidines, which are prevalent in many bioactive molecules. The reactions showcase high yields and enantioselectivities under mild reaction conditions without additives. Successful application of this methodology in a continuous flow fashion further broadened its practical utility. A highly enantioselective method for the complete hydrogenation of pyrimidinium salts using Ir/(S,S)-f-Binaphane complex as the catalyst was developed under batch and flow.

Automated summary

A highly enantioselective method for the complete hydrogenation of pyrimidinium salts using Ir/(S,S)-f-Binaphane complex as the catalyst was developed. This method provides easy access to fully saturated chiral hexahydropyrimidines, which are prevalent in many bioactive molecules. The reactions exhibit high yields and enantioselectivities under mild reaction conditions without additives. Successful application of this methodology in a continuous flow fashion further extends its practical utility.