期刊
EUROPACE
卷 25, 期 12, 页码 -出版社
OXFORD UNIV PRESS
DOI: 10.1093/europace/euad358
关键词
Chronotropic incompetence; Closed-loop stimulation; Cardiopulmonary exercise testing; Peak oxygen uptake; Exercise capacity
This study compared the effectiveness of closed-loop stimulation (CLS) pacing with traditional DDD mode pacing in patients with chronotropic incompetence (CI). The results showed that CLS pacing significantly improved exercise capacity and quality of life in these patients, highlighting its potential as an effective pacing strategy.
Aims This study aimed to investigate the effectiveness of closed-loop stimulation (CLS) pacing compared with the traditional DDD mode in patients with chronotropic incompetence (CI) using bicycle-based cardiopulmonary exercise testing (CPET).Methods and results This single-centre, randomized crossover trial involved 40 patients with CI. Patients were randomized to receive either DDD-CLS or DDD mode pacing for 2 months, followed by a crossover to the alternative mode for an additional 2 months. Bicycling-based CPET was conducted at the 3- and 5-month follow-up visits to assess exercise capacity. Other cardiopulmonary exercise outcome measures and health-related quality of life (QoL) were also assessed. DDD-CLS mode pacing significantly improved exercise capacity, resulting in a peak oxygen uptake (14.8 +/- 4.0 vs. 12.0 +/- 3.6 mL/kg/min, P < 0.001) and oxygen uptake at the ventilatory threshold (10.0 +/- 2.2 vs. 8.7 +/- 1.8 mL/kg/min, P < 0.001) higher than those of the DDD mode. However, there were no significant differences in other cardiopulmonary exercise outcome measures such as ventilatory efficiency of carbon dioxide production slope, oxygen uptake efficiency slope, and end-tidal carbon dioxide between the two modes. Patients in the DDD-CLS group reported a better QoL, and 97.5% expressed a preference for the DDD-CLS mode.Conclusion DDD-CLS mode pacing demonstrated improved exercise capacity and QoL in patients with CI, highlighting its potential as an effective pacing strategy for this patient population.
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