Epigenetic inhibition of CTCF by HN1 promotes dedifferentiation and stemness of anaplastic thyroid cancer

Article Oncology

IGF2BP2-dependent activation of ERBB2 signaling contributes to acquired resistance to tyrosine kinase inhibitor in differentiation therapy of radioiodine-refractory papillary thyroid cancer

Ri Sa et al.

Summary: Study demonstrates that IGF2BP2-dependent ERBB2 signaling activation contributes to acquired resistance to TKI, showing promising differentiation strategy for RR-PTC by targeting IGF2BP2.

CANCER LETTERS (2022)

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Review Biochemistry & Molecular Biology

Structural alteration of the nucleus for the reprogramming of gene expression

Junko Tomikawa et al.

Summary: The regulation of gene expression is crucial for cellular identity, controlled through a chromatin mechanism in the nucleus. Recent studies show that chromatin accessibility and high-order structure impact transcriptional outcomes, especially during development and reprogramming. Additionally, non-chromosomal nucleoskeleton proteins in the cell nucleus can also alter transcription through chromatin and nuclear structure interactions, with unresolved questions in the field.

FEBS JOURNAL (2022)

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Article Cell Biology

NR4A1 promotes LEF1 expression in the pathogenesis of papillary thyroid cancer

Cen Jiang et al.

Summary: NR4A1 is strongly associated with poor survival outcomes in papillary thyroid cancer (PTC) patients, and it promotes the proliferation of PTC cells by regulating the expression of the LEF1 gene, indicating its potential role as a driving factor in PTC pathogenesis and progression.

CELL DEATH DISCOVERY (2022)

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Article Oncology

TRF2 cooperates with CTCF for controlling the oncomiR-193b-3p in colorectal cancer

Roberto Dinami et al.

Summary: TRF2, a key protein involved in telomere integrity, has been found to regulate the expression of miRNAs and affect tumor development. The cooperation between TRF2 and CTCF is required for the control of miR-193b-3p expression, which in turn affects tumor cell proliferation and transcription. The association between TRF2 and miR-193b-3p has prognostic value in patients.

CANCER LETTERS (2022)

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Review Oncology

Functional genomic approaches in acute myeloid leukemia: Insights into disease models and the therapeutic potential of reprogramming

Shyam A. Patel

Summary: Recent advances in functional genomics, including iPS cell technology and CRISPR gene editing, have improved disease modeling for hematologic malignancies and provided insights into molecular characteristics and clonal dynamics, offering potential for novel therapeutic targets.

CANCER LETTERS (2022)

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Article Biochemistry & Molecular Biology

The HN1/HMGB1 axis promotes the proliferation and metastasis of hepatocellular carcinoma and attenuates the chemosensitivity to oxaliplatin

Ruhua Wang et al.

Summary: The study identified the close association between the overexpression of HN1 and adverse outcomes in hepatocellular carcinoma (HCC) patients. HN1 was found to promote the proliferation, migration, and invasion of HCC cells in vitro and increase the sensitivity of HCC cells to oxaliplatin. Mechanistically, HN1 prevented the degradation of HMGB1 protein through the autophagy-lysosome pathway, resulting in increased DNA damage and cell death in oxaliplatin-treated HCC cells. The study suggests that the HN1/HMGB1 axis may be a promising therapeutic target for HCC treatment.

FEBS JOURNAL (2022)

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Review Oncology

Molecular features of aggressive thyroid cancer

Giusy Elia et al.

Summary: Poorly differentiated thyroid cancer (PDTC) and anaplastic thyroid cancer (ATC) have worse prognosis and loss of I-131 uptake capability in aggressive thyroid cancer. Understanding the genomic landscape of thyroid cancer can help discover alterations underlying advanced diseases and develop tailored therapies.

FRONTIERS IN ONCOLOGY (2022)

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Article Oncology

Inhibition of Arid1a increases stem/progenitor cell-like properties of liver cancer

Lan Wang et al.

Summary: Arid1a deficiency may contribute to liver cancer development by dysregulating gene expression and increasing the number of stem/progenitor-like cells.

CANCER LETTERS (2022)

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Review Biochemistry & Molecular Biology

CTCF shapes chromatin structure and gene expression in health and disease

Bondita Dehingia et al.

Summary: CCCTC-binding factor (CTCF) is a multivalent transcriptional regulator that can impact gene expression through multiple mechanisms, including direct transcriptional regulation and control of the three-dimensional structure of the genome and chromatin domains. The binding and architectural functions of CTCF are regulated, and it can act as an insulator and facilitate interactions between regulatory elements to control gene expression.

EMBO REPORTS (2022)

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Article Biochemistry & Molecular Biology

CREB3L1 promotes tumor growth and metastasis of anaplastic thyroid carcinoma by remodeling the tumor microenvironment

Zongfu Pan et al.

Summary: CREB3L1 is upregulated in anaplastic thyroid carcinoma and negatively associated with patient survival. Knockdown of CREB3L1 inhibits invasion of ATC cells, while its overexpression promotes invasion of papillary thyroid carcinoma cells. Additionally, CREB3L1 maintains cancer-associated fibroblast-like properties in ATC cells by activating ECM signaling.

MOLECULAR CANCER (2022)

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Article Cell Biology

CTCF organizes inter-A compartment interactions through RYBP-dependent phase separation

Chao Wei et al.

Summary: This study reveals a novel role of CTCF in organizing long-range chromatin interactions, where CTCF phase separation mediated by RYBP promotes inter-A compartment interactions and enhances the self-renewal ability of embryonic stem cells.

CELL RESEARCH (2022)

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Article Biochemistry & Molecular Biology

FOXE1 Gene Dosage Affects Thyroid Cancer Histology and Differentiation In Vivo

Sara C. Credendino et al.

Summary: Reduced FOXE1 gene dosage affects the phenotype of thyroid cancer by altering cancer characteristics and regulating key markers of tumor differentiation and progression, suggesting FOXE1 may act as a lineage-specific oncogene in follicular cell-derived thyroid cancer.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Multidisciplinary Sciences

CTCF and EGR1 suppress breast cancer cell migration through transcriptional control of Nm23-H1

Ka Ming Wong et al.

Summary: Nm23-H1 is a metastasis suppressor protein whose expression is regulated by transcription factors like CTCF and EGR1, potentially affecting the invasion and metastasis of breast cancer.

SCIENTIFIC REPORTS (2021)

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Article Oncology

HN1 promotes tumor growth and metastasis of anaplastic thyroid carcinoma by interacting with STMN1

Zongfu Pan et al.

Summary: The study demonstrated that HN1 plays a crucial role in promoting the aggressiveness of ATC by enhancing migration, invasion, and epithelial-mesenchymal transition. It also interacts with STMN1 to drive the aggressive properties of ATC cells.

CANCER LETTERS (2021)

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Article Multidisciplinary Sciences

NKX2-1 re-expression induces cell death through apoptosis and necrosis in dedifferentiated thyroid carcinoma cells

Yuko Ito et al.

Summary: NKX2-1, a crucial thyroid transcription factor, induces cell death through apoptosis and necrosis when re-expressed in thyroid cancer cells, with involvement of genes like RGS4 in regulating cell survival and death processes.

PLOS ONE (2021)

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Review Biochemistry & Molecular Biology

Role of Regulatory Non-Coding RNAs in Aggressive Thyroid Cancer: Prospective Applications of Neural Network Analysis

Asumi Iesato et al.

Summary: Thyroid cancer (TC) is the most common endocrine malignancy, with most TCs having a favorable prognosis, while anaplastic thyroid carcinoma (ATC) is a lethal form of cancer. Non-coding RNAs (ncRNAs) play a crucial role in coordinating gene regulatory networks (GRNs) in cancer, and deep neural network analysis could potentially predict and detect TC through ncRNA molecular language. Validation of these analyses may lead to more effective and precise targeted therapies against aggressive TC.

MOLECULES (2021)

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Article Multidisciplinary Sciences

CTCF is a barrier for 2C-like reprogramming

Teresa Olbrich et al.

Summary: The CCCTC-binding factor (CTCF) acts as a barrier for 2C-like reprogramming, while transcriptional activation of the ZSCAN4 cluster is necessary for successful conversion to a 2C-like state.

NATURE COMMUNICATIONS (2021)

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Article Biochemistry & Molecular Biology

CRSP8 promotes thyroid cancer progression by antagonizing IKKα-induced cell differentiation

Yina Liao et al.

Summary: CRSP8 acts as a modulator of IKK alpha signaling and a suppressor of thyroid cancer differentiation, demonstrating potential therapeutic strategy for ATC. Knockdown of CRSP8 inhibits cell growth and invasion while inducing apoptosis and differentiation in thyroid cancer cells. The CRSP8/IKK alpha pathway may be a promising target for ATC treatment.

CELL DEATH AND DIFFERENTIATION (2021)

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Article Multidisciplinary Sciences

The structural basis for cohesin-CTCF-anchored loops

Yan Li et al.

NATURE (2020)

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Article Oncology

SETD5-Coordinated Chromatin Reprogramming Regulates Adaptive Resistance to Targeted Pancreatic Cancer Therapy

Zhentian Wang et al.

CANCER CELL (2020)

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Review Cell Biology

CTCF and CTCFL in cancer

Roxanne E. Debaugny et al.

CURRENT OPINION IN GENETICS & DEVELOPMENT (2020)

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Article Multidisciplinary Sciences

Transcriptional activation during cell reprogramming correlates with the formation of 3D open chromatin hubs

Marco Di Stefano et al.

NATURE COMMUNICATIONS (2020)

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Article Oncology

Evaluation of Overall Survival in Patients With Anaplastic Thyroid Carcinoma, 2000-2019

Anastasios Maniakas et al.

JAMA ONCOLOGY (2020)

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Article Medicine, Research & Experimental

Gastric cancer mesenchymal stem cells regulate PD-L1-CTCF enhancing cancer stem cell-like properties and tumorigenesis

Li Sun et al.

THERANOSTICS (2020)

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Review Cell Biology

Roles of CTCF in conformation and functions of chromosome

Fangming Liu et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2019)

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Review Oncology

Chromatin reprogramming as an adaptation mechanism in advanced prostate cancer

Peder Rustoen Braadland et al.

ENDOCRINE-RELATED CANCER (2019)

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Article Biochemistry & Molecular Biology

WebGestalt 2019: gene set analysis toolkit with revamped UIs and APIs

Yuxing Liao et al.

NUCLEIC ACIDS RESEARCH (2019)

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Article Multidisciplinary Sciences

The regulatory landscape of a core maize domestication module controlling bud dormancy and growth repression

Zhaobin Dong et al.

NATURE COMMUNICATIONS (2019)

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Article Oncology

SIX1 Activates STAT3 Signaling to Promote the Proliferation of Thyroid Carcinoma via EYA1

Deguang Kong et al.

FRONTIERS IN ONCOLOGY (2019)

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Article Oncology

NKX2.5 is expressed in papillary thyroid carcinomas and regulates differentiation in thyroid cells

Ricardo Cortez Cardoso Penha et al.

BMC CANCER (2018)

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Article Oncology

Bivalent Chromatin Domains in Glioblastoma Reveal a Subtype-Specific Signature of Glioma Stem Cells

Amelia Weber Hall et al.

CANCER RESEARCH (2018)

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Article Biochemistry & Molecular Biology

Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation

Tathiane M. Malta et al.

CELL (2018)

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Article Oncology

Genetic Analysis of 779 Advanced Differentiated and Anaplastic Thyroid Cancers

Nikita Pozdeyev et al.

CLINICAL CANCER RESEARCH (2018)

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Chromatin reprogramming in breast cancer

Erin E. Swinstead et al.

ENDOCRINE-RELATED CANCER (2018)

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Article Pathology

LEF-1 is a Sensitive Marker of Cribriform Morular Variant of Papillary Thyroid Carcinoma

Shalini Mohindra et al.

HEAD & NECK PATHOLOGY (2018)

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Article Biochemistry & Molecular Biology

HN1 contributes to migration, invasion, and tumorigenesis of breast cancer by enhancing MYC activity

Chen Zhang et al.

MOLECULAR CANCER (2017)

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Letter Biotechnology & Applied Microbiology

Firmiana: towards a one-stop proteomic cloud platform for data processing and analysis

Jinwen Feng et al.

NATURE BIOTECHNOLOGY (2017)

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Review Endocrinology & Metabolism

Anaplastic thyroid carcinoma: from clinicopathology to genetics and advanced therapies

Eleonora Molinaro et al.

NATURE REVIEWS ENDOCRINOLOGY (2017)

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Article Endocrinology & Metabolism

Genomic Landscape of poorly Differentiated and Anaplastic Thyroid Carcinoma

Bin Xu et al.

ENDOCRINE PATHOLOGY (2016)

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Article Medicine, Research & Experimental

Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers

Inigo Lancia et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

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Article Medicine, Research & Experimental

Cancer stem-like cell behavior in anaplastic thyroid cancer: A challenging dilemma

Vahid Haghpanah et al.

LIFE SCIENCES (2016)

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Article Endocrinology & Metabolism

Aberrant Lipid Metabolism in Anaplastic Thyroid Carcinoma Reveals Stearoyl CoA Desaturase 1 as a Novel Therapeutic Target

Christina A. von Roemeling et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2015)

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A role for cancer stem cells in therapy resistance: Cellular and molecular mechanisms

Monica Cojoc et al.

SEMINARS IN CANCER BIOLOGY (2015)

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Review Endocrinology & Metabolism

Thyroid transcription factors in development, differentiation and disease

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NATURE REVIEWS ENDOCRINOLOGY (2015)

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STRING v10: protein-protein interaction networks, integrated over the tree of life

Damian Szklarczyk et al.

NUCLEIC ACIDS RESEARCH (2015)

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Article Biochemical Research Methods

Trimmomatic: a flexible trimmer for Illumina sequence data

Anthony M. Bolger et al.

BIOINFORMATICS (2014)

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Article Biochemistry & Molecular Biology

Integrated Genomic Characterization of Papillary Thyroid Carcinoma

Nishant Agrawal et al.

CELL (2014)

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Review Endocrinology & Metabolism

Pax-8-PPAR-γ fusion protein in thyroid carcinoma

Priyadarshini Raman et al.

NATURE REVIEWS ENDOCRINOLOGY (2014)

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Article Oncology

A gene expression signature distinguishes normal tissues of sporadic and radiation-induced papillary thyroid carcinomas

G. Dom et al.

BRITISH JOURNAL OF CANCER (2012)

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American Thyroid Association Guidelines for Management of Patients with Anaplastic Thyroid Cancer

Robert C. Smallridge et al.

THYROID (2012)

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Hematological- and Neurological-Expressed Sequence 1 Gene Products in Progenitor Cells during Newt Retinal Development

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STEM CELLS INTERNATIONAL (2012)

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MafB Interacts With Gcm2 and Regulates Parathyroid Hormone Expression and Parathyroid Development

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JOURNAL OF BONE AND MINERAL RESEARCH (2011)

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Review Cell Biology

Open chromatin in pluripotency and reprogramming

Alexandre Gaspar-Maia et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2011)

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Hematopoietic- and neurologic-expressed sequence 1 (Hn1) depletion in B16.F10 melanoma cells promotes a differentiated phenotype that includes increased melanogenesis and cell cycle arrest

Katharine M. Laughlin et al.

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Article Ophthalmology

Induced expression of hematopoietic- and neurologic-expressed sequence 1 in retinal pigment epithelial cells during newt retina regeneration

Tatsushi Goto et al.

EXPERIMENTAL EYE RESEARCH (2006)

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Jupiter, a new Drosophila protein associated with microtubules

N Karpova et al.

CELL MOTILITY AND THE CYTOSKELETON (2006)

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The facial motor nucleus transcriptional program in response to peripheral nerve injury identifies Hn1 as a regeneration-associated gene

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JOURNAL OF NEUROSCIENCE RESEARCH (2005)

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Targeted expression of BRAFV600E in thyroid cells of transgenic mice results in papillary thyroid cancers that undergo dedifferentiation

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CANCER RESEARCH (2005)

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Epigenetic inhibition of CTCF by HN1 promotes dedifferentiation and stemness of anaplastic thyroid cancer

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