Long-term outcomes of neo-adjuvant chemotherapy on borderline resectable oral cavity cancers: Real-world data of 3266 patients and implications for clinical practice

Article Oncology

Assessment of neoadjuvant chemotherapy with docetaxel, cisplatin, and fluorouracil in patients with oral cavity cancer

Jin Ye Fu et al.

Summary: The response of neoadjuvant TPF chemotherapy in patients with oral cavity cancer is related to disease stage, especially the nodal stage. Patients with complete or partial response have fewer progression events and better survival.

CANCER MEDICINE (2023)

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Article Oncology

Pembrolizumab With or Without Chemotherapy in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma: Updated Results of the Phase III KEYNOTE-048 Study

Kevin J. Harrington et al.

Summary: The study presents a post hoc analysis of the long-term efficacy and progression-free survival in recurrent/metastatic head and neck squamous cell carcinoma patients treated with pembrolizumab and pembrolizumab-chemotherapy as next-line therapy. The results demonstrate favorable clinical efficacy and progression-free survival with pembrolizumab and pembrolizumab-chemotherapy in patients with programmed death ligand 1 (PD-L1) combined positive score (CPS) >= 20, CPS >= 1, and total populations. Subsequent treatments after pembrolizumab-based therapy also showed good efficacy.

JOURNAL OF CLINICAL ONCOLOGY (2023)

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Article Oncology

Low-Dose Immunotherapy in Head and Neck Cancer: A Randomized Study

Vijay Maruti Patil et al.

Summary: This study found that only 1%-3% of patients in low- and middle-income countries have access to the approved regimens for treating advanced head and neck squamous cell carcinoma due to cost issues. Previous research has shown that metronomic chemotherapy can improve survival. The study aimed to assess whether the addition of low-dose nivolumab to triple metronomic chemotherapy improved overall survival.

JOURNAL OF CLINICAL ONCOLOGY (2023)

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Article

Neoadjuvant chemotherapy in technically unresectable head and neck cancers: a retrospective audit

Bal Krishna Mishra et al.

eCancerMedicalScience (2022)

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Article Oncology

Long-term outcomes of induction chemotherapy followed by chemoradiotherapy vs chemoradiotherapy alone as treatment of unresectable head and neck cancer: follow-up of the Spanish Head and Neck Cancer Group (TTCC) 2503 Trial

R. Hitt et al.

Summary: In untreated LAHNSCC patients, those treated with IC followed by CRT (TPF or PF) had a longer median progression-free survival for larynx-hypopharynx primary tumors, and patients with ECOG 0 showed improved time to treatment failure compared to those who received CRT alone.

CLINICAL & TRANSLATIONAL ONCOLOGY (2021)

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Article Oncology

A prospective study to determine the cost of illness for oral cancer in India

Arjun Gurmeet Singh et al.

Summary: India bears a significant burden of oral cancer, with high healthcare costs impacting those who cannot afford care. Early detection and prevention strategies could lead to substantial cost savings over the next decade. The study provides valuable insights for reforming oral cancer care in India.

ECANCERMEDICALSCIENCE (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Oncology

Efficacy and safety of neoadjuvant chemotherapy (NACT) with paclitaxel plus carboplatin and oral metronomic chemotherapy (OMCT) in patients with technically unresectable oral squamous cell carcinoma (OSCC)

Lakhan Kashyap et al.

Summary: The combination of paclitaxel-carboplatin and oral metronomic chemotherapy (OMCT) as neoadjuvant chemotherapy shows promising efficacy and safety in patients with unresectable oral squamous cell carcinoma, leading to favorable resection rates and survival outcomes.

ECANCERMEDICALSCIENCE (2021)

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Article Oncology