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Nanoscience & Nanotechnology
Tianxiang Yi et al.
Summary: TP53 missense mutations leading to highly stabilized mutant p53 protein (mutp53) have been observed in a significant proportion of human cancers. Crizotinib, an FDA-approved antitumor drug, has been discovered to effectively degrade mutp53 protein, resulting in reduced cancer cell proliferation, migration, and enhanced sensitivity to doxorubicin. Delivery of crizotinib and doxorubicin using PEG-PLGA nanomicelles has demonstrated promising results, enhancing the therapeutic efficacy of doxorubicin against mutp53 pancreatic cancer in vitro and in vivo. This study suggests a novel combination therapeutic strategy for targeting p53 cancer in clinical application.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Yongju He et al.
Summary: The study presents a size-shrinkable nanocarrier triggered by acid, which efficiently accumulates at the tumor site, penetrates deep into the tumor, and is rapidly cleared from the body. The nanocarrier demonstrates potent antitumor efficacy, showing high potential for solid tumor treatment.
Article
Mehrab Pourmadadi et al.
Pharmaceutical Nanotechnology
(2022)
Review
Pharmacology & Pharmacy
Pearl Moharil et al.
Summary: Combining passive targeting with active targeting is a promising approach to improve the therapeutic efficacy of nanotherapy. In this study, ultra-small-sized gemcitabine-based nanoparticles were combined with folic acid conjugation for enhanced dual targeted delivery to tumor cells and tumor-associated macrophages. The co-delivery system showed small particle size and achieved significant reduction of tumor growth in a breast cancer model.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Pharmacology & Pharmacy
Tingting Du et al.
Summary: The use of tumor-associated macrophage (TAM) membrane-camouflaged polymeric micelles loaded with doxorubicin is an effective strategy to overcome low immunogenicity and tumor immunosuppressive microenvironment, leading to improved cancer immunotherapy.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Wei-Jin Zhang et al.
Summary: In this study, a responsive nanoparticle system was designed for efficient chemotherapy drug delivery and antibacterial applications. The nanoparticles showed superior biocompatibility and stability, and exhibited excellent photothermal conversion efficiency and extinction coefficient. Additionally, the nanoparticles demonstrated both ROS-responsive and pH-responsive release performance of the chemotherapy drug, as well as high antibacterial activity.
Article
Engineering, Biomedical
Junrui Wang et al.
Summary: In this study, a biocompatible nanotheranostic agent was developed for targeted therapy of deep-seated cells in solid tumors. The nanoparticles exhibited excellent magnetothermal conversion and controllable magnetic hyperthermia, allowing for deep penetration in tumors. Furthermore, the study found that magnetic hyperthermia not only induced apoptotic damage in tumor cells but also improved the response rate to immunotherapy, suggesting its potential as a dual therapeutic strategy.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Biotechnology & Applied Microbiology
Sheng Chen et al.
Summary: An injectable magnetic colloidal gel was developed for the combination therapy of postoperative hepatocellular carcinoma (HCC). The gel, composed of magnetic montmorillonites and amphoteric gelatin nanoparticles, exhibited effective magnetic heating effect and remarkable rheological properties. The gel achieved synergistic treatment of HCC through stimuli-responsive drug delivery, hemostasis and magnetic hyperthermia. The gel-induced interventional magnetic hyperthermia therapy (MHT) showed potential in treating postoperative recurrence.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Yue-Ming Yu et al.
Summary: This study demonstrates the feasibility of converting the cocrystal of the anticancer drug 5-fluorouracil (FL) with the phenolic acid nutrient caffeic acid (CF) into a nanomicelle formulation using a self-assembly strategy. The cocrystal nanomicelles exhibit enhanced drug loading and entrapment efficiency compared to FL nanomicelles, leading to more potent cytotoxicity and better absorption in vivo. The cocrystal nanomicelles also demonstrate prominent slowed-release behavior and prolonged retention time, making them a promising option for the development of long-acting and synergistic antitumor formulations.
Article
Chemistry, Multidisciplinary
Edoardo Donadoni et al.
Summary: Strategies based on the active targeting of tumor cells are emerging as smart and efficient nanomedical procedures. This study focuses on the functionalization of TiO2 nanoparticles with folic acid (FA) and polyethylene glycol (PEG) spacers for tumor targeting. The researchers use Quantum Mechanics and Molecular Dynamics simulations to analyze the behavior of the nanoconjugates in different environments and determine the optimal density of FA molecules and the mode of anchoring to the carrier. The results provide valuable insights for the design and optimization of nanocarriers for targeted drug delivery.
Article
Nanoscience & Nanotechnology
Namita Jaiswal et al.
Summary: This study reported two bi-functional gold nanorods-protein nanoconjugates, with high protein loading capacity, serum stability, target specificity, and controlled protein release, enabling targeted cytosolic delivery of therapeutic proteins.
ACS APPLIED BIO MATERIALS
(2022)
Review
Engineering, Biomedical
Hung-Wei Cheng et al.
Summary: Magnetic nanoparticles (MNPs) serve as a versatile theranostic tool for targeted delivery of immunotherapeutics and monitoring of cell/tissue responses. By utilizing magnetic properties for navigation and hyperthermia, MNPs enhance the efficacy of immunotherapy. The multimodal approach induces robust immune responses, minimizes safety issues, and allows simultaneous monitoring of immune activities.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Medicine, Research & Experimental
Shengzhe Zhao et al.
Review
Pharmacology & Pharmacy
Zhen-Tao Zhang et al.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2019)
Article
Chemistry, Multidisciplinary
Sheng Tong et al.
Review
Biotechnology & Applied Microbiology
Ewelina Piktel et al.
JOURNAL OF NANOBIOTECHNOLOGY
(2016)
Article
Engineering, Biomedical
Yajie Gao et al.
ACTA BIOMATERIALIA
(2015)
Article
Chemistry, Multidisciplinary
Lan Yao et al.
JOURNAL OF CONTROLLED RELEASE
(2013)
Article
Biochemistry & Molecular Biology
Ranendra N. Saha et al.
MOLECULAR MEMBRANE BIOLOGY
(2010)
Article
Chemistry, Multidisciplinary
Ahn Na Koo et al.
CHEMICAL COMMUNICATIONS
(2008)
