期刊
INTERNATIONAL JOURNAL OF NANOMEDICINE
卷 18, 期 -, 页码 7647-7660出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S436414
关键词
nanomicelles; synergistic therapy; stimulus-responsive; tumor targeting; Chemo/magnetothermal
This study synthesized folate-modified nanomicelles that can release drugs in response to tumor tissue acidity and magnetic field stimulation, achieving targeted delivery to cancer cells. Experimental results demonstrated that these dual-responsive nanomicelles can enhance drug uptake and anticancer efficacy.
Introduction: Stimulus-responsive nanocarrier systems are promising in cancer treatment. They improve drug stability and facilitate controlled drug release. However, single-responsive nanocarriers still face insufficient tumor targeting and low efficacy. Methods: In this study, we synthesized folate-modified DSPE-PEOz nanomicelles with PEG chains and loaded them with magnetic iron particles and doxorubicin (DOX). Folic acid (FA) was employed as a ligand to target cancer cells actively. The nanomicelles are biocompatible and acid-sensitive drug carriers. Magnetic field-responsive nanoparticles enable moderately controlled magnetothermal therapy of tumors regardless of tumor location. The pH/magnetic field dual-responsive nanomicelles shed their PEG layer in response to tumor tissue acidity and react to magnetic fields through magnetothermal effects. Results: In vitro and in vivo experiments demonstrated that the nanomicelles could efficiently target cancer cells, release drugs in response to pH changes, and enhance drug uptake through magnetothermal effects. Discussion: The dual-responsive magnetic nanomicelles are expected to enhance the anti-cancer efficacy of chemo/magnetothermal synergistic therapy.
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