☆ 4.2 Article

An Organotypic Human Lymph Node Model Reveals the Importance of Fibroblastic Reticular Cells for Dendritic Cell Function

TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Oncology

Modelling metastatic colonization of cholangiocarcinoma organoids in decellularized lung and lymph nodes

Gilles S. van Tienderen et al.

Summary: Cholangiocarcinoma (CCA) is an aggressive type of liver cancer that often metastasizes to the lungs and lymph nodes, resulting in poor patient outcomes. However, the mechanisms behind CCA metastasis are not well understood. In order to study the interactions between CCA tumor cells and the extracellular matrix (ECM) of metastatic sites, researchers created an in vitro model using patient-derived CCA organoids (CCAOs) combined with decellularized human lung and lymph node tissues. This model allowed for the investigation of how the ECM influences metastatic processes and provides new insights into cancer metastasis.

FRONTIERS IN ONCOLOGY (2023)

添加到收藏夹

Article Multidisciplinary Sciences

A synthetic human 3D in vitro lymphoid model enhancing B-cell survival and functional differentiation

Maaike V. J. Braham et al.

Summary: This study aimed to improve in vitro germinal center (GC) simulation by using 3D culture techniques. Human B-cells were incorporated into PEG-4MAL hydrogels, supported by CD40L cells, human tonsil-derived stromal cells, and cytokines. The 3D culture significantly increased plasmablast and plasma cell numbers, promoted antibody production, and enabled class switching of naive B-cells. Formation of large B-cell clusters resembling GC-like structures was also observed. In conclusion, this well-characterized and controllable hydrogel-based 3D lymphoid model supports enhanced B-cell survival, proliferation, differentiation, and antibody production.

ISCIENCE (2023)

添加到收藏夹

Review Multidisciplinary Sciences

The extracellular matrix and the immune system: A mutually dependent relationship

Tara E. Sutherland et al.

Summary: For decades, immunologists have focused on studying circulating immune cells, but recently there is a growing appreciation for the role of immune cells within the tissue microenvironment. However, the understanding of the extracellular matrix (ECM) and its interaction with the immune system remains limited. This review aims to explore the potential for biological discovery at the intersection of immunology and matrix biology.

SCIENCE (2023)

添加到收藏夹

Review Immunology

New tools for immunologists: models of lymph node function from cells to tissues

Tochukwu Ozulumba et al.

Summary: The lymph node is a structured organ that plays a crucial role in the adaptive immune response. Various technologies have been used to explore its biology, from immunofluorescence to spatial biology techniques. However, new approaches are needed to study human immunity. This review presents different models and technologies for studying the lymph node, discusses challenges, and proposes future directions. It aims to benefit immunologists in expanding their toolkit for lymph node research.

FRONTIERS IN IMMUNOLOGY (2023)

添加到收藏夹

Article Immunology

Lymph node medulla regulates the spatiotemporal unfolding of resident dendritic cell networks

Milas Ugur et al.

Summary: This study discovered specific anatomical niches in lymph nodes where preDCs differentiate into immature cDCs. These niches, located in the medullary cords of the lymph nodes, play a role in the development of the cDC1 network. During inflammation, the network can be temporarily impaired, but can be restored by regulating the local density of cDC1s.

IMMUNITY (2023)

添加到收藏夹

Article Chemistry, Multidisciplinary

Ectopic Lymphoid Follicle Formation and Human Seasonal Influenza Vaccination Responses Recapitulated in an Organ-on-a-Chip

Girija Goyal et al.

Summary: In this study, researchers successfully cultured human ectopic lymphoid follicles with similar characteristics to lymphoid follicles in a microfluidic chip. These follicles showed improved immune responses to vaccines and can serve as an alternative to non-human primates for preclinical evaluation.

ADVANCED SCIENCE (2022)

添加到收藏夹

Article Toxicology

A Multi-Organ-on-Chip Approach to Investigate How Oral Exposure to Metals Can Cause Systemic Toxicity Leading to Langerhans Cell Activation in Skin

Jasper J. J. Koning et al.

Summary: This study investigated the systemic toxicity and immune cell activation caused by metal exposure to oral mucosa using a multi-organ-on-chip approach. The results showed that metal exposure did not cause significant histological changes in gingiva and skin tissue, but did activate immune cells in the skin.

FRONTIERS IN TOXICOLOGY (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Modeling human adaptive immune responses with tonsil organoids

Lisa E. Wagar et al.

Summary: By utilizing human tonsils, researchers have developed a functional organotypic system that mimics key features of germinal centers in vitro, allowing for the study of humoral immune responses. This system not only enables a deeper understanding of critical mechanisms underlying adaptive immunity, but also facilitates rapid testing of vaccine candidates and adjuvants in an entirely human system.

NATURE MEDICINE (2021)

添加到收藏夹

Review Immunology

Immunotherapy Goes Local: The Central Role of Lymph Nodes in Driving Tumor Infiltration and Efficacy

Kim M. van Pul et al.

Summary: Immune checkpoint blockade (ICB) has revolutionized oncology treatment, but resistance related to T cell deficiency and the importance of tumor-draining lymph nodes (TDLN) in overcoming this resistance have been overlooked. Targeting TDLN through therapeutic approaches involving DC activation may enhance ICB efficacy.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Nanoscience & Nanotechnology

Immunomodulatory Scaffolds Derived from Lymph Node Extracellular Matrices

Yi Sun Choi et al.

Summary: Lymph node extracellular matrix (LNEM) can mimic lymph node microenvironments and enhance immunomodulatory effects, promoting M2 macrophage polarization and secretion of anti-inflammatory cytokines. In a 3D LNEM environment, macrophage phagocytic function is improved, showing potential for drug testing and tissue healing applications. LNEM hydrogel implantation facilitates macrophage recruitment and polarization towards M2 phenotype for tissue healing, indicating the utility of 3D immune system-mimicking biomaterials in tissue modeling and regenerative medicine.

ACS APPLIED MATERIALS & INTERFACES (2021)

添加到收藏夹

Article Immunology

Gremlin 1+ fibroblastic niche maintains dendritic cell homeostasis in lymphoid tissues

Varun N. Kapoor et al.

Summary: Fibroblastic reticular cells, specifically the Grem1(+) subset, play a crucial role in supporting T cell immunity and maintaining the homeostasis of tissue-resident cDCs in lymph nodes. Single-cell RNA sequencing analyses in both human and mouse lymph nodes reveal the significance of Grem1(+) FRCs in regulating lymphocyte compartmentalization and innate and adaptive immunity.

NATURE IMMUNOLOGY (2021)

添加到收藏夹

Article Immunology

Pattern recognition receptor expression and maturation profile of dendritic cell subtypes in human tonsils and lymph nodes

David Askmyr et al.

Summary: This study identified different subtypes of dendritic cells in human tonsils and lymph nodes through flow cytometry, revealing similar characteristics including subtype frequency and maturity. These findings suggest that both sites may be suitable for vaccine deposition in dendritic cell-mediated immunotherapy.

HUMAN IMMUNOLOGY (2021)

添加到收藏夹

Review Immunology

Lymph node stromal cells: subsets and functions in health and disease

C. Grasso et al.

Summary: Lymph nodes stromal cells are crucial for guiding adaptive immune responses, with recent advancements in single-cell technologies revealing significant heterogeneity among subsets. While most knowledge comes from mouse studies, some similarities with human counterparts suggest their importance.

TRENDS IN IMMUNOLOGY (2021)

添加到收藏夹

Review Immunology

Communication, construction, and fluid control: lymphoid organ fibroblastic reticular cell and conduit networks

Sophie E. Acton et al.

Summary: This article discusses the crucial role of fibroblastic reticular cells in secondary lymphoid organs, focusing on their importance in immune cell interactions and lymphocyte activation and differentiation. The generation of conduit system by FRCs plays a key role in controlling fluid and immune cell movement in secondary lymphoid organs.

TRENDS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Chemistry, Medicinal

Acute Lymph Node Slices Are a Functional Model System to Study Immunity Ex Vivo

Maura C. Belanger et al.

Summary: Live murine lymph node tissue slices provide a versatile platform for studying immunity, maintaining spatial organization and cell populations while reflecting the 3D complexity of the organ. These slices show comparable viability and inflammatory response to cell suspensions, and exhibit stronger reactions to T cell receptor cross-linking in some cases. Additionally, they process protein antigens and respond to ex vivo challenge with antigen-specific cytokine secretion.

ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE (2021)

添加到收藏夹

Review Cell Biology

Infectious Diseases and the Lymphoid Extracellular Matrix Remodeling: A Focus on Conduit System

Fernanda N. Morgado et al.

CELLS (2020)

添加到收藏夹

Review Immunology

Lymph node stromal cells: cartographers of the immune system

Akshay T. Krishnamurty et al.

NATURE IMMUNOLOGY (2020)

添加到收藏夹

Article Oncology

Micro-environmental cross-talk in an organotypic human melanoma-in-skin model directs M2-like monocyte differentiation via IL-10

Lisabetta Michielon et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2020)

添加到收藏夹

Article Oncology

Distinctive Subpopulations of Stromal Cells Are Present in Human Lymph Nodes Infiltrated with Melanoma

Jennifer Eom et al.

CANCER IMMUNOLOGY RESEARCH (2020)

添加到收藏夹

Article Immunology

The Chemoattractant Receptor Ebi2 Drives Intranodal Naive CD4+ T Cell Peripheralization to Promote Effective Adaptive Immunity

Antonio P. Baptista et al.

IMMUNITY (2019)

添加到收藏夹

Article Oncology

Selectively hampered activation of lymph node-resident dendritic cells precedes profound T cell suppression and metastatic spread in the breast cancer sentinel lymph node

Kim M. van Pul et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

添加到收藏夹

Review Immunology

Chemokine and chemotactic signals in dendritic cell migration

Laura Tiberio et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2018)

添加到收藏夹

Article Immunology

Single-Cell RNA Sequencing of Lymph Node Stromal Cells Reveals Niche-Associated Heterogeneity

Lauren B. Rodda et al.

IMMUNITY (2018)

添加到收藏夹

Review Immunology

Human dendritic cell subsets: an update

Matthew Collin et al.

IMMUNOLOGY (2018)

添加到收藏夹

Article Cell Biology

Notch Signaling Facilitates In Vitro Generation of Cross-Presenting Classical Dendritic Cells

Margaret E. Kirkling et al.

CELL REPORTS (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

The human lymph node microenvironment unilaterally regulates T-cell activation and differentiation

Konstantin Knoblich et al.

PLOS BIOLOGY (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Inflammation induces two types of inflammatory dendritic cells in inflamed lymph nodes

Jiyoun Min et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2018)

添加到收藏夹

Editorial Material Immunology

Of Human DC Migrants and Residents

Elodie Segura et al.

IMMUNITY (2017)

添加到收藏夹

Article Immunology

Dendritic cell and antigen dispersal landscapes regulate T cell immunity

Michael Y. Gerner et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Topological Small-World Organization of the Fibroblastic Reticular Cell Network Determines Lymph Node Functionality

Mario Novkovic et al.

PLOS BIOLOGY (2016)

添加到收藏夹

Article Respiratory System

Human lung fibroblasts may modulate dendritic cell phenotype and function: results from a pilot in vitro study

Olivia Freynet et al.

RESPIRATORY RESEARCH (2016)

添加到收藏夹

Article Pharmacology & Pharmacy

MUTZ-3 derived Langerhans cells in human skin equivalents show differential migration and phenotypic plasticity after allergen or irritant exposure

Ilona J. Kosten et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2015)

添加到收藏夹

Article Immunology

Gingiva Equivalents Secrete Negligible Amounts of Key Chemokines Involved in Langerhans Cell Migration Compared to Skin Equivalents

Ilona J. Kosten et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

iDISCO: A Simple, RapidMethod to Immunolabel Large Tissue Samples for Volume Imaging

Nicolas Renier et al.

CELL (2014)

添加到收藏夹

Article Immunology

Sphingosine-1-phosphate lyase is expressed by CD68+ cells on the parenchymal side of marginal reticular cells in human lymph nodes

Saem Mul Park et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2014)

添加到收藏夹

Article Immunology

Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses

Nicolas Fasnacht et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Transcriptional Profiling of Human Dendritic Cell Populations and Models - Unique Profiles of In Vitro Dendritic Cells and Implications on Functionality and Applicability

Kristina Lundberg et al.

PLOS ONE (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Inhibition of the Differentiation of Monocyte-Derived Dendritic Cells by Human Gingival Fibroblasts

Sylvie Seguier et al.

PLOS ONE (2013)

添加到收藏夹

Article Cell Biology

CCL5 and CCL20 mediate immigration of Langerhans cells into the epidermis of full thickness human skin equivalents

Krista Ouwehand et al.

EUROPEAN JOURNAL OF CELL BIOLOGY (2012)

添加到收藏夹

Article Immunology

Histo-Cytometry: A Method for Highly Multiplex Quantitative Tissue Imaging Analysis Applied to Dendritic Cell Subset Microanatomy in Lymph Nodes

Michael Y. Gerner et al.

IMMUNITY (2012)

添加到收藏夹

Article Immunology

Podoplanin-Rich Stromal Networks Induce Dendritic Cell Motility via Activation of the C-type Lectin Receptor CLEC-2

Sophie E. Acton et al.

IMMUNITY (2012)

添加到收藏夹

Review Immunology

HEVs, lymphatics and homeostatic immune cell trafficking in lymph nodes

Jean-Philippe Girard et al.

NATURE REVIEWS IMMUNOLOGY (2012)

添加到收藏夹

Review Immunology

Stromal Cell-Immune Cell Interactions

Ramon Roozendaal et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 29 (2011)

添加到收藏夹

Article Hematology

Characterization of four conventional dendritic cell subsets in human skin-draining lymph nodes in relation to T-cell activation

Rieneke van de Ven et al.

BLOOD (2011)

添加到收藏夹

Article Dermatology

Irritant-Induced Migration of Langerhans Cells Coincides with an IL-10-Dependent Switch to a Macrophage-Like Phenotype

Krista Ouwehand et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2011)

添加到收藏夹

Article Immunology

Reproducible isolation of lymph node stromal cells reveals site-dependent differences in fibroblastic reticular cells

Anne L. Fletcher et al.

FRONTIERS IN IMMUNOLOGY (2011)

添加到收藏夹

Article Immunology

Human CD141+ (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens

Sarah L. Jongbloed et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2010)

添加到收藏夹

Article Dermatology

Dermal Fibroblasts Promote the Migration of Dendritic Cells

Anja Saalbach et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2010)

添加到收藏夹

Article Hematology

Distinctive localization of antigen-presenting cells in human lymph nodes

Catherine E. Angel et al.

BLOOD (2009)

添加到收藏夹

Article Immunology

Transcriptional and functional defects of dendritic cells derived from the MUTZ-3 leukaemia line

Jane Rasaiyaah et al.

IMMUNOLOGY (2009)

添加到收藏夹

Article Immunology

CXCL12/CXCR4 signaling promotes human thymic dendritic cell survival regulating the Bcl-2/Bax ratio

Carmen Hernandez-Lopez et al.

IMMUNOLOGY LETTERS (2008)

添加到收藏夹

Review Immunology

The conduit system of the lymph node

Ramon Roozendaal et al.

INTERNATIONAL IMMUNOLOGY (2008)

添加到收藏夹

Article Immunology

Inducing antitumor T cell immunity: Comparative functional analysis of interstitial versus Langerhans dendritic cells in a human cell line model

Saskia J. A. M. Santegoets et al.

JOURNAL OF IMMUNOLOGY (2008)

添加到收藏夹

Review Cell Biology

Human dendritic cell line models for DC differentiation and clinical DC vaccination studies

Saskia J. A. M. Santegoets et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2008)

添加到收藏夹

Article Immunology

Dermal fibroblasts induce maturation of dendritic cells

Anja Saalbach et al.

JOURNAL OF IMMUNOLOGY (2007)

添加到收藏夹

Article Hematology

Regulation of dendritic-cell differentiation by bone marrow stroma via different Notch ligands

Pingyan Cheng et al.

BLOOD (2007)

添加到收藏夹

Article Oncology

In vitro priming of tumor-specific cytotoxic T lymphocytes using allogeneic dendritic cells derived from the human MUTZ-3 cell line

Saskia J. A. M. Santegoets et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2006)

添加到收藏夹

Article Cell Biology

A CD34+ human cell line model of myeloid dendritic cell differentiation:: evidence for a CD14+ CD11b+ Langerhans cell precursor

Saskia J. A. M. Santegoets et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2006)

添加到收藏夹

Article Immunology

Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes

Marc Bajenoff et al.

IMMUNITY (2006)

添加到收藏夹

Article Immunology

Monocyte-derived human macrophages mediate anergy in allogeneic T cells and induce regulatory T cells

Sabine Hoves et al.

JOURNAL OF IMMUNOLOGY (2006)

添加到收藏夹

Article Immunology

Functional and transcriptional profiling of MUTZ-3, a myeloid cell line acting as a model for dendritic cells

K Larsson et al.

IMMUNOLOGY (2006)

添加到收藏夹

Article Immunology

The conduit system transports soluble antigens from the afferent lymph to resident dendritic cells in the T cell area of the lymph node

M Sixt et al.

IMMUNITY (2005)

添加到收藏夹

Article Pathology

Dynamic populations of dendritic cell-specific ICAM-3 grabbing nonintegrin-positive immature dendritic cells and liver/lymph node-specific ICAM-3 grabbing nonintegrin-positive endothelial cells in the outer zones of the paracortex of human lymph nodes

A Engering et al.

AMERICAN JOURNAL OF PATHOLOGY (2004)

添加到收藏夹

Article Immunology

IL-6 regulates in vivo dendritic cell differentiation through STAT3 activation

SJ Park et al.

JOURNAL OF IMMUNOLOGY (2004)

添加到收藏夹

Article Hematology

MUTZ-3, a human cell line model for the cytokine-induced differentiation of dendritic cells from CD34+ precursors

AJ Masterson et al.

BLOOD (2002)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.