期刊
ANALYSIS & SENSING
卷 -, 期 -, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anse.202300065
关键词
paper-based microfluidics; three-dimensional mu PAD; braiding; valve; multiplexed analysis
Inspired by Chinese bamboo braiding art, we developed a novel fabrication technique using PDMS-impregnated paper substrate to create three-dimensional paper-based microfluidic devices. These devices offer advantages such as compactness, easy disassembly, and real-time flow visualization, making them suitable for various applications.
Three-dimensional paper-based microfluidic devices have shown great potential in various applications, including point-of-care diagnostics, environmental monitoring, and tissue engineering. However, their fabrication is still limited to stacking and origami methods. Inspired by the art of bamboo braiding in China, we developed a novel fabrication technique based on the braiding concept to create three-dimensional paper-based microfluidic devices with PDMS-impregnated paper substrate as the building units. The resulting three-dimensional paper device brings unique advantages, including compactness, facile disassembly, and real-time flow visualization. The multiplexed glucose analysis with a braided device integrated with 16-switchable valves for flow control was further fabricated to demonstrate the device's applicability. We envision braiding-based fabrication technology opening new possibilities and bringing broad applications for three-dimensional paper microfluidic devices.
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