☆ 4.5 Article

Effects of Tulp4 deficiency on murine embryonic development and adult phenotype

MICROSCOPY RESEARCH AND TECHNIQUE (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Biochemistry & Molecular Biology

The International Mouse Phenotyping Consortium: comprehensive knockout phenotyping underpinning the study of human disease

Tudor Groza et al.

Summary: The International Mouse Phenotyping Consortium (IMPC) website provides a curated and analyzed platform for knockout mouse phenotyping data, which is valuable for molecular diagnosis and gene function research in rare diseases. The data and materials have been widely used in over 4,600 publications, indicating their significance.

NUCLEIC ACIDS RESEARCH (2023)

添加到收藏夹

Article Cell Biology

Detailed characterizations of cranial nerve anatomy in E14.5 mouse embryos/fetuses and their use as reference for diagnosing subtle, but potentially lethal malformations in mutants

Lukas F. F. Reissig et al.

Summary: Careful phenotype analysis is crucial for studying the function of pre- and perinatally lethal genes. This study provides detailed anatomical information on cranial nerves in prenatal mice, which can serve as reference data for diagnosing cranial nerve abnormalities. The results show that defects in cranial nerve development can have significant impacts, such as hindering feeding and potentially causing lethal defects in the central nervous system.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

添加到收藏夹

Article Anatomy & Morphology

The venous system of E14.5 mouse embryos-reference data and examples for diagnosing malformations in embryos with gene deletions

Stefan H. Geyer et al.

Summary: This study focuses on the normal anatomy of the venous system in E14.5 embryos, providing detailed descriptive and metric information. By analyzing the venous phenotype, different abnormalities in mutant lines can be identified, shedding light on the maturation and remodeling of the venous system during the transition from embryo to fetal life.

JOURNAL OF ANATOMY (2022)

添加到收藏夹

Review Hematology

Clinical insights into the origins of thrombosis in myeloproliferative neoplasms

Alison R. Moliterno et al.

Summary: Philadelphia chromosome-negative myeloproliferative neoplasms are hematopoietic stem cell disorders characterized by activating mutations in signal transduction pathways, leading to overproduction of blood cells, disease-specific symptoms, and high rates of vascular events. This review critically evaluates the clinical burden of thrombosis in MPNs, examines the clinical associations among clonal hematopoiesis, JAK2V617F burden, inflammation, and thrombosis, and provides insights into novel primary and secondary thrombosis-prevention strategies.

BLOOD (2021)

添加到收藏夹

Review Hematology

The pathobiology of thrombosis, microvascular disease, and hemorrhage in the myeloproliferative neoplasms

Hans Carl Hasselbalch et al.

Summary: Thrombotic, vascular, and bleeding complications are common causes of morbidity and mortality in Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs). Abnormalities in circulating cells in MPNs create a prothrombotic environment, leading to venous, arterial, and microvascular thrombosis. The inflammatory state of MPN stem cells amplifies the clinical thrombotic tendency and promotes further MPN stem cell clonal expansion.

BLOOD (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Smooth Muscle Specific Ablation of CXCL12 in Mice Downregulates CXCR7 Associated with Defective Coronary Arteries and Cardiac Hypertrophy

Santhosh Kumar Ghadge et al.

Summary: The chemokine CXCL12 is essential in cardiovascular development, cell trafficking, and myocardial repair, with downstream loci associated with coronary artery disease and myocardial infarction identified through human genome-wide association studies. A study using a mouse model lacking CXCL12 in smooth muscle cells showed high embryonic lethality and developmental defects, highlighting the critical role of smooth muscle-specific CXCL12 in arterial development and cardiac hypertrophy. Pharmacological stimulation of CXCR7 might be a promising approach to attenuate adverse hypertrophic remodeling.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Radiology, Nuclear Medicine & Medical Imaging

Cross-Modality Imaging of Murine Tumor Vasculature-a Feasibility Study

Lydia M. Zopf et al.

Summary: This study established a novel cross-modality imaging platform to characterize tumor vasculature in melanoma cancer, providing comprehensive vascular parameters and allowing quantification and comparison of vessel densities and morphologies. The platform combines well-established technologies with recent modalities to address challenges in integrating microscopic and macroscopic data across spatial resolutions, enabling truly correlative vascular imaging.

MOLECULAR IMAGING AND BIOLOGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

High Resolution Episcopic Microscopy for Qualitative and Quantitative Data in Phenotyping Altered Embryos and Adult Mice Using the New Histo3D System

Olivia Wendling et al.

Summary: 3D imaging in animal models, particularly with high-resolution HREM technology, allows for the identification and quantification of structural morphological changes, enhancing the visualization and analysis of organ systems. The data generated through this technique can be used for novel computational analysis, providing accurate quantification and comparison of individual embryos. The HREM prototype described in this study showcases its potential for phenotyping experimental cohorts and comparing structure volumes in various stages of development.

BIOMEDICINES (2021)

添加到收藏夹

Article Genetics & Heredity

A Specific CNOT1 Mutation Results in a Novel Syndrome of Pancreatic Agenesis and Holoprosencephaly through Impaired Pancreatic and Neurological Development

Elisa De Franco et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2019)

添加到收藏夹

Article Medicine, General & Internal

Atherosclerosis

Peter Libby et al.

NATURE REVIEWS DISEASE PRIMERS (2019)

添加到收藏夹

Review Genetics & Heredity

The tubby-like proteins kingdom in animals and plants

Meng Wang et al.

GENE (2018)

添加到收藏夹

Review Physiology

Recent Advances in Placenta-Heart Interactions

Cheryl L. Maslen

FRONTIERS IN PHYSIOLOGY (2018)

添加到收藏夹

Review Physiology

Near to One's Heart: The Intimate Relationship Between the Placenta and Fetal Heart

Emily J. Camm et al.

FRONTIERS IN PHYSIOLOGY (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Placentation defects are highly prevalent in embryonic lethal mouse mutants

Vicente Perez-Garcia et al.

NATURE (2018)

添加到收藏夹

Article Physiology

The Role of Abnormal Placentation in Congenital Heart Disease; Cause, Correlate, or Consequence?

Jennifer A. Courtney et al.

FRONTIERS IN PHYSIOLOGY (2018)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Visualising the Cardiovascular System of Embryos of Biomedical Model Organisms with High Resolution Episcopic Microscopy (HREM)

Wolfgang J. Weninger et al.

JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE (2018)

添加到收藏夹

Article Anatomy & Morphology

A staging system for correct phenotype interpretation of mouse embryos harvested on embryonic day 14 (E14.5)

Stefan H. Geyer et al.

JOURNAL OF ANATOMY (2017)

添加到收藏夹

Article Anatomy & Morphology

Morphology, topology and dimensions of the heart and arteries of genetically normal and mutant mouse embryos at stages S21-S23

Stefan H. Geyer et al.

JOURNAL OF ANATOMY (2017)

添加到收藏夹

Article Multidisciplinary Sciences

High-resolution Episcopic Microscopy (HREM) - Simple and Robust Protocols for Processing and Visualizing Organic Materials

Stefan H. Geyer et al.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2017)

添加到收藏夹

Article Radiology, Nuclear Medicine & Medical Imaging

Meconium in Perinatal Imaging: Associations and Clinical Significance

Theodore Jerdee et al.

SEMINARS IN ULTRASOUND CT AND MRI (2015)

添加到收藏夹

Article Cell Biology

Phenotyping structural abnormalities in mouse embryos using high-resolution episcopic microscopy

Wolfgang J. Weninger et al.

DISEASE MODELS & MECHANISMS (2014)

添加到收藏夹

Review Cell Biology

Bloomsbury report on mouse embryo phenotyping: recommendations from the IMPC workshop on embryonic lethal screening

David Adams et al.

DISEASE MODELS & MECHANISMS (2013)

添加到收藏夹

Editorial Material Cell Biology

Deciphering the Mechanisms of Developmental Disorders (DMDD): a new programme for phenotyping embryonic lethal mice

Timothy Mohun et al.

DISEASE MODELS & MECHANISMS (2013)

添加到收藏夹

Article Multidisciplinary Sciences

A conditional knockout resource for the genome-wide study of mouse gene function

William C. Skarnes et al.

NATURE (2011)

添加到收藏夹

Review Biotechnology & Applied Microbiology

The tubby family proteins

Saikat Mukhopadhyay et al.

GENOME BIOLOGY (2011)

添加到收藏夹

Review Biochemistry & Molecular Biology

Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway

Victoria L. Patterson et al.

HUMAN MOLECULAR GENETICS (2009)

添加到收藏夹

Article Anatomy & Morphology

High-resolution episcopic microscopy:: a rapid technique for high detailed 3D analysis of gene activity in the context of tissue architecture and morphology

Wolfgang J. Weninger et al.

ANATOMY AND EMBRYOLOGY (2006)

添加到收藏夹

Article Genetics & Heredity

Molecular cloning and characterization of the mouse and human TUSP gene, a novel member of the tubby superfamily

QZ Li et al.

GENE (2001)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.