4.2 Article

Investigation of the role of von Willebrand factor in shear-induced platelet activation and functional alteration under high non-physiological shear stress

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biophysics

Discrete responses of erythrocytes, platelets, and von Willebrand factor to shear

Chris H. H. Chan et al.

Summary: Despite decades of technological advancements in blood-contacting medical devices, complications related to shear flow-induced blood trauma are still frequently observed in clinic. This study exposed blood to different shear stresses and found that near-physiological shear stress is needed to avoid blood trauma completely.

JOURNAL OF BIOMECHANICS (2022)

Article Biophysics

Models of Shear-Induced Platelet Activation and Numerical Implementation With Computational Fluid Dynamics Approaches

Dong Han et al.

Summary: Shear-induced platelet activation is a critical outcome when blood is exposed to elevated shear stress, which can lead to serious adverse events. Various numerical models have been proposed to study the mechanism and applications of shear-induced platelet activation.

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME (2022)

Article Biochemical Research Methods

Microfluidic assay of antiplatelet agents for inhibition of shear-induced platelet adhesion and activation

Shekh Mojibur Rahman et al.

Summary: A microfluidic system was developed to assess the effectiveness of antiplatelet agents in suppressing shear-induced platelet adhesion and activation. Results showed that certain antiplatelet agents significantly reduced downstream platelet adhesion, with GPIIb/IIIa inhibitors showing particularly strong effects. Antibody blocking of vWf or GPIb alpha effectively diminished platelet adhesion and activation, highlighting the importance of the vWf-GPIb alpha interaction in mediating shear-induced platelet aggregation.

LAB ON A CHIP (2021)

Review Cardiac & Cardiovascular Systems

Shear-Dependent Platelet Aggregation: Mechanisms and Therapeutic Opportunities

Akshita Rana et al.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2019)

Article Cardiac & Cardiovascular Systems

Bleeding and thrombosis associated with ventricular assist device therapy

Palak Shah et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2017)

Article Engineering, Biomedical

Paradoxical Effect of Nonphysiological Shear Stress on Platelets and von Willebrand Factor

Zengsheng Chen et al.

ARTIFICIAL ORGANS (2016)

Article Cardiac & Cardiovascular Systems

Bleeding, Transfusion, and Mortality on Extracorporeal Life Support: ECLS Working Group on Thrombosis and Hemostasis

Michael Mazzeffi et al.

ANNALS OF THORACIC SURGERY (2016)

Article Multidisciplinary Sciences

Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor

Wei Deng et al.

NATURE COMMUNICATIONS (2016)

Article Multidisciplinary Sciences

Platelet activation risk index as a prognostic thrombosis indicator

K. E. Zlobina et al.

Scientific Reports (2016)

Article Biochemistry & Molecular Biology

Regulation of Pannexin-1 channel activity

Kirk A. Taylor et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2015)

Article Engineering, Biomedical

High-Shear Stress Sensitizes Platelets to Subsequent Low-Shear Conditions

Jawaad Sheriff et al.

ANNALS OF BIOMEDICAL ENGINEERING (2010)

Article Multidisciplinary Sciences

Shear-induced unfolding triggers adhesion of von Willebrand factor fibers

S. W. Schneider et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Cell Biology

Pathological shear stress directly regulates platelet αIIbβ3 signaling

Shuju Feng et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2006)

Article Biochemistry & Molecular Biology

Importance of temporal flow gradients and integrin αIIbβ3 mechanotransduction for shear activation of platelets

I Goncalves et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)