Nrf2 enhances the therapeutic efficiency of adipose-derived stem cells in the treatment of neurogenic erectile dysfunction in a rat model

Review Behavioral Sciences

NGF and BDNF in pediatrics syndromes

Giampiero Ferraguti et al.

Summary: Neurotrophins play multiple roles in neuronal development and are implicated in rare pediatric diseases.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2023)

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Review Pharmacology & Pharmacy

Advances and challenges in therapeutic targeting of NRF2

Albena T. Dinkova-Kostova et al.

Summary: Activation of NRF2 has the potential to address oxidative stress, inflammation, and metabolic imbalances in chronic pathologies. This article discusses the rationale for targeting NRF2, recent advances in drug development of NRF2 modulators, and the challenges in fully harnessing NRF2 as a therapeutic target.

TRENDS IN PHARMACOLOGICAL SCIENCES (2023)

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Article Biochemistry & Molecular Biology

The KEAP1-NRF2 System and Neurodegenerative Diseases

Akira Uruno et al.

Summary: Central nervous system (CNS) diseases, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis, can be regulated by the KEAP1-NRF2 system, which protects cells against oxidative stress and inflammation. NRF2 activation has shown positive effects in mouse models of neurodegenerative diseases, while NRF2 depletion exacerbates symptoms. Further research into this system can lead to potential therapeutic targets for CNS diseases.

ANTIOXIDANTS & REDOX SIGNALING (2023)

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Review Chemistry, Medicinal

KEAP1-NRF2 protein-protein interaction inhibitors: Design, pharmacological properties and therapeutic potential

Enrique Crisman et al.

Summary: The translation discusses the importance of the transcription factor NRF2 in the antioxidant response and its association with various diseases. The article also explores the innovative strategy of discovering NRF2 activators through KEAP1-NRF2 protein-protein interaction inhibitors and summarizes the known inhibitors and their design features, as well as the preclinical pharmacological properties of these compounds.

MEDICINAL RESEARCH REVIEWS (2023)

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Article Biochemistry & Molecular Biology

MK-886 protects against cardiac ischaemia/reperfusion injury by activating proteasome-Keap1-NRF2 signalling

Kai-Na Shi et al.

Summary: Oxidative stress is an important factor in cardiac injury after ischemia-reperfusion (I/R). The drug MK-886, which inhibits ALOX5, has been found to have anti-inflammatory and antioxidant effects. This study demonstrated that MK-886 treatment attenuated cardiac dysfunction, reduced infarct area, decreased myocyte apoptosis, and decreased oxidative stress in an I/R-induced heart injury model, possibly through modulation of the keap1-NRF2 pathway.

REDOX BIOLOGY (2023)

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Review Biochemistry & Molecular Biology

BDNF signaling in context: From synaptic regulation to psychiatric disorders

Camille S. Wang et al.

Summary: This review examines the importance of spatial and temporal factors on BDNF activity, particularly in processes such as synaptogenesis, plasticity, and psychiatric disorder treatment. Understanding the fundamental physiology of BDNF and new approaches to control its signaling in time and space can lead to improved therapeutics and patient outcomes.

CELL (2022)

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Article Engineering, Biomedical

Injectable hyaluronic acid hydrogel loaded with BMSC and NGF for traumatic brain injury treatment

Luyu Wang et al.

Summary: The study demonstrates the therapeutic effect of using injectable hyaluronic acid hydrogel encapsulated with bone mesenchymal stem cells and nerve growth factors for traumatic brain injury. The hydrogel loaded with BMSC and NGF improved neurological function recovery by promoting neurotrophic factors release and neuroinflammation regulation, accelerating the repair process.

MATERIALS TODAY BIO (2022)

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Article Engineering, Biomedical

NRF2 is a critical regulator and therapeutic target of metal implant particle-incurred bone damage

Jian Dong et al.

Summary: This study explores the role of NRF2 in a mouse model of osteolysis caused by wear particles from metal implants. Results show that NRF2 suppression is a critical factor in the development of bone damage, and restoring NRF2 can effectively alleviate osteolysis and reduce the incidence of implant loosening.

BIOMATERIALS (2022)

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Article Medicine, Research & Experimental

Protective activity of tert-butylhydroquinone against oxidative stress and apoptosis induced by glutamate agonizts in R28 cells and mice retina

Shirui Dai et al.

Summary: The study found that tBHQ has a protective effect on retinal damage caused by glutamate excitotoxicity. By regulating cellular oxidative stress and apoptosis pathways, tBHQ can reduce cell damage induced by glutamate.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Review Physiology

Molecular pathogenesis and treatment of cavernous nerve injury-induced erectile dysfunction: A narrative review

Guoda Song et al.

Summary: The primary trigger of postoperative erectile dysfunction after radical prostatectomy is surgical injury to the cavernous nerves that control penile erection. Current therapeutic strategies focus on promoting nerve regeneration and preventing changes in penile structure.

FRONTIERS IN PHYSIOLOGY (2022)

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Review Urology & Nephrology

Is there a role for stem cell therapy in erectile dysfunction secondary to cavernous nerve injury? Network meta-analysis from animal studies and human trials

Mudassir M. Wani et al.

Summary: This study conducted a systematic review and network meta-analysis to investigate the effectiveness of stem cell therapy (SCT) in managing erectile dysfunction (ED) secondary to cavernous nerve injury in rats and post-radical prostatectomy (RP) in humans. The results showed that SCT could improve erectile function in rats with cavernous nerve injury and early human trials also showed promising results.

THERAPEUTIC ADVANCES IN UROLOGY (2022)

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Article Surgery

Effect of Denonvilliers' Fascia Preservation Versus Resection During Laparoscopic Total Mesorectal Excision on Postoperative Urogenital Function of Male Rectal Cancer Patients Initial Results of Chinese PUF-01 Randomized Clinical Trial

Bo Wei et al.

Summary: In male patients with rectal cancer, preserving Denonvilliers' fascia during L-TME surgery has been shown to have a better outcome on postoperative urogenital function compared to resection, reducing the incidence of urinary and sexual dysfunction.

ANNALS OF SURGERY (2021)

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Review Biochemistry & Molecular Biology

Diffuse Axonal Injury: Clinical Prognostic Factors, Molecular Experimental Models and the Impact of the Trauma Related Oxidative Stress. An Extensive Review Concerning Milestones and Advances

Mauro Palmieri et al.

Summary: Identifying clinical prognostic factors for diffuse axonal injury (DAI) is crucial, including glycemia, early GCS, oxygen saturation, blood pressure, and time to recover consciousness. Severity of the lesion, based on cerebral anatomical structures involved, is strongly correlated with survival after DAI. Additionally, biomarkers such as GFAP, pNF-H, NF-L, tau, and A beta 42 may be potential targets for future pharmaceutical treatments to prevent DAI-related damages.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Medicine, Research & Experimental

Fidgetin-like 2 negatively regulates axonal growth and can be targeted to promote functional nerve regeneration

Lisa Baker et al.

Summary: FL2 depletion promotes axonal growth and attenuates growth cone retraction in response to inhibitory molecules. Application of FL2-siRNA enhances functional nerve recovery after cavernous nerve injury.

JCI INSIGHT (2021)

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Article Cell Biology