4.3 Article

Dynamic tuft cell expansion during gastric metaplasia and dysplasia

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Microbiology

Tuft cells are key mediators of interkingdom interactions at mucosal barrier surfaces

Madison S. Strine et al.

Summary: Tuft cells, originating from epithelial cells, function similarly to immune cells and play important roles in sensing and responding to microbial infections. They mediate interactions between the host and various microorganisms, such as helminths, protists, viruses, and bacteria. Tuft cells exhibit broad heterogeneity in different tissues and can recognize specific microbes to promote immune responses and tissue repair. They are regulated by commensal and pathogenic bacteria and are involved in modulating mucosal barrier integrity. However, their contributions to microbial sensing in humans and their effector responses are still poorly understood.

PLOS PATHOGENS (2022)

Article Gastroenterology & Hepatology

Up-regulation of Aquaporin 5 Defines Spasmolytic Polypeptide-Expressing Metaplasia and Progression to Incomplete Intestinal Metaplasia

Su-Hyung Lee et al.

Summary: AQP5 is identified as a novel lineage-specific marker for spasmolytic polypeptide-expressing metaplasia (SPEM) cells. Its expression is localized at the base of metaplastic glands and expands after Helicobacter felis infection. AQP5 expression is up-regulated in early chief cell reprogramming and is promoted by interleukin 13. Incomplete intestinal metaplastic glands marked by TROP2 show highly branched structures with AQP5-positive SPEM cells, while complete intestinal metaplastic glands do not contain AQP5-positive cells.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2022)

Article Immunology

BMP signaling in the intestinal epithelium drives a critical feedback loop to restrain IL-13-driven tuft cell hyperplasia

Havard T. Lindholm et al.

Summary: This study investigated immune responses in the intestinal epithelium using organoid image analysis, transcriptomic analysis, and in vivo infection models. The researchers found that IL-13 and IL-22 induce genes associated with goblet cells, but the resulting phenotypes of goblet cells are different. Additionally, only IL-13-driven goblet cells are associated with classical NOTCH signaling. The study also revealed that IL-13 activates the BMP pathway, which negatively regulates type 2 immunity and tuft cell hyperplasia.

SCIENCE IMMUNOLOGY (2022)

Article Gastroenterology & Hepatology

Dysplastic Stem Cell Plasticity Functions as a Driving Force for Neoplastic Transformation of Precancerous Gastric Mucosa

Jimin Min et al.

Summary: It was found that dysplastic stem cells may be the initiating cells for gastric cancer and play a role in maintaining dysplastic cell lineages through Wnt ligand-independent CK1 alpha/beta-catenin signaling. DP-DSCs evolved towards multiple types of gastric adenocarcinomas, contributing to cancer cell heterogeneity by acquiring additional genetic mutations and recruiting the tumor microenvironment. Targeting CK1 alpha controlled the growth and survival of both mouse and human dysplastic organoids.

GASTROENTEROLOGY (2022)

Article Gastroenterology & Hepatology

Decreased number of colonic tuft cells in quiescent ulcerative colitis patients

Sebastian Kjaergaard et al.

Summary: Patients with quiescent ulcerative colitis have a relatively low number of colonic tuft cells compared to controls. Further studies are needed to investigate the potential involvement of tuft cells in the pathogenesis of ulcerative colitis.

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY (2021)

Article Gastroenterology & Hepatology

The Gustatory Sensory G-Protein GNAT3 Suppresses Pancreatic Cancer Progression in Mice

Megan T. Hoffman et al.

Summary: This study demonstrates that inhibiting GNAT3 can increase the release of tumor-promoting cytokines, alter the MDSC population, and promote the progression of metastatic PDA.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2021)

Review Biochemistry & Molecular Biology

Inflammation and tumor progression: signaling pathways and targeted intervention

Huakan Zhao et al.

Summary: Inflammation plays a crucial role in cancer development and therapy, either promoting or inhibiting tumor progression and therapeutic outcomes. Various signaling pathways and factors have been identified as pivotal regulators of inflammation initiation and resolution.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Article Immunology

Airway brush cells generate cysteinyl leukotrienes through the ATP sensor P2Y2

Saltanat Ualiyeva et al.

SCIENCE IMMUNOLOGY (2020)

Article Medicine, Research & Experimental

Distribution of duodenal tuft cells is altered in pediatric patients with acute and chronic enteropathy

Won Jae Huh et al.

BIOMEDICAL RESEARCH-TOKYO (2020)

Article Oncology

Trop2 is upregulated in the transition to dysplasia in the metaplastic gastric mucosa

Katherine M. Riera et al.

JOURNAL OF PATHOLOGY (2020)

Article Gastroenterology & Hepatology

Tuft Cells Inhibit Pancreatic Tumorigenesis in Mice by Producing Prostaglandin D2

Kathleen E. DelGiorno et al.

GASTROENTEROLOGY (2020)

Article Gastroenterology & Hepatology

Succinate Produced by Intestinal Microbes Promotes Specification of Tuft Cells to Suppress Ileal Inflammation

Amrita Banerjee et al.

GASTROENTEROLOGY (2020)

Review Immunology

The Immune Function of Tuft Cells at Gut Mucosal Surfaces and Beyond

Hung-An Ting et al.

JOURNAL OF IMMUNOLOGY (2019)

Article Biochemistry & Molecular Biology

Dclk1 in tuft cells promotes inflammation-driven epithelial restitution and mitigates chronic colitis

Jun Yi et al.

CELL DEATH AND DIFFERENTIATION (2019)

Article Multidisciplinary Sciences

Heterogeneity and dynamics of active Kras-induced dysplastic lineages from mouse corpus stomach

Jimin Min et al.

NATURE COMMUNICATIONS (2019)

Letter Gastroenterology & Hepatology

Active Kras Expression in Gastric Isthmal Progenitor Cells Induces Foveolar Hyperplasia but Not Metaplasia

Eunyoung Choi et al.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2019)

Article Cell Biology

POU2F3 is a master regulator of a tuft cell-like variant of small cell lung cancer

Yu-Han Huang et al.

GENES & DEVELOPMENT (2018)

Article Multidisciplinary Sciences

Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development

Corey N. Miller et al.

NATURE (2018)

Article Medicine, Research & Experimental

Optimized multiplex immunofluorescence single-cell analysis reveals tuft cell heterogeneity

Eliot T. McKinley et al.

JCI INSIGHT (2017)

Article Multidisciplinary Sciences

Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites

Francois Gerbe et al.

NATURE (2016)

Article Multidisciplinary Sciences

Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut

Michael R. Howitt et al.

SCIENCE (2016)

Review Pathology

Menetrier's Disease: Its Mimickers and Pathogenesis

Won Jae Huh et al.

JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE (2016)

Article Gastroenterology & Hepatology

Identification and Manipulation of Biliary Metaplasia in Pancreatic Tumors

Kathleen E. DelGiorno et al.

GASTROENTEROLOGY (2014)

Article Medicine, Research & Experimental

Long-lived intestinal tuft cells serve as colon cancer-initiating cells

C. Benedikt Westphalen et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

Article Multidisciplinary Sciences

Comprehensive molecular characterization of gastric adenocarcinoma

Adam J. Bass et al.

NATURE (2014)

Article Cell Biology

Gastric tuft cells express DCLK1 and are expanded in hyperplasia

Milena Saqui-Salces et al.

HISTOCHEMISTRY AND CELL BIOLOGY (2011)

Article Neurosciences

Skn-1a (Pou2f3) specifies taste receptor cell lineage

Ichiro Matsumoto et al.

NATURE NEUROSCIENCE (2011)

Review Oncology

Eicosanoids and cancer

Dingzhi Wang et al.

NATURE REVIEWS CANCER (2010)

Article Medicine, General & Internal

Treatment of Menetrier's disease with a monoclonal antibody against the epidermal growth factor receptor

JS Burdick et al.

NEW ENGLAND JOURNAL OF MEDICINE (2000)