4.7 Review

Mesenchymal stem cell-based therapy for autoimmune-related fibrotic skin diseases-systemic sclerosis and sclerodermatous graft-versus-host disease

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Mesenchymal Stem Cell-Based Therapy as a New Approach for the Treatment of Systemic Sclerosis

Xiufen Zhuang et al.

Summary: Systemic sclerosis (SSc) is a difficult-to-treat autoimmune disease with limited medical options. Conventional immunosuppressive therapies are not very effective and have noticeable side effects. Stem cell transplantation and mesenchymal stem cells (MSCs) hold promise as alternative treatments for SSc.

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Regulatory B Cells Contribute to the Clinical Response After Bone Marrow-Derived Mesenchymal Stromal Cell Infusion in Patients With Systemic Sclerosis

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Safety and preliminary efficacy of allogeneic bone marrow-derived multipotent mesenchymal stromal cells for systemic sclerosis: a single-centre, open-label, dose-escalation, proof-of-concept, phase 1/2 study

Dominique Farge et al.

Summary: This study aimed to evaluate the safety and feasibility of mesenchymal stromal cell therapy derived from bone marrow to treat severe diffuse systemic sclerosis. The results showed that a single intravenous injection of allogeneic bone marrow-derived mesenchymal stromal cells was safe and well-tolerated in patients with severe diffuse systemic sclerosis.

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LGR5 expressing skin fibroblasts define a major cellular hub perturbed in scleroderma

Chamutal Gur et al.

Summary: This study conducted single-cell genomic analysis of skin and blood samples from patients with systemic sclerosis (SSc) and healthy controls. The results showed immune compartment dysfunction in a specific subtype of diffuse SSc patients, and global dysregulation of the stromal compartment, particularly in a previously undefined subset of LGR5(+)-scleroderma-associated fibroblasts (ScAFs). The findings provide insights into disease development and may contribute to the development of biomarkers and therapeutic strategies.
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Efficacy and safety of mesenchymal stem cells in the treatment of systemic sclerosis: a systematic review and meta-analysis

Jiehan Cui et al.

Summary: This systematic review and meta-analysis found that mesenchymal stem cell (MSC) therapy can improve the degree of skin fibrosis, lung function, and mouth opening, and relieve finger ulcers and pain in patients with systemic sclerosis (SSc) without severe adverse events.

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Combination of Dexamethasone and Tofacitinib Reduces Xenogeneic MSC-Induced Immune Responses in a Mouse Model of Alzheimer's Disease

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Cong Li et al.

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Mesenchymal stromal cells for systemic sclerosis treatment

Dominique Farge et al.

Summary: Systemic sclerosis (SSc) is a rare chronic autoimmune disease characterized by vasculopathy, dysregulation of immune responses, and progressive fibrosis. Mesenchymal stromal cells (MSC) have shown promise as a potential stem cell therapy for SSc, with studies demonstrating proangiogenic, immuno-suppressive, and anti-fibrotic properties. Preclinical studies in animal models and early clinical trials in humans have reported positive results in reducing fibrosis in SSc patients.

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Feasibility of reduced-dose posttransplant cyclophosphamide and cotransplantation of peripheral blood stem cells and umbilical cord-derived mesenchymal stem cells for SAA

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Strategies to address mesenchymal stem/stromal cell heterogeneity in immunomodulatory profiles to improve cell-based therapies

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Mesenchymal stromal cells-derived extracellular vesicles alleviate systemic sclerosis via miR-29a-3p

Pauline Rozier et al.

Summary: This study demonstrates that EVs derived from MSCs and ASCs have a therapeutic effect on systemic sclerosis by slowing down the disease progression. Down-regulating miR-29a-3p in MSCs abolishes the therapeutic efficacy, highlighting the importance of this microRNA in the treatment. Furthermore, EVs from A29a-transfected ASCs failed to improve skin fibrosis, indicating the potential role of miR-29a-3p in regulating methylation and apoptosis pathways in SSc.

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Antifibrotic effects and mechanisms of mesenchymal stem cell-derived exosomes in a systemic sclerosis mouse model: Possible contribution of miR-196b-5p

Hritu Baral et al.

Summary: The study demonstrated that MSCs-derived exosomes inhibited dermal fibrosis in a bleomycin-induced SSc mouse model, potentially through the suppression of collagen type I expression by miR-196b-5p present in the exosomes.

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BMSC-derived extracellular vesicles intervened the pathogenic changes of scleroderma in mice through miRNAs

Jiahui Jin et al.

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Immunosuppressant Drugs Mitigate Immune Responses Generated by Human Mesenchymal Stem Cells Transplanted into the Mouse Parenchyma

Jung Won Hwang et al.

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Adipose-derived stromal/stem cells successfully attenuate the fibrosis of scleroderma mouse models

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Treatment of chronicGvHDwith mesenchymal stromal cells induces durable responses: A phaseIIstudy

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Current immunosuppressive and antifibrotic therapies of systemic sclerosis and emerging therapeutic strategies

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How to influence the mesenchymal stem cells fate? Emerging role of ectoenzymes metabolizing nucleotides

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Priming approaches to improve the efficacy of mesenchymal stromal cell-based therapies

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Cyclosporine A promotes the therapeutic effect of mesenchymal stem cells on transplantation reaction

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Mesenchymal Stem Cells Attenuate the Adverse Effects of Immunosuppressive Drugs on Distinct T Cell Subopulations

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