Design, stereoselective synthesis and anticancer efficacy of a new class of functionalized pyrrolizidine heterocyclic hybrids

Review Biochemistry & Molecular Biology

Spirooxindole: A Versatile Biologically Active Heterocyclic Scaffold

Siva S. S. Panda et al.

Summary: This article summarizes the recent developments in the synthesis of natural and synthetic spirooxindole-containing compounds from isatin or its derivatives, categorizing them based on their mentioned biological properties.

MOLECULES (2023)

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Review Chemistry, Medicinal

Nitrogen Containing Heterocycles as Anticancer Agents: A Medicinal Chemistry Perspective

Adarsh Kumar et al.

Summary: Cancer is a major healthcare challenge worldwide, calling for the development of safer and target-specific anticancer drugs. This study summarizes the use of nitrogen-containing heterocycles in cancer treatment, providing insights into their pharmacological properties and mechanisms of action.

PHARMACEUTICALS (2023)

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Review Biochemistry & Molecular Biology

Oxygen- and Sulphur-Containing Heterocyclic Compounds as Potential Anticancer Agents

Harshita Sachdeva et al.

Summary: Oxygen- and sulphur-based heterocycles, which are the core structure of many biologically active molecules and FDA-approved drugs, have a wide range of biological activities. In recent years, they have gained more attention as potential innovative anticancer drugs. Fused oxygen- and sulphur-based heterocyclic derivatives have been synthesized in attempts to improve the biological profile of molecules. Additionally, fused heterocycles behave as DNA intercalating agents, interacting with DNA and inducing cell death to exert their anticancer effects.

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY (2022)

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Review Cell Biology

cAMP Signaling in Cancer: A PKA-CREB and EPAC-Centric Approach

Muhammad Bilal Ahmed et al.

Summary: Cancer, one of the leading causes of death globally, remains unclear in its fundamental principles. Understanding the key signaling mechanisms that cause cancer cell malignancy may help uncover new pharmaco-targets. Targeting cAMP and its effectors, crucial for tumor growth and development, may serve as a useful cancer treatment strategy.

CELLS (2022)

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Article Chemistry, Organic

Ionic liquid mediated synthesis and in vitro mechanistic exploration of polycyclic cage-like heterocyclic hybrid

Raju Suresh Kumar et al.

Summary: A novel polycyclic cage-like heterocyclic hybrid (PCHH) with broad-spectrum anticancer activity was synthesized and shown to induce apoptosis specifically in Jurkat cells.

JOURNAL OF HETEROCYCLIC CHEMISTRY (2021)

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Review Chemistry, Medicinal

Anticancer potential of spirocompounds in medicinal chemistry: A pentennial expedition

Darshana Bora et al.

Summary: Spirocompounds, an important class of organic frameworks, have shown promising anticancer potential, inspiring medicinal chemists to explore new derivatives with improved pharmacological properties. By investigating the anticancer activity and structure-activity relationships of various spirocompounds, this review may guide the design of novel spiromolecules with enhanced safety and efficacy in the future.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

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Review Pharmacology & Pharmacy