☆ 4.7 Article

HMGB1 in the interplay between autophagy and apoptosis in cancer

CANCER LETTERS (2024)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Cell Biology

Identification of HPCAL1 as a specific autophagy receptor involved in ferroptosis

Xin Chen et al.

Summary: This study identifies HPCAL1 as a novel autophagy receptor for the selective degradation of CDH2 during ferroptosis. Depletion of CDH2 increases susceptibility to ferroptotic death. The phosphorylation of HPCAL1 and the non-classical LC3-interacting region motif play key roles in the autophagic degradation of CDH2. A ferroptosis inhibitor is found to suppress HPCAL1 expression. Inhibition of HPCAL1 prevents ferroptosis-induced tumor suppression and pancreatitis in mouse models.

AUTOPHAGY (2023)

添加到收藏夹

Article Toxicology

Dasatinib causes keratinocyte apoptosis via inhibiting high mobility group Box 1-mediated mitophagy

Zizheng Gao et al.

Summary: Dasatinib, a first-line treatment for chronic myeloid leukemia, has the limitation of severe cutaneous toxicity. This study revealed that dasatinib directly induced cytotoxicity on keratinocytes by inhibiting HMGB1-mediated mitophagy, leading to keratinocyte apoptosis. Saikosaponin A could be a potential strategy for preventing dasatinib-induced cutaneous toxicity.

TOXICOLOGY LETTERS (2023)

添加到收藏夹

Article Environmental Sciences

Genistin modulates high-mobility group box protein 1 (HMGB1) and nuclear factor kappa-B (NF-κB) in Ehrlich-ascites-carcinoma-bearing mice

Mohamed A. Saleh et al.

Summary: Cancer is the second leading cause of death worldwide, and current treatment options are often uncomfortable and ineffective. Plant-derived natural chemicals, such as flavonoids, have gained attention due to their high bioavailability, safety, few side effects, and cost-effectiveness. Flavonoids have shown promising cytotoxic anti-cancer effects and are being researched for their ability to target inflammation and apoptosis. In a laboratory study, genistin, a flavonoid compound, demonstrated good cytotoxic activity against breast cancer cell lines. In vivo studies on animals also showed that genistin reduced tumor weight, volume, and certain biochemical markers associated with cancer progression.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2023)

添加到收藏夹

Article Oncology

Immunogenic hypofractionated radiotherapy sensitising head and neck squamous cell carcinoma to anti-PD-L1 therapy in MDSC-dependent manner

Liang Mao et al.

Summary: Combining immunogenic radiotherapy with anti-PD-L1 treatment can enhance the immune response in immunotherapy-resistant HNSCC mouse models.

BRITISH JOURNAL OF CANCER (2023)

添加到收藏夹

Article Cell Biology

The telomeric protein TERF2/TRF2 impairs HMGB1-driven autophagy

Sara Iachettini et al.

Summary: TERF2 is a telomeric protein that plays a crucial role in tumor formation and progression. This study uncovers a novel function of TERF2 in regulating the autophagic process and reveals its interaction with HMGB1 as functional for protein localization.

AUTOPHAGY (2023)

添加到收藏夹

Article Endocrinology & Metabolism

CircRTN1 stimulates HMGB1 to regulate the malignant progression of papillary thyroid cancer by sponging miR-101-3p

Mei Zheng et al.

Summary: This study discovered that circRTN1 plays an important role in the progression of papillary thyroid cancer (PTC). By regulating the miR-101-3p/HMGB1 pathway, circRTN1 depletion inhibits the malignancy of PTC cells, providing a new targeted therapeutic strategy for PTC.

HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

Antitumoral and Immunogenic Capacity of β-D-Glucose-Reduced Silver Nanoparticles in Breast Cancer

Pedro Felix-Pina et al.

Summary: This study synthesized and characterized beta-D-glucose-reduced silver nanoparticles (AgNPs-G), and evaluated their cytotoxic effect on breast cancer cells in vitro. The study also investigated the immunogenicity of cell death induced by AgNPs-G in vitro and in vivo. The results showed that AgNPs-G can induce dose-dependent cell death and inhibit proliferation of breast cancer cells. Treatment with AgNPs-G also led to exposure of calreticulin and release of HSP70, HSP90, HMGB1, and ATP. In vivo, immunization with AgNPs-G did not completely induce immune response, but it reduced tumor weight and improved survival rate.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

添加到收藏夹

Article Biotechnology & Applied Microbiology

MAP7D2 reduces CD8+cytotoxic T lymphocyte infiltration through MYH9-HMGB1 axis in colorectal cancer

Qian Wu et al.

Summary: Through next-generation sequencing, we identified MAP7D2 as a potential therapeutic target to improve the efficacy of immune checkpoint inhibitors (ICIs) for microsatellite stable (MSS) colorectal cancer (CRC) therapy. MAP7D2 expression was increased in MSS CRC and negatively correlated with the presence of antitumor T lymphocytes. Knockdown of MAP7D2 significantly enhanced CD8+ CTLs infiltration and improved the efficacy of ICIs in MSS CRC murine models. Targeting MAP7D2 may present a novel approach for antitumor immunotherapy in MSS CRC.

MOLECULAR THERAPY (2023)

添加到收藏夹

Article Oncology

Regorafenib induces damage-associated molecular patterns, cancer cell death and immune modulatory effects in a murine triple negative breast cancer model

Ling-Ming Tseng et al.

Summary: This study found that regorafenib, a multi-target angiokinase inhibitor, induces immunogenic cell death in triple negative breast cancer cells and suppresses tumor progression. However, when combined with immune checkpoint inhibitor PD-1 antibody, the efficacy of regorafenib might be affected by the inhibition of STAT3 signaling.

EXPERIMENTAL CELL RESEARCH (2023)

添加到收藏夹

Review Immunology

The multifunctional protein HMGB1: 50 years of discovery

Daolin Tang et al.

Summary: Fifty years since the discovery of HMGB1 protein, its physiological and pathological roles have been extensively studied. This Review covers the structure, localization, and functions of HMGB1 in immune responses, including historical foundations and recent advances.

NATURE REVIEWS IMMUNOLOGY (2023)

添加到收藏夹

Article Peripheral Vascular Disease

Peritumoral B cells drive proangiogenic responses in HMGB1-enriched esophageal squamous cell carcinoma

Ngar Woon Kam et al.

Summary: Different functions and profiles of B-cell subsets in various cancers have been reported. In esophageal squamous cell carcinoma (ESCC), proliferating B cells are predominantly found in the peritumoral region with high expression of HMGB1. Cancer-derived HMGB1 modulates B cells to promote angiogenesis in ESCC microenvironment.

ANGIOGENESIS (2022)

添加到收藏夹

Article Oncology

4-(N)-Docosahexaenoyl 2', 2'-difluorodeoxycytidine induces immunogenic cell death in colon and pancreatic carcinoma models as a single agent

Stephanie Hufnagel et al.

Summary: DHA-dFdC is a bona fide inducer of immunogenic cell death (ICD) and can render pancreatic tumors responsive to anti-PD-1 mAb therapy. The study confirmed the effects of DHA-dFdC on cell lines and provided insights into its potential mechanism of inducing ICD.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

The Apoptosis Paradox in Cancer

Ornella Morana et al.

Summary: Cancer growth is characterized by an imbalance between cell gain and cell loss, with high-grade cancers often having high levels of apoptosis. While cell-autonomous apoptosis serves as a tumor suppressor mechanism, limited apoptosis can promote cell survival and resistance to therapy by conditioning the tumor microenvironment. Understanding the implications of cell death programs in tumor biology is crucial for cancer treatment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

添加到收藏夹

Article Oncology

Harnessing chlorin e6 loaded by functionalized iron oxide nanoparticles linked with glucose for target photodynamic therapy and improving of the immunogenicity of lung cancer

Ting-Ting Yu et al.

Summary: This study demonstrates a promising strategy to improve the distribution of Ce6 in lung cancer using functionalized iron oxide nanoparticles linked with glucose. The results show that this method significantly enhances the uptake of Ce6 by lung cancer cells and increases the production of reactive oxygen species. Additionally, IO-PG-GLU-Ce6 effectively damages the DNA of lung cancer cells and enhances their immunogenicity.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Deubiquitylase USP12 induces pro-survival autophagy and bortezomib resistance in multiple myeloma by stabilizing HMGB1

Hui Li et al.

Summary: This study identified the deubiquitylase USP12 plays an important role in pro-survival autophagy and drug resistance in multiple myeloma by stabilizing HMGB1 protein. The USP12/HMGB1 axis might be a potential diagnostic and therapeutic target in human MM.

ONCOGENE (2022)

添加到收藏夹

Article Medicine, Research & Experimental

miR-340-5p inhibits pancreatic acinar cell inflammation and apoptosis via targeted inhibition of HMGB1

Yazhou Gao et al.

Summary: The study identified an association between miR-340-5p and HMGB1 expression in pancreatic acinar cells, showing that miR-340-5p can inhibit inflammation and apoptosis induced by LPS by suppressing HMGB1 expression. Therefore, the therapeutic application of miR-340-5p may be a useful strategy in AP.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2022)

添加到收藏夹

Article Cell Biology

PINK1 Protects against Staurosporine-Induced Apoptosis by Interacting with Beclin1 and Impairing Its Pro-Apoptotic Cleavage

Francesco Brunelli et al.

Summary: In this study, a novel anti-apoptotic function of PINK1 was discovered, providing new options for treatment in proliferative or neurodegenerative diseases.

CELLS (2022)

添加到收藏夹

Article Cell Biology

Autophagic degradation of CCN2 (cellular communication network factor 2) causes cardiotoxicity of sunitinib

Zhifei Xu et al.

Summary: Excessive macroautophagy induced by sunitinib leads to apoptosis of cardiomyocytes and cardiac dysfunction through the TOLLIP-mediated endosome-related pathway. Additionally, deletion of Hmgb1 or treatment with the HMGB1-specific inhibitor glycyrrhizic acid can significantly mitigate sunitinib-induced autophagy, cardiomyocyte death, and cardiotoxicity. This study reveals a novel target protein of autophagic degradation in the regulation of cardiomyocyte death and suggests HMGB1 inhibition as a promising strategy for enhancing the safety of sunitinib-based cancer therapy.

AUTOPHAGY (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Lactate promotes macrophage HMGB1 lactylation, acetylation, and exosomal release in polymicrobial sepsis

Kun Yang et al.

Summary: High levels of lactate and HMGB1 are associated with the severity and mortality of sepsis. Lactate can promote HMGB1 lactylation and acetylation in macrophages, leading to HMGB1 release and increased endothelium permeability. Targeting lactate-associated signaling pathways may offer a potential strategy to combat sepsis.

CELL DEATH AND DIFFERENTIATION (2022)

添加到收藏夹

Article Engineering, Biomedical

Chemiluminescence resonance energy transfer-based immunostimulatory nanoparticles for sonoimmunotherapy

Jueun Jeon et al.

Summary: Sonodynamic therapy (SDT) has emerged as a promising alternative to photodynamic therapy for treating deeply located tumors accessible by ultrasound. However, the therapeutic potential of conventional sonosensitizers is limited. This study reports immunostimulatory nanoparticles (iCRET NPs) for sonoimmunotherapy, which amplify the reactive oxygen species (ROS) production and induce immunogenic cell death in the tumor microenvironment (TME). The iCRET NPs effectively inhibit tumor growth and metastasis when combined with anti-PD-1 antibodies.

BIOMATERIALS (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

The mechanism of HMGB1 secretion and release

Ruochan Chen et al.

Summary: Inflammation-promoting nuclear protein HMGB1 can be targeted for controlling immune response in diseases linked to excessive inflammation. This article reviews the mechanisms of HMGB1 release and discusses its potential as a therapeutic target for inflammatory diseases and tissue damage.

EXPERIMENTAL AND MOLECULAR MEDICINE (2022)

添加到收藏夹

Article Oncology

miR-495-3p depresses cell proliferation and migration by downregulating HMGB1 in colorectal cancer

Jie Ling Zhang et al.

Summary: This study investigates the role of miR-495-3p and HMGB1 in colorectal cancer (CRC). The findings suggest that miR-495-3p inhibits the progression of CRC by downregulating HMGB1 expression, indicating its potential as a therapeutic target for CRC.

WORLD JOURNAL OF SURGICAL ONCOLOGY (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

A cyclodextrin-based nanoformulation achieves co-delivery of ginsenoside Rg3 and quercetin for chemo-immunotherapy in colorectal cancer

Dandan Sun et al.

Summary: This study confirms the potential of ginsenoside Rg3 as an inducer of immunogenic cell death (ICD) against colorectal cancer (CRC) cells. The effectiveness of Rg3 in inducing ICD is significantly enhanced when combined with quercetin (QTN) that induces reactive oxygen species (ROS). A targeted nanoparticle formulation, co-encapsulating Rg3 and QTN, is developed to improve the in vivo delivery and shows enhanced tumor targeting and prolonged blood circulation in a CRC mouse model. The combination of this nanoparticle formulation with anti-PD-L1 leads to significantly longer survival in animals.

ACTA PHARMACEUTICA SINICA B (2022)

添加到收藏夹

Article Oncology

Carbon ion radiotherapy triggers immunogenic cell death and sensitizes melanoma to anti-PD-1 therapy in mice

Heng Zhou et al.

Summary: Carbon ion radiotherapy (CIRT) enhances tumor immunogenicity and improves the efficacy of subsequent anti-PD-1 immunotherapy by inducing immunogenic cell death.

ONCOIMMUNOLOGY (2022)

添加到收藏夹

Article Oncology

Conventional amphotericin B elicits markers of immunogenic cell death on leukemic blasts, mediates immunostimulatory effects on phagocytic cells, and synergizes with PD-L1 blockade

G. Kofla et al.

Summary: Research demonstrates that Amphotericin B (AmB) can enhance antitumor immune responses by inducing immunogenic cell death and altering the distribution of surface proteins on leukemia cells. The study also suggests that PD-L1 expression may be a feature of immunogenic cell death, serving as a negative feedback mechanism to regulate dendritic cell maturation and affect T-cell priming.

ONCOIMMUNOLOGY (2022)

添加到收藏夹

Article Oncology

PKHB1, a thrombospondin-1 peptide mimic, induces anti-tumor effect through immunogenic cell death induction in breast cancer cells

Kenny Misael Calvillo-Rodriguez et al.

Summary: This study evaluated the antitumoral effect of PKHB1 against breast cancer cells and the immunogenicity of the cell death induced by PKHB1. The results showed that PKHB1 induces cell death in breast cancer cells and has an antitumor effect.

ONCOIMMUNOLOGY (2022)

添加到收藏夹

Editorial Material Cell Biology

Crosstalk of Autophagy and Apoptosis

Maurizio Sorice

Summary: Autophagy and apoptosis are two fundamental mechanisms regulating cell fate, and they are significantly interconnected through various crosstalk mechanisms. The crosstalk between autophagy and apoptosis impacts various pathologies, including rheumatic diseases. This Special Issue focuses on investigating the bioactive properties of antitumor drugs, particularly the role of anthraquinone derivatives in regulating cell death and autophagy crosstalk.

CELLS (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Tumor Treating Fields (TTFields) Concomitant with Immune Checkpoint Inhibitors Are Therapeutically Effective in Non-Small Cell Lung Cancer (NSCLC) In Vivo Model

Yiftah Barsheshet et al.

Summary: The study examined the potential of combining tumor treating fields (TTFields) with immune checkpoint inhibitors (ICI) in the treatment of lung tumors. The results showed that the combination of TTFields and ICI led to significant reduction in tumor volume and increased infiltration of cytotoxic T-cells, suggesting that TTFields may enhance antitumor immunity.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

添加到收藏夹

Article Oncology

Curcumin Suppresses the Progression of Colorectal Cancer by Improving Immunogenic Cell Death Caused by Irinotecan

Cunliang Zhu et al.

Summary: The combination therapy of curcumin and irinotecan has synergistic antitumor effects by promoting immunogenic cell death. This may be an option for first-line chemotherapy in some patients with colorectal cancer.

CHEMOTHERAPY (2022)

添加到收藏夹

Article Immunology

Chromomycin A5 induces bona fide immunogenic cell death in melanoma

Katharine Gurgel Dias Florencio et al.

Summary: Certain cytotoxic chemotherapics can activate the immune system through immunogenic cell death (ICD), leading to better and long-lasting antitumor responses. This study evaluated the ICD induction of four highly cytotoxic chromomycins A (CA(5-8)) in melanoma cells.

FRONTIERS IN IMMUNOLOGY (2022)

添加到收藏夹

Review Cell Biology

Emerging roles of HMGB1-related lncRNA: from molecular biology to clinical application

Tianyi Wang et al.

Summary: This article systematically summarizes the lncRNAs related to HMGB1 and its essential receptors, highlighting the role of lncRNAs in upregulating HMGB1 and its receptors. It also explores the potential application prospects for the treatment of HMGB1-related disorders.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Camptothesome elicits immunogenic cell death to boost colorectal cancer immune checkpoint blockade

Zhiren Wang et al.

Summary: Camptothesome is an innovative nanovesicle therapeutic that has shown promising results in the treatment of colorectal cancer. It is taken up by cancer cells through a specific pathway and induces immunogenic cancer cell death. The use of Camptothesome-treated tumor cells as a vaccine has proven effective in preventing tumor growth. Furthermore, Camptothesome demonstrates superior anti-cancer efficacy and immune response compared to other treatments. It also enhances the effectiveness of immune checkpoint inhibitors in shrinking late-stage CRC tumors and prolonging survival.

JOURNAL OF CONTROLLED RELEASE (2022)

添加到收藏夹

Article Cell Biology

The EXTREME Regimen Associating Cetuximab and Cisplatin Favors Head and Neck Cancer Cell Death and Immunogenicity with the Induction of an Anti-Cancer Immune Response

Justine De Azevedo et al.

Summary: The EXTREME protocol or cetuximab alone are capable of eliciting an anti-tumor immune response in HNSCC under conditions of moderate apoptosis induction.

CELLS (2022)

添加到收藏夹

Article Cell Biology

HMGB1 is a mediator of cuproptosis-related sterile inflammation

Jiao Liu et al.

Summary: This study found that cuproptotic cells release HMGB1 to initiate inflammation. Mechanistically, copper accumulation-induced ATP depletion activates AMPK to promote HMGB1 phosphorylation, resulting in increased release. Inhibiting AMPK activation reduces cuproptosis and HMGB1 release. Cuproptotic cells deficient in HMGB1 show reduced production of inflammatory cytokines. Thus, HMGB1 is a key mediator of sterile inflammation initiated by cuproptosis.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

Targeting HMGB1: An available Therapeutic Strategy for Breast Cancer Therapy

Haonan Dong et al.

Summary: This review summarizes the clinical value of HMGB1 in diagnosis and therapy of breast cancer, as well as its functions and mechanisms in regulating breast cancer. It discusses the strategies of chemotherapy, radiotherapy, immunotherapy, and combination therapies by targeting HMGB1, and emphasizes the importance of HMGB1 as a therapeutic target in breast cancer treatment.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2022)

添加到收藏夹

Article Cell Biology

Autophagy-based unconventional secretion of HMGB1 by keratinocytes plays a pivotal role in psoriatic skin inflammation

Zhen Wang et al.

Summary: This study reveals a novel autophagy mechanism in the pathogenesis of psoriasis, indicating the pivotal role of HMGB1-associated autosecretion in cutaneous inflammation.

AUTOPHAGY (2021)

添加到收藏夹

Article Cell Biology

Raft-like lipid microdomains drive autophagy initiation via AMBRA1-ERLIN1 molecular association within MAMs

Valeria Manganelli et al.

Summary: This study investigates the association of ERLIN1 with MAM raft-like microdomains and its interaction with AMBRA1 in regulating autophagy. The interaction between ERLIN1 and AMBRA1 at MAM raft-like microdomains is crucial for autophagosome formation.

AUTOPHAGY (2021)

添加到收藏夹

Article Cell Biology

Secretory autophagy machinery and vesicular trafficking are involved in HMGB1 secretion

Young Hun Kim et al.

Summary: The study showed that stress-inducible protein HSP90AA1 and other proteins regulate the translocation and secretion of HMGB1, impacting inflammation and immune response. Additionally, secretory autophagy and multivesicular body formation play a role in mediating HMGB1 secretion.

AUTOPHAGY (2021)

添加到收藏夹

Review Cell Biology

Ferroptosis: machinery and regulation

Xin Chen et al.

Summary: Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death caused by lipid peroxidation. Lipoxygenase is the main promoter of ferroptosis, while GPX4 is the central repressor of this process.

AUTOPHAGY (2021)

添加到收藏夹

Article Oncology

REIC/Dkk-3 Gene Therapy Induces Immunogenic Cell Death in a Mouse Model of Malignant Mesothelioma

Kenji Araki et al.

Summary: The study demonstrates that Ad-REIC can induce apoptotic cell death in malignant mesothelioma cells and trigger immunogenic cell death. In vivo experiments showed that Ad-REIC induced the release of damage-associated molecular patterns and exhibited a vaccination effect. Furthermore, the efficacy of Ad-REIC was further enhanced when combined with immune checkpoint blockade therapies.

ANTICANCER RESEARCH (2021)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Circular RNA 0081146 facilitates the progression of gastric cancer by sponging miR-144 and up-regulating HMGB1

Qihua Xu et al.

Summary: The study reveals that circ_0081146 is upregulated in gastric cancer and acts as an oncogene by promoting cell growth, migration, and invasion through modulating the miR-144/HMGB1 axis.

BIOTECHNOLOGY LETTERS (2021)

添加到收藏夹

Article Oncology

Pingyangmycin enhances the antitumor efficacy of anti-PD-1 therapy associated with tumor-infiltrating CD8+ T cell augmentation

Chuan-Kun Shan et al.

Summary: The study showed that PYM induced ICD in murine breast cancer and melanoma cells, and increased nucleic acid fragment release to promote monocytic chemotaxis. In the breast cancer model, PYM alone and in combination with anti-PD-1 antibody significantly suppressed tumor growth, with the combination showing a synergistic effect. The combination treatment also resulted in various immunological changes, including increased CD8(+) cells and decreased Tregs.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2021)

添加到收藏夹

Article Oncology

Targeting neutrophil extracellular traps with thrombomodulin prevents pancreatic cancer metastasis

Hiroki Kajioka et al.

Summary: Surgery is the primary curative treatment for pancreatic cancer, but postsurgical recurrence is common. Inflammation caused by surgery, neutrophils, and neutrophil extracellular traps (NETs) play important roles in cancer metastasis. Targeting NETs with thrombomodulin may be a novel strategy to improve surgical outcomes for pancreatic cancer patients.

CANCER LETTERS (2021)

添加到收藏夹

Article Oncology

Enhanced Antitumor Immunity via Endocrine Therapy Prevents Mammary Tumor Relapse and Increases Immune Checkpoint Blockade Sensitivity

Gonzalo R. Sequeira et al.

Summary: This study demonstrates that anti-progestin therapy induces immunogenic cell death in overexpressing tumors, leading to enhanced immune cell infiltration and improved sensitivity to PD-L1 blockade, potentially playing a crucial role in HR+ breast cancer.

CANCER RESEARCH (2021)

添加到收藏夹

Article Oncology

HMGB1 is a key factor for tamoxifen resistance and has the potential to predict the efficacy of CDK4/6 inhibitors in breast cancer

Han Zhang et al.

Summary: In breast cancer patients, increased expression of HMGB1 is associated with endocrine resistance, and HMGB1-positive patients benefit more in PFS when receiving CDK4/6 inhibitors treatment. HMGB1 promotes tamoxifen resistance through the TLR4-NF-kappa B pathway.

CANCER SCIENCE (2021)

添加到收藏夹

Article Cell Biology

H19/miR-107/HMGB1 axis sensitizes laryngeal squamous cell carcinoma to cisplatin by suppressing autophagy in vitro and in vivo

Liwei Chen et al.

Summary: The study revealed the role of H19-miR-107-HMGB1 axis in regulating drug resistance in LSCC, with interference of H19 suppressing autophagy and drug resistance. Additionally, HMGB1 and miR-107 played crucial roles in this regulatory pathway.

CELL BIOLOGY INTERNATIONAL (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Cellular degradation systems in ferroptosis

Xin Chen et al.

Summary: Ferroptosis is an iron-dependent oxidative cell death driven by lipid peroxidation. Various antioxidant systems play a significant role in preventing ferroptotic death. The cellular degradation systems play a dual role in regulating the ferroptotic response.

CELL DEATH AND DIFFERENTIATION (2021)

添加到收藏夹

Article Cell Biology

Circ-CSPP1 knockdown suppresses hepatocellular carcinoma progression through miR-493-5p releasing-mediated HMGB1 downregulation

Ganghua Yang et al.

Summary: This study demonstrated the crucial role of circ-CSPP1 in hepatocellular carcinoma (HCC) by regulating the expression of miR-493-5p and HMGB1, thereby suppressing HCC development both in vitro and in vivo.

CELLULAR SIGNALLING (2021)

添加到收藏夹

Article Oncology

Dynamic changes in circulating PD-1+CD8+T lymphocytes for predicting treatment response to PD-1 blockade in patients with non-small-cell lung cancer

Chang Gon Kim et al.

Summary: This study investigated the predictive value of circulating PD-1(+) CD8(+) T lymphocytes in response to PD-1 inhibitors in NSCLC patients. Results showed that a reduction in PD-1(+) cells frequency after treatment was associated with higher DCB probability and superior survival outcomes. This suggests that dynamic changes in circulating PD-1(+) CD8(+) T lymphocytes can predict clinical and survival benefit from PD-1 blockade treatment.

EUROPEAN JOURNAL OF CANCER (2021)

添加到收藏夹

Article Cell Biology

HN1L promotes migration and invasion of breast cancer by up-regulating the expression of HMGB1

Dechuang Jiao et al.

Summary: Research has shown that HN1L gene is significantly over-expressed in breast cancer tissues and positively correlated with M metastasis in breast cancer patients. Silencing HN1L can effectively inhibit the invasion and metastasis of breast cancer cells. HN1L interacts with HSPA9 and affects the expression of HMGB1, playing a key role in promoting the invasion and metastasis of breast cancer cells. These findings suggest that HN1L may be a potential drug target for breast cancer.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

添加到收藏夹

Article Genetics & Heredity

Chronic stress promotes acute myeloid leukemia progression through HMGB1/NLRP3/IL-1β signaling pathway

Na Liu et al.

Summary: Chronic restraint stress promotes acute myeloid leukemia (AML) progression and mediates NLRP3 inflammasome activation in xenograft mice. HMGB1 regulates NLRP3 inflammasome activation in AML cells. Knockdown of HMGB1 inhibits AML progression under chronic stress in vivo.

JOURNAL OF MOLECULAR MEDICINE-JMM (2021)

添加到收藏夹

Article Nanoscience & Nanotechnology

Immunogenic Cell Death Induced by Chemoradiotherapy of Novel pH-Sensitive Cargo-Loaded Polymersomes in Glioblastoma

Chen He et al.

Summary: The novel pH-sensitive cargo-loaded polymersomes have been shown to effectively induce immunogenic cell death and synergize with radiotherapy, holding potential significance for cancer therapy.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

添加到收藏夹

Article Oncology

ALKBH5-Modified HMGB1-STING Activation Contributes to Radiation Induced Liver Disease via Innate Immune Response

Genwen Chen et al.

Summary: The study revealed the important role of m6A methylation in regulating the STING-interferon regulatory factor 3 signaling in radiation-induced liver diseases, with ALKBH5 and HMGB1 playing crucial roles. These findings contribute to a better understanding of the mechanisms of liver injury caused by radiation therapy.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2021)

添加到收藏夹

Article Cell Biology

Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells

Sabrina Robichaud et al.

Summary: The study identified multiple lipid droplet-associated proteins involved in lipophagy in macrophages, highlighting their importance in the process. Targeting these proteins to enhance lipophagy for promoting cholesterol efflux in foam cells may represent a novel therapeutic strategy for atherosclerosis.

AUTOPHAGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Activation of autophagy and suppression of apoptosis by dapagliflozin attenuates experimental inflammatory bowel disease in rats: Targeting AMPK/mTOR, HMGB1/RAGE and Nrf2/HO-1 pathways

Hany H. Arab et al.

Summary: Dapagliflozin has a potential protective effect against experimental colitis by enhancing colonic autophagy and suppressing apoptosis through activation of AMPK/mTOR and Nrf2/HO-1 pathways, and inhibition of the HMGB1/RAGE/NF-kappa B cascade.

CHEMICO-BIOLOGICAL INTERACTIONS (2021)

添加到收藏夹

Article Oncology

Extracellular HMGB1 blockade inhibits tumor growth through profoundly remodeling immune microenvironment and enhances checkpoint inhibitor-based immunotherapy

Pascale Hubert et al.

Summary: In this study, it was demonstrated that targeting extracellular HMGB1 can significantly remodel the tumor immune microenvironment for more effective cancer therapy. Inhibition of HMGB1 led to reductions in immunosuppressive cells, such as myeloid-derived suppressor cells and regulatory T lymphocytes, while also enhancing the activation of immune cells like dendritic cells. Additionally, blocking HMGB1 improved the efficacy of anti-PD-1 cancer immunotherapy, suggesting that extracellular HMGB1 blockade could enhance current cancer immunotherapies.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

添加到收藏夹

Article Oncology

The HMGB1/RAGE axis induces bone pain associated with colonization of 4T1 mouse breast cancer in bone

Tatsuo Okui et al.

Summary: Bone pain caused by breast cancer metastasis is a common complication and a major factor in increased mortality. Studies suggest that HMGB1 secreted by breast cancer cells induces BCABP through binding to RAGE on sensory neurons.

JOURNAL OF BONE ONCOLOGY (2021)

添加到收藏夹

Article Engineering, Biomedical

Biomimetic co-assembled nanodrug of doxorubicin and berberine suppresses chemotherapy-exacerbated breast cancer metastasis

Xiao Zheng et al.

Summary: Chemotherapy is a double-edged sword in treating breast cancer, as it can induce cancer progression; Berberine has shown potential as a regulator for Dox-exacerbated breast cancer metastasis by targeting the HMGB1-TLR4 axis; The combination of Dox and Ber in a self-assembled nanodrug can effectively inhibit tumor growth and metastasis.

BIOMATERIALS (2021)

添加到收藏夹

Article Medicine, Research & Experimental

CXCR4 engagement triggers CD47 internalization and antitumor immunization in a mouse model of mesothelioma

Rosanna Mezzapelle et al.

Summary: Enhancing antitumor immunity is a powerful strategy in cancer treatment, involving the release of DAMPs and interfering with the CD47 signal to induce T-cell immune responses. Additionally, CXCR4 activation can also flag tumor cells for immune recognition.

EMBO MOLECULAR MEDICINE (2021)

添加到收藏夹

Article Oncology

YAP promotes autophagy and progression of gliomas via upregulating HMGB1

Min Zhao et al.

Summary: YAP over-expression enhances glioma cell autophagy and progression by promoting the translocation of HMGB1 from nucleus to cytoplasm, suggesting a potential therapeutic target in GBM. The combination of chemo-radiotherapy with pharmacological autophagy inhibition for treating GBM patients with YAP high expression may be a promising clinical opportunity.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

添加到收藏夹

Review Immunology

Emerging mechanisms of immunocoagulation in sepsis and septic shock

Daolin Tang et al.

Summary: Recent advances have shed light on the complex interplay between mammalian immunity and coagulation in sepsis, particularly involving inflammasomes and GSDMD-mediated pyroptosis, along with signaling pathways mediated by HMGB1, STING1, or SQSTM1. Pharmacological modulation of these pathways presents novel and promising therapeutic strategies for sepsis.

TRENDS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Cell Biology

Oleandrin, a cardiac glycoside, induces immunogenic cell death via the PERK/elF2α/ATF4/CHOP pathway in breast cancer

Xiaoxi Li et al.

Summary: Chemotherapeutic agents, including the cardiac glycoside oleandrin, have been shown to induce immunogenic cell death (ICD) in breast cancer cells, enhancing anti-tumor immune responses. Oleandrin treatment triggered ICD in breast cancer cells by inducing calreticulin exposure and release of HMGB1, HSP70/90, and ATP. Mechanistically, oleandrin induced ER stress-associated, caspase-independent ICD mainly through the PERK/elF2 alpha/ATF4/CHOP pathway, suggesting its potential in combination with immune checkpoint inhibitors to improve immunotherapy efficacy.

CELL DEATH & DISEASE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Role of neutrophil extracellular traps in radiation resistance of invasive bladder cancer

Surashri Shinde-Jadhav et al.

Summary: Radioresistance in bladder cancer treatment is linked to the recruitment of neutrophil extracellular traps (NETs) to the tumor immune microenvironment post-radiation therapy, as demonstrated in a mouse model. Inhibition of NETs can improve radiation response, suggesting NETs as a potential therapeutic target to enhance radiation efficacy.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Oncology

Virus-Like Particle-Drug Conjugates Induce Protective, Long-lasting Adaptive Antitumor Immunity in the Absence of Specifically Targeted Tumor Antigens

Rhonda C. Kines et al.

Summary: The study demonstrated that AU-011 has a direct cytotoxic effect on tumor cells and induces long-term antitumor immunity, with enhanced activity when combined with checkpoint inhibitor antibodies.

CANCER IMMUNOLOGY RESEARCH (2021)

添加到收藏夹

Article Oncology

Natural killer T cell immunotherapy combined with oncolytic vesicular stomatitis virus or reovirus treatments differentially increases survival in mouse models of ovarian and breast cancer metastasis

Simon Gebremeskel et al.

Summary: The combination of oncolytic VSV and NKT cell immunotherapy effectively reduces tumor burden in models of metastatic breast and ovarian cancers. VSV showed better tumor cell killing ability in vitro compared to reovirus, and induced greater expression of proinflammatory cytokines, chemokines, and antigen presentation machinery.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

添加到收藏夹

Article Oncology

Astragaloside IV and Saponins of Rhizoma Polygonati Cure Cyclophosphamide-Induced Myelosuppression in Lung Adenocarcinoma via Down-Regulating miR-142-3p

Xian Gu et al.

Summary: Our study revealed that Astragaloside IV and saponins of rhizoma polygonati could alleviate cyclophosphamide-induced bone marrow hematopoietic stem cell injury by suppressing the expression of miR-142-3p. The inhibition of miR-142-3p may be related to the improved hematopoietic function of myelosuppressed lung cancer mice, potentially through its negative regulation of HMGB1 expression.

FRONTIERS IN ONCOLOGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Inhibition of the Receptor for Advanced Glycation End Products Enhances the Cytotoxic Effect of Gemcitabine in Murine Pancreatic Tumors

Priyanka Swami et al.

Summary: Studies have shown that RAGE plays a critical role in promoting pancreatic cancer cell proliferation and resistance to gemcitabine. Blocking the RAGE/HMGB1 interaction can enhance the cytotoxic effect of gemcitabine, reduce autophagy, and protect against excessive weight loss during treatment.

BIOMOLECULES (2021)

添加到收藏夹

Article Cell Biology

GPR30-mediated HMGB1 upregulation in CAFs induces autophagy and tamoxifen resistance in ERα-positive breast cancer cells

Li Liu et al.

Aging-US (2021)

添加到收藏夹

Article Cell Biology

lncRNA ANRIL aggravates the chemoresistance of pancreatic cancer cells to gemcitabine by targeting inhibition of miR-181a and targeting HMGB1-induced autophagy

Lei Wang et al.

Aging-US (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Mechanism of interaction between autophagy and apoptosis in cancer

Shreya Das et al.

Summary: Autophagy and apoptosis play significant roles in cancer, but they may exhibit dual effects on cancer cell survival as the disease progresses. Interactions between a complex array of biomarkers are crucial in maintaining coordination between the two pathways, influencing the survival or death of malignant cells.

APOPTOSIS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Fluvastatin attenuated ischemia/reperfusion-induced autophagy and apoptosis in cardiomyocytes through down-regulation HMGB1/TLR4 signaling pathway

Hua-Sheng Ding et al.

Summary: The study found that fluvastatin exerts cardioprotective effects by inhibiting apoptosis and autophagy, improving left ventricular dysfunction, reducing HMGB1/TLR4/NF-kappa B expressions, and inhibiting cardiomyocyte apoptosis, autophagy, and inflammation reaction during cardiac ischemic reperfusion injury.

MOLECULAR BIOLOGY REPORTS (2021)

添加到收藏夹

Article Cell Biology

Autophagic secretion of HMGB1 from cancer-associated fibroblasts promotes metastatic potential of non-small cell lung cancer cells via NFκB signaling

Yinghui Ren et al.

Summary: The study revealed that autophagy was upregulated in lung cancer-associated CAFs, promoting NSCLC cell migration and invasion through HMGB1 secretion. HMGB1 may be a potential therapeutic target for lung cancer metastasis.

CELL DEATH & DISEASE (2021)

添加到收藏夹

Review Cell Biology

Calcium Signaling Regulates Autophagy and Apoptosis

Pramod Sukumaran et al.

Summary: Calcium serves as a crucial second messenger in regulating various physiological functions, such as cell growth/development, cell survival, and programmed cell death processes. The homeostasis of cytosolic calcium levels, maintained through coordination of proteins/pumps/Ca2+ channels and Ca2+ storage in organelles, is essential for cellular functions. Store operated Ca2+ entry (SOCE) mechanism, activated by calcium depletion, influences functions in both excitable and non-excitable cells, with potential implications in neurodegenerative conditions.

CELLS (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Treating ICB-resistant glioma with anti-CD40 and mitotic spindle checkpoint controller BAL101553 (lisavanbulin)

Vassilis Genoud et al.

Summary: The study suggests that BAL101553 could be a promising therapeutic agent for glioblastoma, potentially synergizing with innate immune stimulation. Different drug combinations and immunotherapy strategies showed varying efficacy in glioblastoma mouse models with different immunogenicity profiles.

JCI INSIGHT (2021)

添加到收藏夹

Article Oncology

Vitexin Inhibits Gastric Cancer Growth and Metastasis through HMGB1-mediated Inactivation of the PI3K/AKT/mTOR/HIF-1α Signaling Pathway

Peng Zhou et al.

Summary: The study showed that vitexin could inhibit the malignant progression of GC by suppressing HMGB1-mediated activation of the PI3K/Akt/HIF-1α signaling pathway, leading to a promising potential therapeutic option for the treatment of GC.

JOURNAL OF GASTRIC CANCER (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

An RNA-RNA crosstalk network involving HMGB1 and RICTOR facilitates hepatocellular carcinoma tumorigenesis by promoting glutamine metabolism and impedes immunotherapy by PD-L1+exosomes activity

Yanping Wei et al.

Summary: The study identified potential HMGB1-driven RNA-RNA crosstalk networks in HCC and explored their roles at different stages of the disease, suggesting the potential for RNA-based precision therapy. Interventions against HMGB1 and RICTOR in HCC cells demonstrated the potential to enhance the effectiveness of immunotherapy.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

添加到收藏夹

Article Oncology

EPHB4 Regulates the Proliferation and Metastasis of Oral Squamous Cell Carcinoma through the HMGB1/NF-κB Signalling Pathway

Chen Yi et al.

Summary: The study revealed that EPHB4 is highly expressed in OSCC tissues, and is related to tumor stage and lymphatic metastasis. Mechanistically, EPHB4 promotes proliferation and metastasis in OSCC tumors by activating the HMGB1-mediated NF-kappa B signaling pathway.

JOURNAL OF CANCER (2021)

添加到收藏夹

Article Oncology

Alternol triggers immunogenic cell death via reactive oxygen species generation

Changlin Li et al.

Summary: Alternol triggers immunogenic cell death in prostate cancer cells through the generation of reactive oxygen species (ROS), leading to an antitumor immune response. This immunogenic cell death induces delayed tumor growth and prolonged survival.

ONCOIMMUNOLOGY (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

The synergistic antitumor activity of 3-(2-nitrophenyl) propionic acid-paclitaxel nanoparticles (NPPA-PTX NPs) and anti-PD-L1 antibody inducing immunogenic cell death

Xiao-Chuan Duan et al.

Summary: Cancer immunotherapy with NPPA-PTX NPs as ICD inducers shows synergistic antitumor activity when combined with aPD-L1, effectively stimulating antitumor immunity and enhancing T cell infiltration and cytokine secretion.

DRUG DELIVERY (2021)

添加到收藏夹

Article Oncology

Telomerase-specific oncolytic immunotherapy for promoting efficacy of PD-1 blockade in osteosarcoma

Yusuke Mochizuki et al.

Summary: Study indicates that telomerase-specific oncolytic virotherapy is a promising strategy to enhance the efficacy of PD-1 blockade in osteosarcoma.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2021)

添加到收藏夹

Review Cell Biology

HMGB1 as a therapeutic target in disease

Jiaming Xue et al.

Summary: HMGB1 has been reassessed as a damage-associated molecular pattern protein with crucial roles in the extracellular matrix; Different isoforms of HMGB1 present distinctive physiological functions in diseases; Targeting HMGB1 as a therapeutic strategy involves antagonists interfering with its activity.

JOURNAL OF CELLULAR PHYSIOLOGY (2021)

添加到收藏夹

Article Cell Biology

MIR-140-5p affects chondrocyte proliferation, apoptosis, and inflammation by targeting HMGB1 in osteoarthritis

Yingjie Wang et al.

INFLAMMATION RESEARCH (2020)

添加到收藏夹

Article Pharmacology & Pharmacy

MiR-142-3p enhances chemosensitivity of breast cancer cells and inhibits autophagy by targeting HMGB1

Lu Liang et al.

ACTA PHARMACEUTICA SINICA B (2020)

添加到收藏夹

Article Medicine, Research & Experimental

Long non-coding RNA NEAT1 promotes bladder progression through regulating miR-410 mediated HMGB1

Guang Shan et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

添加到收藏夹

Article Oncology

SIRT6-PARP1 is involved in HMGB1 polyADP-ribosylation and acetylation and promotes chemotherapy-induced autophagy in leukemia

Qian Kong et al.

CANCER BIOLOGY & THERAPY (2020)

添加到收藏夹

Article Dermatology

Imiquimod Exerts Antitumor Effects by Inducing Immunogenic Cell Death and Is Enhanced by the Glycolytic Inhibitor 2-Deoxyglucose

Shi-Wei Huang et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2020)

添加到收藏夹

Article Medicine, Research & Experimental

HMGB1 upregulates NF-kB by inhibiting IKB-α and associates with diabetic retinopathy

Wen-Jing Liang et al.

LIFE SCIENCES (2020)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Immune Modulation by Telomerase-Specific Oncolytic Adenovirus Synergistically Enhances Antitumor Efficacy with Anti-PD1 Antibody

Nobuhiko Kanaya et al.

MOLECULAR THERAPY (2020)

添加到收藏夹

Article Cell Biology

Tetrahydrobenzimidazole TMQ0153 triggers apoptosis, autophagy and necroptosis crosstalk in chronic myeloid leukemia

Sungmi Song et al.

CELL DEATH & DISEASE (2020)

添加到收藏夹

Article Cell Biology

Clarithromycin inhibits autophagy in colorectal cancer by regulating the hERG1 potassium channel interaction with PI3K

Giulia Petroni et al.

CELL DEATH & DISEASE (2020)

添加到收藏夹

Article Oncology

Mutant BRAF and MEK Inhibitors Regulate the Tumor Immune Microenvironment via Pyroptosis

Dan A. Erkes et al.

CANCER DISCOVERY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Long noncoding RNA LINC00205 enhances the malignant characteristics of retinoblastoma by acting as a molecular sponge of microRNA-665 and consequently increasing HMGB1 expression

Shu Zhang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

添加到收藏夹

Article Oncology

Damage-associated molecular patterns (DAMPs) related to immunogenic cell death are differentially triggered by clinically relevant chemotherapeutics in lung adenocarcinoma cells

Jose Ignacio Gonzalez Solari et al.

BMC CANCER (2020)

添加到收藏夹

Article Oncology

LncRNA NNT-AS1 contributes to the cisplatin resistance of cervical cancer through NNT-AS1/miR-186/HMGB1 axis

Yanjie Liu et al.

CANCER CELL INTERNATIONAL (2020)

添加到收藏夹

Article Medicine, Research & Experimental

Circular RNA circFOXM1 Plays a Role in Papillary Thyroid Carcinoma by Sponging miR-1179 and Regulating HMGB1 Expression

Mao Ye et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2020)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Hypoxia-responsive miR-141-3p is involved in the progression of breast cancer via mediating the HMGB1/HIF-1 alpha signaling pathway

Shanping Sun et al.

JOURNAL OF GENE MEDICINE (2020)

添加到收藏夹

Article Virology

PCV2 Induces Reactive Oxygen Species To Promote Nucleocytoplasmic Translocation of the Viral DNA Binding Protein HMGB1 To Enhance Its Replication

Renjie Sun et al.

JOURNAL OF VIROLOGY (2020)

添加到收藏夹

Review Pharmacology & Pharmacy

Combination of an Autophagy Inducer and an Autophagy Inhibitor: A Smarter Strategy Emerging in Cancer Therapy

Ting Liu et al.

FRONTIERS IN PHARMACOLOGY (2020)

添加到收藏夹

Article Oncology

Autophagy induction by thiostrepton improves the efficacy of immunogenic chemotherapy

Yan Wang et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

添加到收藏夹

Article Oncology

Rafoxanide Induces Immunogenic Death of Colorectal Cancer Cells

Antonio Di Grazia et al.

CANCERS (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Origanum majorana Essential Oil Triggers p38 MAPK-Mediated Protective Autophagy, Apoptosis, and Caspase-Dependent Cleavage of P70S6K in Colorectal Cancer Cells

Khawlah Athamneh et al.

BIOMOLECULES (2020)

添加到收藏夹

Article Oncology

Circular RNA hsa_circ_0005909 modulates osteosarcoma progression via the miR-936/HMGB1 axis

Shuai Ding et al.

CANCER CELL INTERNATIONAL (2020)

添加到收藏夹

Review Immunology

Immunological Significance of HMGB1 Post-Translational Modification and Redox Biology

Man Sup Kwak et al.

FRONTIERS IN IMMUNOLOGY (2020)

添加到收藏夹

Article Oncology

A recombinant oncolytic Newcastle virus expressing MIP-3α promotes systemic antitumor immunity

Feng-Ying Huang et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

添加到收藏夹

Article Medicine, Research & Experimental

LncRNA HOTAIR suppresses cell apoptosis, autophagy and induces cell proliferation in cholangiocarcinoma by modulating the miR-204-5p/HMGB1 axis

Min Lu et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

添加到收藏夹

Article Oncology

A Novel Inhibitor of HSP70 Induces Mitochondrial Toxicity and Immune Cell Recruitment in Tumors

Thibaut Barnoud et al.

CANCER RESEARCH (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Recombinant Lactaptin Induces Immunogenic Cell Death and Creates an Antitumor Vaccination Effect in Vivo with Enhancement by an IDO Inhibitor

Olga Troitskaya et al.

MOLECULES (2020)

添加到收藏夹

Article Oncology

Mitoxantrone triggers immunogenic prostate cancer cell death via p53-dependent PERK expression

Changlin Li et al.

CELLULAR ONCOLOGY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Hepatocellular carcinoma-derived high mobility group box 1 triggers M2 macrophage polarization via a TLR2/NOX2/autophagy axis

Dong-Jer Shiau et al.

SCIENTIFIC REPORTS (2020)

添加到收藏夹

Article Oncology

CircularRNA CirCHIPK3promotes cell proliferation and invasion of breast cancer by spongingmiR-193a/HMGB1/PI3K/AKTaxis

Zhen-Gang Chen et al.

THORACIC CANCER (2020)

添加到收藏夹

Article Oncology

High mobility group box 1 induces bone pain associated with bone invasion in a mouse model of advanced head and neck cancer

Tomoya Nakamura et al.

ONCOLOGY REPORTS (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Asbestos induces mesothelial cell transformation via HMGB1-driven autophagy

Jiaming Xue et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

添加到收藏夹

Article Oncology

Oxaliplatin induces immunogenic cell death in hepatocellular carcinoma cells and synergizes with immune checkpoint blockade therapy

Hanzhang Zhu et al.

CELLULAR ONCOLOGY (2020)

添加到收藏夹

Article Oncology

Circ_0032821 Facilitates Gastric Cancer Cell Proliferation, Migration, Invasion and Glycolysis by Regulating MiR-1236-3p/HMGB1 Axis

Lei Chen et al.

CANCER MANAGEMENT AND RESEARCH (2020)

添加到收藏夹

Article Oncology

CDK12/13 inhibition induces immunogenic cell death and enhances anti-PD-1 anticancer activity in breast cancer

Yi Li et al.

CANCER LETTERS (2020)

添加到收藏夹

Article Medicine, Research & Experimental

Paclitaxel alleviates the sepsis-induced acute kidney injury via lnc-MALAT1/ miR-370-3p/HMGB1 axis

Lina Xu et al.

LIFE SCIENCES (2020)

添加到收藏夹

Review Oncology

The interaction mechanism between autophagy and apoptosis in colon cancer

Qingqiang Xie et al.

TRANSLATIONAL ONCOLOGY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

HMGB1 as a potential biomarker and therapeutic target for severe COVID-19

Ruochan Chen et al.

HELIYON (2020)

添加到收藏夹

Article Oncology

HMGB1 released from GSDME-mediated pyroptotic epithelial cells participates in the tumorigenesis of colitis-associated colorectal cancer through the ERK1/2 pathway

Gao Tan et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

添加到收藏夹

Article Oncology

LncRNA DSCAM-AS1 promotes non-small cell lung cancer progression via regulating miR-577/HMGB1 axis

Z. Qiu et al.

NEOPLASMA (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Autophagy-Dependent Ferroptosis: Machinery and Regulation

Jiao Liu et al.

CELL CHEMICAL BIOLOGY (2020)

添加到收藏夹

Article Oncology

LINC00662 sponges miR-107 accelerating the invasiveness and proliferation of glioma cells

Jinsong Wu et al.

JOURNAL OF CANCER (2020)

添加到收藏夹

Article Biotechnology & Applied Microbiology

The Oncolytic Adenovirus XVir-N-31 as a Novel Therapy in Muscle-Invasive Bladder Cancer

Eva Lichtenegger et al.

HUMAN GENE THERAPY (2019)

添加到收藏夹

Review Cell Biology

Autophagy-dependent secretion: mechanism, factors secreted, and disease implications

Jacob New et al.

AUTOPHAGY (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

The release and activity of HMGB1 in ferroptosis

Qirong Wen et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

添加到收藏夹

Article Medicine, Research & Experimental

MiR-let-7e inhibits invasion and magration and regulates HMGB1 expression in papillary thyroid carcinoma

Chao Ding et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

添加到收藏夹

Article Hematology

In vitro PUVA treatment triggers calreticulin exposition and HMGB1 release by dying T lymphocytes in GVHD: New insights in extracorporeal photopheresis

Celine Coppard et al.

JOURNAL OF CLINICAL APHERESIS (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Cytosolic HMGB1 Mediates Autophagy Activation in an Emulsified Isoflurane Anesthesia Cell Model

Rui-zhu Liu et al.

NEUROCHEMICAL RESEARCH (2019)

添加到收藏夹

Article Oncology

Inhibition of Ataxia-Telangiectasia Mutated and RAD3-Related (ATR) Overcomes Oxaliplatin Resistance and Promotes Antitumor Immunity in Colorectal Cancer

Eve Combes et al.

CANCER RESEARCH (2019)

添加到收藏夹

Article Oncology

Targeting High Mobility Group Box-1 (HMGB1) Promotes Cell Death in Myelodysplastic Syndrome

Angel Y. F. Kam et al.

CLINICAL CANCER RESEARCH (2019)

添加到收藏夹

Article Dermatology

Oxidative Stress-Induced HMGB1 Release from Melanocytes: A Paracrine Mechanism Underlying the Cutaneous Inflammation in Vitiligo

Tingting Cui et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2019)

添加到收藏夹

Review Cell Biology

Location is the key to function: HMGB1 in sepsis and trauma-induced inflammation

Meihong Deng et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2019)

添加到收藏夹

Review Chemistry, Medicinal

Apoptotic cell clearance in the tumor microenvironment: a potential cancer therapeutic target

Seong-Ah Shin et al.

ARCHIVES OF PHARMACAL RESEARCH (2019)

添加到收藏夹

Article Pharmacology & Pharmacy

Triptolide Suppresses Growth of Breast Cancer by Targeting HMGB1 in Vitro and in Vivo

Wei Jiang et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2019)

添加到收藏夹

Article Chemistry, Medicinal

Naphthyl quinoxaline thymidine conjugate is a potent anticancer agent post UVA activation and elicits marked inhibition of tumor growth through vaccination

Ying Yuan et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

添加到收藏夹

Article Oncology

HMGB1-mediated autophagy regulates sodium/iodide symporter protein degradation in thyroid cancer cells

Wenwen Chai et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

添加到收藏夹

Article Oncology

The Folate Pathway Inhibitor Pemetrexed Pleiotropically Enhances Effects of Cancer Immunotherapy

David A. Schaer et al.

CLINICAL CANCER RESEARCH (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Diflunisal targets the HMGB1/CXCL12 heterocomplex and blocks immune cell recruitment

Federica De Leo et al.

EMBO REPORTS (2019)

添加到收藏夹

Article Cell Biology

Extracorporeal photochemotherapy induces bona fide immunogenic cell death

Kazuki Tatsuno et al.

CELL DEATH & DISEASE (2019)

添加到收藏夹

Article Physiology

Evidence for SIRT1 Mediated HMGB1 Release From Kidney Cells in the Early Stages of Hemorrhagic Shock

Siqi Xu et al.

FRONTIERS IN PHYSIOLOGY (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Nanoformulated Codelivery of Quercetin and Alantolactone Promotes an Antitumor Response through Synergistic Immunogenic Cell Death for Microsatellite-Stable Colorectal Cancer

Jing Zhang et al.

ACS NANO (2019)

添加到收藏夹

Article Immunology

BET bromodomain inhibitor JQ1 promotes immunogenic cell death in tongue squamous cell carcinoma

Miao Wang et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2019)

添加到收藏夹

Article Oncology

Resveratrol induces immunogenic cell death of human and murine ovarian carcinoma cells

Yanke Zhang et al.

INFECTIOUS AGENTS AND CANCER (2019)

添加到收藏夹

Article Oncology

Serine/threonine kinase 32C is overexpressed in bladder cancer and contributes to tumor progression

Erlin Sun et al.

CANCER BIOLOGY & THERAPY (2019)

添加到收藏夹

Review Oncology

Apoptosis of tumor-infiltrating T lymphocytes: a new immune checkpoint mechanism

Jingjing Zhu et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Biological Functions of Autophagy Genes: A Disease Perspective

Beth Levine et al.

CELL (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Autophagy-dependent cell death

Donna Denton et al.

CELL DEATH AND DIFFERENTIATION (2019)

添加到收藏夹

Article Cell Biology

Long noncoding RNA NNT-AS1 enhances the malignant phenotype of bladder cancer by acting as a competing endogenous RNA on microRNA-496 thereby increasing HMGB1 expression

Deyao Wu et al.

AGING-US (2019)

添加到收藏夹

Article Oncology

Anticancer Non-narcotic Opium Alkaloid Papaverine Suppresses Human Glioblastoma Cell Growth

Mana Inada et al.

ANTICANCER RESEARCH (2019)

添加到收藏夹

Article Medicine, Research & Experimental

XIAOPI formula promotes breast cancer chemosensitivity via inhibiting CXCL1/HMGB1-mediated autophagy

Neng Wang et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

miR-505 acts as a tumor suppressor in gastric cancer progression through targeting HMGB1

Liang Tian et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

添加到收藏夹

Review Pharmacology & Pharmacy

HMGB1 and repair: focus on the heart

Laura Pellegrini et al.

PHARMACOLOGY & THERAPEUTICS (2019)

添加到收藏夹

Article Medicine, Research & Experimental

HMGB1/TLR4 promotes apoptosis and reduces autophagy of hippocampal neurons in diabetes combined with OSA

Xiangyu Guo et al.

LIFE SCIENCES (2019)

添加到收藏夹

Review Biotechnology & Applied Microbiology

The progression of HMGB1-induced autophagy in cancer biology

Tianwei Xu et al.

ONCOTARGETS AND THERAPY (2019)

添加到收藏夹

Article Cell Biology

Polyphenol-rich extract induces apoptosis with immunogenic markers in melanoma cells through the ER stress-associated kinase PERK

Karol Prieto et al.

CELL DEATH DISCOVERY (2019)

添加到收藏夹

Article Medicine, Research & Experimental

H2Se Induces Reductive Stress in HepG2 Cells and Activates Cell Autophagy by Regulating the Redox of HMGB1 Protein under Hypoxia

Xiaohong Pan et al.

THERANOSTICS (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

PCDH17 increases the sensitivity of colorectal cancer to 5-fluorouracil treatment by inducing apoptosis and autophagic cell death

Shuiping Liu et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Designing a cancer therapeutic peptide by combining the mitochondrial targeting domain of Noxa and ErbB2-targeting moieties

Ji-Hye Han et al.

FEBS LETTERS (2018)

添加到收藏夹

Article Medicine, Research & Experimental

Synergy of theophylline reduces necrotic effect of berberine, induces cell cycle arrest and PARP, HMGB1, Bcl-2 family mediated apoptosis in MDA-MB-231 breast cancer cells

Fatemeh Hashemi-Niasari et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

Lorenzo Galluzzi et al.

CELL DEATH AND DIFFERENTIATION (2018)

添加到收藏夹

Article Gastroenterology & Hepatology

JTC801 Induces pH-dependent Death Specifically in Cancer Cells and Slows Growth of Tumors in Mice

Xinxin Song et al.

GASTROENTEROLOGY (2018)

添加到收藏夹

Article Gastroenterology & Hepatology

High mobility group protein B1 controls liver cancer initiation through yes-associated protein -dependent aerobic glycolysis

Ruochan Chen et al.

HEPATOLOGY (2018)

添加到收藏夹

Article Medicine, Research & Experimental

Dinaciclib induces immunogenic cell death and enhances anti-PD1-mediated tumor suppression

Dewan Md Sakib Hossain et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

添加到收藏夹

Article Medicine, Research & Experimental

HMGB1 links chronic liver injury to progenitor responses and hepatocarcinogenesis (Publication with Expression of Concern. See vol. 129, pg. 1803, 2019)

Celine Hernandez et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Lithium chloride attenuates mitomycin C induced necrotic cell death in MDA-MB-231 breast cancer cells via HMGB1 and Bax signaling

Mandieh Razmi et al.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2018)

添加到收藏夹

Article Medicine, Research & Experimental

Identification and Functional Characterization of Long Non-coding RNA MIR22HG as a Tumor Suppressor for Hepatocellular Carcinoma

Dong-Yan Zhang et al.

THERANOSTICS (2018)

添加到收藏夹

Article Cell Biology

PINK1 and PARK2 Suppress Pancreatic Tumorigenesis through Control of Mitochondrial Iron-Mediated Immunometabolism

Changfeng Li et al.

DEVELOPMENTAL CELL (2018)

添加到收藏夹

Article Oncology

HMGB1 knockdown increases MM cell vulnerability by regulating autophagy and DNA damage repair

Xing Guo et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2018)

添加到收藏夹

Article Oncology

ALA-PDT promotes HPV-positive cervical cancer cells apoptosis and DCs maturation via miR-34a regulated HMGB1 exosomes secretion

Yichao Jin et al.

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY (2018)

添加到收藏夹

Article Multidisciplinary Sciences

The anticancer peptide RT53 induces immunogenic cell death

Ewa Pasquereau-Kotula et al.

PLOS ONE (2018)

添加到收藏夹

Article Biotechnology & Applied Microbiology

HMGBI/RAGE axis mediates the apoptosis, invasion, autophagy, and angiogenesis of the renal cell carcinoma

Cun-Zao Wu et al.

ONCOTARGETS AND THERAPY (2018)

添加到收藏夹

Article Cell Biology

Novel dihydroartemisinin derivative DHA-37 induces autophagic cell death through upregulation of HMGB1 in A549 cells

Xiufeng Liu et al.

CELL DEATH & DISEASE (2018)

添加到收藏夹

Article Oncology

Blocking the Feedback Loop between Neuroendocrine Differentiation and Macrophages Improves the Therapeutic Effects of Enzalutamide (MDV3100) on Prostate Cancer

Chao Wang et al.

CLINICAL CANCER RESEARCH (2018)

添加到收藏夹

Article Cell Biology

HMGB1 Inhibits Apoptosis Following MI and Induces Autophagy via mTORC1 Inhibition

Eleonora Foglio et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2017)

添加到收藏夹

Article Immunology

ROS-dependent HMGB1 secretion upregulates IL-8 in upper airway epithelial cells under hypoxic condition

H. J. Min et al.

MUCOSAL IMMUNOLOGY (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Elimination of dysfunctional mitochondria through mitophagy suppresses benzo[a] pyrene-induced apoptosis

Durgesh Nandini Das et al.

FREE RADICAL BIOLOGY AND MEDICINE (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

LncRNA MALAT-1 Elevates HMGB1 to Promote Autophagy Resulting in Inhibition of Tumor Cell Apoptosis in Multiple Myeloma

Da Gao et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2017)

添加到收藏夹

Article Oncology

Down-regulation of LncRNA TUG1 enhances radiosensitivity in bladder cancer via suppressing HMGB1 expression

Huijuan Jiang et al.

RADIATION ONCOLOGY (2017)

添加到收藏夹

Article Oncology

Effect of irinotecan on HMGB1, MMP9 expression, cell cycle, and cell growth in breast cancer (MCF-7) cells

Saeedeh Keyvani-Ghamsari et al.

TUMOR BIOLOGY (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Resistance to cancer immunotherapy mediated by apoptosis of tumor-infiltrating lymphocytes

Jingjing Zhu et al.

NATURE COMMUNICATIONS (2017)

添加到收藏夹

Article Oncology

Cabozantinib Eradicates Advanced Murine Prostate Cancer by Activating Antitumor Innate Immunity

Akash Patnaik et al.

CANCER DISCOVERY (2017)

添加到收藏夹

Article Oncology

HMGB1 promotes differentiation syndrome by inducing hyperinflammation via MEK/ERK signaling in acute promyelocytic leukemia cells

Lanlan Tang et al.

ONCOTARGET (2017)

添加到收藏夹

Article Oncology

HMGB1 targeting by ethyl pyruvate suppresses malignant phenotype of human mesothelioma

Laura Pellegrini et al.

ONCOTARGET (2017)

添加到收藏夹

Article Oncology

High mobility group box 1 antagonist limits metastatic seeding in the lungs via reduction of cell-cell adhesion

Adi Karsch-Bluman et al.

ONCOTARGET (2017)

添加到收藏夹

Article Oncology

Immunogenic cancer cell death selectively induced by near infrared photoimmunotherapy initiates host tumor immunity

Mikako Ogawa et al.

ONCOTARGET (2017)

添加到收藏夹

Article Oncology

Nano-Pulse Stimulation is a physical modality that can trigger immunogenic tumor cell death

Richard Nuccitelli et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Rhus coriaria increases protein ubiquitination, proteasomal degradation and triggers non-canonical Beclin-1-independent autophagy and apoptotic cell death in colon cancer cells

Khawlah Athamneh et al.

SCIENTIFIC REPORTS (2017)

添加到收藏夹

Article Oncology

[pemetrexed plus sildenafil], via autophagy-dependent HDAC downregulation, enhances the immunotherapy response of NSCLC cells

Laurence Booth et al.

CANCER BIOLOGY & THERAPY (2017)

添加到收藏夹

Article Cell Biology

Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer

Rui Kang et al.

CELL RESEARCH (2017)

添加到收藏夹

Article Oncology

Hepatitis B virus X protein stimulates high mobility group box 1 secretion and enhances hepatocellular carcinoma metastasis

Shuzhen Chen et al.

CANCER LETTERS (2017)

添加到收藏夹

Article Nutrition & Dietetics

The induction of apoptosis and autophagy by Wasabia japonica extract in colon cancer

Shu-Wen Hsuan et al.

EUROPEAN JOURNAL OF NUTRITION (2016)

添加到收藏夹

Review Cell Biology

Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies

Giuseppa Pistritto et al.

AGING-US (2016)

添加到收藏夹

Article Cell Biology

Autophagy promotes ferroptosis by degradation of ferritin

Wen Hou et al.

AUTOPHAGY (2016)

添加到收藏夹

Article Oncology

Blockade of high mobility group box 1 augments antitumor T-cell response induced by peptide vaccination as a co-adjuvant

Kayoko Waki et al.

CANCER SCIENCE (2016)

添加到收藏夹

Article Medicine, Research & Experimental

HMGB1 induces apoptosis and EMT in association with increased autophagy following H/R injury in cardiomyocytes

Fan Ouyang et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2016)

添加到收藏夹

Article Immunology

RAGE Enhances TLR Responses through Binding and Internalization of RNA

Damien Bertheloot et al.

JOURNAL OF IMMUNOLOGY (2016)

添加到收藏夹

Article Pathology

Cytoplasmic expression of high mobility group B1 (HMGB1) is associated with tumor-infiltrating lymphocytes (TILs) in breast cancer

Hee Jin Lee et al.

PATHOLOGY INTERNATIONAL (2016)

添加到收藏夹

Article Oncology

Methylation-mediated repression of microRNA-129-2 suppresses cell aggressiveness by inhibiting high mobility group box 1 in human hepatocellular carcinoma

Zhikui Liu et al.

ONCOTARGET (2016)

添加到收藏夹

Review Oncology

HMGB1 overexpression as a prognostic factor for survival in cancer: a meta-analysis and systematic review

Tengyun Wu et al.

ONCOTARGET (2016)

添加到收藏夹

Article Cell Biology

Poly-ADP-ribosylation of HMGB1 regulates TNFSF10/TRAIL resistance through autophagy

Minghua Yang et al.

AUTOPHAGY (2015)

添加到收藏夹

Article Gastroenterology & Hepatology

Hypoxia induced HMGB1 and mitochondrial DNA interactions mediate tumor growth in hepatocellular carcinoma through Toll-like receptor 9

Yao Liu et al.

JOURNAL OF HEPATOLOGY (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

Shikonin-enhanced cell immunogenicity of tumor vaccine is mediated by the differential effects of DAMP components

Tien-Jen Lin et al.

MOLECULAR CANCER (2015)

添加到收藏夹

Article Oncology

Antiandrogen Therapy with Hydroxyflutamide or Androgen Receptor Degradation Enhancer ASC-J9 Enhances BCG Efficacy to Better Suppress Bladder Cancer Progression

Zhiqun Shang et al.

MOLECULAR CANCER THERAPEUTICS (2015)

添加到收藏夹

Article Cell Biology

Aspirin delays mesothelioma growth by inhibiting HMGB1-mediated tumor progression

H. Yang et al.

CELL DEATH & DISEASE (2015)

添加到收藏夹

Article Cell Biology

Upregulation of heat shock proteins and the promotion of damage-associated molecular pattern signals in a colorectal cancer model by modulated electrohyperthermia

Gabor Andocs et al.

CELL STRESS & CHAPERONES (2015)

添加到收藏夹

Article Oncology

Macrophage Inflammatory Protein Derivative ECI301 Enhances the Alarmin-Associated Abscopal Benefits of Tumor Radiotherapy

Shiro Kanegasaki et al.

CANCER RESEARCH (2014)

添加到收藏夹

Review Oncology

The Four Faces of Autophagy: Implications for Cancer Therapy

David A. Gewirtz

CANCER RESEARCH (2014)

添加到收藏夹

Review Immunology

Molecular mechanism and therapeutic modulation of high mobility group box 1 release and action: an updated review

Ben Lu et al.

EXPERT REVIEW OF CLINICAL IMMUNOLOGY (2014)

添加到收藏夹

Article Oncology

Knockdown of HMGB1 inhibits growth and invasion of gastric cancer cells through the NF-.B pathway in vitro and in vivo

Jing Zhang et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2014)

添加到收藏夹

Article Biochemistry & Molecular Biology

High Mobility Group Box-1 (HMGB1) Participates in the Pathogenesis of Alcoholic Liver Disease (ALD)

Xiaodong Ge et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

添加到收藏夹

Article Surgery

Therapeutic potential of transgenic mesenchymal stem cells engineered to mediate anti-high mobility group box 1 activity: targeting of colon cancer

Hiroto Kikuchi et al.

JOURNAL OF SURGICAL RESEARCH (2014)

添加到收藏夹

Review Biochemistry & Molecular Biology

HMGB1 in health and disease

Rui Kang et al.

MOLECULAR ASPECTS OF MEDICINE (2014)

添加到收藏夹

Article Biochemistry & Molecular Biology

The HMGB1/RAGE inflammatory pathway promotes pancreatic tumor growth by regulating mitochondrial bioenergetics

R. Kang et al.

ONCOGENE (2014)

添加到收藏夹

Article Oncology

Targeting HMGB1 inhibits bladder cancer cells bioactivity by lentivirus-mediated RNA interference

W. Wang et al.

NEOPLASMA (2014)

添加到收藏夹

Article Cell Biology

Capsaicin as an inducer of damage-associated molecular patterns (DAMPs) of immunogenic cell death (ICD) in human bladder cancer cells

Donatella D'Eliseo et al.

CELL STRESS & CHAPERONES (2013)

添加到收藏夹

Article Medicine, General & Internal

Plasma HMGB-1 after the initial dose of epirubicin/docetaxel in cancer

Tobias Arnold et al.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2013)

添加到收藏夹

Article Oncology

Active immunotherapy for mouse breast cancer with irradiated whole-cell vaccine expressing VEGFR2

Heng-Xiu Yan et al.

ONCOLOGY REPORTS (2013)

添加到收藏夹

Article Oncology

Circulating immunogenic cell death biomarkers HMGB1 and RAGE in breast cancer patients during neoadjuvant chemotherapy

Oliver J. Stoetzer et al.

TUMOR BIOLOGY (2013)

添加到收藏夹

Editorial Material Cell Biology

Direct molecular interactions between HMGB1 and TP53 in colorectal cancer

Kristen M. Livesey et al.

AUTOPHAGY (2012)

添加到收藏夹

Article Biochemistry & Molecular Biology

Targeting receptor for advanced glycation end products (RAGE) expression induces apoptosis and inhibits prostate tumor growth

Indira Elangovan et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)

添加到收藏夹

Article Oncology

HMGB1 Promotes Drug Resistance in Osteosarcoma

Jun Huang et al.

CANCER RESEARCH (2012)

添加到收藏夹

Article Oncology

p53/HMGB1 Complexes Regulate Autophagy and Apoptosis

Kristen M. Livesey et al.

CANCER RESEARCH (2012)

添加到收藏夹

Article Oncology

Cancer Cell Secretion of the DAMP Protein HMGB1 Supports Progression in Malignant Mesothelioma

Sandro Jube et al.

CANCER RESEARCH (2012)

添加到收藏夹

Review Cell Biology

The crosstalk between autophagy and apoptosis: where does this lead?

Claire Gordy et al.

PROTEIN & CELL (2012)

添加到收藏夹

Article Oncology

Apicidin and Docetaxel Combination Treatment Drives CTCFL Expression and HMGB1 Release Acting as Potential Antitumor Immune Response Inducers in Metastatic Breast Cancer Cells

Maria Buoncervello et al.

NEOPLASIA (2012)

添加到收藏夹

Article Biochemistry & Molecular Biology

High Mobility Group Box 1 (HMGB1) Activates an Autophagic Response to Oxidative Stress

Daolin Tang et al.

ANTIOXIDANTS & REDOX SIGNALING (2011)

添加到收藏夹

Article Biochemistry & Molecular Biology

The Receptor for Advanced Glycation End-Products (RAGE) Protects Pancreatic Tumor Cells Against Oxidative Injury

Rui Kang et al.

ANTIOXIDANTS & REDOX SIGNALING (2011)

添加到收藏夹

Editorial Material Cell Biology

Metabolic regulation by HMGB1-mediated autophagy and mitophagy

Rui Kang et al.

AUTOPHAGY (2011)

添加到收藏夹

Editorial Material Cell Biology

DAMP-mediated autophagy contributes to drug resistance

Liying Liu et al.

AUTOPHAGY (2011)

添加到收藏夹

Article Cell Biology

High-Mobility Group Box 1 Is Essential for Mitochondrial Quality Control

Daolin Tang et al.

CELL METABOLISM (2011)

添加到收藏夹

Article Oncology

HMGB1-induced autophagy promotes chemotherapy resistance in leukemia cells

L. Liu et al.

LEUKEMIA (2011)

添加到收藏夹

Editorial Material Cell Biology

The redox protein HMGB1 regulates cell death and survival in cancer treatment

Daolin Tang et al.

AUTOPHAGY (2010)

添加到收藏夹

Editorial Material Cell Biology

HMGB1 A novel Beclin 1-binding protein active in autophagy

Rui Kang et al.

AUTOPHAGY (2010)

添加到收藏夹

Review Biochemistry & Molecular Biology

High-mobility group box 1 and cancer

Daolin Tang et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2010)

添加到收藏夹

Article Biochemistry & Molecular Biology

The receptor for advanced glycation end products (RAGE) sustains autophagy and limits apoptosis, promoting pancreatic tumor cell survival

R. Kang et al.

CELL DEATH AND DIFFERENTIATION (2010)

添加到收藏夹

Article Biotechnology & Applied Microbiology

The Anti-Inflammatory Activity of HMGB1 A Box Is Enhanced When Fused with C-Terminal Acidic Tail

Wei Gong et al.

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY (2010)

添加到收藏夹

Article Cell Biology

Endogenous HMGB1 regulates autophagy

Daolin Tang et al.

JOURNAL OF CELL BIOLOGY (2010)

添加到收藏夹

Article Biochemistry & Molecular Biology

HMGB1 release and redox regulates autophagy and apoptosis in cancer cells

D. Tang et al.

ONCOGENE (2010)

添加到收藏夹

Article Cell Biology

Ethyl pyruvate administration inhibits hepatic tumor growth

Xiaoyan Liang et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2009)

添加到收藏夹

Article Multidisciplinary Sciences

HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses

Hideyuki Yanai et al.

NATURE (2009)

添加到收藏夹

Article Medicine, General & Internal

HMGB1 Mediates Endogenous TLR2 Activation and Brain Tumor Regression

James F. Curtin et al.

PLOS MEDICINE (2009)

添加到收藏夹

Article Immunology

Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein

Hirotaka Kazama et al.

IMMUNITY (2008)

添加到收藏夹

Article Biochemistry & Molecular Biology

Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy

Lionel Apetoh et al.

NATURE MEDICINE (2007)

添加到收藏夹

Article Immunology

The relationship between apoptosis and high-mobility group protein 1 release from murine macrophages stimulated with lipopolysaccharide or polyinosinic-polycytidylic acid

Weiwen Jiang et al.

JOURNAL OF IMMUNOLOGY (2007)

添加到收藏夹

Article Cell Biology

Factors masking HMGB1 in human serum and plasma

Vilma Urbonaviciute et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2007)

添加到收藏夹

Article Cell Biology

Cytolytic cells induce HMGB1 release from melanoma cell lines

Norimasa Ito et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2007)

添加到收藏夹

Review Cell Biology

Self-eating and self-killing: crosstalk between autophagy and apoptosis

M. Chiara Maiuri et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)

添加到收藏夹

Article Cell Biology

The extracellular release of HMGB1 during apoptotic cell death

Charles W. Bell et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2006)

添加到收藏夹

Article Immunology

Role of HMGB1 in apoptosis-mediated sepsis lethality

Shixin Qin et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2006)

添加到收藏夹

Review Immunology

High-mobility group box 1 protein (HMGB): Nuclear weapon in the immune arsenal

MT Lotze et al.

NATURE REVIEWS IMMUNOLOGY (2005)

添加到收藏夹

Review Medicine, General & Internal

Amphoterin as an extracellular regulator of cell motility: from discovery to disease

HJ Huttunen et al.

JOURNAL OF INTERNAL MEDICINE (2004)

添加到收藏夹

Article Biochemistry & Molecular Biology

Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion

T Bonaldi et al.

EMBO JOURNAL (2003)

添加到收藏夹

Article Biochemistry & Molecular Biology

Structural basis for the proinflammatory cytokine activity of high mobility group box 1

JH Li et al.

MOLECULAR MEDICINE (2003)

添加到收藏夹

Article Multidisciplinary Sciences

Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

P Scaffidi et al.

NATURE (2002)

添加到收藏夹

Article Biochemistry & Molecular Biology

HMG 1 and 2: architectural DNA-binding proteins

JO Thomas

BIOCHEMICAL SOCIETY TRANSACTIONS (2001)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.