Integrating network pharmacology and experimental validation to explore the mechanisms of luteolin in alleviating fumonisin B1-induced intestinal inflammatory injury

Article Agriculture, Dairy & Animal Science

Chitosan nanoparticles attenuate intestinal damage and inflammatory responses in LPS-challenged weaned piglets via prevention of IκB degradation

Yinglei Xu et al.

Summary: Chitosan nanoparticles (CNP) were found to attenuate intestinal damage and inflammatory responses in LPS-challenged weaned piglets by impairing the NF-kappa B signaling pathway.

JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION (2023)

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Article Agriculture, Multidisciplinary

Quercetin Alleviates Deoxynivalenol-Induced Intestinal Damage by Suppressing Inflammation and Ferroptosis in Mice

Yingrong Ye et al.

Summary: This research investigates the potential function of quercetin (QUE) as a treatment for DON-induced intestinal damage. The results show that QUE can attenuate DON-induced intestinal damage in mice by improving jejunal structural injury and suppressing inflammation and oxidative stress. Furthermore, QUE can also reduce DON-induced intestinal ferroptosis. These findings provide a foundation for future prevention and treatment strategies for DON.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2023)

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Article Agriculture, Dairy & Animal Science

Dietary emodin alleviates lipopolysaccharide-induced intestinal mucosal barrier injury by regulating gut microbiota in piglets

Wenjuan Xun et al.

Summary: This study aimed to investigate the effects of dietary emodin (ED) on the intestinal mucosal barrier, NF-kB pathways, and gut microbial flora in LPS-induced piglets. The results showed that ED supplementation improved the intestinal mucosal barrier, reduced inflammation, and enhanced antioxidant capacity, as well as modulated the gut microbial composition. These findings suggest that ED can alleviate LPS-induced intestinal mucosal barrier injury by modulating gut microbiota.

ANIMAL NUTRITION (2023)

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Article Cell Biology

Luteolin Protects Chondrocytes from H2O2-Induced Oxidative Injury and Attenuates Osteoarthritis Progression by Activating AMPK-Nrf2 Signaling

Zhiqiang Zhou et al.

Summary: Luteolin, a flavonoid compound, has shown anti-inflammatory and antioxidative effects, and can inhibit cell death and inflammatory mediator production in chondrocytes. In addition, it activates the AMPK and Nrf2 pathways, which have therapeutic potential for OA.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

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Article Chemistry, Multidisciplinary

Luteolin alleviates cognitive impairment in Alzheimer's disease mouse model via inhibiting endoplasmic reticulum stress-dependent neuroinflammation

Jie-jian Kou et al.

Summary: Luteolin, a flavonoid found in fruits, vegetables, and herbs, shows beneficial effects on memory deficits and neuroinflammation in an Alzheimer's disease mouse model. The treatment with luteolin improves learning and memory deficits, inhibits astrocyte activation and neuroinflammation, and reduces ER stress markers in brain tissues. Further research on luteolin as a therapeutic agent for Alzheimer's disease is warranted based on these results.

ACTA PHARMACOLOGICA SINICA (2022)

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Article Endocrinology & Metabolism

Mechanism and Experimental Verification of Luteolin for the Treatment of Osteoporosis Based on Network Pharmacology

Guihong Liang et al.

Summary: This study explored the molecular mechanism of luteolin in treating osteoporosis through network pharmacological prediction and experimentation. The results suggest that luteolin has multitarget and multichannel effects in the treatment of osteoporosis. It can reduce bone loss by promoting the osteogenic differentiation of bone marrow mesenchymal stem cells through regulation of the PI3K-Akt signaling pathway.

FRONTIERS IN ENDOCRINOLOGY (2022)

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Review Biochemistry & Molecular Biology

Protective effect of luteolin against chemical and natural toxicants by targeting NF-κB pathway

Sina Mahdiani et al.

Summary: This review summarizes the potential protective role of luteolin against pharmaceuticals-, metals-, and environmental compounds-induced toxicities, especially through inhibition of the NF-kappa B pathway.

BIOFACTORS (2022)

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Article Food Science & Technology

Fumonisin B1 induced intestinal epithelial barrier damage through endoplasmic reticulum stress triggered by the ceramide synthase 2 depletion

Mengcong Li et al.

Summary: This study found that FB1 contamination has a toxic effect on the intestine and disrupts its barrier function. FB1 also leads to excessive production of cytokines, further damaging the intestinal immune barrier. By inhibiting the expression of CerS2, FB1 induces endoplasmic reticulum stress, resulting in the destruction of the intestinal barrier. However, this damage can be restored by overexpression of CerS2 or the use of an ER stress inhibitor.

FOOD AND CHEMICAL TOXICOLOGY (2022)

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Article Pharmacology & Pharmacy

Luteolin alleviates vascular dysfunctions in CLP-induced polymicrobial sepsis in mice

Soya Rungsung et al.

Summary: The present study suggests that luteolin pre-treatment can restore the vasoplegic state to NA in the aorta of septic mice through the iNOS pathway and reverse endothelial dysfunction via eNOS and NO production pathway.

PHARMACOLOGICAL REPORTS (2022)

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Article Food Science & Technology

Effect of Fumonisin B1 on Proliferation and Apoptosis of Intestinal Porcine Epithelial Cells

Tianjie Wang et al.

Summary: This study found that FB1 can induce damage, cell cycle arrest, and cell apoptosis in IPEC-J2 cells.

TOXINS (2022)

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Review Nutrition & Dietetics

Bioactive compounds modulating Toll-like 4 receptor (TLR4)-mediated inflammation: pathways involved and future perspectives

Karen S. Coutinho-Wolino et al.

Summary: Chronic inflammation is linked to the development and progression of various non-communicable diseases, and Toll-like receptor 4 (TLR4) plays a crucial role in chronic inflammation. Bioactive compounds have the potential to modulate the TLR4 pathway and alleviate inflammation.

NUTRITION RESEARCH (2022)

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Article Microbiology

Luteolin restricts ASFV replication by regulating the NF-κB/STAT3/ATF6 signaling pathway

Yang Chen et al.

Summary: This study demonstrated the antiviral activity of luteolin against African swine fever virus (ASFV) by regulating the NF-κB/STAT3/ATF6 signaling pathway and provided a rationale for developing anti-ASFV drugs.

VETERINARY MICROBIOLOGY (2022)

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Article Cell Biology

Luteolin Relieved DSS-Induced Colitis in Mice via HMGB1-TLR-NF-κB Signaling Pathway

Ting Zuo et al.

Summary: The study demonstrated that luteolin effectively improved colon health indicators and reduced inflammation levels in the affected areas by regulating the signaling pathways in the intestine to alleviate colitis.

INFLAMMATION (2021)

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Article Biochemistry & Molecular Biology

Effect of fumonisin B1 on oxidative stress and gene expression alteration of nutrient transporters in porcine intestinal cells

Zhigang Chen et al.

Summary: The study found that FB1 mainly exerts its toxicity on porcine intestinal cells by affecting cell proliferation and the expression levels of nutrient transporter-associated genes, particularly decreasing the levels of fatty acid and glucose transporters while increasing the expression levels of peptide transporter and metal ion transport-related genes.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2021)

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Article Medicine, Research & Experimental

Luteolin alleviates inflammation and modulates gut microbiota in ulcerative colitis rats

Bolin Li et al.

Summary: The study showed that luteolin significantly reduced colonic damage and inflammation in UC rats, and altered the diversity and composition of gut microbiota. The findings suggest that gut microbiota could serve as promising biomarkers for understanding how luteolin improves UC.

LIFE SCIENCES (2021)

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Article Physiology

Capsaicin Attenuates Lipopolysaccharide-Induced Inflammation and Barrier Dysfunction in Intestinal Porcine Epithelial Cell Line-J2

Xiaoya Zhao et al.

Summary: The study demonstrated that capsaicin can attenuate LPS-induced inflammation response through TLR4/NF-kappa B pathway, and improve barrier integrity and glucose absorption.

FRONTIERS IN PHYSIOLOGY (2021)

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Article Agriculture, Multidisciplinary

Reparative Effects of Ethanol-Induced Intestinal Barrier Injury by Flavonoid Luteolin via MAPK/NF-κB/MLCK and Nrf2 Signaling Pathways

Jinwen Yuan et al.

Summary: The study showed that luteolin could alleviate ethanol-induced intestinal barrier damage by regulating the expression of tight junction proteins and inhibiting key signaling pathways. Additionally, luteolin acted as an indirect antioxidant to relieve oxidative damage and improve tight junction function.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

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Article Food Science & Technology

Effects of Deoxynivalenol and Mycotoxin Adsorbent Agents on Mitogen-Activated Protein Kinase Signaling Pathways and Inflammation-Associated Gene Expression in Porcine Intestinal Epithelial Cells

Yu-Hsiang Yu et al.

Summary: The study reveals that DON induces inflammation in porcine intestinal epithelial cells (IPEC-J2) through phosphorylation of MAPK signaling pathways. However, co-treatment with DON and lipopolysaccharide (LPS) does not further enhance the expression of inflammation and tight junction-associated genes. Mycotoxin adsorbent agents can attenuate DON-induced inflammatory responses in IPEC-J2 cells by modulating the phosphorylation of p38, ERK, and JNK.

TOXINS (2021)

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Article Oncology

Luteolin and its derivative apigenin suppress the inducible PD-L1 expression to improve anti-tumor immunity in KRAS-mutant lung cancer

Ze-Bo Jiang et al.

Summary: The study showed that luteolin and apigenin can effectively inhibit the proliferation of KRAS-mutant lung cancer cells, reduce the expression of IFN-gamma-induced PD-L1, and induce apoptosis by suppressing STAT3 phosphorylation. Combined treatment with PD-1 blockade and apigenin/luteolin had a synergistic effect, offering a potential therapeutic strategy for NSCLC with KRAS mutations.

CANCER LETTERS (2021)

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Review Integrative & Complementary Medicine

Network Pharmacology in Research of Chinese Medicine Formula: Methodology, Application and Prospective

Ting-ting Luo et al.

CHINESE JOURNAL OF INTEGRATIVE MEDICINE (2020)

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Article Pharmacology & Pharmacy

Luteolin prevents irinotecan-induced intestinal mucositis in mice through antioxidant and anti-inflammatory properties

Thaise Boeing et al.

BRITISH JOURNAL OF PHARMACOLOGY (2020)

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Article Environmental Sciences

Fumonisins B1 exposure triggers intestinal tract injury via activating nuclear xenobiotic receptors and attracting inflammation response

Xinran Li et al.

ENVIRONMENTAL POLLUTION (2020)

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Article Food Science & Technology

Luteolin ameliorates experimental colitis in mice through ERK-mediated suppression of inflammation, apoptosis and autophagy

Iva Vukelic et al.

FOOD AND CHEMICAL TOXICOLOGY (2020)

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Article Biochemical Research Methods

Analysis of the stability and affinity of BlaR-CTD protein to -lactam antibiotics based on docking and mutagenesis studies

Jianan Ning et al.

JOURNAL OF BIOLOGICAL ENGINEERING (2019)

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Article Biochemistry & Molecular Biology

Swiss Target Prediction: updated data and new features for efficient prediction of protein targets of small molecules

Antoine Daina et al.

NUCLEIC ACIDS RESEARCH (2019)

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Article Toxicology

Hydrolyzed fumonisin B1 induces less inflammatory responses than fumonisin B1 in the co-culture model of porcine intestinal epithelial and immune cells

Min Jeong Gu et al.

TOXICOLOGY LETTERS (2019)

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Review Biochemistry & Molecular Biology

Molecular Docking: Shifting Paradigms in Drug Discovery

Luca Pinzi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Biochemistry & Molecular Biology

Fumonisin B1 damages the barrier functions of porcine intestinal epithelial cells in vitro

Zhigang Chen et al.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2019)

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Article Biochemistry & Molecular Biology

Cecropin A Modulates Tight Junction-Related Protein Expression and Enhances the Barrier Function of Porcine Intestinal Epithelial Cells by Suppressing the MEK/ERK Pathway

Zhenya Zhai et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Article Biochemistry & Molecular Biology

SWISS-MODEL: homology modelling of protein structures and complexes

Andrew Waterhouse et al.

NUCLEIC ACIDS RESEARCH (2018)

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Article Biochemistry & Molecular Biology

PharmMapper 2017 update: a web server for potential drug target identification with a comprehensive target pharmacophore database

Xia Wang et al.

NUCLEIC ACIDS RESEARCH (2017)

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Article Biochemistry & Molecular Biology

Luteolin suppresses the JAK/STAT pathway in a cellular model of intestinal inflammation

Carla Nunes et al.

FOOD & FUNCTION (2017)

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Article Environmental Sciences

Toxic Mechanisms Induced by Fumonisin B1 Mycotoxin on Human Intestinal Cell Line

Fiorenza Minervini et al.

ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY (2014)

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Article Food Science & Technology

Fumonisin B1 contamination in breast milk and its exposure in infants under 6 months of age in Rombo, Northern Tanzania

Happy Magoha et al.

FOOD AND CHEMICAL TOXICOLOGY (2014)

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Article Chemistry, Multidisciplinary

TCMSP: a database of systems pharmacology for drug discovery from herbal medicines

Jinlong Ru et al.

JOURNAL OF CHEMINFORMATICS (2014)

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Article Toxicology

Individual and combined effects of Fusarium toxins on the mRNA expression of pro-inflammatory cytokines in swine jejunal epithelial cells

Lam-Yim Murphy Wan et al.

TOXICOLOGY LETTERS (2013)

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Article Food Science & Technology

Effect of Low Dose of Fumonisins on Pig Health: Immune Status, Intestinal Microbiota and Sensitivity to Salmonella

Christine Burel et al.

TOXINS (2013)

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Article Oncology

Fumonisin B1 Contamination of Cereals and Risk of Esophageal Cancer in a High Risk Area in Northeastern Iran

Ali Mohammad Alizadeh et al.

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION (2012)

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Article Nutrition & Dietetics

Chronic ingestion of deoxynivalenol and fumonisin, alone or in interaction, induces morphological and immunological changes in the intestine of piglets

Ana-Paula F. L. Bracarense et al.

BRITISH JOURNAL OF NUTRITION (2012)

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Review Gastroenterology & Hepatology

Intestinal barrier function in health and gastrointestinal disease

M. Camilleri et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2012)

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Article Chemistry, Medicinal

LigPlot+: Multiple Ligand-Protein Interaction Diagrams for Drug Discovery

Roman A. Laskowski et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2011)

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Article Mycology

Complex etiology and pathology of mycotoxic nephropathy in South African pigs

Stoycho D. Stoev et al.

Mycotoxin Research (2009)

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Review Food Science & Technology

The intestine as a possible target for fumonisin toxicity

Sandrine Bouhet et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2007)

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Article Food Science & Technology

Mycotoxin fumonisin B1 selectively down-regulates the basal IL-8 expression in pig intestine:: in vivo and in vitro studies

Sandrine Bouhet et al.

FOOD AND CHEMICAL TOXICOLOGY (2006)

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Article Immunology

The flavonoid luteolin prevents lipopolysaccharide-induced NF-κB signalling and gene expression by blocking IκB kinase activity in intestinal epithelial cells and bone-marrow derived dendritic cells

JS Kim et al.

IMMUNOLOGY (2005)

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Article Biochemistry & Molecular Biology

Cytoscape: A software environment for integrated models of biomolecular interaction networks

P Shannon et al.

GENOME RESEARCH (2003)

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Integrating network pharmacology and experimental validation to explore the mechanisms of luteolin in alleviating fumonisin B1-induced intestinal inflammatory injury

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