☆ 4.5 Article

Proinflammatory pattern in the lower airways of non-asthmatic obese adolescents

CYTOKINE (2024)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Respiratory System

Correlation between levels of adipokines and inflammatory mediators with spirometric parameters in individuals with obesity and symptoms of asthma: Cross-sectional study

L. Baltieri et al.

Summary: This study aimed to investigate the correlation between levels of adipokines and inflammatory mediators and lung function in individuals with obesity and bronchial asthma symptoms. The results showed that an increase in interleukin-6 in the sputum was associated with worse pulmonary function, even in patients with controlled asthma, especially in measures of airway permeability.

PULMONOLOGY (2022)

添加到收藏夹

Article Allergy

Bronchial inflammation biomarker patterns link humoral immunodeficiency with bronchiectasis-related small airway dysfunction

Ulrich M. Zissler et al.

Summary: This study aims to assess the severity of chronic lower airway inflammation and small airway dysfunction in patients with humoral immunodeficiency and bronchiectasis, and to discriminate patients affected by bronchiectasis-related Small Airway Dysfunction (SAD) through induced sputum analysis.

CLINICAL AND EXPERIMENTAL ALLERGY (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Obesity modulates the immune macroenvironment associated with breast cancer development

Aleida Nunez-Ruiz et al.

Summary: There is a strong correlation between obesity and an increased risk of breast cancer. Obesity can promote tumor growth through inducing systemic alterations of the immune cell homeostasis. The interaction between adipocytes, cancer cells, and immune cells plays a role in breast cancer development in obesity.

PLOS ONE (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

GATA3 as an immunomodulator in obesity-related metabolic dysfunction associated with fatty liver disease, insulin resistance, and type 2 diabetes

Amr Ahmed El-Arabey et al.

Summary: Obesity is closely associated with fatty liver disease, insulin resistance, and type 2 diabetes. The deterioration of adipogenesis plays a crucial role in the development of these diseases. GATA3, a transcription factor, is highly expressed in obese individuals and reducing its expression can improve adipocyte differentiation. The interaction between macrophages and adipocytes significantly impacts obesity-related inflammation and insulin resistance.

CHEMICO-BIOLOGICAL INTERACTIONS (2022)

添加到收藏夹

Article Pediatrics

Obesity in Children

Nikita Nagpal et al.

Summary: Childhood obesity is a widespread issue that requires the involvement of pediatricians in identification and care. Understanding the complex causes, intergenerational transmission, and epidemiologic trends is essential for proper evaluation and treatment. The American Academy of Pediatrics has provided guidelines based on evidence, though implementation can be challenging due to gaps in knowledge. Optimal care in primary and multidisciplinary settings, as well as larger-scale prevention and policies, are crucial in managing obesity and improving child health.

PEDIATRICS IN REVIEW (2022)

添加到收藏夹

Article Allergy

Allergen-specific immunotherapy induces the suppressive secretoglobin 1A1 in cells of the lower airways

Ulrich M. Zissler et al.

Summary: In this study, allergen-specific immunotherapy was found to inhibit the expression of pro-inflammatory cytokines in the respiratory tract and induce the expression of other genes independently of asthma status and allergen season. In a validation cohort, an increase in SCGB1A1 was observed alongside a decrease in IL-24 during the course of AIT. SCGB1A1 was identified as a suppressor of epithelial gene expression in the airways.

ALLERGY (2021)

添加到收藏夹

Review Immunology

The metabolism-modulating activity of IL-17 signaling in health and disease

Rami Bechara et al.

Summary: IL-17, a cytokine discovered almost 30 years ago, has been found to play a crucial role in coordinating cellular and organismal metabolism. Understanding the relationship between IL-17 and downstream metabolic processes could potentially lead to new therapeutic opportunities for diseases associated with IL-17, even those not traditionally linked to this cytokine pathway.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

添加到收藏夹

Article Medicine, General & Internal

Predictors of Worse Prognosis in Young and Middle-Aged Adults Hospitalized with COVID-19 Pneumonia: A Multi-Center Italian Study (COVID-UNDER50)

Martina Bonifazi et al.

Summary: Obesity and older age are significant independent predictors for the need of mechanical ventilation in young and middle-aged adults, while comorbidities such as hypertension, diabetes, asthma, and increased D-dimer levels are significantly associated with higher mortality risk. Factors like age of onset, body mass index, and mechanical ventilation do not change the impact of these comorbidities on survival.

JOURNAL OF CLINICAL MEDICINE (2021)

添加到收藏夹

Article Allergy

Sputum microRNA-screening reveals Prostaglandin EP3 receptor as selective target in allergen-specific immunotherapy

Constanze A. Jakwerth et al.

Summary: This study analyzed miR expression patterns in the sputum of allergic patients and uncovered an association between miR-3935 and the PGE(2)-PTGER3 axis, which might mediate AIT effects on allergic asthma.

CLINICAL AND EXPERIMENTAL ALLERGY (2021)

添加到收藏夹

Article Endocrinology & Metabolism

Associations between body-mass index and COVID-19 severity in 6.9 million people in England: a prospective, community-based, cohort study

Min Gao et al.

Summary: The study found that above a BMI of 23 kg/m(2), there is a linear increase in the risk of severe consequences of COVID-19 leading to hospital admission and death, and a linear increase in ICU admission risk across the entire BMI range. The impact of increasing BMI is particularly notable in individuals younger than 40 years and of Black ethnicity.

LANCET DIABETES & ENDOCRINOLOGY (2021)

添加到收藏夹

Article Allergy

Correlation between eosinophil count, its genetic background and body mass index: The Nagahama Study

Hironobu Sunadome et al.

ALLERGOLOGY INTERNATIONAL (2020)

添加到收藏夹

Article Endocrinology & Metabolism

High Prevalence of Obesity in Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) Requiring Invasive Mechanical Ventilation

Arthur Simonnet et al.

OBESITY (2020)

添加到收藏夹

Article Pediatrics

Epidemiology, Clinical Features, and Disease Severity in Patients With Coronavirus Disease 2019 (COVID-19) in a Children's Hospital in New York City, New York

Philip Zachariah et al.

JAMA PEDIATRICS (2020)

添加到收藏夹

Review Endocrinology & Metabolism

Effect of obesity and body mass index on coronavirus disease 2019 severity: A systematic review and meta-analysis

Tu-Hsuan Chang et al.

OBESITY REVIEWS (2020)

添加到收藏夹

Review Endocrinology & Metabolism

Obesity and nonalcoholic fatty liver disease: From pathophysiology to therapeutics

Stergios A. Polyzos et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2019)

添加到收藏夹

Article Physiology

Ablation of the leptin receptor in myeloid cells impairs pulmonary clearance of Streptococcus pneumoniae and alveolar macrophage bactericidal function

Peter Mancuso et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2018)

添加到收藏夹

Article Respiratory System

Cell distribution and cytokine levels in induced sputum from healthy subjects and patients with asthma after using different nebulizer techniques

Sinem Koc-Guenel et al.

BMC PULMONARY MEDICINE (2018)

添加到收藏夹

Article Allergy

Biomatrix for upper and lower airway biomarkers in patients with allergic asthma

Ulrich M. Zissler et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)

添加到收藏夹

Article Medicine, General & Internal

Early IL-10 producing B-cells and coinciding Th/Tr17 shifts during three year grass-pollen AIT

Ulrich M. Zissler et al.

EBIOMEDICINE (2018)

添加到收藏夹

Article Respiratory System

Airway inflammation in mild cystic fibrosis

Jonas Eckrich et al.

JOURNAL OF CYSTIC FIBROSIS (2017)

添加到收藏夹

Review Multidisciplinary Sciences

Inflammation, metaflammation and immunometabolic disorders

Gokhan S. Hotamisligil

NATURE (2017)

添加到收藏夹

Article Critical Care Medicine

Effects of Childhood Asthma on the Development of Obesity among School-aged Children

Zhanghua Chen et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2017)

添加到收藏夹

Review Nutrition & Dietetics

Association between obesity and asthma - epidemiology, pathophysiology and clinical profile

Magdalena Muc et al.

NUTRITION RESEARCH REVIEWS (2016)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

IL-17 protein levels in both induced sputum and plasma are increased in stable but not acute asthma individuals with obesity

Jian-Hui Chen et al.

RESPIRATORY MEDICINE (2016)

添加到收藏夹

Article Allergy

Burden of Obesity on Pediatric Inpatients with Acute Asthma Exacerbation in the United States

Yusuke Okubo et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2016)

添加到收藏夹

Article Medicine, General & Internal

Prevalence of Childhood and Adult Obesity in the United States, 2011-2012

Cynthia L. Ogden et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2014)

添加到收藏夹

Article Critical Care Medicine

An Association between L-Arginine/Asymmetric Dimethyl Arginine Balance, Obesity, and the Age of Asthma Onset Phenotype

Fernando Holguin et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2013)

添加到收藏夹

Article Genetics & Heredity

A comprehensive investigation of variants in genes encoding adiponectin (ADIPOQ) and its receptors (ADIPOR1/R2), and their association with serum adiponectin, type 2 diabetes, insulin resistance and the metabolic syndrome

Kirsten E. Peters et al.

BMC MEDICAL GENETICS (2013)

添加到收藏夹

Article Pharmacology & Pharmacy

Effects of obesity and weight loss on airway physiology and inflammation in asthma

Olga Sideleva et al.

PULMONARY PHARMACOLOGY & THERAPEUTICS (2013)

添加到收藏夹

Article Respiratory System

Airway responses and inflammation in subjects with asthma after four days of repeated high-single-dose allergen challenge

Johannes Schulze et al.

RESPIRATORY RESEARCH (2012)

添加到收藏夹

Article Critical Care Medicine

Impact of Obesity in Patients Infected With 2009 Influenza A(H1N1)

Emili Diaz et al.

CHEST (2011)

添加到收藏夹

Review Medicine, Research & Experimental

Inflammatory links between obesity and metabolic disease

Carey N. Lumeng et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

添加到收藏夹

Article Biochemistry & Molecular Biology

Sputum biomarker profiles in cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) and association between pulmonary function

Olaf Eickmeier et al.

CYTOKINE (2010)

添加到收藏夹

Article Immunology

A novel subset of CD4+ TH2 memory/effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthma

Yui-Hsi Wang et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2010)

添加到收藏夹

Article Pediatrics

Multiple Markers of Inflammation and Weight Status: Cross-sectional Analyses Throughout Childhood

Asheley Cockrell Skinner et al.

PEDIATRICS (2010)

添加到收藏夹

Article Public, Environmental & Occupational Health

Potential determinants of obesity among children and adolescents in Germany: results from the cross-sectional KiGGS study

Christina Kleiser et al.

BMC PUBLIC HEALTH (2009)

添加到收藏夹

Article Medical Laboratory Technology

The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments

Stephen A. Bustin et al.

CLINICAL CHEMISTRY (2009)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Methacholine challenge - Comparison of an ATS protocol to a new rapid single concentration technique

Johannes Schulze et al.

RESPIRATORY MEDICINE (2009)

添加到收藏夹

Article Critical Care Medicine

The association between obesity and asthma - Interactions between systemic and airway inflammation

Tim J. T. Sutherland et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2008)

添加到收藏夹

Review Medicine, Research & Experimental

Insulin sensitivity: modulation by nutrients and inflammation

Simon Schenk et al.

JOURNAL OF CLINICAL INVESTIGATION (2008)

添加到收藏夹

Review Respiratory System

Obesity and the lung: 1 . Epidemiology

K. M. McClean et al.

THORAX (2008)

添加到收藏夹

Article Allergy

Effect of obesity on airway inflammation: a cross-sectional analysis of body mass index and sputum cell counts

D. C. Todd et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2007)

添加到收藏夹

Article Critical Care Medicine

Overweight, obesity, and incident asthma - A meta-analysis of prospective epidemiologic studies

David A. Beuther et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2007)

添加到收藏夹

Article Immunology

Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation

Arian Laurence et al.

IMMUNITY (2007)

添加到收藏夹

Article Immunology

Interleukin-23 drives innate and T cell-mediated intestinal inflammation

Sophie Hue et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2006)

添加到收藏夹

Article Immunology

Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology

Holm H. Uhlig et al.

IMMUNITY (2006)

添加到收藏夹

Article Respiratory System

Standardisation of spirometry

MR Miller et al.

EUROPEAN RESPIRATORY JOURNAL (2005)

添加到收藏夹

Review Immunology

IL-12 and IL-23: master regulators of innate and adaptive immunity

CL Langrish et al.

IMMUNOLOGICAL REVIEWS (2004)

添加到收藏夹

Article Nutrition & Dietetics

Serum levels of interleukin-6 and C-reactive protein correlate with body mass index across the broad range of obesity

L Khaodhiar et al.

JOURNAL OF PARENTERAL AND ENTERAL NUTRITION (2004)

添加到收藏夹

Article Immunology

Divergent pro- and Antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation

CA Murphy et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2003)

添加到收藏夹

Article Multidisciplinary Sciences

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

DJ Cua et al.

NATURE (2003)

添加到收藏夹

Article Endocrinology & Metabolism

Plasma interleukin-8 concentrations are increased in obese subjects and related to fat mass and tumor necrosis factor-α system

M Straczkowski et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2002)

添加到收藏夹

Article Biochemical Research Methods

Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method

KJ Livak et al.

METHODS (2001)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.