4.7 Review

Tanshinone IIA: a Chinese herbal ingredient for the treatment of atherosclerosis

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Tan IIA mitigates vascular smooth muscle cell proliferation and migration induced by ox-LDL through the miR-137/TRPC3 axis

Wei Li et al.

Summary: This study aimed to identify the specific molecular mechanism by which Tanshinone IIA (Tan IIA) regulates oxidized low-density lipoprotein (ox-LDL)-mediated vascular smooth muscle cell (VSMC) proliferation and migration. The results showed that Tan IIA suppresses ox-LDL-stimulated VSMC proliferation and migration through regulation of the miR-137/TRPC3 axis.

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Sodium tanshinone IIA sulfonate protects against hyperhomocysteine-induced vascular endothelial injury via activation of NNMT/SIRT1-mediated NRF2/HO-1 and AKT/MAPKs signaling in human umbilical vascular endothelial cells

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Summary: Sodium tanshinone IIA sulfonate (STS) exhibits potent endothelial protective effect against Hcy-induced cell injury, which is related to the inhibition of oxidative stress and mitochondrial dysfunction, as well as activation of AKT/MAPKs, SIRT1/NRF2/HO-1, and NNMT/MNA signaling pathways.

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Tanshinone IIA Regulates MAPK/mTOR Signal-Mediated Autophagy to Alleviate Atherosclerosis through the miR-214-3p/ATG16L1 Axis

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Summary: This study revealed that Tanshinone IIA can alleviate atherosclerosis (AS) by promoting autophagy through the miR-214-3p/ATG16L1 axis and inhibiting the MAPK/mTOR pathway. In vivo and in vitro experiments confirmed that Tanshinone IIA reduces lipid accumulation, inflammatory factor levels, and foam cell formation.

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Salvia miltiorrhiza and Tanshinone IIA reduce endothelial inflammation and atherosclerotic plaque formation through inhibiting COX-2

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Summary: This study investigated the mechanisms of Salvia miltiorrhiza (SM) and Tanshinone IIA (Tan IIA) in the treatment of atherosclerosis. The findings showed that SM alleviates atherosclerosis by reducing the expression of key pro-inflammatory factors, and Tan IIA is identified as the primary effective component, with TNF and PTGS2 being its main targets. In vitro/in vivo experiments further validated these results.

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Tanshinone IIA alleviates atherosclerosis in LDLR-/- mice by regulating efferocytosis of macrophages

Jiarou Wang et al.

Summary: This study suggests that Tanshinone IIA (TIIA) may reduce lipid accumulation and treat atherosclerosis by enhancing macrophage efferocytosis.

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Low-dose metformin targets the lysosomal AMPK pathway through PEN2

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Sodium tanshinone IIA sulfonate enhances the BMP9-BMPR2-Smad1/5/9 signaling pathway in rat pulmonary microvascular endothelial cells and human embryonic stem cell-derived endothelial cells

Jian Wang et al.

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Sodium Tanshinone IIA Sulfonate Inhibits Vascular Endothelial Cell Pyroptosis via the AMPK Signaling Pathway in Atherosclerosis

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Summary: This study investigated the protective role of sodium tanshinone IIA sulfonate (STS) in atherosclerosis (AS). The results showed that STS can regulate endothelial cell mitochondrial function and pyroptosis through an AMPK-dependent mitochondrial pathway. The study found that STS treatment enhanced maintenance of mitochondrial homeostasis and inhibited mitochondrial ROS overproduction via AMPK, thereby improving endothelial cell pyroptosis during AS. These findings suggest that STS has potential therapeutic effects in AS through its antioxidant and anti-inflammatory properties.

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Tanshinone IIA protects human coronary artery endothelial cells from ferroptosis by activating the NRF2 pathway

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Tanshinone IIA Stimulates Cystathionine γ-Lyase Expression and Protects Endothelial Cells from Oxidative Injury

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