Prospectives and retrospectives of microfluidics devices and lab-on-A-chip emphasis on cancer

Article

A snapshot of lung cancer: where are we now?—a narrative review

Gogo-ogute Ibodeng et al.

Annals of Translational Medicine (2023)

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Editorial Material Biochemistry & Molecular Biology

Ovarian Cancer: Advances in Pathophysiology and Therapies

Giovanni Tossetta et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Review Biochemistry & Molecular Biology

Recent Advances in Methods for Circulating Tumor Cell Detection

Monika Vidlarova et al.

Summary: Circulating tumor cells (CTCs) are released from primary tumors and have been identified as a negative prognostic factor for survival in many types of cancer. They also provide valuable insights into tumor progression, cell senescence, and cancer dormancy. Various methods with different specificity, utility, costs, and sensitivity have been developed for isolating and characterizing CTCs, with novel techniques being developed to overcome limitations of existing methods. This literature review describes the current and emerging methods for enriching, detecting, isolating, and characterizing CTCs.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Article Biochemistry & Molecular Biology

Extracellular matrix in high-grade serous ovarian cancer: Advances in understanding of carcinogenesis and cancer biology

Yazmin Brown et al.

Summary: High-grade serous ovarian cancer (HGSOC) is a deadly gynaecological cancer with insidious progression. It is now widely accepted that HGSOC originates from the fallopian tube epithelium. This review explores the involvement of the extracellular matrix (ECM) in HGSOC development, including its role in tumourigenesis, metastasis, and drug resistance.

MATRIX BIOLOGY (2023)

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Article Radiology, Nuclear Medicine & Medical Imaging

Breast Cancer Screening and Diagnosis Recent Advances in Imaging and Current Limitations

Alison R. Gegios et al.

PET CLINICS (2023)

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Article Oncology

Identifying and Reducing Barriers to Breast Imaging

Shanen Jean et al.

Summary: The purpose of this review is to discuss disparities in breast health care access and outcomes related to race, gender, cultural diversity, sexual orientation, socioeconomic status, geographic location, and disability. The authors recognize the complexity of eliminating inequalities in health care but are optimistic that all patients will one day have equal access to care through dialogue, acknowledgment, recognition, and action.

CURRENT BREAST CANCER REPORTS (2023)

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Review Chemistry, Analytical

Microfluidic-Based Droplets for Advanced Regenerative Medicine: Current Challenges and Future Trends

Hojjatollah Nazari et al.

Summary: Microfluidics is a promising approach for the fabrication of monodispersed droplets, offering potential solutions to the limitations of regenerative medicine. This technology has been applied in various fields such as stem cell therapy, tissue engineering, reproductive biology, and gene therapy.

BIOSENSORS-BASEL (2022)

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Review Biochemical Research Methods

Recent advances for cancer detection and treatment by microfluidic technology, review and update

Nasrin Bargahi et al.

Summary: Microfluidic systems provide a precise and user-friendly technique for cancer diagnosis and treatment, with high sensitivity, high throughput, and low cost. Although not yet widely used in clinical settings, they are expected to become the main technology for cancer diagnosis and treatment, offering more sensitive and accurate detection of cancer biomarkers and therapeutic strategies. Microfluidic lab-on-a-chip platforms have shown remarkable potential in designing novel procedures for cancer detection, therapy, and disease follow-up, as well as in developing new drug delivery systems for cancer treatment.

BIOLOGICAL PROCEDURES ONLINE (2022)

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Editorial Material Biochemistry & Molecular Biology

Recent Advances in Thyroid Cancer Research

Daniela Grimm

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Genetics & Heredity

Human organs-on-chips for disease modelling, drug development and personalized medicine

Donald E. Ingber

Summary: This Review discusses the types of single and multiple human organ-on-a-chip (organ chip) microfluidic devices and their diverse applications for disease modeling, drug development, and personalized medicine. It also addresses the challenges that must be overcome for organ chips to reach their full potential and discusses recent advances in the field.

NATURE REVIEWS GENETICS (2022)

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Review Medicine, General & Internal

Increasing Incidence of Early-Onset Colorectal Cancer

Frank A. Sinicrope

Summary: Early-onset colorectal cancer, which accounts for 10% of cases, is increasing in incidence, particularly in high-income countries. Patients often present with advanced disease in the left colon, and one in six patients has deficient DNA mismatch repair. Screening is recommended to begin at 45 years of age.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Article Oncology

Colorectal Cancer: A Review of Carcinogenesis, Global Epidemiology, Current Challenges, Risk Factors, Preventive and Treatment Strategies

Md Sanower Hossain et al.

Summary: Colorectal cancer (CRC) is a highly lethal disease with increasing incidence and mortality worldwide. Early detection and treatment are essential for survival, but recurrence and drug resistance pose significant challenges. This comprehensive review addresses the development, risk factors, and management strategies of CRC. In addition, natural products as potential therapeutics are also discussed. Public awareness is crucial for improving CRC management, especially in developing countries where access to diagnosis and treatment resources is limited.

CANCERS (2022)

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Article Oncology

Molecular Imaging and Theragnostics of Thyroid Cancers

Luca Giovanella et al.

Summary: Molecular imaging plays a crucial role in the evaluation and management of thyroid cancer, contributing to the optimization of treatment decisions and the improvement of risk stratification models. Different molecular imaging techniques can be used to detect various types of thyroid cancer, and new theragnostic approaches offer promising prospects for treatment.

CANCERS (2022)

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Review Cell Biology

Gene expressions and their significance in organoid cultures obtained from breast cancer patient-derived biopsies

P. Pranav et al.

Summary: Gene expression changes play an important role in breast cancers, which are classified based on the expression of specific genes. Organoid cultures derived from patient biopsies provide a relevant and effective model for studying gene expression and personalized medicine in breast cancer.

ACTA HISTOCHEMICA (2022)

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Article Nanoscience & Nanotechnology

MyCTC chip: microfluidic-based drug screen with patient-derived tumour cells from liquid biopsies

Fabienne D. Schwab et al.

Summary: In this study, we introduce a novel microfluidic device called MyCTC chip, which enables the isolation, culture, and drug susceptibility testing of cancer cells from liquid biopsies. The chip uses a label-free, antigen-agnostic enrichment method to capture cancer cells, followed by cultivation and drug screening. We demonstrate the chip's effectiveness in spike-in experiments with breast circulating tumor cells, as well as in processing blood from breast cancer patients and ascites fluid from patients with ovarian, tubal, and endometrial cancer. The MyCTC chip has the potential to identify personalized drug response patterns in patients with advanced metastatic disease and limited treatment options.

MICROSYSTEMS & NANOENGINEERING (2022)

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Article Engineering, Biomedical

Optical diagnostic imaging and therapy for thyroid cancer

Chengying Shao et al.

Summary: Optical imaging shows promising potential in screening, diagnosis, and treatment of thyroid cancer. Despite the increasing research in this field, there is a lack of comprehensive review on this topic.

MATERIALS TODAY BIO (2022)

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Review Oncology

Current and Emerging Methods for Ovarian Cancer Screening and Diagnostics: A Comprehensive Review

Juliane M. Liberto et al.

Summary: Ovarian high-grade serous carcinoma (HGSC) has a high mortality rate due to delays in diagnosis and a lack of sensitive and specific biomarkers for early-stage detection. This review provides an overview of the current landscape of ovarian cancer diagnostics and focuses on emerging methodologies for non-invasive detection of HGSC, particularly in high-risk populations.

CANCERS (2022)

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Article Biotechnology & Applied Microbiology

A comparative study of tumour-on-chip models with patient-derived xenografts for predicting chemotherapy efficacy in colorectal cancer patients

Louis Jun Ye Ong et al.

Summary: Inter-patient and intra-tumour heterogeneity have led to the need for personalized cancer therapy. Patient-derived xenograft (PDX) models are specific to individual patients, but they are not cost-effective and scalable. Tumour Organ-on-Chip (OoC) models can replicate aspects of the 3D tumour microenvironment and can be used for drug screening. However, there is limited validation to compare drug responses between tumour OoCs and PDX models.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

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Article Oncology

Ultrasound super-resolution imaging for the differential diagnosis of thyroid nodules: A pilot study

Ge Zhang et al.

Summary: This study evaluated the feasibility and value of ultrasound super-resolution imaging in the differentiation of thyroid nodules. The results showed that super-resolution imaging can successfully visualize the microvasculature of thyroid nodules and provide useful clinical information for differential diagnosis.

FRONTIERS IN ONCOLOGY (2022)

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Review Chemistry, Analytical

Application of Microfluidics in Drug Development from Traditional Medicine

Xue Li et al.

Summary: Traditional drug development strategies cannot meet the demand for drugs with low or no risk of side effects, highlighting the need for new development strategies. Microfluidics has played a crucial role in traditional medicine drug development, addressing many challenges. This review provides an overview of the applications of microfluidics in drug development, with a focus on its use in traditional medicine.

BIOSENSORS-BASEL (2022)

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Review Engineering, Biomedical

Cancer-on-chip technology: current applications in major cancer types, challenges and future prospects

Zakaria Baka et al.

Summary: Conventional 2D cell cultures are being questioned for their relevance in drug development, and there is a need to develop new experimental models that better mimic the complexity of in vivo tumors. Microfluidic technology-based "cancer-on-chip" shows promise in simulating the characteristics of human tissues and organs.

PROGRESS IN BIOMEDICAL ENGINEERING (2022)

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Review Nanoscience & Nanotechnology

Advances in Organ-on-a-Chip Materials and Devices

Bishal Kumar Nahak et al.

Summary: The organ-on-a-chip (OoC) technology provides an accurate pathway for biomedical applications from preclinical to clinical translational precision. It accurately represents human physiology in vitro and allows noninvasive real-time monitoring and treatment. The technology combines emerging approaches such as advanced materials, artificial intelligence, machine learning, three-dimensional bioprinting, and genomics, and has broad application prospects.

ACS APPLIED BIO MATERIALS (2022)

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Article Medicine, Research & Experimental

Development of integrated microfluidic platform coupled with Surface-enhanced Raman Spectroscopy for diagnosis of COVID-19

Siddhita A. Jadhav et al.

Summary: The COVID-19 pandemic has highlighted the urgent need for a swift, sensitive, and inexpensive diagnostic protocol. The authors propose a new diagnostic approach based on Surface-enhanced Raman Spectroscopy (SERS) coupled with microfluidic devices to trap and identify viruses from diverse biological fluids. If successful, this approach could serve as a valuable tool for mass screening of COVID-19 and future viral pandemics.

MEDICAL HYPOTHESES (2021)

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Review Oncology

A 3D View of Colorectal Cancer Models in Predicting Therapeutic Responses and Resistance

Eileen Reidy et al.

Summary: Colorectal cancer is a common solid tumor with many patients developing resistance to treatment. 3D models allow for studying interactions between cancer cells and other cells in the colon, aiding in understanding drug effects.

CANCERS (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Review Nanoscience & Nanotechnology

Microfluidic chips: recent advances, critical strategies in design, applications and future perspectives

Prapti Pattanayak et al.

Summary: Microfluidic chip technology is a new tool in the biomedical field, with interconnected microchannels engraved on materials like glass, silicon, or polymers. It offers advantages such as time and reagent savings, simultaneous execution of multiple operations, and fast reaction times due to its miniature size. The chip is used in various biomedical applications like food safety sensing, peptide analysis, tissue engineering, medical diagnosis, DNA purification, PCR activity, pregnancy, and glucose estimation.

MICROFLUIDICS AND NANOFLUIDICS (2021)

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Review Biochemistry & Molecular Biology

Fabrication and Applications of Microfluidic Devices: A Review

Adelina-Gabriela Niculescu et al.

Summary: Microfluidics is an emerging field that combines principles from various disciplines to fabricate miniaturized chips with channels and chambers. These chips, made using diverse methods, can be utilized in nanoparticle preparation, cell analysis, and diagnosis, among other biomedical applications.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Chemistry, Analytical

Microfluidic Systems for Cancer Diagnosis and Applications

Semra Akgonullu et al.

Summary: Microfluidic devices have enabled novel biological advancements by mimicking and measuring micro systems, particularly in cancer diagnostics and management.

MICROMACHINES (2021)

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Article Oncology

Identification of soluble tissue-derived biomarkers from human thyroid tissue explants maintained on a microfluidic device

Andrew Riley et al.

Summary: This study validated a novel method of maintaining live human ex vivo thyroid tissue in a tissue-on-chip format. The analysis of the tissue effluent identified potential biomarkers associated with thyroid cancer aggressiveness, demonstrating the usability of microfluidic technology for identifying novel biomarkers.

ONCOLOGY LETTERS (2021)

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Editorial Material Cell & Tissue Engineering

Organs-on-chip: The way forward

Massimo Mastrangeli et al.

Summary: Organ-on-chip (OoC) technology is thriving due to the availability of stem cells and international OoC programs. Coordinated standardization, qualification, and independent testing of devices are needed to further develop OoC technology and maximize its potential in drug development, disease modeling, and personalized medicine. The OoC roadmap can guide the way forward.

STEM CELL REPORTS (2021)

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Review Biochemistry & Molecular Biology

Circulating tumor cells: biology and clinical significance

Danfeng Lin et al.

Summary: CTCs, tumor cells that have sloughed off the primary tumor and circulate in the blood, have potential for identifying targets against cancer metastasis. Detecting these rare CTCs in the massive pool of blood cells is challenging, but emerging detection technologies have deepened our understanding of their biology and clinical applications. Molecular markers, such as epithelial cell adhesion molecule, play a key role in CTC detection, with properties like epithelial-to-mesenchymal transition and stemness indicating increased metastatic capacity.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Review Engineering, Biomedical

Organ-on-a-chip: recent breakthroughs and future prospects

Qirui Wu et al.

BIOMEDICAL ENGINEERING ONLINE (2020)

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Review Oncology

Theranostic Pretargeting Drug Delivery and Imaging Platforms in Cancer Precision Medicine

Sudath Hapuarachchige et al.

FRONTIERS IN ONCOLOGY (2020)

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Review Surgery

The Changing Face of in vitro Culture Models for Thyroid Cancer Research: A Systematic Literature Review

Dylan Chew et al.

FRONTIERS IN SURGERY (2020)

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Review Chemistry, Multidisciplinary

Organ-on-a-chip: the next generation platform for risk assessment of radiobiology

Yi Quan et al.

RSC ADVANCES (2020)

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Article Biochemical Research Methods

An integrated microfluidic system for rapid, automatic and high-throughput staining of clinical tissue samples for diagnosis of ovarian cancer

Sheng-Po Huang et al.

LAB ON A CHIP (2020)

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Article Oncology

A novel microfluidic device capable of maintaining functional thyroid carcinoma specimens ex vivo provides a new drug screening platform

Andrew Riley et al.

BMC CANCER (2019)

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Article Chemistry, Multidisciplinary

Soft, Skin-Integrated Multifunctional Microfluidic Systems for Accurate Colorimetric Analysis of Sweat Biomarkers and Temperature

Jungil Choi et al.

ACS SENSORS (2019)

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Review Chemistry, Analytical

Recent advances in microfluidic platforms for single-cell analysis in cancer biology, diagnosis and therapy

Hamed Tavakoli et al.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2019)

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Review Biotechnology & Applied Microbiology

Microfluidics for studying metastatic patterns of lung cancer

Monika Ruzycka et al.

JOURNAL OF NANOBIOTECHNOLOGY (2019)

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Review Pharmacology & Pharmacy

Application of microfluidic chip technology in pharmaceutical analysis: A review

Ping Cui et al.

JOURNAL OF PHARMACEUTICAL ANALYSIS (2019)

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Article Nanoscience & Nanotechnology

Microfluidic-Based Immunomodulation of Immune Cells Using Upconversion Nanoparticles in Simulated Blood Vessel-Tumor System

Dulani Chandima Wimalachandra et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Pharmacology & Pharmacy

Microfluidics for personalized drug screening of cancer

Chwee Teck Lim

CURRENT OPINION IN PHARMACOLOGY (2019)

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Review Oncology

Circulating tumor cells in precision oncology: clinical applications in liquid biopsy and 3D organoid model

Chang Yang et al.

CANCER CELL INTERNATIONAL (2019)

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Article Oncology

Evaluating natural killer cell cytotoxicity against solid tumors using a microfluidic model

Jose M. Ayuso et al.

ONCOIMMUNOLOGY (2019)

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Review Chemistry, Analytical

Review: Microfluidics technologies for blood-based cancer liquid biopsies

Yuxi Sun et al.

ANALYTICA CHIMICA ACTA (2018)

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Review Pharmacology & Pharmacy

Organ/body-on-a-chip based on microfluidic technology for drug discovery

Hiroshi Kimura et al.

DRUG METABOLISM AND PHARMACOKINETICS (2018)

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Review Oncology

Organotypic 3D Models of the Ovarian Cancer Tumor Microenvironment

Karen M. Watters et al.

CANCERS (2018)

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Article Biochemical Research Methods

Development of a microfluidic platform integrating high-resolution microstructured biomaterials to study cell-material interactions

D. Barata et al.

LAB ON A CHIP (2017)

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Article Biochemical Research Methods

A vascularized and perfused organ-on-a-chip platform for large-scale drug screening applications

Duc T. T. Phan et al.

LAB ON A CHIP (2017)

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Article Engineering, Biomedical

Microfluidic device for novel breast cancer screening by blood test using miRNA beacon probe

Bindu Salim et al.

BIOMEDICAL MICRODEVICES (2017)

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Article Biochemistry & Molecular Biology

Transcriptional activation of NANOG by YBX1 promotes lung cancer stem-like properties and metastasis

Tao Guo et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

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Article Multidisciplinary Sciences

CD47 Promotes Tumor Invasion and Metastasis in Non-small Cell Lung Cancer

Hui Zhao et al.

SCIENTIFIC REPORTS (2016)

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Article Multidisciplinary Sciences

Microfluidic co-culture system for cancer migratory analysis and anti-metastatic drugs screening

Shengli Mi et al.

SCIENTIFIC REPORTS (2016)

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Article Biophysics

Advantages and challenges of microfluidic cell culture in polydimethylsiloxane devices

Skarphedinn Halldorsson et al.

BIOSENSORS & BIOELECTRONICS (2015)

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Review Biotechnology & Applied Microbiology

Evaluating Biomaterial- and Microfluidic-Based 3D Tumor Models

Mariana R. Carvalho et al.

TRENDS IN BIOTECHNOLOGY (2015)

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Review Biochemical Research Methods

New materials for microfluidics in biology

Kangning Ren et al.

CURRENT OPINION IN BIOTECHNOLOGY (2014)

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Article Biotechnology & Applied Microbiology

Microfluidic organs-on-chips

Sangeeta N. Bhatia et al.

NATURE BIOTECHNOLOGY (2014)

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Editorial Material Biotechnology & Applied Microbiology

Commercialization of microfluidic devices

Lisa R. Volpatti et al.

TRENDS IN BIOTECHNOLOGY (2014)

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Review Pharmacology & Pharmacy

Theranostics: A treasured tailor for tomorrow

S. Jeelani et al.

JOURNAL OF PHARMACY AND BIOALLIED SCIENCES (2014)

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Review Chemistry, Multidisciplinary

Materials for Microfluidic Chip Fabrication

Kangning Ren et al.

ACCOUNTS OF CHEMICAL RESEARCH (2013)

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Article Materials Science, Biomaterials

Applications of Microfluidics in Stem Cell Biology

Qiucen Zhang et al.

BIONANOSCIENCE (2012)

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Article Multidisciplinary Sciences

Reconstituting Organ-Level Lung Functions on a Chip

Dongeun Huh et al.

SCIENCE (2010)

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Article Oncology

New technologies for human cancer imaging

John V. Frangioni

JOURNAL OF CLINICAL ONCOLOGY (2008)

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Review Biochemical Research Methods

Microfabrication and microfluidics for tissue engineering: state of the art and future opportunities

H Andersson et al.

LAB ON A CHIP (2004)

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Prospectives and retrospectives of microfluidics devices and lab-on-A-chip emphasis on cancer

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