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ELSEVIER
DOI: 10.1016/j.inat.2023.101921
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Convexity; Histology; Meningioma; Skull base; Spatial distribution; 2016 WHO classification
This study analyzed the preferred locations of meningiomas and their association with different gradings. The most frequent locations were found to be convexity and parafalcine, and the predominant subtypes were transitional and fibroblastic meningiomas.
Background: Meningiomas are extra-axial tumors that arise from meningothelial cells, accounting for about onethird of primary central nervous system malignancies. While they are often classified by location and histology, the role of the molecular profile in their development and progression is significant. The topographic distribution of meningiomas has not been extensively studied, and it is unclear whether specific histological subtypes have predilection sites. Therefore, this study analyzes the preferred locations of meningiomas according to different biological characteristics and their association with different gradings. Methods: This is a retrospective chart review of patients in tertiary institutes over 14 years. The data were retrieved from medical and pathological record archives. An association between the biological nature of tumors and the location of meningiomas was analyzed. SPSS version 25 was used to analyze the data. Results: Out of 272 patients, the predominant location for meningioma distribution was convexity (33.5%), followed by parafalcine (12.5%). WHO Grade I meningiomas were the most common, accounting for 84.2% of all meningiomas. The transitional histological subtype is the common variant (34.6%). The distribution of the histological subtype of meningioma in relation to tentorium was statistically significant. However, that was not the case with the skull base. Conclusion: The spatial distribution of meningiomas within the brain is not uniform. The most frequent locations for meningiomas were found to be convexity and parafalcine. Transitional and fibroblastic meningiomas were the predominant subtypes.
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