☆ 4.5 Review

Unraveling the role of Xist RNA in cardiovascular pathogenesis

PATHOLOGY RESEARCH AND PRACTICE (2024)

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Article Cardiac & Cardiovascular Systems

Protocatechuic Aldehyde Alleviates d-Galactose-Induced Cardiomyocyte Senescence by Regulating the TCF3/ATG5 Axis

Pengjun Wang et al.

Summary: Cardiomyocyte senescence is a risk factor for cardiovascular diseases. Protocatechuic aldehyde (PCA) in Salvia miltiorrhiza protects against oxidative stress and inflammation in the cardiovascular system. This study investigates the role of PCA in myocardial cell senescence and finds that it alleviates senescence by downregulating TCF3, promoting ATG5-mediated autophagy, and inhibiting inflammation in H9C2 cells.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2023)

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Article

Emodin Regulates lncRNA XIST/miR-217 Axis to Protect Myocardial Ischemia-Reperfusion Injury

Shuai Huang et al.

Oxidative Medicine and Cellular Longevity (2023)

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Article Biochemistry & Molecular Biology

RelB represses miR-193a-5p expression to promote the phenotypic transformation of vascular smooth muscle cells in aortic aneurysm

Yisi Liu et al.

Summary: This study investigated the role and mechanism of miR-193a-5p in abdominal aortic aneurysms (AAA). The results showed that miR-193a-5p can inhibit the proliferation and migration of VSMCs, and mediate these effects by regulating CCNE1, CCND1, and CXCR4 genes. The expression of miR-193a-5p in the vasculature is regulated by Ang II and significantly downregulated in the serum of AAA patients. This study may provide new intervention targets for the prevention and treatment of AAA.

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2023)

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Article Biochemistry & Molecular Biology

Long Noncoding RNA XIST Regulates Myocardial Infarction via miR-486-5p/SIRT1 Axis

Jiayong Xie

Summary: This study reveals that lncRNA XIST can protect against hypoxia-induced myocardial infarction by regulating the miR-486-5p/SIRT1 axis.

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY (2023)

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Review Biochemistry & Molecular Biology

Galangin as an inflammatory response modulator: An updated overview and therapeutic potential

Riya Thapa et al.

Summary: Numerous chronic diseases are caused by inflammation, and flavonols have shown potent anti-inflammatory properties in various models. The natural flavonol galangin (GAL) has the ability to control apoptosis and inflammation by suppressing ERK and NF-kappa Bp65 phosphorylation. GAL has been used to treat arthritis, inflammatory bronchitis, stroke, and cognitive dysfunction. This review aims to demonstrate the anti-inflammatory properties of GAL and its protective effects in the treatment of various chronic illnesses.

CHEMICO-BIOLOGICAL INTERACTIONS (2023)

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Article Oncology

LncRNA JPX targets SERCA2a to mitigate myocardial ischemia/reperfusion injury by binding to EZH2

Jieli Bao et al.

Summary: This study investigates the role of lncRNA JPX in regulating SERCA2a expression through binding to EZH2 and its protective effect against myocardial I/R injury. Results suggest that JPX may serve as a potential therapeutic target for I/R injury.

EXPERIMENTAL CELL RESEARCH (2023)

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Editorial Material Biotechnology & Applied Microbiology

Advanced drug-delivery approaches in managing P53-mediated lung diseases remodeling

Asif Ahmad Bhat et al.

NANOMEDICINE (2023)

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Article Medicine, General & Internal

Ubiquitin-specific protease 11 Aggravates Ischemia-reperfusion-induced Cardiomyocyte Pyroptosis and Injury by Promoting TRAF3 Deubiquitination

Yunfei Zhang et al.

Summary: The deubiquitinating enzyme USP11 plays a protective role in myocardial ischemia-reperfusion injury by downregulating TRAF3. This suggests that USP11 may be a potential target for treating myocardial infarction.

BALKAN MEDICAL JOURNAL (2023)

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Review Cell Biology

The role of lncRNAs/miRNAs/Sirt1 axis in myocardial and cerebral injury

Samira Barangi et al.

Summary: In recent years, researchers have recognized the importance of non-coding RNAs, such as lncRNAs and miRNAs, in the treatment of cancer and cardiovascular and neurological diseases. These non-coding RNAs play a role in regulating gene expression and activating mRNA translation. Sirtuins, especially Sirt1, are critical in regulating physiological processes and have been found to interact with non-coding RNAs in the progression and prevention of diseases. This review focuses on the crosstalk between non-coding RNAs and Sirt1 in myocardial and cerebral injuries, providing insight for novel treatment approaches.

CELL CYCLE (2023)

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Article Biology

EZH2 controls epicardial cell migration during heart development

Haobin Jiang et al.

Summary: In this study, the role of EZH2 in epicardial development was investigated. The results demonstrate that EZH2 promotes epicardial cell migration by suppressing TIMP3 transcription, which is vital for heart development. Moreover, epicardial Ezh2 deficiency-induced TIMP3 upregulation leads to extracellular matrix reconstruction in the embryonic myocardium.

LIFE SCIENCE ALLIANCE (2023)

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Review Chemistry, Multidisciplinary

Unlocking the potential of mesoporous silica nanoparticles in breast cancer treatment

Riya Thapa et al.

Summary: Breast cancer, the most common cancer among women, is typically managed with surgery, radiation therapy, and chemotherapy. However, chemotherapy drugs often lack specificity, resulting in adverse effects. Mesoporous silica nanoparticles (MSNPs) have emerged as a potential solution to enhance drug delivery in cancer treatment by offering advantageous properties such as high porosity, large surface area, versatile pore sizes, and compatibility with biological systems. MSNPs can effectively load chemotherapeutic agents and improve drug uptake and release, resulting in enhanced anticancer activity. Additionally, MSNP-based drug delivery improves pharmacodynamic and pharmacokinetic characteristics, ultimately improving therapeutic outcomes for breast cancer treatment.

JOURNAL OF NANOPARTICLE RESEARCH (2023)

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Review Pathology

Unveiling the connection: Long-chain non-coding RNAs and critical signaling pathways in breast cancer

Riya Thapa et al.

Summary: This review explores the interaction between long-chain non-coding RNAs (lncRNAs) and various signaling pathways in breast cancer, including AKT/PI3K/mTOR, Wnt/β-catenin, Notch, DNA damage response, TGF-beta, Hedgehog, and NF-κB. Specific lncRNAs have been found to influence the functioning of these pathways, playing a role in breast cancer development.

PATHOLOGY RESEARCH AND PRACTICE (2023)

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Article Cardiac & Cardiovascular Systems

Up-regulated lncRNA SNHG9 mediates the pathogenesis of dilated cardiomyopathy via miR-326/EPHB3 axis

Fan Zhang et al.

Summary: In this study, serum SNHG9 was identified as a biomarker for dilated cardiomyopathy. The expression alterations of several lncRNAs, including SNHG9, were evaluated using ROC curves. The results showed that elevated SNHG9 levels were associated with DCM and worse heart function, and deletion of SNHG9 alleviated heart injury in a mouse model of DCM induced by doxorubicin.

JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2023)

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Article Cardiac & Cardiovascular Systems

Transient Cell Cycle Induction in Cardiomyocytes to Treat Subacute Ischemic Heart Failure

Riham R. E. Abouleisa et al.

Summary: This study provides mechanistic insights into forced cardiomyocyte proliferation and advances the clinical feasibility of this approach for the treatment of ischemic heart failure by minimizing the oncogenic potential of cell cycle factors and using a novel viral construct.

CIRCULATION (2022)

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Review Biochemistry & Molecular Biology

Mitochondrial sirtuins, metabolism, and aging

Zhejun Ji et al.

Summary: This article reviews the role of mitochondrial sirtuins (SIRT3, SIRT4, and SIRT5) in metabolic regulation, aging, and aging-related diseases. By understanding how sirtuins regulate metabolic processes and their functional differences in canonical pathways and signaling networks, a deeper understanding of the mechanisms underlying the delay or acceleration of biological aging can be achieved.

JOURNAL OF GENETICS AND GENOMICS (2022)

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Article Medicine, Research & Experimental

The proliferation and migration of atherosclerosis-related HVSMCs were inhibited by downregulation of lncRNA XIST via regulation of the miR-761/BMP9 axis

Long Mo et al.

Summary: In this study, it was found that XIST regulates the proliferation and migration of HVSMCs through the miR-761/BMP9/ALK1/endoglin pathway. Knockdown of XIST reduced proliferation and migration of HVSMCs, while miR-761 played a key role by targeting-inhibiting BMP9.

KAOHSIUNG JOURNAL OF MEDICAL SCIENCES (2022)

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Review Pathology

Atherosclerosis: Known and unknown

Jianglin Fan et al.

Summary: Atherosclerotic disease is a global killer caused by multiple factors. While progress has been made in understanding its pathogenesis, further research is needed to develop new treatments.

PATHOLOGY INTERNATIONAL (2022)

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Article Plant Sciences

Protocatechuic aldehyde prevents ischemic injury by attenuating brain microvascular endothelial cell pyroptosis via lncRNA Xist

Yan Guo et al.

Summary: The study demonstrated that PCA effectively attenuates BMEC pyroptosis under ischemic injury by enhancing antioxidant activity, regulating protein expression, reducing cerebral infarct volume in MCAO rats, and promoting cell survival in rBMECs. The crucial role of lncRNA Xist in mediating the anti-pyroptosis effects of PCA on rBMECs was also highlighted in this research.

PHYTOMEDICINE (2022)

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Article Health Care Sciences & Services

mir-204-5p Acts as a Tumor Suppressor by Targeting DNM2 in Osteosarcoma Cells

Liangliang Qu et al.

Summary: The study found that in osteosarcoma, mir-204-5p exerts a tumor suppressive effect by targeting DNM2, inhibiting cell proliferation and accelerating apoptosis. This research provides new insights for clinical treatment.

JOURNAL OF HEALTHCARE ENGINEERING (2022)

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Article Cardiac & Cardiovascular Systems

Knockdown of XIST up-regulates 263294miR-340-5p to relieve myocardial ischaemia-reperfusion injury via inhibiting cyclin D1

Qijun Bai et al.

Summary: The XIST/miR-340-5p/CCND1 axis plays a crucial role in myocardial ischemia-reperfusion injury, with knockdown of XIST up-regulating miR-340-5p to inhibit CCND1 and alleviate MIRI.

ESC HEART FAILURE (2022)

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Article Biology

The Role of TLR2 in Infectious Diseases Caused by Mycobacteria: From Cell Biology to Therapeutic Target

Wanbin Hu et al.

Summary: This review summarizes the functions of Toll-like receptor 2 (TLR2) in innate immunity and metabolism, and suggests future research directions.

BIOLOGY-BASEL (2022)

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Article Cell Biology

A novel lncRNA-miRNA-mRNA triple network identifies lncRNA XIST as a biomarker for acute myocardial infarction

Peng-Fei Zheng et al.

Aging-US (2022)

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Article Genetics & Heredity

Integrative analyses of biomarkers and pathways for heart failure

Shaowei Fan et al.

Summary: This study identified differentially expressed genes (DEGs) associated with heart failure through analyzing gene expression data in heart failure patients. Further functional enrichment analysis and protein-protein interaction network construction revealed the molecular mechanisms of heart failure. The findings may provide potential biomarkers and therapeutic targets for the prediction, diagnosis, and treatment strategies of heart failure.

BMC MEDICAL GENOMICS (2022)

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Editorial Material Pharmacology & Pharmacy

A European pharmacotherapeutic agent roflumilast exploring integrated preclinical and clinical evidence for SARS CoV-2 mediated inflammation to organ damage

Yogendra Singh et al.

Summary: COVID-19 has affected nearly 160 million people worldwide, with the elderly and pre-existing patients being more susceptible to severe illness. Roflumilast, a PDE4 inhibitor, has shown potential in protecting renal tissues and major organ systems by reducing immune cell infiltration after COVID-19 infection. Its immune-balancing effects are associated with decreased oxidative and inflammatory burden, caspase-3 suppression, and increased PKA/cAMP levels in renal and other organ tissue.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2022)

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Article Pharmacology & Pharmacy

TRAF3 promoted ROS-induced oxidative stress in model of cardiac infarction through the regulation of ULK1 ubiquitination

Shaobing Zhu et al.

Summary: This study identified that TRAF3 promotes ROS-induced oxidative stress in a model of cardiac infarction through the regulation of ULK1 ubiquitination, which could potentially give rise to a new strategy for the treatment of cardiac infarction.

CLINICAL AND EXPERIMENTAL HYPERTENSION (2022)

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Review Immunology

SARS-CoV-2/COVID-19 and its relationship with NOD2 and ubiquitination

Edgardo Guzman Rivera et al.

Summary: COVID-19 infection activates the immune system to cause autoimmune and autoinflammatory diseases. A comprehensive review on the relationship between SARS-CoV-2, NOD2, and ubiquitination reveals reciprocal interactions among them.

CLINICAL IMMUNOLOGY (2022)

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Review Medicine, General & Internal

Diagnosis and Treatment of Pulmonary Arterial Hypertension A Review

Nicole F. Ruopp et al.

Summary: Pulmonary arterial hypertension, a subtype of pulmonary hypertension characterized by pulmonary arterial remodeling, can progress to right heart failure and death if left untreated. Approved therapies targeting multiple biological pathways have significantly improved survival rates.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2022)

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Review Cardiac & Cardiovascular Systems

Antepartum acute Stanford type A aortic dissection: a case report and literature review

Shibo Song et al.

Summary: This case report describes a pregnant woman diagnosed with acute type A aortic dissection at 28 weeks of gestation. With emergency surgery and the use of deep hypothermic circulatory arrest technique, both the mother and the baby survived. The article also includes a literature review on antepartum acute aortic dissection during pregnancy and highlights the importance of pre-pregnancy examinations and blood pressure monitoring during pregnancy to prevent this condition.

JOURNAL OF CARDIOTHORACIC SURGERY (2022)

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Article Cardiac & Cardiovascular Systems

MNK2-eIF4E axis promotes cardiac repair in the infarcted mouse heart by activating cyclin D1

Bing-Rui Chen et al.

Summary: Adult mammals have limited cardiac regeneration potential after injury, while neonatal mouse hearts can completely regenerate within 7 days of birth. This study demonstrated the critical role of mitogen-activated protein kinase-interacting serine/threonine-protein kinase 2 (MNK2) in cardiac regeneration, promoting cardiomyocyte proliferation through activation of the eIF4E-cyclin D1 axis.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2022)

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Review Medicine, General & Internal

Pulmonary arterial hypertension

Raquel Luna-Lopez et al.

Summary: Pulmonary arterial hypertension is a rare disease with adverse remodeling of the arterial tree, leading to increased vascular resistance, right ventricular overload, and heart failure. Diagnosis and treatment are often delayed due to nonspecific clinical manifestations and lack of understanding of the pathology, resulting in a poor prognosis. The latest recommendations emphasize early differential diagnosis from other causes of pulmonary hypertension to initiate appropriate treatment based on risk assessment. In recent years, improvements in diagnostic processes, the development of new treatments, and the establishment of specialized referral units have significantly improved the prognosis and quality of life for patients with pulmonary arterial hypertension.

MEDICINA CLINICA (2022)

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Article Peripheral Vascular Disease

Inhibition of XIST attenuates abdominal aortic aneurysm in mice by regulating apoptosis of vascular smooth muscle cells through miR-762/ MAP2K4 axis

Dongbin Zhang et al.

Summary: This study demonstrates that inhibition of XIST attenuates AAA in mice, which is achieved by inhibiting apoptosis of VSMCs through regulating the miR-762/MAP2K4 axis.

MICROVASCULAR RESEARCH (2022)

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Article Cell Biology

LncRNA XIST facilitates hypoxia-induced myocardial cell injury through targeting miR-191-5p/TRAF3 axis

Yonghong Wang et al.

Summary: This study investigated the molecular and functional association of long non-coding RNA XIST, miR-191-5p, and TRAF3. The results showed that downregulation of XIST and upregulation of miR-191-5p protected cardiomyocytes from hypoxia-induced cell injury by regulating the miR-191-5p/TRAF3 signaling pathway.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2022)

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Article Cardiac & Cardiovascular Systems

NEU1 Regulates Mitochondrial Energy Metabolism and Oxidative Stress Post-myocardial Infarction in Mice via the SIRT1/PGC-1 Alpha Axis

Zhen Guo et al.

Summary: This study found that NEU1 was significantly upregulated in MI cardiac tissue. Cardiomyocyte-specific NEU1 deficiency restored cardiac function, hypertrophy, and interstitial fibrosis, while inhibiting mitochondrial dysfunction and oxidative stress induced by MI. The beneficial effects of NEU1 deficiency may be mediated through enhancing the SIRT1/PGC-1 alpha signaling pathway.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2022)

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Review Biochemistry & Molecular Biology

A narrative review on the biology of piezo1 with platelet-rich plasma in cardiac cell regeneration

Khalid Saad Alharbi et al.

Summary: Current studies have found that Piezo1 plays an important role in the heart, closely related to cardiac regeneration and angiogenesis, providing new research directions for cardiomyocyte regeneration.

CHEMICO-BIOLOGICAL INTERACTIONS (2022)

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Article Genetics & Heredity

FOS gene associated immune infiltration signature in perivascular adipose tissues of abdominal aortic aneurysm

Suping Ding et al.

Summary: This study explores the association between immune cell infiltration and key gene expression profiles in the perivascular adipose tissue (PAT) of abdominal aortic aneurysms (AAA). The results show a higher proportion of activated mast cells and follicular helper T (Tfh) cells in the dilated PAT, as well as the involvement of AP-1 family members in the gene expression profile. Furthermore, the expression of AP-1 family members is significantly correlated with the infiltration of activated mast cells, plasma cells, and Tfh cells in the dilated PAT of AAA.

GENE (2022)

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Article Orthopedics

miR-204-5p inhibits inflammation of synovial fibroblasts in osteoarthritis by suppressing FOXC1

Xiao He et al.

Summary: The study reveals that miR-204-5p ameliorates inflammatory responses of osteoarthritic synovial fibroblasts by down-regulating FOXC1. Results demonstrate that miR-204-5p negatively regulates FOXC1 in both normal SFs and osteoarthritic SFs.

JOURNAL OF ORTHOPAEDIC SCIENCE (2022)

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Review Pharmacology & Pharmacy

Polysaccharide-Based Nanomedicines Targeting Lung Cancer

Asif Ahmad Bhat et al.

Summary: Lung cancer, a common chronic tumor, can be effectively treated using polysaccharide-based nanomedicines that minimize side effects and enhance immune response.

PHARMACEUTICS (2022)

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Article Plant Sciences

Isoorientin attenuates doxorubicin-induced cardiac injury via the activation of MAPK, Akt, and Caspase-dependent signaling pathways

Shaoguang Li et al.

Summary: The combination of isoorientin (ISO) and doxorubicin (DOX) synergistically enhances the anti-proliferative effect of DOX on various tumor cells and improves the survival rate of DOX-injured cardiomyocytes by reducing reactive oxygen species, maintaining mitochondrial function, and inhibiting apoptosis. ISO also exhibits a dose-dependent protective effect on DOX-induced heart injury in mice, possibly through the inhibition of MAPK and caspase-dependent apoptosis pathways.

PHYTOMEDICINE (2022)

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Article Biotechnology & Applied Microbiology

Exosomes from human induced pluripotent stem cells-derived keratinocytes accelerate burn wound healing through miR-762 mediated promotion of keratinocytes and endothelial cells migration

Yunyao Bo et al.

Summary: This study investigated the effects of exosomes produced by induced pluripotent stem cell-derived keratinocytes in deep second-degree burn wound healing and found that they promoted wound closure, angiogenesis, and re-epithelialization. The enrichment of miR-762 in these exosomes was shown to regulate cell migration through targeting promyelocytic leukemia and integrin betal. These findings provide a foundation for the development of novel cell-free treatments for deep second-degree burns.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Review Cardiac & Cardiovascular Systems

Wnt Signaling in Heart Development and Regeneration

Dongliang Li et al.

Summary: Wnt/β-catenin signaling plays important roles in heart development and regeneration. It exhibits biphasic and antagonistic effects on cardiac specification and differentiation depending on the stage of embryogenesis. Understanding the mechanisms of Wnt signaling pathway in injured animal hearts will contribute to the development of potential therapeutics for human diseased hearts.

CURRENT CARDIOLOGY REPORTS (2022)

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Article Biochemistry & Molecular Biology

Notoginsenoside R1-loaded mesoporous silica nanoparticles targeting the site of injury through inflammatory cells improves heart repair after myocardial infarction

Han Li et al.

Summary: This study developed a targeted drug delivery system to deliver Notoginsenoside R1 (NGR1) to the infarcted myocardium, improving cardiac function and angiogenesis. The mechanism of NGR1 in myocardial protection was found to involve the AKT, MAPK, and Hippo signaling pathways.

REDOX BIOLOGY (2022)

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Article Medicine, General & Internal

Targeting miR-30d reverses pathological cardiac hypertrophy

Jin Li et al.

Summary: MiR-30d is decreased in pathological cardiac hypertrophy and its overexpression can ameliorate hypertrophic phenotypes by regulating target genes MAP4K4 and GRP78 and inhibiting NFAT. MiR-30d is reduced in the serum of patients with chronic heart failure and its overexpression significantly improves pathological hypertrophy in human embryonic stem cell-derived cardiomyocytes.

EBIOMEDICINE (2022)

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Review Biochemistry & Molecular Biology

Recent developments in plant-derived edible nanoparticles as therapeutic nanomedicines

Neha Jain et al.

Summary: The use of nanotechnology in treating various disorders has been proven effective. Plant-derived edible nanoparticles (PDNPs) are predicted to be potential therapeutic agents in treating diseases or delivering drugs. PDNPs structurally resemble exosomes extracted from mammals and selectively target cancer cells via unique endocytic pathways. They can be produced in large quantities, are non-toxic, and have tissue-specific targeting abilities.

JOURNAL OF FOOD BIOCHEMISTRY (2022)

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Review Biochemistry & Molecular Biology

Molecular explanation of Wnt/βcatenin antagonist pyrvinium mediated calcium equilibrium changes in aging cardiovascular disorders

Khalid Saad Alharbi et al.

Summary: This study examines the impact of ageing on the cardiovascular system and its association with cardiovascular disease. The findings suggest that oxidative stress, inflammatory stress, immune cell infiltration, and disturbed intracellular calcium homeostasis are key factors in the development of cardiovascular diseases in ageing individuals. Suppression of Wnt/beta signals can prevent cardiovascular dysfunction, but the effects of pharmacological disruption of this pathway on hypertension and cardiac fibrosis remain inconclusive. Calcium overload and mitochondrial dysfunction are identified as key mechanisms underlying age-related cardiovascular diseases. Therefore, this study suggests that targeting calcium dyshomeostasis may delay pathological changes.

MOLECULAR BIOLOGY REPORTS (2022)

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Article Immunology

Integrated Bioinformatics and Validation of lncRNA-Mediated ceRNA Network in Myocardial Ischemia/Reperfusion Injury

Ying Han et al.

Summary: This study explores the molecular mechanism of lncRNA-mediated ceRNA network in myocardial ischemia/reperfusion (MI/R) injury. By analyzing dataset profiles and performing bioinformatics analyses, an lncRNA-mediated ceRNA network was constructed, revealing the involvement of lncRNA Xist/miR-133c/Slc30a9 axis in oxidative stress and calcium signaling pathway.

JOURNAL OF IMMUNOLOGY RESEARCH (2022)

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Article Cardiac & Cardiovascular Systems

Knockdown of lncRNA XIST Ameliorates IL-1β-Induced Apoptosis of HUVECs and Change of Tissue Factor Level via miR-103a-3p/HMGB1 Axis in Deep Venous Thrombosis by Regulating the ROS/NF-κB Signaling Pathway

Guangxin Cao et al.

Summary: This study reveals the mechanism by which lncRNA XIST induces deep vein thrombosis through intracellular signaling pathways, leading to HUVEC apoptosis via activation of the ROS/NF-κB pathway. This finding suggests that lncRNA XIST may be a potential therapeutic target for DVT.

CARDIOVASCULAR THERAPEUTICS (2022)

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Article Biochemistry & Molecular Biology

Long non-coding RNA XIST negatively regulates thoracic aortic aneurysm cell proliferation by targeting the miR-193a-5p/KLF7 axis

Ming Zhu et al.

Summary: This study found that miR-193a-5p is expressed at low levels in the blood of TAA patients, and XIST may be involved in TAA pathogenesis via regulation of the miR-193a-5p/KLF7 axis.

CELLULAR AND MOLECULAR BIOLOGY (2022)

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Review Pharmacology & Pharmacy

Emodin in atherosclerosis prevention: Pharmacological actions and therapeutic potential

Ning Luo et al.

Summary: Emodin is a pharmacologically bioactive constituent isolated from the traditional Chinese medicinal herb Radix rhizoma Rhei, with antioxidant, anti-inflammatory, anti-proliferative, anti-apoptotic, and lipid-modulating effects. Experimental studies have shown that emodin can attenuate and stabilize atherosclerotic plaques, highlighting its therapeutic potential in patients with cardiovascular disease.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

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Review Pharmacology & Pharmacy

Long non-coding RNAs: From disease code to drug role

Yuanyuan Chen et al.

Summary: Extensive studies have shown that long non-coding RNAs (lncRNAs) play crucial roles in physiological processes and are closely linked to various diseases. Using lncRNAs as biomarkers or intervention targets can provide new perspectives for disease diagnosis and treatment. Research is shifting towards utilizing lncRNAs as pharmacological targets, with a focus on preclinical research and clinical trial progress.

ACTA PHARMACEUTICA SINICA B (2021)

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Article Cardiac & Cardiovascular Systems

Myocardial Ischemia in the Management of Chronic Coronary Artery Disease Past and Present

Raymond J. Gibbons

Summary: Stress-induced myocardial ischemia has long been considered important in the management of chronic coronary artery disease. However, recent studies have shown inconsistent results regarding the benefit of revascularization in patients with moderate-severe ischemia.

CIRCULATION-CARDIOVASCULAR IMAGING (2021)

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Review Biochemistry & Molecular Biology

The cardiovascular disorders and prognostic cardiac biomarkers in COVID-19

Xingjuan Shi et al.

Summary: This review focuses on the association between COVID-19 and cardiovascular disorders, including potential mechanisms such as direct myocardial injury caused by viral infection and reduced ACE2 levels. Understanding the implications of cardiovascular diseases in COVID-19 may predict clinical outcomes and guide more rational treatment strategies in clinical practice.

MOLECULAR BIOLOGY REPORTS (2021)

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Review Urology & Nephrology

Cardiovascular disorders in autosomal dominant polycystic kidney disease

Mouad Hamzaoui et al.

Summary: Patients with autosomal dominant polycystic kidney disease have a higher prevalence of cardiovascular disorders such as hypertension, left ventricular hypertrophy, and atrial fibrillation, which may be related to chronic kidney disease. Additionally, they are more prone to arterial diseases compared to the general population.

NEPHROLOGIE & THERAPEUTIQUE (2021)

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Article Biochemistry & Molecular Biology

XIST knockdown suppresses vascular smooth muscle cell proliferation and induces apoptosis by regulating miR-1264/WNT5A/β-catenin signaling in aneurysm

Liang Zou et al.

Summary: The study revealed that XIST regulates the proliferation and apoptosis of VSMCs in AAA development through miR-1264 and the WNT/β-catenin signaling pathway. XIST acts as a ceRNA to upregulate WNT5A expression by repressing miR-1264. Inhibition of miR-1264 promotes HA-VSMCs proliferation and suppresses apoptosis via WNT/β-catenin signaling.

BIOSCIENCE REPORTS (2021)

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Article Cardiac & Cardiovascular Systems

LARP7 Protects Against Heart Failure by Enhancing Mitochondrial Biogenesis

Huijing Yu et al.

Summary: LARP7 plays a crucial role in mitochondrial biogenesis, energy production, and cardiac function by modulating SIRT1 homeostasis and activity. Reduction of LARP7 in diseased hearts contributes to heart failure pathogenesis, while restoring LARP7 in the injured heart confers myocardial protection, identifying the ATM-LARP7-SIRT1 pathway as a potential therapeutic target in heart failure.

CIRCULATION (2021)

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Article Cell Biology

LncRNA XIST Promotes Atherosclerosis by Regulating miR-599/TLR4 Axis

Kechun Yang et al.

Summary: XIST levels were found to be elevated in the serum of AS patients and ox-LDL-treated AS cell models. XIST depletion restrained cell proliferation and induced apoptosis in AS cell models, while miR-599 was identified as a direct downstream target of XIST reversing the effects of XIST knockdown on AS progression. XIST was also shown to increase TLR4 expression by serving as a ceRNA of miR-599, implicating the XIST/miR-599/TLR4 axis in AS development.

INFLAMMATION (2021)

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Article Cell Biology

Mangiferin prevents myocardial infarction-induced apoptosis and heart failure in mice by activating the Sirt1/FoxO3a pathway

Lingli Chen et al.

Summary: Mangiferin prevents cardiomyocyte apoptosis and subsequent heart failure in myocardial infarction by activating the Sirt1/FoxO3a pathway, showing potential in future clinical evaluation studies.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Article Biochemistry & Molecular Biology

Emodin-A natural anthraquinone derivative with diverse pharmacological activities

Ruchi Badoni Semwal et al.

Summary: Emodin is a natural anthraquinone derivative that acts as a protein tyrosine kinase inhibitor and an anticancer drug, showing activity against various tumor cells. It is increasingly being studied for its potential in combination chemotherapy and its broad range of therapeutic activities.

PHYTOCHEMISTRY (2021)

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Article Cell Biology

LncRNA-MIAT promotes thyroid cancer progression and function as ceRNA to target EZH2 by sponging miR-150-5p

Kai Guo et al.

Summary: This study identified MIAT as a ceRNA in papillary thyroid carcinoma (PTC) that inhibits EZH2 expression via the miR-150/EZH2 pathway, promoting cell invasion. MIAT may serve as a valuable prognostic biomarker and therapeutic target for PTC.

CELL DEATH & DISEASE (2021)

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Article Pharmacology & Pharmacy

Protocatechuic aldehyde protects cardiomycoytes against ischemic injury via regulation of nuclear pyruvate kinase M2

Xunxun Wu et al.

Summary: PCA regulates nuclear PKM2 function to protect cardiomyocytes, indicating the potential of pharmacological intervention of PKM2 shuttle to combat myocardial infarction.

ACTA PHARMACEUTICA SINICA B (2021)

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Article Medicine, Research & Experimental

LncRNA Xist induces arterial smooth muscle cell apoptosis in thoracic aortic aneurysm through miR-29b-3p/Eln pathway

Kai Liang et al.

Summary: This study demonstrates that inhibition of Eln protects rat arterial smooth muscle cells from apoptosis, miR-29b-3p binds to Eln, and Xist promotes Eln expression by absorbing miR-29b-3p. Furthermore, Eln overexpression counteracts the inhibitory effect of silenced Xist on apoptosis of rat arterial smooth muscle cells. Importantly, this ceRNA network exacerbates apoptosis in human aortic smooth muscle cells.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Review Cardiac & Cardiovascular Systems

Vascular Smooth Muscle Cells in Aortic Aneurysm: From Genetics to Mechanisms

Haocheng Lu et al.

Summary: Aortic aneurysm, including thoracic and abdominal types, is a prevalent aortic disease and a major cause of death globally. Treatments include open surgery and endovascular procedures. Thoracic aneurysm is more genetically influenced, while both types share common features like loss of VSMCs and inflammation.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2021)

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Review Multidisciplinary Sciences

The changing landscape of atherosclerosis

Peter Libby

Summary: Emerging evidence has led to a significant evolution of concepts related to atherosclerosis, with a shifting risk profile that is no longer limited to specific regions or demographics. Recent research has highlighted new risk factors and mechanisms underlying atherosclerosis, opening doors to potential therapeutic interventions for this widespread disease.

NATURE (2021)

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Article Biochemistry & Molecular Biology

MiR-599 targeting TOP2A inhibits the malignancy of bladder cancer cells

Fan Zhang et al.

Summary: MiR-599 is significantly downregulated in bladder cancer and its overexpression can inhibit the malignancy of BC cells, with TOP2A identified as a downstream target contributing to enhanced tumorigenesis in BC cells.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

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Article Biology

Fine-tuning multiciliated cell differentiation at the post-transcriptional level: contribution of miR-34/449 family members

Ioannis Loukas et al.

Summary: Cell differentiation towards a multiciliated cell fate is a tightly regulated process involving a transcriptional cascade and the formation of multiple centrioles and cilia. Micro-RNAs, particularly miR-34 and miR-449, play crucial roles in fine-tuning the expression of genes related to centrioles and cilia, ensuring proper commitment and maintenance of the multiciliated cell fate. Their spatiotemporal regulation during multiciliogenesis is essential for the coordinated movement of cilia and directional fluid flow across epithelia.

BIOLOGICAL REVIEWS (2021)

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Article Medicine, Research & Experimental

Notoginsenoside R1 activates the NAMPT-NAD+-SIRT1 cascade to promote postischemic angiogenesis by modulating Notch signaling

Ting Zhu et al.

Summary: The study showed that R1 promotes post-stroke angiogenesis by activating the NAMPT-NAD+SIRT1 cascade, while modulating Notch signaling and VEGFR-2 can contribute to angiogenesis after stroke. These findings offer insight for exploring new therapeutic strategies for neurorestoration via R1 treatment after ischemic stroke.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Review Cardiac & Cardiovascular Systems

Stanford type A acute aortic dissection with proximal intimo-intimal intussusception: a case report and literature review

Hao Pan et al.

Summary: The case illustrates the rare and potentially lethal occurrence of acute aortic circumferential dissection with intimo-intimal intussusception. Intraoperative transesophageal echocardiography plays a crucial role in determining accurate diagnosis and optimal intervention strategies for acute aortic dissection, highlighting the importance of routine screening in patients with this condition.

JOURNAL OF CARDIOTHORACIC SURGERY (2021)

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Article Oncology

EIF4A3-induced circ_0084615 contributes to the progression of colorectal cancer via miR-599/ONECUT2 pathway

Zhipeng Jiang et al.

Summary: The study revealed that circ_0084615 was upregulated in CRC tissues and associated with TNM stages, lymph node metastasis, differentiation, and overall survival rate. Knockdown of circ_0084615 inhibited CRC cell proliferation, migration, invasion, and angiogenesis in vitro and impeded tumorigenesis in vivo. Circ_0084615 acted as an oncogene in CRC development through the miR-599/ONECUT2 axis induced by EIF4A3.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Article Biochemistry & Molecular Biology

miR-124-3p targeted SIRT1 to regulate cell apoptosis, inflammatory response, and oxidative stress in acute myocardial infarction in rats via modulation of the FGF21/CREB/PGC1α pathway

Yun-Jie Wei et al.

Summary: Inhibiting miR-124-3p expression may activate the FGF21/CREB/PGC1 alpha pathway to reduce cell apoptosis, alleviate the inflammatory response, and attenuate oxidative stress in AMI rats by targeting SIRT1.

JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY (2021)

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Article Plant Sciences

Notoginsenoside R1 intervenes degradation and redistribution of tight junctions to ameliorate blood-brain barrier permeability by Caveolin-1/MMP2/9 pathway after acute ischemic stroke

Bowen Liu et al.

Summary: Notoginsenoside R1 treatment significantly reduced BBB leakage and cerebral infarction volume, weakened neurological deficits in post-stroke rats. Moreover, it inhibited the activity of MMPs in infarcted cortex and striatum, down-regulated MMP2, 9 and up-regulated zo1 and claudin5 expressions in penumbra. In vitro, Notoginsenoside R1 treatment decreased OGD-induced endothelial barrier permeability, restored expressions of zo1, claudin5 on cellular membrane and cytoplasm, as well as mediated membrane redistribution of occludin and caveolin1 from actin cytoskeletal fraction.

PHYTOMEDICINE (2021)

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Article Multidisciplinary Sciences

Inhibition of the canonical Wnt signaling pathway by a β-catenin/CBP inhibitor prevents heart failure by ameliorating cardiac hypertrophy and fibrosis

Thanachai Methatham et al.

Summary: ICG001 prevents cardiac hypertrophy and fibrosis by inhibiting beta-catenin-mediated gene transcription, regulating gene expression and immune activation pathways, possibly mediating the glycolysis pathway, and altering oxidative stress.

SCIENTIFIC REPORTS (2021)

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Article Biochemistry & Molecular Biology

Tubular cell-derived exosomal miR-150-5p contributes to renal fibrosis following unilateral ischemia-reperfusion injury by activating fibroblast in vitro and in vivo

Xiangjun Zhou et al.

Summary: Unilateral ischemia reperfusion injury (UIRI) with longer ischemia time is associated with an increased risk of acute renal injury and chronic kidney disease. Exosomes play a key role in mediating communication between epithelial and mesenchymal cells relevant to renal fibrosis after UIRI. Inhibition of exosome secretion or miRNA activity could be a potential therapeutic target for preventing progression to renal fibrosis following UIRI.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

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Article Cardiac & Cardiovascular Systems

Myocardial ischemia and coronary disease in heart failure

Beniamino R. Pagliaro et al.

HEART FAILURE REVIEWS (2020)

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Review Cardiac & Cardiovascular Systems

Cardiovascular Disorders Mediated by Autonomic Nervous System Dysfunction

Pravin Khemani et al.

CARDIOLOGY IN REVIEW (2020)

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Article Chemistry, Medicinal

Molecular signaling of G-protein-coupled receptor in chronic heart failure and associated complications

Mohammad Altamish et al.

DRUG DEVELOPMENT RESEARCH (2020)

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Article Cardiac & Cardiovascular Systems

Aortic dissection reconsidered: type, entry site, malperfusion classification adding clarity and enabling outcome prediction

Hans-Hinrich Sievers et al.

INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY (2020)

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Review Pharmacology & Pharmacy

Mechanisms for the transition from physiological to pathological cardiac hypertrophy

Christopher J. Oldfield et al.

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2020)

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Review Medicine, General & Internal

Acute Myocardial Infarction in Young Individuals

Rajiv Gulati et al.

MAYO CLINIC PROCEEDINGS (2020)

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Article Cell Biology

LncRNA XIST promotes myocardial infarction by regulating FOS through targeting miR-101a-3p

Bin Lin et al.

AGING-US (2020)

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Article Oncology

Circ_0008035 contributes to cell proliferation and inhibits apoptosis and ferroptosis in gastric cancer via miR-599/EIF4A1 axis

Chang Li et al.

CANCER CELL INTERNATIONAL (2020)

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Article Biology

LncRNA XIST knockdown ameliorates oxidative low-density lipoprotein-induced endothelial cells injury by targeting miR-204-5p/TLR4

Guoyong Lu et al.

JOURNAL OF BIOSCIENCES (2020)

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Article Cardiac & Cardiovascular Systems

Long Noncoding RNA XIST/miR-17/PTEN Axis Modulates the Proliferation and Apoptosis of Vascular Smooth Muscle Cells to Affect Stanford Type A Aortic Dissection

Xiaoyun Zhang et al.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2020)

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Article Cell Biology

Sex differences in the proliferation of pulmonary artery endothelial cells: implications for plexiform arteriopathy

Shanshan Qin et al.

JOURNAL OF CELL SCIENCE (2020)

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Review Endocrinology & Metabolism

MicroRNAs as Biomarker for Breast Cancer

Taru Aggarwal et al.

ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS (2020)

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Review Pharmacology & Pharmacy

Interfering with S100B-effector protein interactions for cancer therapy

Ke-Jia Wu et al.

DRUG DISCOVERY TODAY (2020)

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Article Cell Biology

miR-762 regulates the proliferation and differentiation of retinal progenitor cells by targeting NPDC1

Huiqin Gao et al.

CELL CYCLE (2020)

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Review Immunology

NOD1 and NOD2 in inflammatory and infectious diseases

Bruno C. Trindade et al.

IMMUNOLOGICAL REVIEWS (2020)

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Article Cardiac & Cardiovascular Systems

Elevated AT1R Antibody and Morbidity in Patients Bridged to Heart Transplant Using Continuous Flow Left Ventricular Assist Devices

Vinh Q. Chau et al.

JOURNAL OF CARDIAC FAILURE (2020)

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Article Cardiac & Cardiovascular Systems

LncRNA Gm4419 Regulates Myocardial Ischemia/Reperfusion Injury Through Targeting the miR-682/TRAF3 Axis

Guixiang Zhao et al.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2020)

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Review Respiratory System

Guidelines for the Treatment of Pulmonary Arterial Hypertension

Zoe G. S. Vazquez et al.

LUNG (2020)

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Article Multidisciplinary Sciences

Multi-faceted epigenetic dysregulation of gene expression promotes esophageal squamous cell carcinoma

Wei Cao et al.

NATURE COMMUNICATIONS (2020)

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Review Pharmacology & Pharmacy

Small interfering RNA for cancer treatment: overcoming hurdles in delivery

Nitin Bharat Charbe et al.

ACTA PHARMACEUTICA SINICA B (2020)

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Article Cell Biology

Notoginsenoside R1 alleviates oxidized low-density lipoprotein-induced apoptosis, inflammatory response, and oxidative stress in HUVECS through modulation of XIST/miR-221-3p/TRAF6 axis

Jian Zhao et al.

CELLULAR SIGNALLING (2020)

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Article Medicine, General & Internal

Down-regulation of Xist and Mir-7a-5p improves LPS-induced myocardial injury

Dongshi Liang et al.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2020)

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Review Chemistry, Organic

TLR2 agonists and their structure-activity relationships

Benjamin L. Lu et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2020)

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Article Cell Biology

LncRNA XIST regulates myocardial infarction by targeting miR-130a-3p

Tao Zhou et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Review Biochemistry & Molecular Biology

Role of Ox-LDL and LOX-1 in Atherogenesis

Ajoe John Kattoor et al.

CURRENT MEDICINAL CHEMISTRY (2019)

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Review Cardiac & Cardiovascular Systems

Targeting mitochondria for cardiovascular disorders: therapeutic potential and obstacles

Massimo Bonora et al.

NATURE REVIEWS CARDIOLOGY (2019)

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Article Cardiac & Cardiovascular Systems

Cellular Mechanisms of Aortic Aneurysm Formation

Raymundo Alain Quintana et al.

CIRCULATION RESEARCH (2019)

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Article Cell Biology

Notoginsenoside R1 Ameliorates Diabetic Retinopathy through PINK1-Dependent Activation of Mitophagy

Ping Zhou et al.

CELLS (2019)

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Article Urology & Nephrology

Wnt/β-catenin signaling mediates both heart and kidney injury in type 2 cardiorenal syndrome

Yue Zhao et al.

KIDNEY INTERNATIONAL (2019)

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Article Cell Biology

Overexpression of miR-27b-3p Targeting Wnt3a Regulates the Signaling Pathway of Wnt/β-Catenin and Attenuates Atrial Fibrosis in Rats with Atrial Fibrillation

Xiangwei Lv et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

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Article Biochemistry & Molecular Biology

Combinational effect of angiotensin receptor blocker and folic acid therapy on uric acid and creatinine level in hyperhomocysteinemia-associated hypertension

Yogendra Singh et al.

BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY (2019)

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Article Integrative & Complementary Medicine

Salidroside protects against ox-LDL-induced endothelial injury by enhancing autophagy mediated by SIRT1-FoxO1 pathway

Zhongsheng Zhu et al.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2019)

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Review Biochemistry & Molecular Biology

LncRNA MALAT1 promotes osteoarthritis by modulating miR-150-5p/AKT3 axis

Ying Zhang et al.

CELL AND BIOSCIENCE (2019)

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Article Oncology

Integrated analysis of lncRNA-miRNA-mRNA ceRNA network in squamous cell carcinoma of tongue

Rui-Sheng Zhou et al.

BMC CANCER (2019)

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Article Cell Biology

MAP2K4 interacts with Vimentin to activate the PI3K/AKT pathway and promotes breast cancer pathogenesis

Shu Liu et al.

AGING-US (2019)

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Article Respiratory System

Paediatric pulmonary arterial hypertension: updates on definition, classification, diagnostics and management

Erika B. Rosenzweig et al.

EUROPEAN RESPIRATORY JOURNAL (2019)

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Article Cell Biology

The long noncoding RNA XIST regulates cardiac hypertrophy by targeting miR-101

Lili Xiao et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Article Cell & Tissue Engineering

LncRNA KLF3-AS1 in human mesenchymal stem cell-derived exosomes ameliorates pyroptosis of cardiomyocytes and myocardial infarction through miR-138-5p/Sirt1 axis

Qing Mao et al.

STEM CELL RESEARCH & THERAPY (2019)

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Review Biochemistry & Molecular Biology

The Role of Sirtuins in Antioxidant and Redox Signaling

Chandra K. Singh et al.

ANTIOXIDANTS & REDOX SIGNALING (2018)

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Article Biochemistry & Molecular Biology

Knockdown of long noncoding RNA XIST alleviates oxidative low-density lipoprotein-mediated endothelial cells injury through modulation of miR-320/NOD2 axis

Xiaohui Xu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

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Article Biotechnology & Applied Microbiology

MicroRNAs as possible biomarkers for screening of aortic aneurysms: a systematic review and validation study

Areti Moushi et al.

BIOMARKERS (2018)

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Article Biochemistry & Molecular Biology

Regulation of Cell Cycle to Stimulate Adult Cardiomyocyte Proliferation and Cardiac Regeneration

Tamer M. A. Mohamed et al.

CELL (2018)

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Article Biochemistry & Molecular Biology

Interleukin-6 promotes pancreatic cancer cell migration by rapidly activating the small GTPase CDC42

Gina L. Razidlo et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

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Review Cardiac & Cardiovascular Systems

Mechanisms of physiological and pathological cardiac hypertrophy

Michinari Nakamura et al.

NATURE REVIEWS CARDIOLOGY (2018)

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Article Hematology

Diagnosis of deep-vein thrombosis

Enrico Bernardi et al.

THROMBOSIS RESEARCH (2018)

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Article Pharmacology & Pharmacy

Protocatechuic aldehyde protects against isoproterenol-induced cardiac hypertrophy via inhibition of the JAK2/STAT3 signaling pathway

Xiuli Fang et al.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2018)

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Article Biochemistry & Molecular Biology

The long noncoding RNA XIST protects cardiomyocyte hypertrophy by targeting miR-330-3p

Yuewu Chen et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

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Article Genetics & Heredity

EZH2 RIP-seq Identifies Tissue-specific Long Non-coding RNAs

Yan Wang et al.

CURRENT GENE THERAPY (2018)

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Review Medicine, General & Internal

A clinical update on metformin and lung cancer in diabetic patients

Gaurav Gupta et al.

PANMINERVA MEDICA (2018)

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Review Medicine, General & Internal

Tumor suppressor role of miR-503

Gaurav Gupta et al.

PANMINERVA MEDICA (2018)

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Review Medicine, General & Internal

Role of microRNAs (miRNAs) in the pathophysiology of diabetes mellitus

Juhi Tiwari et al.

PANMINERVA MEDICA (2018)

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Article Cardiac & Cardiovascular Systems

LncRNATUG1 spongesmiR-204-5p to promote osteoblast differentiation through upregulating Runx2 in aortic valve calcification

Cong Yu et al.

CARDIOVASCULAR RESEARCH (2018)

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Article Oncology

miR-204-5p and miR-211-5p Contribute to BRAF Inhibitor Resistance in Melanoma

Marta Diaz-Martinez et al.

CANCER RESEARCH (2018)

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Review Biochemistry & Molecular Biology

Research Progress on the Relationship between Atherosclerosis and Inflammation

Yuhua Zhu et al.

BIOMOLECULES (2018)

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Editorial Material Dermatology

S100B: Correlation with Active Vitiligo Depigmentation

Stanca A. Birlea

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2017)

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Article Immunology

Microglial-derived miRNA let-7 and HMGB1 contribute to ethanol-induced neurotoxicity via TLR7

Leon G. Coleman et al.

JOURNAL OF NEUROINFLAMMATION (2017)

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Article Biochemistry & Molecular Biology

1ncRNA-Map2k4 sequesters miR-199a to promote FGF1 expression and spinal cord neuron growth

Hao-ran Lv

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

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Article Neurosciences

Stimulus-specific combinatorial functionality of neuronal c-fos enhancers

Jae-Yeol Joo et al.

NATURE NEUROSCIENCE (2016)

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Article Oncology

miR-449 overexpression inhibits papillary thyroid carcinoma cell growth by targeting RET kinase-β-catenin signaling pathway

Zongyu Li et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2016)

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Review Cardiac & Cardiovascular Systems

Physiological and pathological cardiac hypertrophy

Ippei Shimizu et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2016)

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Review Medicine, General & Internal

Deep vein thrombosis and pulmonary embolism

Marcello Di Nisio et al.

LANCET (2016)

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Review Chemistry, Medicinal

Emodin: A Review of its Pharmacology, Toxicity and Pharmacokinetics

Xiaoxv Dong et al.

PHYTOTHERAPY RESEARCH (2016)

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Review Toxicology

Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets

Yow Keat Tham et al.

ARCHIVES OF TOXICOLOGY (2015)

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Article Genetics & Heredity

ceRNA in cancer: possible functions and clinical implications

Xiaolong Qi et al.

JOURNAL OF MEDICAL GENETICS (2015)

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Article Endocrinology & Metabolism

New approaches to the Klinefelter syndrome

Eberhard Nieschlag et al.

ANNALES D ENDOCRINOLOGIE (2014)

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Review Immunology

NOD1 and NOD2: Signaling, Host Defense, and Inflammatory Disease

Roberta Caruso et al.

IMMUNITY (2014)

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Review Endocrinology & Metabolism

SIRT1 and other sirtuins in metabolism

Hung-Chun Chang et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2014)

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Article Cell Biology

Anti-inflammatory Effect of Protocatechuic Aldehyde on Myocardial Ischemia/Reperfusion Injury In Vivo and In Vitro

Guo Wei et al.

INFLAMMATION (2013)

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Article Genetics & Heredity

A mutation in the c-Fos gene associated with congenital generalized lipodystrophy

Birgit Knebel et al.

ORPHANET JOURNAL OF RARE DISEASES (2013)

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Review Clinical Neurology

S100B and schizophrenia

Silvia Yelmo-Cruz et al.

PSYCHIATRY AND CLINICAL NEUROSCIENCES (2013)

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Article Medicine, General & Internal

Pulmonary embolism and deep vein thrombosis

Samuel Z. Goldhaber et al.

LANCET (2012)

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Article Cardiac & Cardiovascular Systems

Pathogenesis of atherosclerosis

E Falk

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2006)

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Review Biochemistry & Molecular Biology

Extracellular HMGB1 as a proinflammatory cytokine

GQ Chen et al.

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH (2004)

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Article Biochemistry & Molecular Biology

Unbalanced X;autosome translocations provide evidence for sequence specificity in the association of XIST RNA with chromatin

LL Hall et al.

HUMAN MOLECULAR GENETICS (2002)

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