Photoactivable liposomes for controlled delivery: Recent progress and design considerations

Recent strides in drug delivery have aimed at precise control over therapeutic agent release and targeting. Liposomes, lipid-based vesicles, have stood out for their capacity to encapsulate diverse agents. While their structural features offer biocompatibility and stability, the inability to provide on-demand drug release limits their efficacy. Addressing these limitations, photoactivable liposomes, leveraging light as a trigger, offer a compelling solution. This strategy surpasses established controlled systems, providing spatiotemporal precision and non-invasive external triggering. Furthermore, the versatility of photoactivation, achieved through the manipulation of light-responsive components, enables meticulous control over release kinetics. While extant reviews predominantly concentrate on release strategies and materials, this paper takes a novel approach by spotlighting recent advancements in categorized photoactivable liposomes. Moreover, drawing from contemporary illustrations, the article accentuates design considerations that encompass physicochemical properties and light-related constituents. These insights collectively contribute to the evolution of sophisticated drug delivery systems.

Automated summary

This paper introduces the latest advancements in photoactivable liposomes in drug delivery, highlighting their advantages in precise control over drug release and targeted delivery, as well as the fine control over release kinetics achieved through the manipulation of light-responsive components. Additionally, the paper emphasizes the design considerations of physicochemical properties and light-related constituents.