Recurrence of Henoch Schoenlein Purpura Nephritis in Children: A Retrospective Study

The aim of the study was to identify predictive patient characteristics for Henoch Schoenlein Purpura (HSPN) relapse in childhood HSPN. One hundred and thirty-five Chinese children with HSPN were enrolled in this study, mean age 10.25 +/- 3.39 years. The pathology of HSPN was according to the International Study of Kidney Disease in Children criteria.(ISKDC); ISKDC II (mesangial proliferation (MP)) AND ISKDC III (MP with <50 % crescents).Recurrence of HSPN was observed in 66.3 % patients; male to female ratio (2:1)Statistically significant correlation existed between biopsy grade(p < 0.001), gender(p < 0.001),age ranges(p = 0.002) and treatment regimen (p < 0.001)in the frequency of recurrent HSPN episodes. We identified some significant predictors for HSPN relapse such as the severity of HSPN, adjunctive therapies administered to these patients,and close attention should be paid in patients between the ages 7 and 12 years old. In addition, the use of mycophenolate mofetil as an adjunctive therapy in the treatment of HSPN may reduce the frequency of HSPN relapse episodes in children.

Automated summary

The aim of this study was to identify predictive patient characteristics for HSPN relapse in childhood HSPN. The results showed that there were significant correlations between biopsy grade, gender, age ranges, and treatment regimen with the frequency of HSPN relapses. We also identified important predictors for HSPN relapse, including the severity of HSPN, adjunctive therapies, and specific age group of patients that require special attention.