☆ 4.6 Review

Potential applications of ferroptosis inducers and regulatory molecules in hematological malignancy therapy

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2024)

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Article Pharmacology & Pharmacy

Synergistic disruption of BTK and BCL-2 causes apoptosis while inducing ferroptosis in double-hit lymphoma

Syahru Agung Setiawan et al.

Summary: In this study, the synergistic effects of the second generation BTK inhibitor zanubrutinib and the BCL-2 inhibitor navitoclax in suppressing Double-hit lymphoma (DHL) were demonstrated. Comprehensive in silico analysis from single-cell to bulk-level profiling validated the combination's ability to induce apoptosis and ferroptosis, effectively inhibiting DHL cell proliferation. Mechanistically, the combination disrupted NRF2 and HMOX1 while deactivating GPX4, triggering ferroptosis. In vivo studies showed that the combination of zanubrutinib and navitoclax effectively suppressed tumor growth.

EUROPEAN JOURNAL OF PHARMACOLOGY (2023)

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Article Hematology

Zanubrutinib in patients with previously treated B-cell malignancies intolerant of previous Bruton tyrosine kinase inhibitors in the USA: a phase 2, open-label, single-arm study

Mazyar Shadman et al.

Summary: The study aimed to evaluate the safety and efficacy of zanubrutinib, a highly selective next-generation Bruton tyrosine kinase (BTK) inhibitor, in patients with previously treated B-cell malignancies who were intolerant of ibrutinib or acalabrutinib. The results suggest that zanubrutinib is a viable treatment option for patients intolerant of previous BTK inhibitors, as it can reduce treatment-related toxicities and discontinuations.

LANCET HAEMATOLOGY (2023)

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Article Oncology

CircZBTB46 Protects Acute Myeloid Leukemia Cells from Ferroptotic Cell Death by Upregulating SCD

Fei Long et al.

Summary: It is urgent to identify new biomarkers for the diagnosis, prognostication, and treatment of acute myeloid leukemia (AML). This study provides evidence that circZBTB46 is an important oncogenic circRNA and a potential diagnostic or prognostic biomarker for AML. CircZBTB46 protects AML cells from ferroptosis by promoting the expression of SCD, suggesting it as a potential therapeutic target for AML.

CANCERS (2023)

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Article Oncology

Hsa_circ_0015278 Regulates FLT3-ITD AML Progression via Ferroptosis-Related Genes

Jiquan Jiang et al.

Summary: The FLT3-ITD mutation in acute myeloid leukemia (AML) poses a serious threat to human health, with a poor prognosis and high risk of recurrence. Ferroptosis, an iron-dependent regulated cell death, plays a role in the development and progression of AML. This study identified a circRNA, hsa_circ_0015278, that regulates ferroptosis-related genes through miRNA sponge, promoting FLT3-ITD AML progression. This finding contributes to the identification of biomarkers for diagnosis and prognosis, and provides insights into the pathogenesis and therapeutic targets of AML with FLT3-ITD mutation.

CANCERS (2023)

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Article Chemistry, Multidisciplinary

A Ferroptosis-Inducing and Leukemic Cell- Targeting Drug Nanocarrier Formed by Redox-Responsive Cysteine Polymer for Acute Myeloid Leukemia Therapy

Yanhui Yu et al.

Summary: The study developed GSH-responsive cysteine polymer-based ferroptosis-inducing nanomedicine (GCFN) as an effective therapy for acute myeloid leukemia (AML). GCFN depleted intracellular GSH and inhibited glutathione peroxidase 4 to induce ferroptosis in AML cells. PTX@GCFN targeted AML cells and reduced myeloablation side effects caused by paclitaxel, leading to extended survival of AML mice with simultaneous ferroptosis induction.

ACS NANO (2023)

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Article Chemistry, Multidisciplinary

Dysregulation of iron homeostasis by TfR-1 renders EZH2 wild type diffuse large B-cell lymphoma resistance to EZH2 inhibition

Lei Yu et al.

Summary: The study discovered a novel EZH1/2 inhibitor, HH2853, which showed a better antitumor effect than EPZ-6438 in preclinical studies. It was found that EZH2 inhibition increased intracellular iron through upregulation of transferrin receptor 1 (TfR-1), leading to resistance to EZH2 inhibitors in DLBCL cells. In addition, EZH2 inhibitors impaired ferroptosis by upregulating HSPA5 and stabilizing GPX4, and co-treatment with ferroptosis inducer erastin effectively overcame the resistance of DLBCL to EZH2 inhibitors.

ACTA PHARMACOLOGICA SINICA (2023)

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Article Oncology

ACSL4: a double-edged sword target in multiple myeloma, promotes cell proliferation and sensitizes cell to ferroptosis

Jiasi Zhang et al.

Summary: ACSL4 is abnormally overexpressed in multiple myeloma (MM) and plays a role in regulating lipid metabolism genes and determining the sensitivity of MM cells to ferroptosis. Targeting ACSL4 and inducing ferroptosis could be a promising therapeutic strategy for MM.

CARCINOGENESIS (2023)

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Article Biochemistry & Molecular Biology

PRMT1 inhibition promotes ferroptosis sensitivity via ACSL1 upregulation in acute myeloid leukemia

Lixin Zhou et al.

Summary: Acute myeloid leukemia (AML) requires novel therapeutic targets, and recent studies have identified ferroptosis as a potential method for targeting AML. In this study, protein arginine methyltransferase 1 (PRMT1) was identified as a regulator of ferroptosis in AML. The PRMT1 inhibitor GSK3368715 promoted ferroptosis sensitivity both in vitro and in vivo. Mechanistically, PRMT1 knockout and GSK3368715 treatment upregulated ACSL1, a ferroptosis promoter, while knockout ACSL1 reduced ferroptosis sensitivity following GSK3368715 treatment. These findings suggest the potential of combining PRMT1 inhibitors with ferroptosis inducers for AML treatment.

MOLECULAR CARCINOGENESIS (2023)

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Article Pharmacology & Pharmacy

Inhibitory effect and related mechanism of decitabine combined with gemcitabine on proliferation of NK/T cell lymphoma cells

Lanke Lin et al.

Summary: This study found that the combination of decitabine and gemcitabine can inhibit the proliferation of NK/T cell lymphoma cells and promote apoptosis. This combination treatment may inhibit cell proliferation by increasing the expression of ferroptosis-related signaling molecules, and it may provide clinical benefits.

FRONTIERS IN PHARMACOLOGY (2023)

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Article Hematology

Eprenetapopt combined with venetoclax and azacitidine in TP53-mutated acute myeloid leukaemia: a phase 1, dose-finding and expansion study

Guillermo Garcia-Manero et al.

Lancet Haematology (2023)

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Review Oncology

Rational Targets of Therapy in Extranodal NK/T-Cell Lymphoma

Ajay Major et al.

Summary: This review summarizes the research on the biological causes of ENKTL and the identification of new therapeutic targets and biomarkers, which may enable a personalized medicine approach towards ENKTL therapy.

CANCERS (2023)

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Article Cell Biology

Dihydroartemisinin-induced ferroptosis in acute myeloid leukemia: links to iron metabolism and metallothionein

E. Grignano et al.

Summary: This study demonstrated that dihydroartemisinin induces ferroptosis by promoting ferritinophagy and subsequent iron increase. It also activates zinc metabolism signaling and upregulates metallothionein. In addition, it alters the glutathione pool, which is dependent on metallothionein-driven antioxidant response.

CELL DEATH DISCOVERY (2023)

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Article Oncology

Targeting NRF2 uncovered an intrinsic susceptibility of acute myeloid leukemia cells to ferroptosis

Xin Liu et al.

Summary: Drug resistance and poor treatment response pose challenges in AML treatment. This study explores the role of NRF2 and GPX4 in AML and their involvement in ferroptosis. Inhibition of both NRF2 and GPX4 shows promise in targeting AML cells and inducing ferroptosis. Combination therapy targeting NRF2 and GPX4 may hold potential for treating AML.

EXPERIMENTAL HEMATOLOGY & ONCOLOGY (2023)

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Article Biochemistry & Molecular Biology

Targeting ABCB6 with nitidine chloride inhibits PI3K/AKT signaling pathway to promote ferroptosis in multiple myeloma

Zhao Yin et al.

Summary: It has been discovered that Nitidine Chloride (NC), an extract from Zanthoxylum nitidum, can induce cell death in multiple myeloma (MM) cells by promoting ferroptosis. The research also found that the target of NC is ABCB6 protein. Increased expression of ABCB6 in MM patients is significantly associated with MM relapse and poor prognosis. This discovery suggests that ABCB6 can be a potential therapeutic target and prognostic biomarker in MM, and NC can be a novel drug for MM treatment.

FREE RADICAL BIOLOGY AND MEDICINE (2023)

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Article Biochemistry & Molecular Biology

Andrographolide induced ferroptosis in multiple myeloma cells by regulating the P38/Nrf2/HO-1 pathway

Wenxia Li et al.

Summary: Andrographis paniculata, a traditional Chinese medicine, has been used as a functional food in Asia. Andrographolide, a compound isolated from Andrographis paniculata, has potent anticancer activity. In this study, researchers found that Andro induced cell death in multiple myeloma (MM) cells through a type of cell death called ferroptosis, and this mechanism may provide a potential preventative and therapeutic approach for MM.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2023)

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Targeting Cellular Iron Homeostasis with Ironomycin in Diffuse Large B-cell Lymphoma

Julie Devin et al.

Summary: Diffuse large B-cell lymphoma (DLBCL) is a common hematological malignancy, and alterations in iron metabolism may be targeted for therapy. Iron score (IS), a gene expression-based risk score, can identify high-risk DLBCL patients who may benefit from targeting iron homeostasis. Ironomycin, a potential treatment for DLBCL, inhibits cell proliferation and induces cell death.

CANCER RESEARCH (2022)

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Article Hematology

APR-246 induces early cell death by ferroptosis in acute myeloid leukemia

Rudy Birsen et al.

Summary: APR 246 is a promising therapeutic agent for myelodysplastic syndromes and acute myeloid leukemia that targets p53 mutated proteins. It has been found to reactivate the transcriptional activity of p53 mutants and induce p53-independent cell death. The study also demonstrates the association between APR 246 and ferroptosis, a recently described cell death process. The detoxification capacity of AML cells to maintain glutathione biosynthesis may play a key role in determining sensitivity to APR 246.

HAEMATOLOGICA (2022)

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Review Medicine, General & Internal

Diagnosis and Management of Multiple Myeloma A Review

Andrew J. Cowan et al.

Summary: Multiple myeloma is a hematologic malignancy characterized by abnormal plasma cells in the bone marrow, often leading to anemia, bone disease, and kidney injury. Diagnosis involves measuring various biomarkers, while treatment options include chemotherapy, autologous hematopoietic stem cell transplantation, and maintenance therapy.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2022)

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Article Biotechnology & Applied Microbiology

Perillaldehyde inhibits bone metastasis and receptor activator of nuclear factor-κB ligand (RANKL) signaling-induced osteoclastogenesis in prostate cancer cell lines

Zhuoyuan Lin et al.

Summary: Perillaldehyde (PAH), an active ingredient of Perilla frutescens, has been shown to inhibit proliferation, invasion and migration of prostate cancer cells. It also prevents stem cell characteristics and inhibits bone metastasis and osteoclastogenesis by suppressing the activation of NF-kappa B pathway and RANKL.

BIOENGINEERED (2022)

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Article Oncology

Discovery of Sulforaphane as an Inducer of Ferroptosis in U-937 Leukemia Cells: Expanding Its Anticancer Potential

Giulia Greco et al.

Summary: Sulforaphane, a natural anticancer compound, can induce different types of cell death, including apoptosis and ferroptosis, making it a promising agent for anticancer therapy.

CANCERS (2022)

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Review Oncology

Ferroptosis: Redox Imbalance and Hematological Tumorigenesis

Hongying Lan et al.

Summary: This review summarizes the recent progress in the molecular regulation of ferroptosis and discusses the physiological roles and therapeutic potential of targeting ferroptosis in hematological malignancies.

FRONTIERS IN ONCOLOGY (2022)

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Article Engineering, Biomedical

Glycyrrhetinic acid nanoparticles combined with ferrotherapy for improved cancer immunotherapy

Qing Li et al.

Summary: Programmed cell death protein 1 (PD-1)/Programmed Cell Death Ligand 1 (PD-L1) blockade immunotherapy is limited by low response rates in many patients. This study developed a nanoplatform that induces immunogenic cell death and enhances tumor immunotherapy through synergistic effects with ferrotherapy. The combination of glycyrrhetinic acid-based nanomaterials and ferumoxytol improved T-cell immune response and showed potential for treating cancer.

ACTA BIOMATERIALIA (2022)

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Article Biochemistry & Molecular Biology

Poricoic acid A (PAA) inhibits T-cell acute lymphoblastic leukemia through inducing autophagic cell death and ferroptosis

Lin Chen et al.

Summary: The study found that poricoic acid A (PAA) can inhibit the cell growth of T-cell acute lymphoblastic leukemia (T-ALL) and induce apoptosis. The mechanisms of action involve mitochondrial dysfunction and increased production of reactive oxygen species (ROS). Furthermore, PAA can suppress T-ALL growth by regulating autophagy and ferroptosis pathways. In vivo experiments confirmed the effectiveness of PAA in inhibiting T-ALL tumor growth without detectable toxicity.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2022)

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Article Oncology

Cystine uptake inhibition potentiates front-line therapies in acute myeloid leukemia

Bryann Pardieu et al.

Summary: By analyzing multiple AML datasets, we identified SLC7A11 as a potential gene that is essential for AML cell survival. Inhibition of SLC7A11 using genetic and chemical methods reduced the viability and clonogenic capacity of AML cell lines. Sulfasalazine, a drug with xCT inhibitory activity, showed anti-leukemic effects against primary AML samples in vitro. Inhibition of xCT affected multiple metabolic pathways, leading to depletion of glutathione pools and oxidative stress-induced cell death in leukemic cells.

LEUKEMIA (2022)

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Article Oncology

HIVEP3 cooperates with ferroptosis gene signatures to confer adverse prognosis in acute myeloid leukemia

Xiaoning Zhang et al.

Summary: Our study found that the expression level of HIVEP3 is elevated in AML patients and is associated with AML subtypes, age, cytogenetic risk, and disease-related molecules. Co-expressed gene clusters of HIVEP3 are enriched in functional pathways related to AML leukemogenesis, such as ribosome, metabolism, and calcium signaling. We proposed an integrated LASSO model with HIVEP3 and ferroptosis regulators AIFM2 and LPCAT3 to predict the outcome for AML patients.

CANCER MEDICINE (2022)

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Article Pharmacology & Pharmacy

Honokiol Induces Ferroptosis by Upregulating HMOX1 in Acute Myeloid Leukemia Cells

Xingrong Lai et al.

Summary: Honokiol is an effective anti-leukemia agent that reduces the viability of AML cells and induces cell cycle arrest. It triggers a noncanonical ferroptosis pathway by upregulating intracellular lipid peroxide and HMOX1 levels.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Oncology

Eprenetapopt Plus Azacitidine After Allogeneic Hematopoietic Stem-Cell Transplantation for TP53-Mutant Acute Myeloid Leukemia and Myelodysplastic Syndromes

Asmita Mishra et al.

Summary: This study evaluated the efficacy and safety of Eprenetapopt combined with azacitidine as maintenance therapy after HCT in patients with mTP53 AML and MDS. The results showed that this treatment regimen was well tolerated and achieved encouraging RFS and OS outcomes in this high-risk population.

JOURNAL OF CLINICAL ONCOLOGY (2022)

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Article Oncology

APR-246 triggers ferritinophagy and ferroptosis of diffuse large B-cell lymphoma cells with distinct TP53 mutations

Yuheng Hong et al.

Summary: TP53 mutations are associated with poor prognosis in DLBCL, particularly in GCB and UNC subtypes. APR-246 shows anti-tumor effects by restoring binding of mutant p53 to target genes. Mutations in exons 5, 6, and 7 of TP53 are predictors of progression and survival in DLBCL.

LEUKEMIA (2022)

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Article Oncology

Systematic discrimination of the repetitive genome in proximity of ferroptosis genes and a novel prognostic signature correlating with the oncogenic lncRNA CRNDE in multiple myeloma

Jiading Qin et al.

Summary: New insights into iron-dependent form of regulated cell death ferroptosis in cancer have shown its potential use in cancer therapy. Systematic profiling of ferroptosis gene signatures as prognostic factors has gained attention in several cancers. In this study, the presence of repetitive genomes near ferroptosis genes and a prognostic gene signature associated with multiple myeloma (MM) were investigated.

FRONTIERS IN ONCOLOGY (2022)

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Review Cell Biology

Regulatory pathways and drugs associated with ferroptosis in tumors

Dan Wang et al.

Summary: In this article, we reviewed the regulation of ferroptosis in tumor cells and introduced the tumor-related signaling pathways of ferroptosis. Special attention was given to the role of noncoding RNA, nanomaterials, drug effects, and targeted treatment using ferroptosis drugs. The currently unresolved issues and future research directions for ferroptosis in tumor cells were discussed, along with the prospects of this emerging field.

CELL DEATH & DISEASE (2022)

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Article Biochemistry & Molecular Biology

Ferroptosis-related gene signature predicts the clinical outcome in pediatric acute myeloid leukemia patients and refines the 2017 ELN classification system

Yu Tao et al.

Summary: In this study, an FGL model consisting of 22 ferroptosis-related signatures was identified as an independent parameter for prognostic prediction in pediatric acute myeloid leukemia (P-AML) patients. The FGL model showed better performance compared to other models and can provide a reference for treatment strategies.

FRONTIERS IN MOLECULAR BIOSCIENCES (2022)

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Article Medicine, Research & Experimental

Perillaldehyde is a new ferroptosis inducer with a relevant clinical potential for acute myeloid leukemia therapy

Elena Catanzaro et al.

Summary: This study investigates the potential of the monoterpene compound perillaldehyde to induce ferroptosis in leukemia cells. Perillaldehyde induces lipid peroxidation, decreases the expression of a specific protein, and reduces intracellular glutathione. Additionally, it stimulates the secretion of ATP.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Article Chemistry, Medicinal

Neratinib inhibits proliferation and promotes apoptosis of acute myeloid leukemia cells by activating autophagy-dependent ferroptosis

Hongxia Ma et al.

Summary: Neratinib is able to suppress the progression of AML by promoting cell ferroptosis and autophagy, inhibiting cell proliferation, and promoting apoptosis.

DRUG DEVELOPMENT RESEARCH (2022)

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Review Oncology

Targeting ferroptosis as a vulnerability in cancer

Guang Lei et al.

Summary: This article provides an overview of the importance and potential of ferroptosis in cancer research, summarizes the mechanisms of ferroptosis induction and defense, analyzes its roles and mechanisms in tumor suppression and tumor immunity, and explores therapeutic strategies targeting ferroptosis in cancer.

NATURE REVIEWS CANCER (2022)

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Article Hematology

Circ_0000745 promotes acute lymphoblastic leukemia progression through mediating miR-494-3p/NET1 axis

Xi Yang et al.

Summary: The study reveals that circ_0000745 can promote the development of acute lymphoblastic leukemia (ALL) by regulating the expression of miR-494-3p and NET1, suggesting its important regulatory role.

HEMATOLOGY (2022)

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Article Genetics & Heredity

Identification of seven novel ferroptosis-related long non-coding RNA signatures as a diagnostic biomarker for acute myeloid leukemia

Zhiyuan Zheng et al.

Summary: This study identified seven novel ferroptosis-related lncRNA signatures in AML, which were shown to accurately predict the prognosis of AML as independent prognostic predictors. These signatures provide new insights into strategies for the development of new AML therapies.

BMC MEDICAL GENOMICS (2021)

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Article Cell Biology

Artesunate induces apoptosis, autophagy and ferroptosis in diffuse large B cell lymphoma cells by impairing STAT3 signaling

Yingying Chen et al.

Summary: The study found that artemisinin inhibited proliferation, induced apoptosis, cell cycle arrest, autophagy, and ferroptosis in diffuse large B cell lymphoma cells. Inhibition of autophagy and ferroptosis alleviated increased apoptosis induced by artemisinin. Furthermore, artemisinin acted through inhibition of STAT3 activation, and genetic knockdown of STAT3 enhanced autophagy and ferroptosis induced by artemisinin.

CELLULAR SIGNALLING (2021)

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Article Oncology

Eprenetapopt (APR-246) and Azacitidine in TP53-Mutant Myelodysplastic Syndromes

David A. Sallman et al.

Summary: The combination treatment with eprenetapopt and azacitidine is well-tolerated and results in high rates of clinical response and molecular remissions in patients with TP53-mutant MDS and oligoblastic AML.

JOURNAL OF CLINICAL ONCOLOGY (2021)

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Review Cell Biology

Ferroptosis: mechanisms, biology and role in disease

Xuejun Jiang et al.

Summary: Ferroptosis, as a form of regulated cell death driven by iron-dependent phospholipid peroxidation, has seen significant growth in research in recent years. Studies have focused on molecular mechanisms, regulation, and functions of ferroptosis, linking this cell death modality to various pathologies and proposing its roles in normal physiology and potential therapeutic targeting.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

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Article Oncology

Eprenetapopt Plus Azacitidine in TP53-Mutated Myelodysplastic Syndromes and Acute Myeloid Leukemia: A Phase II Study by the Groupe Francophone des Myelodysplasies (GFM)

Thomas Cluzeau et al.

Summary: The combination of Eprenetapopt with AZA showed potentially higher overall response rate (ORR) and complete remission (CR) rate, as well as longer overall survival (OS) in untreated high-risk TP53m MDS and AML patients, with main treatment-related adverse events being febrile neutropenia and neurologic adverse events.

JOURNAL OF CLINICAL ONCOLOGY (2021)

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Article Cell Biology

TXNRD1: A Key Regulator Involved in the Ferroptosis of CML Cells Induced by Cysteine Depletion In Vitro

Shuhan Liu et al.

Summary: Cysteine depletion can induce ferroptosis in CML cells, while the GSH/GPX4 pathways of both CML cell lines are blocked after cysteine depletion.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Editorial Material Cell Biology

Cytochrome P450 reductase (POR) as a ferroptosis fuel

Pranavi Koppula et al.

PROTEIN & CELL (2021)

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Article Hematology

Dimethyl fumarate induces ferroptosis and impairs NF-κB/STAT3 signaling in DLBCL

Anja Schmitt et al.

Summary: The study demonstrates the broad antitumor effect of dimethyl fumarate (DMF) on both subtypes of DLBCL by inducing ferroptosis, especially in GCB DLBCL. In ABC DLBCL cells, DMF treatment efficiently inhibits the activity of the IKK complex and Janus kinases. Additionally, the combination of BCL-2-specific BH3 mimetic ABT-199 and an inhibitor of ferroptosis suppressor protein 1 synergize with DMF in inducing cell death in DLBCL.

BLOOD (2021)

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Article Environmental Sciences

CircKDM4C upregulates P53 by sponging hsa-let-7b-5p to induce ferroptosis in acute myeloid leukemia

Li-hua Dong et al.

Summary: The study revealed that circKDM4C is downregulated in AML patients, and overexpression of circKDM4C in AML cell lines can inhibit proliferation, migration, invasion, and promote ferroptosis. CircKDM4C acts as a sponge of hsa-let-7b-5p to regulate P53 expression in AML. CircKDM4C is negatively correlated with hsa-let-7b-5p, but positively correlated with P53 in AML patients.

ENVIRONMENTAL TOXICOLOGY (2021)

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Review Biochemical Research Methods

Non-coding RNA in cancer

Huiwen Yan et al.

Summary: The majority of the human genome is transcribed into non-coding RNAs (ncRNAs) that play crucial roles in regulating cancer initiation and progression. This review focuses on recent studies of the function, regulatory mechanisms, and therapeutic potential of ncRNAs such as microRNA (miRNA), long ncRNA (lncRNA), circular RNA (circRNA), and PIWI interacting RNA (piRNA) in various types of cancers.

NON-CODING GENOME (2021)

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Article Medicine, Research & Experimental

Inhibitory effect of hydnocarpin D on T-cell acute lymphoblastic leukemia via induction of autophagy-dependent ferroptosis

Siyue Lou et al.

Summary: Hydnocarpin D (HD) inhibits T-ALL proliferation by inducing cell cycle arrest and apoptosis, while also promoting autophagy and ferroptosis. Inhibition of autophagy can alleviate HD-induced apoptosis, indicating that autophagy enhances the efficacy of HD.

EXPERIMENTAL BIOLOGY AND MEDICINE (2021)

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Review Oncology

Molecular Mechanisms of Ferroptosis and Its Roles in Hematologic Malignancies

Yan Zhao et al.

Summary: Ferroptosis is a unique mode of regulated cell death characterized by excess accumulation of iron-dependent lipid peroxide and reactive oxygen species. It plays an important role in various diseases, particularly in hematological malignancies. Understanding the key molecular mechanisms of ferroptosis may offer novel therapeutic approaches for these malignancies.

FRONTIERS IN ONCOLOGY (2021)

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Article Immunology

PAQR3 inhibits proliferation and aggravates ferroptosis in acute lymphoblastic leukemia through modulation Nrf2 stability

Ling Jin et al.

Summary: PAQR3 was found to be downregulated in ALL, suppressing cell proliferation and exacerbating ferroptosis in ALL cells.

IMMUNITY INFLAMMATION AND DISEASE (2021)

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Article Biochemistry & Molecular Biology

Cisplatin synergizes with PRLX93936 to induce ferroptosis in non-small cell lung cancer cells

Zhigang Liang et al.

Summary: Synergistic induction of ferroptosis by cisplatin and PRLX93936 is a promising new therapeutic strategy for non-small cell lung cancer (NSCLC), involving upregulation of ROS, lipid peroxidation, Fe2+, inhibition of GPX4, and modulation of the Nrf2/Keap1 pathway.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

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Review Biochemistry & Molecular Biology

Personalized Medicine for TP53 Mutated Myelodysplastic Syndromes and Acute Myeloid Leukemia

Thomas Cluzeau et al.

Summary: This article reviews the progress in targeting TP53 mutated myelodysplastic syndromes and acute myeloid leukemia, focusing on the use of active agents and future treatment directions. It emphasizes the importance of understanding the clinical characteristics of the disease and the impact of TP53 mutant burden on patient clinical trajectory.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Oncology

Dipetidyl peptidase-4 and transferrin receptor serve as prognostic biomarkers for acute myeloid leukemia

Jie Wei et al.

Summary: This study identified DPP4 and TFRC as biomarkers for predicting and diagnosing AML, as well as their significant correlations with patient prognosis and drug resistance. Various FRGs show differential expression in AML, with some affecting patient prognosis. Through validation experiments and prognostic modeling, these findings were confirmed.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

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Review Biochemistry & Molecular Biology

Close interactions between lncRNAs, lipid metabolism and ferroptosis in cancer

Jingjing Huang et al.

Summary: The review summarizes the role of long noncoding RNAs in regulating aberrant lipid metabolism and ferroptosis in cancer, as well as how lipid metabolism can influence the expression of lncRNAs, and discusses the mechanisms by which lncRNAs affect ferroptosis. Understanding the interactions between lncRNAs, lipid metabolism, and ferroptosis could lead to the development of novel strategies for precise cancer treatment in the future.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

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Artesunate attenuates proliferation of epithelial cells by downregulating the NF-κB and AKT signaling pathways in benign mammary gland hyperplasia rats

Wei Li et al.

Summary: The study showed that artemisinin blocks estrogen-induced breast hyperplasia by inhibiting the phosphorylation of AKT and NFkB, and also reduces cell proliferation and inflammation in mammary epithelial cells.

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Article Hematology

Synergistic effects of PRIMA-1Met (APR-246) and 5-azacitidine in TP53-mutated myelody-splastic syndromes and acute myeloid leukemia

Nabih Maslah et al.

HAEMATOLOGICA (2020)

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Ferroptosis, a novel pharmacological mechanism of anti-cancer drugs

Yanwei Su et al.

CANCER LETTERS (2020)

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The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression

Guang Lei et al.

CELL RESEARCH (2020)

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Article Cell Biology

Elevated Glutathione Peroxidase 2 Expression Promotes Cisplatin Resistance in Lung Adenocarcinoma

He Du et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

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Review Cell Biology

Ferroptosis: past, present and future

Jie Li et al.

CELL DEATH & DISEASE (2020)

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Article Pharmacology & Pharmacy

Evaluation of artesunate for the treatment of adult T-cell leukemia/lymphoma

Chie Ishikawa et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

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Review Pharmacology & Pharmacy

Non-coding Natural Antisense RNA: Mechanisms of Action in the Regulation of Target Gene Expression and Its Clinical Implications

Tominori Kimura

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN (2020)

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Circular RNAs in Blood Malignancies

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FRONTIERS IN MOLECULAR BIOSCIENCES (2020)

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Targeting ferroptosis contributes to ATPR-induced AML differentiation via ROS-autophagy-lysosomal pathway

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hsa_circ_0001947 suppresses acute myeloid leukemia progression via targeting hsa-miR-329-5p/CREBRF axis

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EPIGENOMICS (2020)

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Review Cell Biology

The Metabolic Underpinnings of Ferroptosis

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CELL METABOLISM (2020)

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Prognostic and therapeutic impacts of mutant TP53 variant allelic frequency in newly diagnosed acute myeloid leukemia

Nicholas J. Short et al.

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Review Oncology

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R. R. Kansara et al.

CURRENT ONCOLOGY (2020)

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The role of ferroptosis regulators in the prognosis, immune activity and gemcitabine resistance of pancreatic cancer

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ANNALS OF TRANSLATIONAL MEDICINE (2020)

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FTY720 induces ferroptosis and autophagy via PP2A/AMPK pathway in multiple myeloma cells

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LIFE SCIENCES (2020)

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The ferroptosis and iron-metabolism signature robustly predicts clinical diagnosis, prognosis and immune microenvironment for hepatocellular carcinoma

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CELL COMMUNICATION AND SIGNALING (2020)

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Nigerian antimalarial plants and their anticancer potential: A review

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DHA inhibits proliferation and induces ferroptosis of leukemia cells through autophagy dependent degradation of ferritin

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FREE RADICAL BIOLOGY AND MEDICINE (2019)

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FDA-approved ferumoxytol displays anti-leukaemia efficacy against cells with low ferroportin levels

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NATURE NANOTECHNOLOGY (2019)

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Review Oncology

Not Only Mutations Matter: Molecular Picture of Acute Myeloid Leukemia Emerging from Transcriptome Studies

Luiza Handschuh

JOURNAL OF ONCOLOGY (2019)

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Typhaneoside prevents acute myeloid leukemia (AML) through suppressing proliferation and inducing ferroptosis associated with autophagy

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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

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Review Genetics & Heredity

The biogenesis, biology and characterization of circular RNAs

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NATURE REVIEWS GENETICS (2019)

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Ferritin heavy chain protects the developing wing from reactive oxygen species and ferroptosis

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PLOS GENETICS (2019)

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Recent Progress in Ferroptosis Inducers for Cancer Therapy

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Artesunate activates the ATF4-CHOP-CHAC1 pathway and affects ferroptosis in Burkitt's Lymphoma

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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

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Review Biochemistry & Molecular Biology

Programmed Cell-Death by Ferroptosis: Antioxidants as Mitigators

Naroa Kajarabille et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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The chemical basis of ferroptosis

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NATURE CHEMICAL BIOLOGY (2019)

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Nitidine chloride exerts anti-inflammatory action by targeting Topoisomerase I and enhancing IL-10 production

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PHARMACOLOGICAL RESEARCH (2019)

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Article Biochemistry & Molecular Biology

Perilaldehyde activates AMP-activated protein kinase to suppress the growth of gastric cancer via induction of autophagy

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JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

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Article Biochemistry & Molecular Biology

Imidazole Ketone Erastin Induces Ferroptosis and Slows Tumor Growth in a Mouse Lymphoma Model

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CELL CHEMICAL BIOLOGY (2019)

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Review Pharmacology & Pharmacy

Effects of 5-Aza-2-deoxycytidine (decitabine) on gene expression

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DRUG METABOLISM REVIEWS (2018)

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Review Dermatology

A review of the mechanisms of action of dimethylfumarate in the treatment of psoriasis

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Glutathione peroxidase 4 overexpression inhibits ROS-induced cell death in diffuse large B-cell lymphoma

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LABORATORY INVESTIGATION (2018)

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Review Food Science & Technology

Isothiocyanates: Translating the Power of Plants to People

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Article Biochemistry & Molecular Biology

FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation

Michael M. Gaschler et al.

NATURE CHEMICAL BIOLOGY (2018)

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Article Cell Biology

APR-246 reactivates mutant p53 by targeting cysteines 124 and 277

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CELL DEATH & DISEASE (2018)

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Article Chemistry, Medicinal

4-Amino-2-trifluoromethyl-phenyl retinate inhibits proliferation, invasion, and migration of breast cancer cells by independently regulating CRABP2 and FABP5

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Modeling the effects of lipid peroxidation during ferroptosis on membrane properties

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SCIENTIFIC REPORTS (2018)

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The essential oil of Algerian Ammodaucus leucotrichus Coss. & Dur. and its effect on the cholinesterase and monoamine oxidase activities

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FITOTERAPIA (2018)

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Review Hematology

The emerging role of immune checkpoint inhibition in malignant lymphoma

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HAEMATOLOGICA (2017)

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Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

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NATURE CHEMICAL BIOLOGY (2017)

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Article Biochemistry & Molecular Biology

Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth

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NATURE MEDICINE (2017)

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Review Hematology

The emerging role of immune checkpoint inhibition in malignant lymphoma

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HAEMATOLOGICA (2017)

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Salinomycin kills cancer stem cells by sequestering iron in lysosomes

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NATURE CHEMISTRY (2017)

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Autophagy contributes to 4-Amino-2-Trifluoromethyl-Phenyl Retinate-induced differentiation in human acute promyelocytic leukemia NB4 cells

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TOXICOLOGY AND APPLIED PHARMACOLOGY (2017)

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Role of NF-E2 related factor 2 (Nrf2) on chemotherapy resistance in acute myeloid leukemia (AML) and the effect of pharmacological inhibition of Nrf2

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PLOS ONE (2017)

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Neratinib: First Global Approval

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DRUGS (2017)

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Review Biochemistry & Molecular Biology

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

Brent R. Stockwell et al.

CELL (2017)

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Review Oncology

Long Noncoding RNA and Cancer: A New Paradigm

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CANCER RESEARCH (2017)

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Article Oncology

Targeting Aberrant Epigenetic Networks Mediated by PRMT1 and KDM4C in Acute Myeloid Leukemia

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CANCER CELL (2016)

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Review Biochemistry & Molecular Biology

Ferroptosis: process and function

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CELL DEATH AND DIFFERENTIATION (2016)

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Article Biochemistry & Molecular Biology

Dihydroartemisinin induces apoptosis preferentially via a Bim-mediated intrinsic pathway in hepatocarcinoma cells

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APOPTOSIS (2015)

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Treatment and survival among 1594 patients with ATL

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BLOOD (2015)

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Article Oncology

Ferroptosis is Involved in Acetaminophen Induced Cell Death

Tamas Lorincz et al.

PATHOLOGY & ONCOLOGY RESEARCH (2015)

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Article Oncology

Shikonin, dually functions as a proteasome inhibitor and a necroptosis inducer in multiple myeloma cells

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INTERNATIONAL JOURNAL OF ONCOLOGY (2015)

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Review Hematology

How I treat Burkitt lymphoma in adults

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BLOOD (2014)

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Article Oncology

Dihydroartemisinin induces apoptosis of cervical cancer cells via upregulation of RKIP and downregulation of bcl-2

Chun-jie Hu et al.

CANCER BIOLOGY & THERAPY (2014)

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Regulation of Ferroptotic Cancer Cell Death by GPX4

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Review Oncology

Human T-cell leukaemia virus type I and adult T-cell leukaemia-lymphoma

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Article Cell Biology

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

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NATURE CELL BIOLOGY (2014)

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FTY720 for cancer therapy

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ONCOLOGY REPORTS (2013)

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Article Chemistry, Medicinal

Potentiating Effect of the Flavonolignan (-)-Hydnocarpin in Combination with Vincristine in a Sensitive and P-gp-Expressing Acute Lymphoblastic Leukemia Cell Line

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PHYTOTHERAPY RESEARCH (2013)

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Review Oncology

Iron and cancer: more ore to be mined

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NATURE REVIEWS CANCER (2013)

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Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

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CELL (2012)

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Review Pharmacology & Pharmacy

Thinking Outside the Cleft to Understand Synaptic Activity: Contribution of the Cystine-Glutamate Antiporter (System xc-) to Normal and Pathological Glutamatergic Signaling

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FDA report: Ferumoxytol for intravenous iron therapy in adult patients with chronic kidney disease

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AMERICAN JOURNAL OF HEMATOLOGY (2010)

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Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity

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LANCET ONCOLOGY (2010)

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Review Biochemistry & Molecular Biology

How mitochondria produce reactive oxygen species

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BIOCHEMICAL JOURNAL (2009)

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Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells

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CHEMISTRY & BIOLOGY (2008)

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Review Pharmacology & Pharmacy

Natural products in drug discovery

Alan L. Harvey

DRUG DISCOVERY TODAY (2008)

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Article Multidisciplinary Sciences

RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels

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NATURE (2007)

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Review Biotechnology & Applied Microbiology

Sulforaphane as a promising molecule for fighting cancer

Carmela Fimognari et al.

MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH (2007)

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Article Chemistry, Medicinal

Free radical scavenging, enzyme inhibitory constituents from antidiabetic ayurvedic medicinal plant Hydnocarpus wightiana blume

SV Reddy et al.

PHYTOTHERAPY RESEARCH (2005)

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Article Oncology

Alteration in copy numbers of genes as a mechanism for acquired drug resistance

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CANCER RESEARCH (2004)

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Review Plant Sciences

Natural products as sources of new drugs over the period 1981-2002

DJ Newman et al.

JOURNAL OF NATURAL PRODUCTS (2003)

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Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells

S Dolma et al.

CANCER CELL (2003)

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Article Oncology

Sulfasalazine, a potent suppressor of lymphoma growth by inhibition of the xc- cystine transporter:: a new action for an old drug

PW Gout et al.

LEUKEMIA (2001)

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Article Plant Sciences

Synthesis and structures of regioisomeric hydnocarpin-type flavonolignans

NR Guz et al.

JOURNAL OF NATURAL PRODUCTS (2000)

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