☆ 4.7 Article

Approach to the Patient With Raised Thyroid Hormones and Nonsuppressed TSH

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Endocrinology & Metabolism

Different FT3/TSH correlation in acquired and congenital hypothyroid patients reveals a different hypothalamic set-point

Marco Russo et al.

Summary: This study aimed to investigate the differences in thyroid hormone replacement therapy between acquired and congenital hypothyroid patients. It found that adult congenital hypothyroid patients require a higher dose of levo-thyroxine than thyroidectomized patients. Additionally, the correlation between TSH and FT3 differed between the two groups, suggesting a difference in hypothalamic-pituitary-thyroid axis regulation.

CLINICAL ENDOCRINOLOGY (2023)

添加到收藏夹

Article Endocrinology & Metabolism

Prevalence and Pathogenesis of Macro-Thyrotropin in Neonates: Analysis of Umbilical Cord Blood from 939 Neonates and Their Mothers

Naoki Hattori et al.

Summary: Macro-thyrotropin (macro-TSH) was found in 0.43% of neonates, and their mothers all had macro-TSH as well. It is recommended that if a baby's serum TSH concentration is high enough to consider congenital hypothyroidism but the free thyroxine level is normal, their mother's macro-TSH should be checked.

THYROID (2023)

添加到收藏夹

Article Endocrinology & Metabolism

Severe Resistance to Thyroid Hormone Beta in a Patient with Athyreosis

Federico Salas-Lucia et al.

Summary: This study reports a patient with congenital hypothyroidism caused by a thyroid hormone receptor beta gene mutation. The patient's father is a carrier of the mutant allele, with a very mild phenotype. Correlating TSH with fT4 allows for prediction of the required fT4 dose for treatment.

THYROID (2022)

添加到收藏夹

Article Radiology, Nuclear Medicine & Medical Imaging

Localization of TSH-secreting pituitary adenoma using 11C-methionine image subtraction

Daniel Gillett et al.

Summary: The study found that normalizing to the cerebellum can reduce the effect of physiological variation in pituitary gland uptake of 11C-methionine. Subtraction imaging following endocrine suppression of tumor function can improve the lateralization of pituitary adenomas, but it is only effective if the images are normalized to the cerebellum.

EJNMMI RESEARCH (2022)

添加到收藏夹

Review Endocrinology & Metabolism

Clinically Symptomatic Resistance to Thyroid Hormone β Syndrome Because of THRB Gene Mosaicism

Anne Donnars et al.

Summary: A patient with clinical and biological signs of RTH beta was found to have a mosaic pathogenic variant in the THRB gene, demonstrating the importance of high-throughput sequencing in detecting such variants.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2022)

添加到收藏夹

Review Endocrinology & Metabolism

Genetic disorders of thyroid development, hormone biosynthesis and signalling

Carla Moran et al.

Summary: Development and differentiation of the thyroid gland are regulated by specific transcription factors, and thyroid hormones enter tissues through membrane transporters and regulate gene expression via hormone-inducible nuclear receptors. Congenital hypothyroidism can be caused by defects in transcription factors or thyroid stimulating hormone receptor function, while dyshormonogenic hypothyroidism is usually due to mutations in genes related to thyroidal iodide transport, organification, or iodotyrosine synthesis and recycling. Disorders of thyroid hormone signaling can be caused by defects in membrane transporters, deficiency of deiodinases, or pathogenic variants in TR alpha or TR beta.

CLINICAL ENDOCRINOLOGY (2022)

添加到收藏夹

Article Endocrinology & Metabolism

Thyroid function tests of iodine deficiency goiter can mimic thyroid hormone resistance alpha

Sabitha Sasidharan Pillai et al.

Summary: Iodine deficiency goiter can present with low FT4, elevated T3, and normal TSH, mimicking thyroid hormone resistance alpha, and should be considered in children on a restrictive diet.

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM (2022)

添加到收藏夹

Article Endocrinology & Metabolism

Tissue sensitivity to thyroid hormones may change over time

Giorgio Radetti et al.

Summary: This study reports patients with congenital hypothyroidism who developed an unexplained pituitary resistance to thyroid hormones. This resistance was observed independently of the cause of hypothyroidism and could be seen in patients with ectopic or eutopic glands or even in cases of athyreosis.

EUROPEAN THYROID JOURNAL (2022)

添加到收藏夹

Article Endocrinology & Metabolism

TSHB R75G is a founder variant and prevalent cause of low or undetectable TSH in Indian Jews

David Shaki et al.

Summary: This study identified and characterized the carrier rate of the p.R75G TSHB variant in euthyroid Bene Israel Indian Jews, revealing a high prevalence of this variant in this population. Additionally, a haplotype block shared by Bene Israel and individuals of South Asian origin near the TSHB gene was detected, suggesting a possible founder origin and shared ancestry of carriers of the R75G TSHB variant.

EUROPEAN THYROID JOURNAL (2022)

添加到收藏夹

Review Endocrinology & Metabolism

The Clinical Spectrum of Resistance to Thyroid Hormone Alpha in Children and Adults

Ibrahim Mert Erbas et al.

Summary: Resistance to thyroid hormone alpha is caused by pathogenic variants in the THRA gene, with diverse clinical and laboratory features. Symptoms are similar to primary hypothyroidism, but with normal thyroid-stimulating hormone levels. Treatment with L-thyroxine can improve some clinical findings.

JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Human Genetic Disorders Resulting in Systemic Selenoprotein Deficiency

Erik Schoenmakers et al.

Summary: Selenium, an essential trace element for human health, is incorporated into selenoproteins through the amino acid selenocysteine. Mutations in genes essential for selenocysteine incorporation pathway can result in systemic selenoprotein deficiency, leading to a complex disorder affecting specific tissues and impairing antioxidant and stress defense mechanisms. Antioxidant therapy shows promise in ameliorating oxidative damage, but the long-term benefits are still unclear.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Medical Laboratory Technology

Interference of anti-streptavidin antibodies: More common than we thought? In relation to six confirmed cases

Valentina Ricci et al.

Summary: Automated immunoassays have advantages in diagnosing endocrine disorders, but are limited by interference in the immunochemical reactions. This study reports six cases of abnormal thyroid function tests due to interference from endogenous ASA, emphasizing the importance of considering interference when hormone profiles do not correlate with clinical symptoms.

CLINICAL BIOCHEMISTRY (2021)

添加到收藏夹

Article Endocrinology & Metabolism

Biotin Interference in Assays for Thyroid Hormones, Thyrotropin and Thyroglobulin

Dorina Ylli et al.

Summary: This study found that biotin intake can lead to variations in thyroid-related laboratory test results, especially in data measured on the Roche Cobas 6000 and Siemens IMMULITE 2000 platforms. Taking 10 mg of biotin per day can interfere with the measurement results of specific indices such as TSH, fT4, TT3, and Tg.

THYROID (2021)

添加到收藏夹

Article Endocrinology & Metabolism

Defective Levothyroxine Response in a Patient with Dyshormonogenic Congenital Hypothyroidism Caused by a Concurrent Pathogenic Variant in Thyroid Hormone Receptor-β

Peter Lauffer et al.

Summary: This study describes a case of a girl with congenital hypothyroidism (CH) who was found to have pathogenic variants in SLC5A5 and THRB, causing both CH and resistance to thyroid hormone (RTH-beta) simultaneously.

THYROID (2021)

添加到收藏夹

Article Endocrinology & Metabolism

Free Thyroxine Concentrations in Sera of Individuals with Familial Dysalbuminemic Hyperthyroxinemia: A Comparison of Three Methods of Measurement

Samuel Refetoff et al.

THYROID (2020)

添加到收藏夹

Article Endocrinology & Metabolism

Familial dysalbuminaemic hyperthyroxinaemia interferes with current free thyroid hormone immunoassay methods

Serena Khoo et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2020)

添加到收藏夹

Article Endocrinology & Metabolism

Disease characteristics of MCT8 deficiency: an international, retrospective, multicentre cohort study

Stefan Groeneweg et al.

LANCET DIABETES & ENDOCRINOLOGY (2020)

添加到收藏夹

Article Endocrinology & Metabolism

The Differential Diagnosis of Discrepant Thyroid Function Tests: Insistent Pitfalls and Updated Flow-Chart Based on a Long-Standing Experience

Irene Campi et al.

FRONTIERS IN ENDOCRINOLOGY (2020)

添加到收藏夹

Article Endocrinology & Metabolism

Hyperthyroxinemia and Hypercortisolemia due to Familial Dysalbuminemia

Carla Moran et al.

THYROID (2020)

添加到收藏夹

Article Endocrinology & Metabolism

Mild TPO deficiency characterized by progressive goiter and normal serum TSH level

Jie Zhang et al.

ENDOCRINE (2020)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Amiodarone and thyroid physiology, pathophysiology, diagnosis and management

Richard G. Trohman et al.

TRENDS IN CARDIOVASCULAR MEDICINE (2019)

添加到收藏夹

Article Endocrinology & Metabolism

Apparent resistance to thyroid hormones: From biological interference to genetics

Xavier Dieu et al.

ANNALES D ENDOCRINOLOGIE (2019)

添加到收藏夹

Article Endocrinology & Metabolism

A Novel G385E Variant in the Cold Region of the T3-Binding Domain of Thyroid Hormone Receptor Beta Gene and Investigations to Assess Its Clinical Significance

Manassawee Korwutthikulrangsri et al.

EUROPEAN THYROID JOURNAL (2019)

添加到收藏夹

Review Endocrinology & Metabolism

Nonthyroidal Illness Syndrome Across the Ages

Lies Langouche et al.

JOURNAL OF THE ENDOCRINE SOCIETY (2019)

添加到收藏夹

Letter Endocrinology & Metabolism

High-dose biotin in infants mimics biochemical hyperthyroidism with some commercial assays

Ved Bhushan Arya et al.

CLINICAL ENDOCRINOLOGY (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Concurrent TSHR mutations and DIO2 T92A polymorphism result in abnormal thyroid hormone metabolism

Eunkuk Park et al.

SCIENTIFIC REPORTS (2018)

添加到收藏夹

Review Endocrinology & Metabolism

Interferences With Thyroid Function Immunoassays: Clinical Implications and Detection Algorithm

Julien Favresse et al.

ENDOCRINE REVIEWS (2018)

添加到收藏夹

Review Endocrinology & Metabolism

Factitious Graves' Disease Due to Biotin Immunoassay Interference-A Case and Review of the Literature

Marianne S. Elston et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2016)

添加到收藏夹

Article Endocrinology & Metabolism

Unexpected Elevated Free Thyroid Hormones in Pregnancy

Claudia Teti et al.

THYROID (2016)

添加到收藏夹

Article Endocrinology & Metabolism

Inherited defects of thyroxine-binding proteins

Theodora Pappa et al.

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM (2015)

添加到收藏夹

Article Endocrinology & Metabolism

A Patient With a Thyrotropin-Secreting Microadenoma and Resistance to Thyroid Hormone (P453T)

Xiaochun Teng et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2015)

添加到收藏夹

Article Endocrinology & Metabolism

A TSHβ Variant with Impaired Immunoreactivity but Intact Biological Activity and Its Clinical Implications

Theodora Pappa et al.

THYROID (2015)

添加到收藏夹

Article Endocrinology & Metabolism

Two Novel Mutations in the Serpina7 Gene Are Associated with Complete Deficiency of Thyroxine- Binding Globulin

Lars C. Moeller et al.

EUROPEAN THYROID JOURNAL (2015)

添加到收藏夹

Article Endocrinology & Metabolism

Falsely Undetectable TSH in a Cohort of South Asian Euthyroid Patients

Julia C. Drees et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2014)

添加到收藏夹

Article Endocrinology & Metabolism

Guidelines for the Treatment of Hypothyroidism: Prepared by the American Thyroid Association Task Force on Thyroid Hormone Replacement

Jacqueline Jonklaas et al.

THYROID (2014)

添加到收藏夹

Article Endocrinology & Metabolism

A Progress Report of the IFCC Committee for Standardization of Thyroid Function Tests

Linda M. Thienpont et al.

EUROPEAN THYROID JOURNAL (2014)

添加到收藏夹

Article Endocrinology & Metabolism

Pitfalls in the measurement and interpretation of thyroid function tests

Olympia Koulouri et al.

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM (2013)

添加到收藏夹

Article Endocrinology & Metabolism

Determination of free thyroid hormones

Linda M. Thienpont et al.

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM (2013)

添加到收藏夹

Article Endocrinology & Metabolism

A clinically euthyroid child with a large goiter due to a thyroglobulin gene defect: clinical features and genetic studies

Pia Hermanns et al.

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM (2013)

添加到收藏夹

Review Endocrinology & Metabolism

Macro-Thyrotropin: A Case Report and Review of Literature

Tze Ping Loh et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2012)

添加到收藏夹

Article Medical Laboratory Technology

Thyroxin overdose due to rheumatoid factor interferences in thyroid-stimulating hormone assays

Agnes Georges et al.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2011)

添加到收藏夹

Article Endocrinology & Metabolism

What should be done when thyroid function tests do not make sense?

Mark Gurnell et al.

CLINICAL ENDOCRINOLOGY (2011)

添加到收藏夹

Article Medicine, General & Internal

Interference in thyroid-stimulating hormone determination

Mauro Imperiali et al.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2010)

添加到收藏夹

Article Endocrinology & Metabolism

How do you approach the problem of TSH elevation in a patient on high-dose thyroid hormone replacement?

John C. Morris

CLINICAL ENDOCRINOLOGY (2009)

添加到收藏夹

Letter Medical Laboratory Technology

Influence of thyroid hormone autoantibodies on 7 thyroid hormone assays

Soha A. Zouwail et al.

CLINICAL CHEMISTRY (2008)

添加到收藏夹

Article Medicine, General & Internal

Triiodothyronine levels in athyreotic individuals during levothyroxine therapy

Jacqueline Jonklaas et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2008)

添加到收藏夹

Editorial Material Medical Laboratory Technology

Polyethylene glycol precipitation: proceed with care

Michael Fahie-Wilson et al.

ANNALS OF CLINICAL BIOCHEMISTRY (2008)

添加到收藏夹

Article Medical Laboratory Technology

Simultaneous quantification of free triiodothyronine and free thyroxine by isotope dilution tandem mass spectrometry

Jianghong Gu et al.

CLINICAL BIOCHEMISTRY (2007)

添加到收藏夹

Article Endocrinology & Metabolism

Thyroglobulin gene mutations producing defective intracellular transport of thyroglobulin are associated with increased thyroidal type 2 iodothyronine deiodinase activity

Yasuhiko Kanou et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2007)

添加到收藏夹

Letter Medical Laboratory Technology

Efficacy of a new blocker against anti-ruthenium antibody interference in the Elecsys free triiodothyronine assay

Remy Sapin et al.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2007)

添加到收藏夹

Letter Medical Laboratory Technology

Macro thyrotropin-IgG complex causes factitious increases in thyroid-stimulating hormone screening tests in a neonate and mother

David J. Halsall et al.

CLINICAL CHEMISTRY (2006)

添加到收藏夹

Article Endocrinology & Metabolism

Mosaicism of a thyroid hormone receptor-β gene mutation in resistance to thyroid hormone

Sunee Mamanasiri et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2006)

添加到收藏夹

Article Endocrinology & Metabolism

Disturbance of the fetal thyroid hormone state has long-term consequences for treatment of thyroidal and central congenital hypothyroidism

MJE Kempers et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2005)

添加到收藏夹

Letter Medicine, General & Internal

Resistance to thyroid hormone in Hashimoto's thyroiditis.

S Fukata et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)

添加到收藏夹

Article Endocrinology & Metabolism

Different responses to chronic somatostatin analogues in patients with central hyperthyroidism

D Mannavola et al.

CLINICAL ENDOCRINOLOGY (2005)

添加到收藏夹

Article Endocrinology & Metabolism

The changing spectrum of TSH-secreting pituitary adenomas: diagnosis and management in 43 patients

HV Socin et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2003)

添加到收藏夹

Letter Medical Laboratory Technology

Negative thyrotropin assay interference associated with an IgGκ paraprotein

VI Luzzi et al.

CLINICAL CHEMISTRY (2003)

添加到收藏夹

Article Endocrinology & Metabolism

Overexpression of type 2 iodothyronine deiodinase in follicular carcinoma as a cause of low circulating free thyroxine levels

BW Kim et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2003)

添加到收藏夹

Article Endocrinology & Metabolism

Free thyroid hormone measurement - A critical appraisal

JR Stockigt

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA (2001)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.