Radiofrequency driving antitumor effect of graphene oxide-based nanocomposites: a Hill model analysis

Aim: This report proposes using the Hill model to assess the benchmark dose, the 50% lethal dose, the cooperativity and the dissociation constant while analyzing cell viability data using nanomaterials to evaluate the antitumor potential while combined with radiofrequency therapy. Materials & methods: A nanocomposite was synthesized (graphene oxide-polyethyleneimine-gold) and the viability was evaluated using two tumor cell lines, namely LLC-WRC-256 and B16-F10. Results: Our findings demonstrated that while the nanocomposite is biocompatible against the LLC-WRC-256 and B16-F10 cancer cell lines in the absence of radiofrequency, the application of radiofrequency enhances the cell toxicity by orders of magnitude. Conclusion: This result points to prospective studies with the tested cell lines using tumor animal models.

Automated summary

This study proposed using the Hill model to assess the antitumor potential of nanomaterials combined with radiofrequency therapy. The findings showed that the nanocomposite was biocompatible against cancer cells in the absence of radiofrequency, but the application of radiofrequency significantly enhanced cell toxicity.