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Article
Multidisciplinary Sciences
Yuanzhen Su et al.
Summary: Two types of chiral polypeptide nanoparticles were used as nanoadjuvants for cancer prevention and therapy, exhibiting excellent performance in inducing immune response and anti-tumor effects.
Article
Chemistry, Multidisciplinary
Xiaoxuan Xu et al.
Summary: A drug-laden M1 macrophage system was designed to selectively accumulate and release therapeutic drugs in lung metastatic lesions, enhancing the treatment of lung metastasis. This system significantly increased the infiltration of CD3+CD8+ T cells and inhibited lung metastasis. Therefore, the drug-laden FAP-sensitive M1 macrophage system is a feasible strategy to target lung metastasis and enhance anti-tumor immunity.
Article
Multidisciplinary Sciences
Maud Debaugnies et al.
Summary: This study reveals that cancer cells undergoing EMT are highly resistant to various anti-cancer therapies. RHOJ, a small GTPase preferentially expressed in EMT cancer cells, controls resistance to therapy by enhancing the response to replicative stress and activating the DNA-damage response. RHOJ interacts with proteins that regulate nuclear actin, and inhibition of actin polymerization sensitizes EMT tumor cells to chemotherapy-induced cell death in a RHOJ-dependent manner.
Article
Chemistry, Multidisciplinary
Shuang Chen et al.
Summary: As an important noncovalent interaction, cation-p interaction plays a crucial role in various biological and chemical applications. In this study, peptide amphiphiles were designed with cation-p interaction pairs, which could self-assemble into supramolecular hydrogels under physiological conditions. The influence of cation-p interaction on peptide folding propensity, morphology, and rigidity of the hydrogel was thoroughly investigated. The results showed that cation-p interaction can serve as a major driving force for peptide folding, resulting in the formation of fibril-rich hydrogels. Additionally, the designed peptides showed high efficacy in cytosolic protein delivery. This work provides a novel strategy to generate supramolecular biomaterials using cation-p interactions for the first time.
Article
Chemistry, Physical
Limin Xie et al.
Summary: The researchers constructed a multifunctional drug-loaded peptide nanomedicine (Comp. 4) for ICD-based cancer therapy. Comp. 4 interferes with mitochondrial functions, targets the cell membrane and mitochondria, and forms peptide assemblies in the presence of ALP. Comp. 4 induces mitochondrial oxidative stress, provokes robust ICD responses, and successfully inhibits colon cancer growth by eliciting a systemic ICD-based antitumor immunity.
Review
Biochemistry & Molecular Biology
Shanze Chen et al.
Summary: Macrophages are vital to the innate immune system and play a central role in various immune tasks. They possess polarization settings that are crucial for immune regulation, and their clinical importance in cancer and other diseases is increasingly recognized. Macrophages have a significant impact on processes such as angiogenesis, tumor cell proliferation, metastasis, and immune suppression.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Bastien Nguyen et al.
Summary: This study investigates the genomic mechanisms driving metastasis in cancer patients. By analyzing a cohort of over 25,000 patients with metastatic diseases, the researchers identify associations between genomic alterations and patterns of metastatic dissemination across different tumor types. The study highlights the complex role of chromosomal instability in cancer progression and provides valuable insights for further research on metastatic spread.
Article
Chemistry, Multidisciplinary
Mengqi Sun et al.
Summary: The study introduces a novel amphiphilic bifunctional PD-1/PD-L1 peptide antagonist PCP, co-delivering doxorubicin (DOX) and R848 through co-assembly of a multi-agent prodrug (PCP@R848/DOX) specifically cleaved by fibroblast activation protein-alpha (FAP-alpha) in the tumor stroma. This activation leads to the localized release of DOX and R848, triggering immunogenic cell death (ICD) and reprogramming tumor-associated macrophages (TAMs) to elicit antitumor immunity, while sustained release of PD-1/PD-L1 antagonists further blocks the PD-L1 pathway for cytotoxic T lymphocyte activation, presenting a new paradigm in combination immunotherapy for cancer treatment.
Article
Chemistry, Multidisciplinary
Xilin Li et al.
Summary: In this study, a localized drug delivery system based on a hierarchical-structured fiber device was developed to precisely reprogram tumor-associated macrophages (TAMs) and combine them with immunogenic cell death (ICD), aiming to enhance the antitumor immunotherapeutic effect.
Article
Engineering, Biomedical
Jun Dai et al.
Summary: Immunotherapy offers a promising approach for cancer treatment by re-activating the immune system. However, the response rate of current strategies is still low. In this study, a cascade amplification nanocomposite was designed to enhance the response rate. The nanocomposite consists of an immune adjuvant, a matrix metalloproteinase 2 responsive sequence, a photosensitizer, and an immune checkpoint inhibitor. In vivo experiments demonstrated that this nanocomposite achieved almost 100% objective response rate by promoting T lymphocyte activation and immune cell infiltration in tumors.
Article
Chemistry, Applied
Asif Mohd Itoo et al.
Summary: In this study, a chitosan/vitamin E conjugate was synthesized and used for the assembly of oxaliplatin micelles. The micelles showed promising therapeutic efficacy in breast cancer treatment, overcoming drug resistance and reducing nephrotoxicity.
CARBOHYDRATE POLYMERS
(2022)
Review
Biochemistry & Molecular Biology
Rebecca C. Fitzgerald et al.
Summary: Proactively detecting cancer at an early stage is crucial, but distinguishing inconsequential changes from life-threatening lesions can be challenging. Advancements in technology will aid real-time detection of personalized cancer signals. Risk-based detection and prevention should be cost effective and widely accessible.
Article
Multidisciplinary Sciences
Zhaoting Li et al.
Summary: This study reports a method to enhance the effectiveness of anti-tumor immunotherapy by locally depleting tumor-associated macrophages (TAMs) using a hydrogel reservoir. TAMs are depleted by releasing the colony-stimulating factor 1 receptor (CSF1R) inhibitor Pexidartinib and delivering anti-PD-1 antibody-conjugated platelets locally and systemically, effectively inhibiting post-surgery tumor recurrence.
NATURE COMMUNICATIONS
(2022)
Article
Engineering, Biomedical
Jie Zhan et al.
Summary: Organelles are responsible for the storage and transport of substances in living systems. Researchers have developed a biomimetic delivery strategy inspired by natural cargo delivery by organelles, which can improve the efficiency of cancer therapy.
BIOACTIVE MATERIALS
(2022)
Review
Biotechnology & Applied Microbiology
Alberto Mantovani et al.
Summary: This review discusses the molecular mechanisms of macrophage reprogramming in the tumor microenvironment and provides an overview of macrophage-targeted therapies for cancer treatment.
NATURE REVIEWS DRUG DISCOVERY
(2022)
Article
Chemistry, Multidisciplinary
Zhu Li et al.
Summary: In this study, a smart micelle system was developed using an amphiphilic copolymer to encapsulate manganese zinc sulfide nanoparticles and triggered release by near infrared light. The micelles effectively enhanced reactive oxygen species generation, leading to immunogenic cell death and improved antitumor immunity in melanoma.
Article
Engineering, Biomedical
Xu Liao et al.
Summary: The overproduction of reactive oxygen species (ROS) and burst of inflammation following cardiac ischemia-reperfusion (I/R) are the leading causes of cardiomyocyte injury. Monotherapeutic strategies designed to enhance anti-inflammatory or anti-ROS activity explicitly for treating I/R injury have demonstrated limited success because of the complex mechanisms involved. In this study, an injectable hydrogel system was designed and prepared to block the ROS-inflammation cycle, leading to improved treatment outcomes.
ACTA BIOMATERIALIA
(2022)
Article
Biochemistry & Molecular Biology
Jinting Liu et al.
Summary: Our study revealed that CDCA suppresses AML progression by synergistically promoting LDs accumulation and lipid peroxidation via the ROS/p38 MAPK/DGAT1 pathway caused by mitochondrial dysfunction in leukemia cells, as well as inhibiting M2 macrophage polarization.
Article
Chemistry, Multidisciplinary
Yiling Zhong et al.
Summary: Photothermal therapy is an effective treatment for tumors, but it can induce inflammatory responses and have undesirable side effects. This study developed multifunctional nanoparticles that can scavenge proinflammatory molecules and alleviate the inflammatory response caused by photothermal therapy. The nanoparticles also inhibit tumor recurrence and metastasis.
Review
Biochemistry & Molecular Biology
Lei Ye et al.
Summary: Metabolites of glycolytic metabolism play roles as signaling molecules and regulators of gene expression in immune cells. Recent studies have revealed the non-metabolic signaling functions of intermediates of the mitochondrial pathway and glycolysis. Lactate, as the end product of glycolysis, plays important roles in immune cell biology and associated pathologies.
CYTOKINE & GROWTH FACTOR REVIEWS
(2022)
Review
Cell Biology
Aadhya Tiwari et al.
Summary: Tumor microenvironment (TME) is a specialized ecosystem designed by tumor cells for successful development and metastasis. Advanced bioinformatic methodologies and 3D culture have allowed for the study of TME components and their interplay. Understanding TME diversity and immune therapeutic interventions could potentially overcome immunotherapeutic resistance.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Dong-Rui Wang et al.
Summary: Cancers are complex diseases characterized by malignant cell overgrowth and altered immune response. Immunotherapy, including immune checkpoint blockade and adoptive cell transfer, has shown success in inducing long-term regression of refractory tumors. Combination therapy and biomarker discovery are important for improving the overall clinical response rate of tumor immunotherapy.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Review
Oncology
Matthew J. Lin et al.
Summary: The article discusses the current status and potential of cancer vaccines, emphasizing the need for accurate immune monitoring of early trials to advance the most promising vaccines. It also classifies cancer vaccines based on the included antigens and their colocalization with antigen-presenting cells, highlighting the challenges and opportunities in advancing these vaccines to the clinic.
Article
Engineering, Biomedical
Gowri Rangaswamy Gunassekaran et al.
Summary: In this study, M1 macrophage-derived exosomes were engineered to reprogram TAMs into M1-like macrophages for inhibiting tumor growth. The results showed that systemic administration of these exosomes increased anti-tumor immunity more efficiently than untargeted and control peptide-labeled exosomes.
Article
Pharmacology & Pharmacy
Chuanrui Ma et al.
Summary: The study demonstrates that D-Nap-GFFY-T0901317 reduces atherosclerosis without affecting hepatic lipogenesis by targeting macrophage LXRs selectively, suggesting its potential application for atherosclerosis treatment. This novel approach could provide a new avenue for therapeutic interventions in atherosclerosis.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Oncology
Hyuna Sung et al.
Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.
CA-A CANCER JOURNAL FOR CLINICIANS
(2021)
Review
Biochemistry & Molecular Biology
Swati Mohapatra et al.
Summary: Noncoding RNA transcripts, as important regulators in the tumor microenvironment, play crucial roles in modulating macrophage polarization and influencing tumor progression and clinical outcomes. More research is needed to further understand the mechanisms underlying these processes and the potential therapeutic implications.
Review
Biochemistry & Molecular Biology
Longzheng Xia et al.
Summary: The overlapping metabolic reprogramming between cancer and immune cells is an important factor affecting the antitumor immune response, involving metabolic competition, nutrient limitation, and impaired immune cell function. Studies have shown that metabolic reprogramming is essential for maintaining immune cell homeostasis and executing effector functions during immune responses.
Review
Pharmacology & Pharmacy
Zhenghao Zhang et al.
Summary: Peptide-based supramolecular hydrogels have shown great promise as drug delivery systems due to their excellent biocompatibility, response to external stimuli, and ability to self-assemble into specific nanostructures in different environments. Utilizing inherent biological microenvironment as stimuli can provide spatiotemporal controllability for transporting therapeutics more accurately. These materials formed by weak non-covalent interactions exhibit shear-thinning and immediate recovery behavior, making them injectable and ideal for drug delivery.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Chemistry, Multidisciplinary
Baicheng Wei et al.
Summary: A new cancer treatment strategy has been developed, where tumor-associated macrophage polarization therapy combined with ICD induced by low-dose chemotherapy drugs can significantly enhance the efficacy of immunotherapy.
Article
Chemistry, Multidisciplinary
Mengshi Jiang et al.
Summary: By inhibiting both ER stress and oxidative stress, M2-tumor associated macrophages (TAMs) can be effectively repolarized, providing significant implications for anti-tumor therapy.
Article
Chemistry, Multidisciplinary
Chen Sun et al.
Summary: A novel supramolecular-peptide derived nanodrug capable of transforming into microfibers within cancer cells has been developed, leading to enhanced accumulation and retention of the drug in tumor tissue. The polyamine-responsive nanodrug exhibits low toxicity against non-cancerous cells, offering a promising strategy for specific tumor therapy with minimal side effects. This work provides insights into the design of stimuli-responsive nanomaterials for precision medicine.
Review
Engineering, Biomedical
Muyue Yang et al.
Summary: The development and metastasis of tumors are closely linked to the tumor microenvironment (TME). Nanoparticles, with their unique physical properties and design, show potential in efficiently penetrating TME and delivering therapeutic agents to specific components. However, the heterogeneity of tumors and individuals may limit the effectiveness of nanoparticle delivery systems in all types of tumors, calling for further understanding of TME changes at different stages of tumor development for the design of more personalized nanoplatforms.
BIOACTIVE MATERIALS
(2021)
Article
Medicine, Research & Experimental
Joon Woo Song et al.
Summary: A theranostic nanodrug targeting macrophage mannose receptor was developed to deliver specific medication to high-risk plaques with high inflammatory activity, rapidly stabilizing inflamed plaques in coronary arteries, providing a promising therapeutic strategy for high-risk coronary plaques.
Review
Oncology
Mark Esposito et al.
Summary: The systemic spread of tumor cells is the major cause of cancer deaths, with few effective therapeutic strategies targeting metastasis. Recent advances in understanding tumor-intrinsic pathways, immune-activating strategies, and emerging areas offer potential for innovative treatments against metastatic cancer. Kang and colleagues review recent progress and challenges in developing therapies for metastatic disease and discuss the clinical implications of ongoing and completed studies.
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Chemistry, Multidisciplinary
Tian Xu et al.
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Oncology
Cheng-Liang Kuo et al.
Review
Oncology
Dimitrios Schizas et al.
CANCER TREATMENT REVIEWS
(2020)
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Chemistry, Multidisciplinary
Xilin Li et al.
ADVANCED FUNCTIONAL MATERIALS
(2020)
Article
Chemistry, Multidisciplinary
Lingqiao Liu et al.
Article
Immunology
Fanghui Zhang et al.
Article
Pathology
Massimo Locati et al.
Annual Review of Pathology-Mechanisms of Disease
(2019)
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Chemistry, Multidisciplinary
Xiao Wei et al.
JOURNAL OF CONTROLLED RELEASE
(2019)
Article
Immunology
Mingen Liu et al.
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Chemistry, Multidisciplinary
Keman Cheng et al.
Review
Pharmacology & Pharmacy
Gantumur Battogtokh et al.
ACTA PHARMACEUTICA SINICA B
(2018)
Review
Immunology
Jan Van den Bossche et al.
TRENDS IN IMMUNOLOGY
(2017)
Article
Nanoscience & Nanotechnology
Didem Mumcuoglu et al.
ACS APPLIED MATERIALS & INTERFACES
(2016)
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Biochemistry & Molecular Biology
Andy J. Minn et al.
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Yan Zhang et al.
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M. Ri et al.
BLOOD CANCER JOURNAL
(2012)