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Review
Chemistry, Organic
Maria Grazia Martina et al.
Summary: It is widely recognized that the building blocks of life, purines and pyrimidines, were created through multicomponent reactions on early abiotic Earth. These structures evolved into biologically relevant molecules and served as templates for drug development. The synthetic community has dedicated efforts to replicate the abiotic synthesis of purines and pyrimidines, resulting in the development of various multicomponent synthesis methods. The importance of multicomponent synthesis of new heterocycles is highlighted by the shift towards green chemistry and pharmaceutical sustainability. This review provides an overview of the most important multicomponent approaches for synthesizing purine and pyrimidine derivatives for potential pharmacological applications.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Nikita A. Frolov et al.
Summary: This article summarizes recent scientific literature on intra- and intermolecular reactions leading to the formation of various piperidine derivatives. It also covers the pharmaceutical applications of synthetic and natural piperidines, as well as the latest scientific advances in the discovery and biological evaluation of potential drugs containing piperidine moiety. The review aims to assist both novice researchers and experienced scientists in the synthesis of biologically active piperidines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Gollagani Vijaya Bhavani et al.
Summary: Novel isoniazid-based pyridinium salts were designed, synthesized, and tested for their antimycobacterial activities, and 4k, 4l, and 7d showed exceptional activities. In vitro and in silico studies suggested that 4k is a potentially promising lead compound for the development of antitubercular candidates.
DRUG DEVELOPMENT RESEARCH
(2023)
Review
Chemistry, Organic
Mayur I. Morja et al.
Summary: In the present scenario, innovative carbon disulfide-involving multicomponent protocols offer practical and efficient strategies for constructing acyclic and heterocyclic building blocks. Carbon disulfide has been widely recognized as a versatile synthetic component, enabling the synthesis of highly functionalized organic scaffolds. These protocols provide environmentally friendly alternatives by utilizing the features of bond-forming efficiency, resource effectiveness, availability of starting compounds, and atom economy in organic chemistry.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Mary A. Seferyan et al.
Summary: High biocidal activity has traditionally been the main focus in developing new antiseptic formulations. However, the spread of antimicrobial resistance raises concerns and the emphasis is now on formulations that maintain effectiveness even with prolonged exposure to pathogens. Researchers have developed a method using isocyanuric acid alkylation to create a range of multi-QACs with varying alkyl chain lengths. These compounds showed higher antibacterial activity against ESKAPE pathogens compared to commercial QACs, and demonstrated a sustained biocidal effect without significant tolerance development. This study highlights the potential of multi-QACs based on isocyanuric acid against multiresistant bacterial strains.
ACS INFECTIOUS DISEASES
(2023)
Review
Chemistry, Medicinal
Evgeniya A. Saverina et al.
Summary: In the past, the focus was mainly on individual antibacterial activity, but now there is a shift towards affecting more complex cellular frameworks and using multiple strategies to combat biofilms at different stages. Quaternary ammonium compounds (QACs) play a key role in these treatments. This review summarizes the literature data on the effectiveness of using commercially available and newly synthesized QACs, as well as synergistic treatment techniques based on them. It also discusses the development and application of antimicrobial coatings to prevent biofilm formation on various surfaces.
ACS INFECTIOUS DISEASES
(2023)
Review
Chemistry, Multidisciplinary
S. O. Kushch et al.
Summary: The review summarizes and systematizes the published data on multicomponent reactions involving ethyl trifluoroacetoacetate, carbonyl compounds, and nucleophilic reagents. It analyzes recent advances in the Hantzsch and Biginelli reactions utilizing polyfluoroalkyl-3-oxo esters. These transformations allow the synthesis of various hetero- and carbocyclic compounds, including derivatives of pyridine, pyrimidine, pyrazole, pyran, dioxane, isoxazole, and their heterofused derivatives, by tolerating a broad range of nucleophilic reagents. The reactivity characteristics of ethyl trifluoroacetoacetate with different reagents in these multicomponent transformations are discussed.
RUSSIAN CHEMICAL BULLETIN
(2023)
Article
Chemistry, Applied
Evgeny Pospelov et al.
Summary: This study demonstrated that bis(beta-oximinoalkyl)malonates are convenient platforms for synthesizing saturated N-heterocycles. Heterogeneous catalytic hydrogenation of these compounds leads to reductive cyclization and the formation of substituted piperidine-4,4'-dicarboxylates, which are important building blocks in medicinal chemistry. The synthesis of initial bis(beta-oximinoalkyl)malonates was achieved through the sequential Michael addition of nitrosoalkene molecules to malonic ester. The mechanism of the reductive cyclization of dioximes to piperidines was investigated using isotope scrambling experiments and intermediates were isolated.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Chemistry, Multidisciplinary
Taigib M. Iliyasov et al.
Summary: This study demonstrates the convenient and stereoselective formation of compounds with multiple stereogenic centers through the Michael-Mannich cascade cyclization of cyano olefins, ethyl 4,4,4-trifluoro-3-oxobutanoate, aromatic aldehydes, and ammonium acetate, with the latter playing a dual role as both a base and a nitrogen source.
MENDELEEV COMMUNICATIONS
(2022)
Review
Chemistry, Multidisciplinary
Michail N. Elinson et al.
Summary: This review systematically presents data on the methods for the preparation of chromeno[2,3-b]pyridines, including multicomponent and pseudo-multicomponent synthetic approaches. It also discusses the characteristics and mechanisms of reactions, as well as the biological activity and other applications of the obtained compounds.
RUSSIAN CHEMICAL REVIEWS
(2021)
Article
Chemistry, Organic
Anatoly N. Vereshchagin et al.
Summary: A novel four-component diastereoselective synthesis of polysubstituted tetrahydropyridines was reported, with high yields and strong stereoselectivity, confirmed by structural analysis of the synthesized compounds.
CHEMISTRY OF HETEROCYCLIC COMPOUNDS
(2021)
Review
Chemistry, Multidisciplinary
Simon L. Roessler et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Article
Biochemistry & Molecular Biology
Anatoly N. Vereshchagin et al.
MOLECULAR DIVERSITY
(2020)
Article
Chemistry, Multidisciplinary
Anatoly N. Vereshchagin et al.
RESEARCH ON CHEMICAL INTERMEDIATES
(2018)
Article
Chemistry, Medicinal
Sara Fahs et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2014)
Article
Microbiology
Muthuraman Sundararaman et al.
JOURNAL OF MEDICAL MICROBIOLOGY
(2013)
Article
Chemistry, Medicinal
Yosup Rew et al.
JOURNAL OF MEDICINAL CHEMISTRY
(2012)
Review
Biochemistry & Molecular Biology
Sara Kallstrom et al.
BIOORGANIC & MEDICINAL CHEMISTRY
(2008)
Article
Chemistry, Applied
Tao Zhao et al.
JOURNAL OF SURFACTANTS AND DETERGENTS
(2006)
