期刊
VIRAL IMMUNOLOGY
卷 36, 期 10, 页码 627-641出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/vim.2023.0096
关键词
hepatitis E virus; immune response; extrahepatic manifestations; neurological disorders
This review summarizes the recent advances in understanding the replication factors of hepatitis E virus (HEV) in diverse organs and the associations between HEV infection and various extrahepatic manifestations. It reveals that HEV may replicate directly in peripheral tissues and highlights the crucial role of immune response in the development of the disease.
Hepatitis E virus (HEV) exhibits tropism toward hepatocytes and thus affects the liver; however, HEV may also affect other tissues, including the heart, kidneys, intestines, testicles, and central nervous system. To date, the pathophysiological links between HEV infection and extrahepatic manifestations have not yet been established. Considering that HEV infects multiple types of cells, the direct effects of virus replication in peripheral tissues represent a plausible explanation for extrahepatic manifestations. In addition, since the immune response is crucial in the development of the disease, the immune characteristics of affected tissues should be revisited to identify commonalities explaining the effects of the virus. This review summarizes the most recent advances in understanding the virus biology and immune-privileged status of specific tissues as major elements for HEV replication in diverse organs. These discoveries may open avenues to explain the multiple extrahepatic manifestations associated with HEV infection and ultimately to design effective strategies for infection control.
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