Relationship Between Human FCγRIIA rs1801274 G Allele and Risk of Death Among Different SARS-CoV-2 Variants

Coronavirus disease 2019 (COVID-19), the illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in late 2019 and spread very quickly across the world. Different responses to infections have been related to fragment crystallizable gamma-receptor II alpha (Fc gamma RIIA) polymorphisms. The purpose of this investigation was to determine if FC gamma RIIA rs1801274 polymorphism was related to COVID-19 mortality among different variants of SARS-CoV-2. The FC gamma RIIA rs1801274 polymorphism was genotyped using the polymerase chain reaction-restriction fragment length polymorphism technique in 1,734 recovered and 1,450 deceased patients. Deceased patients had significantly higher minor allele frequency of the FC gamma RIIA rs1801274 G allele than in the recovered cases. The COVID-19 mortality was associated with FC gamma RIIA rs1801274 GG and AG genotypes in the Delta variant and with FC gamma RIIA rs1801274 GG genotypes in the Alpha and Omicron BA.5 variants. The reverse transcription-quantitative polymerase chain reaction Ct values revealed statistically significant differences between individuals with a G allele and those with an A allele. In conclusion, among the several SARS-CoV-2 variants, there may be a correlation between the mortality rate of COVID-19 and the G allele of FC gamma RIIA rs1801274. To confirm our findings, thorough research is still required.

Automated summary

This study found a potential correlation between the G allele of FCγRIIA rs1801274 and the mortality rate of COVID-19 among different variants of SARS-CoV-2.