4.7 Article

Lianhua Qingwen protects LPS-induced acute lung injury by promoting M2 macrophage infiltration

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Pharmacology & Pharmacy

Xuanfei Baidu Decoction reduces acute lung injury by regulating infiltration of neutrophils and macrophages via PD-1/IL17A pathway

Yuying Wang et al.

Summary: This study demonstrated the pharmacodynamic effects and molecular mechanism of Xuanfei Baidu Decoction (XFBD) in an acute lung injury (ALI) model. XFBD inhibited the secretion of inflammatory factors, improved pulmonary injury, and regulated the infiltration of neutrophils and macrophages through the PD-1/IL17A pathway.

PHARMACOLOGICAL RESEARCH (2022)

Article Plant Sciences

Lianhuaqingwen capsule inhibits non-lethal doses of influenza virus-induced secondary Staphylococcus aureus infection in mice

Jian Song et al.

Summary: Lianhuaqingwen capsule has been proven to have antiviral and antibacterial effects, reducing lung damage and inflammatory mediators like IL-6, IL-1 beta, IL-10, TNF-alpha, IFN-beta, MCP-1, and RANTES. It shows promise in treating influenza secondary bacterial infection.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

Article Plant Sciences

Efficacy and safety of Lianhuaqingwen capsules, a repurposed Chinese herb, in patients with coronavirus disease 2019: A multicenter, prospective, randomized controlled trial

Ke Hu et al.

Summary: The study found that the use of LH capsules in treating patients with Covid-19 significantly improved the symptom recovery rate, shortened the time to symptom relief, and had positive effects on the patients' imaging manifestations and clinical cure rate.

PHYTOMEDICINE (2021)

Article Pharmacology & Pharmacy

Identifying potential anti-COVID-19 pharmacological components of traditional Chinese medicine Lianhuaqingwen capsule based on human exposure and ACE2 biochromatography screening

Xiaofei Chen et al.

Summary: This study confirms the effectiveness of Lianhuaqingwen (LHQW) capsule in treating COVID-19 pneumonia, providing chemical and biochemical evidence for exploring its therapeutic effects based on human exposure to its components and pharmacological activities. It demonstrates the utility of the human exposure-based approach in identifying pharmaceutically active components in Chinese herb medicines.

ACTA PHARMACEUTICA SINICA B (2021)

Article Medicine, Research & Experimental

The mechanisms and clinical application of Traditional Chinese Medicine Lianhua-Qingwen capsule

Xuhui Shen et al.

Summary: Lianhua-Qingwen capsule is a widely used traditional Chinese medicine for treating various respiratory diseases, such as SARS and COVID-19. Its main active ingredients can target specific molecules and have therapeutic effects.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Review Cell Biology

Macrophages in Lung Injury, Repair, and Fibrosis

Peiyong Cheng et al.

Summary: Fibrosis progression in the lung can lead to impaired gas exchange, respiratory failure, or even death. Macrophages play a crucial role in response to lung injury, repair, and fibrosis, with their activation and polarization being key factors in the process. Targeting macrophages may offer potential benefits in alleviating pulmonary fibrosis.
Article Plant Sciences

Lianhuaqingwen capsule inhibits influenza-induced bacterial adhesion to respiratory epithelial cells through down-regulation of cell adhesion molecules

Qiuling Du et al.

Summary: The study demonstrated that Lianhuaqingwen capsule significantly reduced MRSA adhesion to PR8-infected lung epithelial cells, suppressed the up-regulation of bacterial receptors, and decreased the overexpression of inflammatory cytokines. In a severe pneumonia model, LHQW alleviated abnormal changes in lung index in dual-infected mice, but did not significantly improve survival rate or prolong survival time.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

Article Plant Sciences

The TCM prescription Ma-xing-shi-gan-tang inhibits Streptococcus pneumoniae pathogenesis by targeting pneumolysin

Tingting Guo et al.

Summary: This study found that Ma-xing-shi-gan-tang (MXSGT) is an effective inhibitor of PLY, a key virulence factor for Streptococcus pneumoniae. MXSGT inhibits PLY oligomerization without impacting bacterial growth or PLY production, and demonstrates effectiveness against S. pneumoniae infection both in vitro and in vivo.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

Review Medicine, General & Internal

Acute respiratory distress syndrome

Nuala J. Meyer et al.

Summary: This article summarizes the epidemiology, diagnosis, and treatment of acute respiratory distress syndrome (ARDS), while also discussing the similarities and differences between ARDS caused by COVID-19 and ARDS caused by other factors.

LANCET (2021)

Review Pharmacology & Pharmacy

Traditional Chinese Medicine (TCM) in the treatment of COVID-19 and other viral infections: Efficacies and mechanisms

Kai Huang et al.

Summary: This review article discusses the six most effective Traditional Chinese Medicine recipes used for treating COVID-19 in China, recommending different recipes for different severity of the disease. The article also explores the applications of TCM in treating other viral infections, providing insights for the treatment of COVID-19.

PHARMACOLOGY & THERAPEUTICS (2021)

Editorial Material Medicine, General & Internal

A novel coronavirus outbreak of global health concern

Chen Wang et al.

LANCET (2020)

Review Medicine, Research & Experimental

Lianhua Qingwen prescription for Coronavirus disease 2019 (COVID-19) treatment: Advances and prospects

Liu-Cheng Li et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

Review Integrative & Complementary Medicine

Reflections on treatment of COVID-19 with traditional Chinese medicine

Hua Luo et al.

CHINESE MEDICINE (2020)

Review Cell Biology

Macrophage plasticity, polarization, and function in health and disease

Abbas Shapouri-Moghaddam et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2018)

Review Cell Biology

The Role of Macrophages in the Pathogenesis of ALI/ARDS

Xiaofang Huang et al.

MEDIATORS OF INFLAMMATION (2018)

Review Pharmacology & Pharmacy

Macrophage polarization in response to epigenetic modifiers during infection and inflammation

Urmi Patel et al.

DRUG DISCOVERY TODAY (2017)

Article Integrative & Complementary Medicine

The Chinese prescription lianhuaqingwen capsule exerts anti-influenza activity through the inhibition of viral propagation and impacts immune function

Yuewen Ding et al.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2017)

Review Immunology

Interleukin-4-and Interleukin-13-Mediated Alternatively Activated Macrophages: Roles in Homeostasis and Disease

Steven J. Van Dyken et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 31 (2013)

Review Multidisciplinary Sciences

Macrophage biology in development, homeostasis and disease

Thomas A. Wynn et al.

NATURE (2013)

Article Biochemistry & Molecular Biology

Pulmonary Macrophage Subpopulations in the Induction and Resolution of Acute Lung Injury

Laura K. Johnston et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2012)

Article Plant Sciences

Mechanism by which ma-xing-shi-gan-tang inhibits the entry of influenza virus

Chung-Fan Hsieh et al.

JOURNAL OF ETHNOPHARMACOLOGY (2012)

Article Biochemistry & Molecular Biology

Macrophage activation and polarization

Fernando Oneissi Martinez et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2008)