4.7 Article

IFITM3 overexpression reverses insufficient healing benefits of small extracellular vesicles from high-fat-diet BMSCs in sepsis via the HMGB1 pathway

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Immunology

Extracellular vesicles derived from mesenchymal stem cells - a novel therapeutic tool in infectious diseases

Tasaduq Manzoor et al.

Summary: Extracellular vesicles (EVs) are cell-derived nano-sized lipid-bilayer encapsulated vesicles released into the surrounding space, playing an important role in intercellular communication. In treating infectious diseases, mesenchymal stem cell-derived EVs (MSC-EVs) have shown therapeutic value by eliminating pathogens, modulating resistance, and repairing tissue damage. This is achieved by producing antimicrobial substances, inhibiting pathogen multiplication, and activating macrophage phagocytic activity. EVs also play a key role in infectious pathogenesis and hold great promise for innovative treatments.

INFLAMMATION AND REGENERATION (2023)

Article Endocrinology & Metabolism

Resveratrol mediates the miR-149/HMGB1 axis and regulates the ferroptosis pathway to protect myocardium in endotoxemia mice

Xiaoli Wang et al.

Summary: This study explored the effect of resveratrol on endotoxemia and found that resveratrol improved LPS-induced endotoxemia cardiomyocyte injury by upregulating miR-149 and inhibiting ferroptosis. It was also shown that resveratrol inhibited HMGB1 expression by upregulating miR-149. The findings suggest a potential mechanism for the therapeutic effects of resveratrol in sepsis treatment.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2022)

Article Cell & Tissue Engineering

Attenuation of Lipopolysaccharide-induced Liver Injury by Bone Marrow Mesenchymal Stem Cells via Inhibiting the NLRP3 Inflammasome and Hepatocyte Pyroptosis

Yunyu Yin et al.

Summary: This study explored the ability of BMSCs to attenuate hepatic damage in a pyroptosis-related manner in a rat model of lipopolysaccharide-induced liver injury. The results showed that BMSC transplantation significantly improved rat survival and reduced the expression of pyroptosis-related proteins.

CURRENT STEM CELL RESEARCH & THERAPY (2022)

Article Cell Biology

Single-cell dissection of the obesity-exercise axis in adipose-muscle tissues implies a critical role for mesenchymal stem cells

Jiekun Yang et al.

Summary: This study reveals the complexity of the effects of exercise training and obesity on different tissues and cell types. It identifies a significant role of mesenchymal stem cells (MSCs) in tissue adaptation induced by obesity and exercise, with pathways such as extracellular matrix remodeling and circadian rhythm being prominently regulated.

CELL METABOLISM (2022)

Article Cell Biology

Extracellular vesicles mediate the communication of adipose tissue with brain and promote cognitive impairment associated with insulin resistance

Jin Wang et al.

Summary: Adipose tissue-derived extracellular vesicles and their cargo microRNAs play a role in the communication between adipose tissue and the brain, affecting cognitive function adversely. Inhibiting the miRNAs can mitigate the negative effects on cognitive function.

CELL METABOLISM (2022)

Article Cardiac & Cardiovascular Systems

Obesity, Adipose Tissue and Vascular Dysfunction

Mascha Koenen et al.

Summary: Cardiovascular diseases, as the leading cause of death worldwide, are strongly associated with overweight and obesity, which contribute to vascular dysfunction and cardiovascular diseases. The abnormal remodeling of specific adipose tissue depots during obesity plays a critical role in the development of hypertension, endothelial dysfunction, and vascular stiffness, with fat distribution being a key determinant of the risk for cardiovascular diseases.

CIRCULATION RESEARCH (2021)

Article Immunology

IFITM3 incorporation sensitizes influenza A virus to antibody-mediated neutralization

Caroline Lanz et al.

Summary: The severity of influenza varies greatly in humans, and the IFITM3 gene is a genetic determinant responsible for these differences. IFITM3 blocks cytosolic entry of influenza A virus by competing with viral hemagglutinin incorporation into virions. This inhibition leads to increased sensitivity of IAV to antibody-mediated neutralization and affects infection outcomes.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

Article Cell Biology

MicroRNA-181b Inhibits Inflammatory Response and Reduces Myocardial Injury in Sepsis by Downregulating HMGB1

Lan Ling et al.

Summary: This study aimed to investigate the role of miR-181b in regulating inflammatory response in sepsis-induced myocardial injury through targeting HMGB1. The results showed that miR-181b directly targeted HMGB1, leading to decreased inflammatory factors, reduced myocardial injury, and inhibited cardiomyocyte apoptosis in sepsis. This suggests that a better understanding of the miR-181b-HMGB1 pathway could potentially lead to the development of novel therapeutic agents for sepsis.

INFLAMMATION (2021)

Article Medicine, Research & Experimental

microRNA-193-3p attenuates myocardial injury of mice with sepsis via STAT3/HMGB1 axis

Jianyuan Pan et al.

Summary: In septic mice, miR-193-3p expression is decreased while STAT3 expression is increased. Down-regulating STAT3 or up-regulating miR-193-3p can improve cardiac function, reduce myocardial injury, inflammation, and cardiomyocyte apoptosis in septic mice.

JOURNAL OF TRANSLATIONAL MEDICINE (2021)

Article Endocrinology & Metabolism

FOS/GOS attenuates high-fat diet induced bone loss via reversing microbiota dysbiosis, high intestinal permeability and systemic inflammation in mice

Zheng Zhang et al.

Summary: This study revealed that long-term high-fat diet can lead to decreased bone mass, dysbiosis of gut microbiota, leaky gut, and systemic inflammation. Administration of fructooligosaccharides (FOS) and/or galactooligosaccharides (GOS) significantly improved bone loss, regulated imbalanced differentiation of intestinal cells, reduced dysbiosis and gut permeability, decreased expression of inflammatory cytokines, ultimately protecting against high-fat diet-induced osteopenia.

METABOLISM-CLINICAL AND EXPERIMENTAL (2021)

Review Cell Biology

Stem cell therapy for COVID-19, ARDS and pulmonary fibrosis

Zhongwen Li et al.

CELL PROLIFERATION (2020)

Review Urology & Nephrology

Advances in the understanding and treatment of sepsis-induced immunosuppression

Fabienne Venet et al.

NATURE REVIEWS NEPHROLOGY (2018)

Article Cell Biology

Overexpression of CTRP3 protects against sepsis-induced myocardial dysfunction in mice

Wen-Ying Wei et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2018)

Article Medicine, General & Internal

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

Mervyn Singer et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2016)

Review Biochemistry & Molecular Biology

HMGB1 in health and disease

Rui Kang et al.

MOLECULAR ASPECTS OF MEDICINE (2014)

Article Critical Care Medicine

Triggering Receptor Expressed on Myeloid Cells-2 Protects against Polymicrobial Sepsis by Enhancing Bacterial Clearance

QiXing Chen et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2013)

Article Multidisciplinary Sciences

IFITM3 restricts the morbidity and mortality associated with influenza

Aaron R. Everitt et al.

NATURE (2012)

Article Virology

The IFITM Proteins Inhibit HIV-1 Infection

Jennifer Lu et al.

JOURNAL OF VIROLOGY (2011)

Article Critical Care Medicine

HMGB1 as a predictor of organ dysfunction and outcome in patients with severe sepsis

Sari Karlsson et al.

INTENSIVE CARE MEDICINE (2008)