期刊
MEDICAL HYPOTHESES
卷 182, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.mehy.2023.111211
关键词
Morphine; Pruritis; NMDA receptors; Esketamine
Morphine is commonly used and effective for pain relief, but its side effect of itching limits its clinical use. This paper discusses the potential of using esketamine to treat morphine-induced itching.
Morphine is one of the most commonly used and effective analgesic drugs in clinical practice. Morphine injected directly into the epidural and subarachnoid space acts directly on the central nervous system compared to oral or intravenous administration. This route of morphine delivery requires only a small dose to achieve satisfactory analgesia and greatly reduces the risk of adverse effects. However, morphine-induced itching significantly limits the clinical use of morphine and the maximization of its analgesic effects. Drugs commonly used worldwide to treat morphine-induced pruritus have different degrees of limitations. N-Methyl-D-aspartate (NMDA) receptors are involved in the mechanisms associated with morphine-induced itching. Theoretically, esketamine, an NMDA antagonist, which is commonly used in clinical practice to exert analgesic and sedative effects and contributes to circulatory stability, has the potential to effectively relieve morphine-induced itching without compromising its analgesic effects. In this paper, we discuss the possibility of co-administration of esketamine in cases of morphine-induced pruritus based on the current clinical situation and relevant mechanisms, with the intention of developing novel therapeutic options for morphine-induced pruritus.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据