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SEMINARS IN CANCER BIOLOGY (2023)
Doublecortin-like kinase 1 activates NF-κB to induce inflammatory responses by binding directly to IKKβ
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CELL DEATH AND DIFFERENTIATION (2023)
Macrophage DCLK1 promotes atherosclerosis via binding to IKKβ and inducing inflammatory responses
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DCLK1 Suppresses Tumor-Specific Cytotoxic T Lymphocyte Function Through Recruitment of MDSCs via the CXCL1-CXCR2 Axis
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CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2023)
Macrophage DCLK1 promotes obesity-induced cardiomyopathy via activating RIP2/TAK1 signaling pathway
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CELL DEATH & DISEASE (2023)
Targeting DCLK1 attenuates tumor stemness and evokes antitumor immunity in triple-negative breast cancer by inhibiting IL-6/STAT3 signaling
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BREAST CANCER RESEARCH (2023)
Design, synthesis and biological evaluation of novel DCLK1 inhibitor containing purine skeleton for the treatment of pancreatic cancer
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2023)
Inhibition of DCLK1 sensitizes resistant lung adenocarcinomas to EGFR-TKI through suppression of Wnt/β-Catenin activity and cancer stemness
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CANCER LETTERS (2022)
Long noncoding RNA BMPR1B-AS1 facilitates endometrial cancer cell proliferation and metastasis by sponging miR-7-2-3p to modulate the DCLK1/Akt/NF-kappa B pathway
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CELL CYCLE (2022)
Novel lissencephaly-associated DCX variants in the C-terminal DCX domain affect microtubule binding and dynamics
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EPILEPSIA (2022)
Inhibition of DCLK1 kinase reverses epithelial-mesenchymal transition and restores T-cell activity in pancreatic ductal adenocarcinoma
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Targeting DCLK1 overcomes 5-fluorouracil resistance in colorectal cancer through inhibiting CCAR1/β-catenin pathway-mediated cancer stemness
Lanqing Wang et al.
CLINICAL AND TRANSLATIONAL MEDICINE (2022)
Targeting colon cancer stem cells using novel doublecortin like kinase 1 antibody functionalized folic acid conjugated hesperetin encapsulated chitosan nanoparticles
Lizha Mary Lazer et al.
COLLOIDS AND SURFACES B-BIOINTERFACES (2022)
Doublecortin-like kinase 1 is a therapeutic target in squamous cell carcinoma
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MOLECULAR CARCINOGENESIS (2022)
DCLK1 promotes colorectal cancer stemness and aggressiveness via the XRCC5/COX2 axis
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THERANOSTICS (2022)
DCLK1, a promising colorectal cancer stem cell marker, regulates tumor progression and invasion through miR-137 and miR-15a dependent manner
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CLINICAL AND EXPERIMENTAL MEDICINE (2021)
DCLK1, a Putative Stem Cell Marker in Human Cholangiocarcinoma
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HEPATOLOGY (2021)
Structural basis for small molecule targeting of Doublecortin Like Kinase 1 with DCLK1-IN-1
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COMMUNICATIONS BIOLOGY (2021)
DCLK1 isoforms and aberrant Notch signaling in the regulation of human and murine colitis
Badal C. Roy et al.
CELL DEATH DISCOVERY (2021)
Identification of potential novel drug resistance mechanisms by genomic and transcriptomic profiling of colon cancer cells with p53 deletion
Onat Kadioglu et al.
ARCHIVES OF TOXICOLOGY (2021)
Notch signaling drives development of Barrett's metaplasia from Dclk1-positive epithelial tuft cells in the murine gastric mucosa
Bettina Kunze et al.
SCIENTIFIC REPORTS (2021)
Inhibition of DCLK1 with DCLK1-IN-1 Suppresses Renal Cell Carcinoma Invasion and Stemness and Promotes Cytotoxic T-Cell-Mediated Anti-Tumor Immunity
Ling Ding et al.
CANCERS (2021)
Autoregulatory control of microtubule binding in doublecortin-like kinase 1
Regina L. Agulto et al.
ELIFE (2021)
Doublecortin-Like Kinase 1 (DCLK1) Is a Novel NOTCH Pathway Signaling Regulator in Head and Neck Squamous Cell Carcinoma
Esther C. Broner et al.
FRONTIERS IN ONCOLOGY (2021)
DCLK1 integrates induction of TRIB3, EMT, drug resistance and poor prognosis in colorectal cancer
Shunichiro Makino et al.
CARCINOGENESIS (2020)
Inhibition of DCLK1 down-regulates PD-L1 expression through Hippo pathway in human pancreatic cancer
Rui Yan et al.
LIFE SCIENCES (2020)
DCLK1 Monoclonal Antibody-Based CAR-T Cells as a Novel Treatment Strategy against Human Colorectal Cancers
Sripathi M. Sureban et al.
CANCERS (2020)
Cancer Stem Cell Marker DCLK1 Correlates with Tumorigenic Immune Infiltrates in the Colon and Gastric Adenocarcinoma Microenvironments
Xiangyan Wu et al.
CANCERS (2020)
DCLK1-Isoform2 Alternative Splice Variant Promotes Pancreatic Tumor Immunosuppressive M2-Macrophage Polarization
Parthasarathy Chandrakesan et al.
MOLECULAR CANCER THERAPEUTICS (2020)
DCLK1 Regulates Tumor Stemness and Cisplatin Resistance in Non-small Cell Lung Cancer via ABCD-Member-4
Janani Panneerselvam et al.
MOLECULAR THERAPY-ONCOLYTICS (2020)
Discovery of a selective inhibitor of doublecortin like kinase 1
Fleur M. Ferguson et al.
NATURE CHEMICAL BIOLOGY (2020)
Resistance Mechanisms of Anti-PD1/PDL1 Therapy in Solid Tumors
Qingyang Lei et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)
DCLK1 inhibition attenuates tumorigenesis and improves chemosensitivity in esophageal squamous cell carcinoma by inhibiting β-catenin/c-Myc signaling
Lianqun Zhang et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2020)
Role of doublecortin-like kinase 1 and leucine-rich repeat-containing G-protein-coupled receptor 5 in patients with stage II/III colorectal cancer: Cancer progression and prognosis
Xue-Ling Kang et al.
WORLD JOURNAL OF GASTROENTEROLOGY (2020)
Chemical Biology Toolkit for DCLK1 Reveals Connection to RNA Processing
Yan Liu et al.
CELL CHEMICAL BIOLOGY (2020)
Whole Genome Messenger RNA Profiling Identifies a Novel Signature to Predict Gastric Cancer Survival
Jin Dai et al.
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY (2019)
Induction of let-7e gene expression attenuates oncogenic phenotype in HCT-116 colorectal cancer cells through targeting of DCLK1 regulation
Alisa Khodadadi Kohlan et al.
LIFE SCIENCES (2019)
Large-scale Discovery of Substrates of the Human Kinome
Naoyuki Sugiyama et al.
SCIENTIFIC REPORTS (2019)
Markers of pancreatic cancer stem cells and their clinical and therapeutic implications
Arkadiusz Gzil et al.
MOLECULAR BIOLOGY REPORTS (2019)
Overexpression of DCLK1-AL Increases Tumor Cell Invasion, Drug Resistance, and KRAS Activation and Can Be Targeted to Inhibit Tumorigenesis in Pancreatic Cancer
Dongfeng Qu et al.
JOURNAL OF ONCOLOGY (2019)
Dclk1 in tuft cells promotes inflammation-driven epithelial restitution and mitigates chronic colitis
Jun Yi et al.
CELL DEATH AND DIFFERENTIATION (2019)
EMT Transition States during Tumor Progression and Metastasis
Ievgenia Pastushenko et al.
TRENDS IN CELL BIOLOGY (2019)
Evaluation of the cancer stem cell marker DCLK1 in patients with lymph node metastases of head and neck cancer
Lorenz Kadletz et al.
PATHOLOGY RESEARCH AND PRACTICE (2019)
Modified miR-15a has therapeutic potential for improving treatment of advanced stage colorectal cancer through inhibition of BCL2, BMI1, YAP1 and DCLK1
Andrew Fesler et al.
ONCOTARGET (2018)
Gene expression profile of Dclk1(+) cells in intestinal tumors
Yuichi Yamaga et al.
DIGESTIVE AND LIVER DISEASE (2018)
Immune Cell Production of Interleukin 17 Induces Stem Cell Features of Pancreatic Intraepithelial Neoplasia Cells
Yu Zhang et al.
GASTROENTEROLOGY (2018)
Alternative splice variants of DCLK1 mark cancer stem cells, promote self-renewal and drug-resistance, and can be targeted to inhibit tumorigenesis in kidney cancer
Yang Ge et al.
INTERNATIONAL JOURNAL OF CANCER (2018)
Dclk1 Inhibition Cancels 5-FU-induced Cell-cycle Arrest and Decreases Cell Survival in Colorectal Cancer
Yuki Suehiro et al.
ANTICANCER RESEARCH (2018)
Doublecortin-Like Kinase 1 (DCLK1) Regulates B Cell-Specific Moloney Murine Leukemia Virus Insertion Site 1 (Bmi-1) and is Associated with Metastasis and Prognosis in Pancreatic Cancer
Jian Li et al.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)
MicroRNA-424 inhibits cell migration, invasion, and epithelial mesenchymal transition by downregulating doublecortin-like kinase 1 in ovarian clear cell carcinoma
Xin Wu et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2017)
Doublecortin and CaM kinase-like-1 expression in pathological stage I non-small cell lung cancer
Hiroyuki Tao et al.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2017)
A novel antibody against cancer stem cell biomarker, DCLK1-S, is potentially useful for assessing colon cancer risk after screening colonoscopy
Shubhashish Sarkar et al.
LABORATORY INVESTIGATION (2017)
Dclk1, a tumor stem cell marker, regulates pro-survival signaling and self-renewal of intestinal tumor cells
Parthasarathy Chandrakesan et al.
MOLECULAR CANCER (2017)
Pancreatic Neuroendocrine Tumors and EMT Behavior Are Driven by the CSC Marker DCLK1
Yu Ikezono et al.
MOLECULAR CANCER RESEARCH (2017)
Enhancement of cytotoxic effects of gemcitabine by Dclk1 inhibition through suppression of Chk1 phosphorylation in human pancreatic cancer cells
Daichi Kawamura et al.
ONCOLOGY REPORTS (2017)
Role of cancer stem-cell marker doublecortin-like kinase 1 in head and neck squamous cell carcinoma
Lorenz Kadletz et al.
ORAL ONCOLOGY (2017)
COX2/mPGES1/PGE2 pathway regulates PD-L1 expression in tumor-associated macrophages and myeloid-derived suppressor cells
Victor Prima et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
DCAMKL1 is associated with the malignant status and poor outcome in bladder cancer
Shiqing Zhang et al.
TUMOR BIOLOGY (2017)
Lgr5High/DCLK1High phenotype is more common in early stage and intestinal subtypes of gastric carcinomas
Elham Kalantari et al.
CANCER BIOMARKERS (2017)
MicroRNA-195 Suppresses the Progression of Pancreatic Cancer by Targeting DCLK1
Bin Zhou et al.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2017)
Doublecortin-like kinase 1 is a novel biomarker for prognosis and regulates growth and metastasis in basal-like breast cancer
Yuetao Lv et al.
BIOMEDICINE & PHARMACOTHERAPY (2017)
Survival of Patients with Gastrointestinal Cancers Can Be Predicted by a Surrogate microRNA Signature for Cancer Stem-like Cells Marked by DCLK1 Kinase
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CANCER RESEARCH (2016)
Dclk1 Defines Quiescent Pancreatic Progenitors that Promote Injury-Induced Regeneration and Tumorigenesis
C. Benedikt Westphalen et al.
CELL STEM CELL (2016)
Inhibition of Notch rescues the angiogenic potential impaired by cardiovascular risk factors in epicardial adipose stem cells
Maria Teresa Bejar et al.
FASEB JOURNAL (2016)
DCLK1 is up-regulated and associated with metastasis and prognosis in colorectal cancer
Tianbo Gao et al.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2016)
miR-137 Regulates the Tumorigenicity of Colon Cancer Stem Cells through the Inhibition of DCLK1
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MOLECULAR CANCER RESEARCH (2016)
Biochemical and Structural Insights into Doublecortin-like Kinase Domain 1
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STRUCTURE (2016)
Dominant Expression of DCLK1 in Human Pancreatic Cancer Stem Cells Accelerates Tumor Invasion and Metastasis
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PLOS ONE (2016)
Intestinal tuft cells regulate the ATM mediated DNA Damage response via Dclk1 dependent mechanism for crypt restitution following radiation injury
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SCIENTIFIC REPORTS (2016)
Doublecortin-Like Kinases Promote Neuronal Survival and Induce Growth Cone Reformation via Distinct Mechanisms
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NEURON (2015)
Plasma DCLK1 is a marker of hepatocellular carcinoma (HCC): Targeting DCLK1 prevents HCC tumor xenograft growth via a microRNA-dependent mechanism
Sripathi M. Sureban et al.
ONCOTARGET (2015)
Inflammatory and oncogenic roles of a tumor stem cell marker doublecortin-like kinase (DCLK1) in virus-induced chronic liver diseases
Naushad Ali et al.
ONCOTARGET (2015)
DCLK1 is a broadly dysregulated target against epithelial-mesenchymal transition, focal adhesion, and stemness in clear cell renal carcinoma
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ONCOTARGET (2015)
Epigenetic changes and alternate promoter usage by human colon cancers for expressing DCLK1-isoforms: Clinical Implications
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SCIENTIFIC REPORTS (2015)
Doublecortin-Like Kinase 1 Is Elevated Serologically in Pancreatic Ductal Adenocarcinoma and Widely Expressed on Circulating Tumor Cells
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PLOS ONE (2015)
Ablation of Doublecortin-Like Kinase 1 in the Colonic Epithelium Exacerbates Dextran Sulfate Sodium-Induced Colitis
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PLOS ONE (2015)
Inhibition of Notch signaling reduces the number of surviving Dclk1+ reserve crypt epithelial stem cells following radiation injury
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AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2014)
Epigenetics of cancer stem cells: Pathways and therapeutics
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BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2014)
XMD8-92 inhibits pancreatic tumor xenograft growth via a DCLK1-dependent mechanism
Sripathi M. Sureban et al.
CANCER LETTERS (2014)
The DNA damage response: The omics era and its impact
Kasper W. J. Derks et al.
DNA REPAIR (2014)
DCLK1 Marks a Morphologically Distinct Subpopulation of Cells With Stem Cell Properties in Preinvasive Pancreatic Cancer
Jennifer M. Bailey et al.
GASTROENTEROLOGY (2014)
Small molecule kinase inhibitor LRRK2-IN-1 demonstrates potent activity against colorectal and pancreatic cancer through inhibition of doublecortin-like kinase 1
Nathaniel Weygant et al.
MOLECULAR CANCER (2014)
Brief Report: Dclk1 Deletion in Tuft Cells Results in Impaired Epithelial Repair After Radiation Injury
Randal May et al.
STEM CELLS (2014)
Dclk1 distinguishes between tumor and normal stem cells in the intestine
Yuki Nakanishi et al.
NATURE GENETICS (2013)
DCLK1 Regulates Pluripotency and Angiogenic Factors via microRNA-Dependent Mechanisms in Pancreatic Cancer
Sripathi M. Sureban et al.
PLOS ONE (2013)
Discovery of a benzo[e]pyrimido-[5,4-b][1,4]diazepin-6(11H)-one as a Potent and Selective Inhibitor of Big MAP Kinase 1
Xianming Deng et al.
ACS MEDICINAL CHEMISTRY LETTERS (2011)
Variants in Doublecortin- and Calmodulin Kinase Like 1, a Gene Up-Regulated by BDNF, Are Associated with Memory and General Cognitive Abilities
Stephanie Le Hellard et al.
PLOS ONE (2009)
Molecular identification and characterization of a family of kinases with homology to Ca2+/calmodulin-dependent protein kinases I/IV
Shogo Ohmae et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
doublecortin-like kinase functions with doublecortin to mediate fiber tract decussation and neuronal migration
H Koizumi et al.
NEURON (2006)
Doublecortin-like kinase controls neurogenesis by regulating mitotic spindles and M phase progression
TZ Shu et al.
NEURON (2006)
Catalytic and regulatory domains of doublecortin kinase-1
LM Shang et al.
BIOCHEMISTRY (2003)
Alternative splice variants of doublecortin-like kinase are differentially expressed and have different kinase activities
HA Burgess et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Caspase-mediated cleavage of the Ca2+/calmodulin-dependent protein kinase-like kinase facilitates neuronal apoptosis
M Kruidering et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Cleavage of doublecortin-like kinase by calpain releases an active kinase fragment from a microtubule anchorage domain
HA Burgess et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Interaction between LIS1 and doublecortin, two lissencephaly gene products
M Caspi et al.
HUMAN MOLECULAR GENETICS (2000)
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