4.7 Article

Epigenetic downregulation of O6-methylguanine-DNA methyltransferase contributes to chronic hexavalent chromium exposure-caused genotoxic effect and cell transformation

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Genetics & Heredity

The dual role of DNA repair protein MGMT in cancer prevention and treatment

Peiying Bai et al.

Summary: Alkylating agents are genotoxic chemicals that induce and treat cancer by bonding with cellular macromolecules, particularly DNA. O6-alkylguanine (O6-AlkylG) adducts are the most potent DNA lesions. If not repaired correctly, these adducts can cause DNA mutations, chromosome aberrations, and cell death. O6-methylguanine-DNA methyltransferase (MGMT) can remove alkyl groups from O6-AlkylG adducts and prevent the adverse biological effects. However, MGMT can also protect tumor cells from chemotherapy. It is important to explore the clinical exploitation of MGMT as a therapeutic target.

DNA REPAIR (2023)

Review Environmental Sciences

A review of chromium (Cr) epigenetic toxicity and health hazards

Mahalaxmi Iyer et al.

Summary: Carcinogenic metals, particularly chromium (Cr) and its derivatives, including Cr(VI)-induced, have widespread distribution and pose a concern for adverse environmental and human health effects. They cause DNA epigenetic alterations resulting in heritable changes in gene expression. This review discusses the role of Cr(VI) in epigenetic changes, highlighting the importance of considering epigenetics as a possible mechanism underlying Cr(VI) toxicity and cell-transforming ability. More clinical and preventative measures are needed to better understand the toxicity and safeguard employees against cancer.

SCIENCE OF THE TOTAL ENVIRONMENT (2023)

Article Toxicology

Chronic Hexavalent Chromium Exposure Upregulates the RNA Methyltransferase METTL3 Expression to Promote Cell Transformation, Cancer Stem Cell-Like Property, and Tumorigenesis

Zhishan Wang et al.

Summary: This study reveals that chronic exposure to hexavalent chromium can alter cellular epitranscriptome by increasing m(6)A RNA modification through upregulation of the RNA methyltransferase METTL3 expression, which plays an important role in Cr(VI)-induced cell transformation, CSC-like property, and tumorigenesis.

TOXICOLOGICAL SCIENCES (2022)

Review Biochemistry & Molecular Biology

The Epitranscriptomic Mechanism of Metal Toxicity and Carcinogenesis

Chengfeng Yang et al.

Summary: Metals are common toxic environmental pollutants that cause severe adverse health effects and even cancer. The emerging field of epitranscriptomic study provides new insights into the mechanisms of metal toxicity and carcinogenesis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Chemistry, Multidisciplinary

Nanoparticle-delivered miriplatin ultrasmall dots suppress triple negative breast cancer lung metastasis by targeting circulating tumor cells

Yunfei Li et al.

Summary: The study developed a novel ultrasmall Pt(II) dot that displayed superior DNA damage capability and significantly reduced the CSC-like properties of TNBC cells, as well as targeted circulating tumor cells in vivo to suppress breast cancer metastasis. The ultrasmall Pt(II) dots represent a promising therapeutic agent for reducing cancer metastasis through metal-based nanomedicines.

JOURNAL OF CONTROLLED RELEASE (2021)

Article Pharmacology & Pharmacy

Down-regulation of lncRNA MEG3 promotes chronic low dose cadmium exposure-induced cell transformation and cancer stem cell-like property

Hsuan-Pei Lin et al.

Summary: This study found that chronic exposure to cadmium can reduce the expression of tumor suppressive lncRNA MEG3, promoting cell transformation and cancer stem cell-like properties. By regulating cell cycle progression and apoptosis resistance, down-regulation of MEG3 plays an important role in cadmium-induced malignant cell transformation.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2021)

Article Biochemistry & Molecular Biology

Chromate exposure induces DNA hypermethylation of the mismatch repair gene MLH1 in lung cancer

Mitsuhiro Tsuboi et al.

MOLECULAR CARCINOGENESIS (2020)

Review Biotechnology & Applied Microbiology

Epigenetic regulation of DNA repair genes and implications for tumor therapy

Markus Christmann et al.

MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH (2019)

Article Pharmacology & Pharmacy

Molecular and epigenetic mechanisms of Cr(VI)-induced carcinogenesis

Qiao Yi Chen et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2019)

Review Clinical Neurology

MGMT testing-the challenges for biomarker-based glioma treatment

Wolfgang Wick et al.

NATURE REVIEWS NEUROLOGY (2014)

Article Cell & Tissue Engineering

Mesenchymal Stem Cells Cancel Azoxymethane-Induced Tumor Initiation

Masanao Nasuno et al.

STEM CELLS (2014)

Review Oncology

Use of the γ-H2AX assay to monitor DNA damage and repair in cancer research

Alesia Ivashkevich et al.

CANCER LETTERS (2012)

Review Biotechnology & Applied Microbiology

O6-methylguanine-DNA methyltransferase (MGMT): impact on cancer risk in response to tobacco smoke

Markus Christmann et al.

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2012)

Article Biochemistry & Molecular Biology

Aberrant DNA Methylation of Some Tumor Suppressor Genes in Lung Cancers From Workers With Chromate Exposure

Abdellah H. K. Ali et al.

MOLECULAR CARCINOGENESIS (2011)

Article Environmental Sciences

Hexavalent Chromium-Induced DNA Damage and Repair Mechanisms

Sandra S. Wise et al.

REVIEWS ON ENVIRONMENTAL HEALTH (2011)

Article Biochemistry & Molecular Biology

Epigenetic silencing of the MGMT gene in cancer

H Soejima et al.

BIOCHEMISTRY AND CELL BIOLOGY (2005)

Review Chemistry, Medicinal

Importance of chromium-DNA adducts in mutagenicity and toxicity of chromium(VI)

A Zhitkovich

CHEMICAL RESEARCH IN TOXICOLOGY (2005)

Review Oncology

MGMT: Its role in cancer aetiology and cancer therapeutics

SL Gerson

NATURE REVIEWS CANCER (2004)

Review Biochemistry & Molecular Biology

Oxidative stress and apoptosis in metal ion-induced carcinogenesis

HL Shi et al.

FREE RADICAL BIOLOGY AND MEDICINE (2004)

Article Multidisciplinary Sciences

Spontaneous hepatocellular carcinoma is reduced in transgenic mice overexpressing human O6-methylguanine-DNA methyltransferase

ZQ Zhou et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)