期刊
JOURNAL OF GINSENG RESEARCH
卷 40, 期 3, 页码 285-291出版社
KOREAN SOC GINSENG
DOI: 10.1016/j.jgr.2015.09.005
关键词
endothelial nitric oxide synthase; mitogen-activated protein kinases; nitric oxide; pulmonary hypertension; total ginsenoside
资金
- National Natural Science Foundation of China [81472038, 81370899, 81222026, 81170741, 81071440/H0601]
- New Century Excellent Talents from the Ministry of Education, China [NCET-11-0437]
Background: Ginsenosides have been shown to exert beneficial pharmacological effects on the central nervous, cardiovascular, and endocrine systems. We sought to determine whether total ginsenosides (TG) inhibit monocrotaline (MCT)-induced pulmonary hypertension and to elucidate the underlying mechanism. Methods: MCT-intoxicated rats were treated with gradient doses of TG, with or without NG-nitro-Larginine methyl ester. The levels of molecules involving the regulation of nitric oxide and mitogen-activated protein kinase pathways were determined. Results: TG ameliorated MCT-induced pulmonary hypertension in a dose-dependent manner, as assessed by the right ventricular systolic pressure, the right ventricular hypertrophy index, and pulmonary arterial remodeling. Furthermore, TG increased the levels of pulmonary nitric oxide, endothelial nitric oxide synthase, and cyclic guanosine monophosphate. Lastly, TG increased mitogen-activated protein kinase phosphatase-1 expression and promoted the dephosphorylation of extracellular signal-regulated protein kinases 1/2, p38 mitogen-activated protein kinase, and c-Jun NH2-terminal kinase 1/2. Conclusion: TG attenuates MCT-induced pulmonary hypertension, which may involve in part the regulation of nitric oxide and mitogen-activated protein kinase pathways. Copyright (C) 2015, The Korean Society of Ginseng, Published by Elsevier.
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