☆ 4.4 Review

Cardiovascular diseases crossroads: cGAS-STING signaling and disease progression

CURRENT PROBLEMS IN CARDIOLOGY (2024)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Cell Biology

Lipotoxicity-induced mtDNA release promotes diabetic cardiomyopathy by activating the cGAS-STING pathway in obesity-related diabetes

Xiu Mei Ma et al.

Summary: The cytosolic mtDNA-induced cGAS-STING activation plays a critical role in the pathogenesis of obesity-related DCM. Increased mtDNA in the cytosol is a result of excessive mitochondrial ROS production, leading to the activation of the cGAS/STING system and subsequent inflammation and apoptosis. Inhibition or knockdown of STING can effectively block the progression of DCM.

CELL BIOLOGY AND TOXICOLOGY (2023)

添加到收藏夹

Review Pharmacology & Pharmacy

The cGAS-STING Pathway: A Ubiquitous Checkpoint Perturbing Myocardial Attributes

Xueqi Wan et al.

Summary: The cGAS-STING signaling pathway is closely linked to cardiovascular diseases, as it not only participates in inflammatory responses and enhances the expression of pro-inflammatory genes, but also interacts with other pathophysiological activities such as autophagy and apoptosis. In recent decades, researchers have investigated the relationship between the activation of the cGAS-STING pathway and the development of cardiovascular diseases, finding that its overactivation or suppression can lead to myocardial damage. This review focuses on the interplay between the cGAS-STING pathway and other pathways, providing new insights for the treatment of cardiomyopathy.

CURRENT VASCULAR PHARMACOLOGY (2023)

添加到收藏夹

Review Biochemistry & Molecular Biology

How the Innate Immune DNA Sensing cGAS-STING Pathway Is Involved in Apoptosis

Wanglong Zheng et al.

Summary: The cGAS-STING signaling axis is activated by cytosolic DNA, both non-self and self DNA. This pathway is used by the innate immune system to monitor invading pathogens and/or damage. It not only facilitates inflammatory responses and IFN production, but also activates other cellular processes like apoptosis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

Injectable Polyzwitterionic Lubricant for Complete Prevention of Cardiac Adhesion

Yi Wang et al.

Summary: After cardiac surgery, adhesion between the heart and its surrounding tissues can occur, leading to limited cardiac function, decreased surgical quality, and increased bleeding risk. To overcome this, an injectable polyzwitterionic lubricant was developed to prevent adhesion and maintain normal heart function. The lubricant was evaluated in a rat heart adhesion model and showed promising results in preventing adhesion and maintaining lubricating properties and biocompatibility.

MACROMOLECULAR BIOSCIENCE (2023)

添加到收藏夹

Review Immunology

Function and regulation of cGAS-STING signaling in infectious diseases

Yang Du et al.

Summary: The DNA-sensing receptor cGAS and its downstream signaling adaptor STING play crucial roles in immune defense against infectious pathogens, and the interplay between the cGAS-STING pathway and pathogens provides insight into the development of pharmacological approaches for treating infectious diseases.

FRONTIERS IN IMMUNOLOGY (2023)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Nanoparticle: A Promising Player in Nanomedicine and its Theranostic Applications for the Treatment of Cardiovascular Diseases

Sumbul Saeed et al.

Summary: Cardiovascular diseases (CVDs) are the leading cause of death worldwide, and this trend will continue to increase. With the development of nanotechnology, innovative nanoparticles (NPs) have been effectively used for disease diagnosis and treatment. This review focuses on the recent advances in NPs synthesis for imaging, diagnosis, and treatment of CVDs. NPs serve as carriers for drug delivery, reaching different areas of the heart and arteries, making them potential therapeutic agents for CVDs. The article also discusses the current challenges and limitations in detecting CVDs.

CURRENT PROBLEMS IN CARDIOLOGY (2023)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Genome Editing Technology: A New Frontier for the Treatment and Prevention of Cardiovascular Diseases

Sumbul Saeed et al.

Summary: Over the past 2 decades, genome-editing technique has revolutionized biomedicine by generating disease-resistance models, treating and preventing various diseases, and enabling the manipulation of desired genes. The CRISPR/Cas9 system, a versatile and novel tool, has overcome the limitations of other genome editing techniques and has potential applications in treating cardiovascular diseases (CVDs). Newly developed base editing and prime editing techniques have further expanded the accuracy range for treating CVDs.

CURRENT PROBLEMS IN CARDIOLOGY (2023)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

A Comprehensive Review: Epidemiological Strategies, Catheterization and Biomarkers used as a Bioweapon in Diagnosis and Management of Cardio Vascular Diseases

Ali Abbas et al.

Summary: Coronary artery disease (CAD) is a serious health problem leading to significant mortality globally. Atherosclerosis and thrombosis are the main pathophysiological pathways involved in acute coronary syndrome (ACS). Medication therapy, including antiplatelet agents, nitrates, calcium antagonists, and blockers, is commonly used for angina relief in CAD. Biomarkers play a crucial role in the diagnosis and management of CAD.

CURRENT PROBLEMS IN CARDIOLOGY (2023)

添加到收藏夹

Review Oncology

Role of the cGAS-STING pathway in radiotherapy for non-small cell lung cancer

Chunsheng Yang et al.

Summary: Radiotherapy is a crucial intervention for non-small cell lung cancer, with ionizing radiation acting as a direct cytotoxic agent against cancer cells and also inducing antitumor immunological responses. A better understanding of the immunological pathways created by radiation can determine the most effective therapeutic combinations and enhance treatment outcomes for resistant malignancies.

RADIATION ONCOLOGY (2023)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Crafting a Blueprint for MicroRNA in Cardiovascular Diseases (CVDs)

Shahid Ullah Khan et al.

Summary: Cardiovascular diseases (CVDs) are a group of disorders that include various complications leading to heart failure. Gene and microRNA (miRNA) expression variations play significant roles in CVD progression. MiRNAs serve as regulators of gene expression and have potential as diagnostic biomarkers and therapeutic targets in CVDs. This study focuses on the latest advancements in identifying and characterizing microRNAs, exploring their manipulation and clinical application, and discussing future perspectives.

CURRENT PROBLEMS IN CARDIOLOGY (2023)

添加到收藏夹

Article Engineering, Biomedical

Endoscope image mosaic based on pyramid ORB

Ziyan Zhang et al.

Summary: This paper introduces an improved ORB algorithm using Gaussian Pyramid for endoscopic image mosaic, which achieves high accuracy, efficiency, and real-time performance.

BIOMEDICAL SIGNAL PROCESSING AND CONTROL (2022)

添加到收藏夹

Article Medicine, Research & Experimental

Small molecule STING inhibition improves myocardial infarction remodeling

Lavinia Rech et al.

Summary: This study investigated the protective effects of pharmacologic STING inhibition after myocardial infarction. The results showed that pharmacologic STING inhibition can reduce infarct expansion and scarring, improve left ventricular systolic function, and attenuate myocardial hypertrophy. This suggests that selective small-molecule STING inhibition has the potential to improve wound healing responses and pathological remodeling after myocardial infarction.

LIFE SCIENCES (2022)

添加到收藏夹

Review Pharmacology & Pharmacy

The cGAS-STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy

Patrick Kwabena Oduro et al.

Summary: The cGAS-STING signaling pathway is closely related to cardiovascular and metabolic disorders and plays an important regulatory role in various sterile inflammatory diseases. Studying this signaling pathway is of great significance for understanding the relationship between cardiovascular and metabolic tissues and diseases.

ACTA PHARMACEUTICA SINICA B (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

Recent progress in the mechanistic understanding of NET formation in neutrophils

Ming-Lin Liu et al.

Summary: The article discusses the formation of neutrophil extracellular traps (NETs) and their relationship with immune, autoimmune responses, and the development of various human diseases. It emphasizes the anti-infective role of externalized chromatin in animals ranging from lower invertebrates to higher vertebrates, while also pointing out potential issues in higher vertebrate animals.

FEBS JOURNAL (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

Potential cardioprotective effect of octreotide via NOXs mitigation, mitochondrial biogenesis and MAPK/Erk1/2/STAT3/NF-kβ pathway attenuation in isoproterenol-induced myocardial infarction in rats

Asmaa A. Khalifa et al.

Summary: This study investigated the cardioprotective effect of octreotide in myocardial infarction (MI), and found that octreotide has dose-dependent cardioprotective properties through its antioxidant, anti-inflammatory, and anti-apoptotic capabilities.

EUROPEAN JOURNAL OF PHARMACOLOGY (2022)

添加到收藏夹

Article Immunology

The selective STING inhibitor H-151 preserves myocardial function and ameliorates cardiac fibrosis in murine myocardial infarction

Shiyu Hu et al.

Summary: The selective STING inhibitor H-151 can alleviate myocardial infarction (MI) injury and cardiac fibrosis by inhibiting the type I interferon response triggered by cardiac dsDNA.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

添加到收藏夹

Article Neurosciences

Neurogenesis and Proliferation of Neural Stem/Progenitor Cells Conferred by Artesunate via FOXO3a/p27Kip1 Axis in Mouse Stroke Model

Kaiyuan Zhang et al.

Summary: This study demonstrates that treatment with artesunate promotes neurogenesis and proliferation of endogenous neural stem/progenitor cells (NSPCs), leading to functional recovery after stroke through rescuing ischemia/reperfusion damage and alleviating white matter injury.

MOLECULAR NEUROBIOLOGY (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Serum Metal Ion-Induced Cross-Linking of Photoelectrochemical Peptides and Circulating Proteins for Evaluating Cardiac Ischemia/Reperfusion

Panpan Hao et al.

Summary: Patients who have experienced the ischemia-reperfusion process are at a higher risk of subsequent heart attacks. A novel assay using synthetic small molecules for detecting free copper ions and cathepsin G in serum has shown potential for evaluating the severity and prognosis of cardiac ischemia/reperfusion.

ACS SENSORS (2022)

添加到收藏夹

Article Cell Biology

Mitochondrial damage and activation of the cytosolic DNA sensor cGAS-STING pathway lead to cardiac pyroptosis and hypertrophy in diabetic cardiomyopathy mice

Meiling Yan et al.

Summary: This study found that the cGAS-STING signaling pathway is activated in diabetic hearts, leading to the activation of the NLRP3 inflammasome and release of proinflammatory cytokines. Knockdown of STING can alleviate cardiac pyroptosis and inflammation, and prevent diabetes-induced cardiac hypertrophy.

CELL DEATH DISCOVERY (2022)

添加到收藏夹

Article Immunology

Activating cGAS-STING axis contributes to neuroinflammation in CVST mouse model and induces inflammasome activation and microglia pyroptosis

Rui Ding et al.

Summary: The study demonstrates that inhibiting the cGAS-STING pathway can reduce neuroinflammation in CVST and may serve as a potential therapeutic approach for CVST-related pathologies.

JOURNAL OF NEUROINFLAMMATION (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Targeting loop3 of sclerostin preserves its cardiovascular protective action and promotes bone formation

Yuanyuan Yu et al.

Summary: This study demonstrates that sclerostin has different mechanisms in protecting the cardiovascular system and inhibiting bone formation. By targeting sclerostin loop3, a drug can promote bone formation without affecting the cardiovascular system.

NATURE COMMUNICATIONS (2022)

添加到收藏夹

Review Medicine, Research & Experimental

Ferroptosis and its role in cardiomyopathy

Danlei Li et al.

Summary: Heart disease is the leading cause of death globally. Cardiomyopathy, a type of heart disease, is characterized by heart muscle damage that leads to structural and functional changes in the heart, resulting in heart failure and sudden cardiac death. The loss of cardiomyocytes is a key factor in the development of cardiomyopathy, and recent studies have highlighted the role of ferroptosis, a regulated form of cell death involving iron accumulation and lipid peroxidation, in this disease.

BIOMEDICINE & PHARMACOTHERAPY (2022)

添加到收藏夹

Article Microbiology

Gut microbiome dysbiosis contributes to abdominal aortic aneurysm by promoting neutrophil extracellular trap formation

Zhenyu Tian et al.

Summary: This study reveals significant abnormalities in the gut microbe composition of abdominal aortic aneurysm (AAA) patients and confirms that gut microbiota dysbiosis is an important cause of AAA. The researchers found that a specific bacterium and its metabolite can alleviate AAA development.

CELL HOST & MICROBE (2022)

添加到收藏夹

Article Chemistry, Analytical

Usefulness of enzyme-free and enzyme-resistant detection of complement component 5 to evaluate acute myocardial infarction

Lei Zhou et al.

Summary: This research presents a new method for detecting the C5 protein using synthetic probes and metal ion-catalyzed cross-linking reaction. The method successfully detects C5 in blood samples from healthy individuals, patients with unstable angina, and those with acute myocardial infarction. The signal response is higher in patients with acute myocardial infarction and correlates with cardiac remodeling and dysfunction. This method shows potential as a fast and low-cost kit for C5 detection in myocardial infarction-related scenarios.

SENSORS AND ACTUATORS B-CHEMICAL (2022)

添加到收藏夹

Article Medicine, Research & Experimental

Therapeutic aptamer targeting sclerostin loop3 for promoting bone formation without increasing cardiovascular risk in osteogenesis imperfecta mice

Luyao Wang et al.

Summary: The sclerostin loop3-specific aptamer Apc001PE has been shown to promote bone formation without increasing cardiovascular risk in osteogenesis imperfecta (OI) mice, as granted orphan drug designation by US-FDA in 2019.

THERANOSTICS (2022)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

The Link Between Ferroptosis and Cardiovascular Diseases: A Novel Target for Treatment

Huilin Hu et al.

Summary: Ferroptosis is an iron-dependent form of cell death that is closely associated with various cardiovascular diseases, suggesting it could be a potential therapeutic target.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

The Innate Immune cGAS-STING-Pathway in Cardiovascular Diseases - A Mini Review

Lavinia Rech et al.

Summary: Recent studies have shown that the cGAS-STING pathway is involved in cardiovascular diseases, particularly in response to pathogens. Additionally, self-DNA released during conditions like obesity or myocardial infarction may also activate this pathway. Further research is needed to better understand the interaction of cGAS-STING with cardiovascular risk factors and disease.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

添加到收藏夹

Article Cell Biology

Synergistic inflammatory signaling by cGAS may be involved in the development of atherosclerosis

Guan-Feng Lu et al.

Aging-US (2021)

添加到收藏夹

Article Engineering, Biomedical

An improved method for soft tissue modeling

Yushan Tang et al.

Summary: The study combined the finite element method with mass-spring model to estimate parameters and determine the soft tissue model using real measurement data. The improved model can better consider timeliness and accuracy, and accurately simulate soft tissue, showing higher data fitting and smaller force values under the same displacement.

BIOMEDICAL SIGNAL PROCESSING AND CONTROL (2021)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Bending the Curve in Cardiovascular Disease Mortality Bethesda+40 and Beyond

David Calvin Goff et al.

Summary: More than 40 years after the 1978 Bethesda Conference on the Declining Mortality from Coronary Heart Disease provided a blueprint for understanding declining rates of coronary heart disease, recent data suggests that the decline may have ended or even reversed. While mortality rates for overall cardiovascular disease are decelerating, those for heart failure are increasing. The symposium discussed trends in cardiovascular disease, obesity, and diabetes epidemics, as well as opportunities for promoting cardiovascular health and preventing disease.

CIRCULATION (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Long noncoding RNA p21 enhances autophagy to alleviate endothelial progenitor cells damage and promote endothelial repair in hypertension through SESN2/AMPK/TSC2 pathway

Chao Li et al.

Summary: The number and function of EPCs are significantly decreased in hypertensive patients, with decreased autophagy being responsible for senescence and damage. LncRNA-p21 plays a critical role in regulating EPC senescence and dysfunction, and its activation of the SESN2/AMPK/TSC2 pathway enhances autophagy to protect against AngII-induced EPC damage, making it a potential therapeutic target for vascular endothelial repair in hypertension.

PHARMACOLOGICAL RESEARCH (2021)

添加到收藏夹

Review Neurosciences

Signaling by cGAS-STING in Neurodegeneration, Neuroinflammation, and Aging

Bindu D. Paul et al.

Summary: Recognition of foreign or misplaced nucleic acids is crucial for immune system to detect pathogens. The cGAS-STING pathway plays a key role in this process, but excessive engagement may lead to neuroinflammation and disease progression.

TRENDS IN NEUROSCIENCES (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Deep learning-based predictive identification of neural stem cell differentiation

Yanjing Zhu et al.

Summary: The differentiation of neural stem cells into neurons is crucial for potential cell-based therapeutic strategies for CNS diseases. Using deep learning, researchers have developed a reliable model for predicting NSCs fate, demonstrating high precision in identifying differentiated cell types early in culture and applicability across various inducers.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Arginine methyltransferase PRMT5 negatively regulates cGAS-mediated antiviral immune response

Dapeng Ma et al.

Summary: PRMT5 catalyzes arginine symmetrical dimethylation of cGAS, attenuating the antiviral immune response by blocking cGAS' DNA binding ability. Inhibitors of PRMT5 protect mice from HSV-1 infection and prolong their survival time, indicating the potential of modulating PRMT5 as an antiviral strategy.

SCIENCE ADVANCES (2021)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

STING, a cytosolic DNA sensor, plays a critical role in atherogenesis: a link between innate immunity and chronic inflammation caused by lifestyle-related diseases

Phuong Tran Pham et al.

Summary: The study indicates that the stimulator of interferon genes (STING) plays a role in atherosclerosis, and its signaling may serve as a potential therapeutic target for the disease by inhibiting STING activation to improve atherosclerosis progression.

EUROPEAN HEART JOURNAL (2021)

添加到收藏夹

Article Public, Environmental & Occupational Health

Is Health Contagious?-Based on Empirical Evidence From China Family Panel Studies' Data

Feng Hu et al.

Summary: The study found that the health level of others in the community has a significant positive impact on individual self-rated health, indicating that health is contagious. The contagion effect of health varies with different groups and regions, showing heterogeneity in its effects.

FRONTIERS IN PUBLIC HEALTH (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Atractylenolide I enhances responsiveness to immune checkpoint blockade therapy by activating tumor antigen presentation

Hanchen Xu et al.

Summary: The compound atractylenolide I (ATT-I) has been found to enhance tumor antigen presentation and boost the cytotoxic response of CD8(+) T cells by targeting the function of the immunoproteasome, ultimately improving the tumor response to immunotherapy.

JOURNAL OF CLINICAL INVESTIGATION (2021)

添加到收藏夹

Review Immunology

The cGAS-STING pathway as a therapeutic target in inflammatory diseases

Alexiane Decout et al.

Summary: The cGAS-STING signaling pathway plays a crucial role in inflammation in infection, cellular stress, and tissue damage settings. It has the ability to sense and regulate cellular responses to DNA and has the potential to be targeted in the treatment of various inflammatory diseases.

NATURE REVIEWS IMMUNOLOGY (2021)

添加到收藏夹

Review Medicine, Research & Experimental

Ferroptosis as a novel therapeutic target for cardiovascular disease

Xiaoguang Wu et al.

Summary: Cell death is a significant factor in cardiovascular disease pathophysiology. Ferroptosis, a regulated cell death form characterized by iron overload and lipid hydroperoxide accumulation, is closely associated with various diseases and plays critical roles in cardiomyopathy, myocardial infarction, ischemia/reperfusion injury, and heart failure. Targeting ferroptosis may offer potential novel therapeutic strategies for cardiovascular diseases.

THERANOSTICS (2021)

添加到收藏夹

Review Oncology

Cellular senescence and senescence-associated secretory phenotype via the cGAS-STING signaling pathway in cancer

Tze Mun Loo et al.

CANCER SCIENCE (2020)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Cytosolic DNA sensor cGAS plays an essential pathogenetic role in pressure overload-induced heart failure

Dan Hu et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2020)

添加到收藏夹

Article Medicine, Research & Experimental

STING is an essential regulator of heart inflammation and fibrosis in mice with pathological cardiac hypertrophy via endoplasmic reticulum (ER) stress

Yan Zhang et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

添加到收藏夹

Article Medicine, Research & Experimental

Inhibition of double-strand DNA-sensing cGAS ameliorates brain injury after ischemic stroke

Qian Li et al.

EMBO MOLECULAR MEDICINE (2020)

添加到收藏夹

Article Immunology

mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury

Long Shuang Huang et al.

IMMUNITY (2020)

添加到收藏夹

Article Microbiology

PARP1-cGAS-NF-κB pathway of proinflammatory macrophage activation by extracellular vesicles released during Trypanosoma cruzi infection and Chagas disease

Subhadip Choudhuri et al.

PLoS Pathogens (2020)

添加到收藏夹

Article Geriatrics & Gerontology

First evidence for STING SNP R293Q being protective regarding obesity-associated cardiovascular disease in age-advanced subjects - a cohort study

Lutz Hamann et al.

IMMUNITY & AGEING (2020)

添加到收藏夹

Review Immunology

Research Advances in How the cGAS-STING Pathway Controls the Cellular Inflammatory Response

Dongshan Wan et al.

FRONTIERS IN IMMUNOLOGY (2020)

添加到收藏夹

Article Biochemical Research Methods

The DNA Sensor cGAS is Decorated by Acetylation and Phosphorylation Modifications in the Context of Immune Signaling

Bokai Song et al.

MOLECULAR & CELLULAR PROTEOMICS (2020)

添加到收藏夹

Review Cell Biology

Molecular mechanisms and cellular functions of cGAS-STING signalling

Karl-Peter Hopfner et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

添加到收藏夹

Review Immunology

Structures and Mechanisms in the cGAS-STING Innate Immunity Pathway

Xuewu Zhang et al.

IMMUNITY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS

Chien-Hsiung Yu et al.

CELL (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Crosstalk between cGAS-STING signaling and cell death

Ambika M. V. Murthy et al.

CELL DEATH AND DIFFERENTIATION (2020)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Myocardial ischaemia-reperfusion injury and cardioprotection in perspective

Gerd Heusch

NATURE REVIEWS CARDIOLOGY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Structural basis for the inhibition of cGAS by nucleosomes

Tomoya Kujirai et al.

SCIENCE (2020)

添加到收藏夹

Review Immunology

Oxidative Stress in Ozone-Induced Chronic Lung Inflammation and Emphysema: A Facet of Chronic Obstructive Pulmonary Disease

Coen H. Wiegman et al.

FRONTIERS IN IMMUNOLOGY (2020)

添加到收藏夹

Review Medicine, General & Internal

Challenges and Opportunities in the Clinical Development of STING Agonists for Cancer Immunotherapy

Leila Motedayen Aval et al.

JOURNAL OF CLINICAL MEDICINE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Streptavidin Promotes DNA Binding and Activation of cGAS to Enhance Innate Immunity

Yanqiong Zhang et al.

ISCIENCE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

STING Mediates Lupus via the Activation of Conventional Dendritic Cell Maturation and Plasmacytoid Dendritic Cell Differentiation

Arthid Thim-uam et al.

ISCIENCE (2020)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Beclin1 Haploinsufficiency accentuates second-hand smoke exposure-induced myocardial Remodeling and contractile dysfunction through a STING-mediated mechanism

Fangpeng Liu et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

ALDH2 contributes to melatonin-induced protection against APP/PS1 mutation-prompted cardiac anomalies through cGAS-STING-TBK1-mediated regulation of mitophagy

Shuyi Wang et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA

Katherine C. Barnett et al.

CELL (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Acetylation Blocks cGAS Activity and Inhibits Self-DNA-Induced Autoimmunity

Jiang Dai et al.

CELL (2019)

添加到收藏夹

Article Cell Biology

Induction of neutrophil extracellular traps during tissue injury: Involvement of STING and Toll-like receptor 9 pathways

Li Liu et al.

CELL PROLIFERATION (2019)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Heart Disease and Stroke Statistics-2019 Update A Report From the American Heart Association

Emelia J. Benjamin et al.

CIRCULATION (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Autophagy induction via STING trafficking is a primordial function of the cGAS pathway

Xiang Gui et al.

NATURE (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP

Guijun Shang et al.

NATURE (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Ferroptosis as a target for protection against cardiomyopathy

Xuexian Fang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

添加到收藏夹

Review Multidisciplinary Sciences

cGAS in action: Expanding roles in immunity and inflammation

Andrea Ablasser et al.

SCIENCE (2019)

添加到收藏夹

Article Multidisciplinary Sciences

A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1

Baoyu Zhao et al.

NATURE (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation

Wei Xie et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

添加到收藏夹

Article Cell Biology

Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation

Carina C. de Oliveira Mann et al.

CELL REPORTS (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition

Sabrina L. Ergun et al.

CELL (2019)

添加到收藏夹

Review Cell Biology

The effect of palmitic acid on inflammatory response in macrophages: an overview of molecular mechanisms

Jan Korbecki et al.

INFLAMMATION RESEARCH (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Manassantin B shows antiviral activity against coxsackievirus B3 infection by activation of the STING/TBK-1/IRF3 signalling pathway

Jae-Hyoung Song et al.

SCIENTIFIC REPORTS (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

STING-IRF3 contributes to lipopolysaccharide-induced cardiac dysfunction, inflammation, apoptosis and pyroptosis by activating NLRP3

Ning Li et al.

REDOX BIOLOGY (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Chromatin-bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death

Hui Jiang et al.

EMBO JOURNAL (2019)

添加到收藏夹

Editorial Material Medicine, General & Internal

Angiotensin Receptor-Neprilysin Inhibition (ARNI) Therapy and Reverse Remodeling in Heart Failure With Reduced Ejection Fraction

Mark H. Drazner

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Rhinovirus-induced IFNβ expression is NFκB-dependent and regulated by the macrophage microenvironment

Mandy Menzel et al.

SCIENTIFIC REPORTS (2019)

添加到收藏夹

Review Geriatrics & Gerontology

STING SNP R293Q Is Associated with a Decreased Risk of Aging-Related Diseases

Lutz Hamann et al.

GERONTOLOGY (2019)

添加到收藏夹

Editorial Material Immunology

STIM1 moonlights as an anchor for STING

Jianjun Wu et al.

NATURE IMMUNOLOGY (2019)

添加到收藏夹

Review Immunology

DNA-stimulated cell death: implications for host defence, inflammatory diseases and cancer

Soren R. Paludan et al.

NATURE REVIEWS IMMUNOLOGY (2019)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Cytosolic DNA Sensing Promotes Macrophage Transformation and Governs Myocardial Ischemic Injury

Dian J. Cao et al.

CIRCULATION (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Involvement of partial EMT in cancer progression

Masao Saitoh

JOURNAL OF BIOCHEMISTRY (2018)

添加到收藏夹

Review Immunology

The cGAS-cGAMP-STING pathway connects DNA damage to inflammation, senescence, and cancer

Tuo Li et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2018)

添加到收藏夹

Review Rheumatology

Type I interferon in rheumatic diseases

Theresa L. Wampler Muskardin et al.

NATURE REVIEWS RHEUMATOLOGY (2018)

添加到收藏夹

Article Cell Biology

Analysis of Drosophila STING Reveals an Evolutionarily Conserved Antimicrobial Function

Marina Martin et al.

CELL REPORTS (2018)

添加到收藏夹

Article Rheumatology

Inhibition of Cyclic GMP-AMP Synthase Using a Novel Antimalarial Drug Derivative in Trex1-Deficient Mice

Jie An et al.

ARTHRITIS & RHEUMATOLOGY (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis

Joel S. Riley et al.

EMBO JOURNAL (2018)

添加到收藏夹

Article Immunology

Inflammasome Activation Triggers Caspase-1-Mediated Cleavage of cGAS to Regulate Responses to DNA Virus Infection

Yutao Wang et al.

IMMUNITY (2017)

添加到收藏夹

Article Immunology

NEMO-IKKβ Are Essential for IRF3 and NF-κB Activation in the cGAS-STING Pathway

Run Fang et al.

JOURNAL OF IMMUNOLOGY (2017)

添加到收藏夹

Review Immunology

Regulating STING in health and disease

Yang Li et al.

JOURNAL OF INFLAMMATION-LONDON (2017)

添加到收藏夹

Article Cell Biology

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

Selene Gluck et al.

NATURE CELL BIOLOGY (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

IRF3 and type I interferons fuel a fatal response to myocardial infarction

Kevin R. King et al.

NATURE MEDICINE (2017)

添加到收藏夹

Article Multidisciplinary Sciences

cGAS is essential for cellular senescence

Hui Yang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

添加到收藏夹

Article Cell Biology

Trafficking-Mediated STING Degradation Requires Sorting to Acidified Endolysosomes and CanBe Targeted to Enhance Anti-tumor Response

Vijay K. Gonugunta et al.

CELL REPORTS (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3

Moritz M. Gaidt et al.

CELL (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

STING Senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum

Julien Moretti et al.

CELL (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

cGAS is activated by DNA in a length-dependent manner

Stefanie Luecke et al.

EMBO REPORTS (2017)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Inflammatory Cardiomyopathic Syndromes

Barry H. Trachtenberg et al.

CIRCULATION RESEARCH (2017)

添加到收藏夹

Article Hematology

STING-IRF3 Triggers Endothelial Inflammation in Response to Free Fatty Acid-Induced Mitochondrial Damage in Diet-Induced Obesity

Yun Mao et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2017)

添加到收藏夹

Review Microbiology

The cGAS-STING Defense Pathway and Its Counteraction by Viruses

Zhe Ma et al.

CELL HOST & MICROBE (2016)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Myocarditis

Gabriel Fung et al.

CIRCULATION RESEARCH (2016)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Chronic Heart Failure and Inflammation What Do We Really Know?

Sarah A. Dick et al.

CIRCULATION RESEARCH (2016)

添加到收藏夹

Letter Cardiac & Cardiovascular Systems

Angiotensin converting enzyme inhibitors for heart failure with reduced ejection fraction or left ventricular dysfunction: A complementary network meta-analyses

Wen-Qin Guo et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Activation of STING requires palmitoylation at the Golgi

Kojiro Mukai et al.

NATURE COMMUNICATIONS (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

Mitochondrial dysfunction in cardiac aging

Autumn Tocchi et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2015)

添加到收藏夹

Meeting Abstract Biophysics

Mitochondrial DNA Stress Primes the Antiviral Innate Immune Response

Phillip West

BIOPHYSICAL JOURNAL (2015)

添加到收藏夹

Article Microbiology

STING Activation by Translocation from the ER Is Associated with Infection and Autoinflammatory Disease

Nicole Dobbs et al.

CELL HOST & MICROBE (2015)

添加到收藏夹

Article Microbiology

Inhibition of cGAS DNA Sensing by a Herpesvirus Virion Protein

Jian-jun Wu et al.

CELL HOST & MICROBE (2015)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Effects of Xanthine Oxidase Inhibition in Hyperuricemic Heart Failure Patients The Xanthine Oxidase Inhibition for Hyperuricemic Heart Failure Patients (EXACT-HF) Study

Michael M. Givertz et al.

CIRCULATION (2015)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Immune Cell and Other Noncardiomyocyte Regulation of Cardiac Hypertrophy and Remodeling

Ryan A. Frieler et al.

CIRCULATION (2015)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Innate Immunity and the Failing Heart The Cytokine Hypothesis Revisited

Douglas L. Mann

CIRCULATION RESEARCH (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

Siqi Liu et al.

SCIENCE (2015)

添加到收藏夹

Review Immunology

STING: infection, inflammation and cancer

Glen N. Barber

NATURE REVIEWS IMMUNOLOGY (2015)

添加到收藏夹

Article Virology

Cytosolic-DNA-Mediated, STING-Dependent Proinflammatory Gene Induction Necessitates Canonical NF-κB Activation through TBK1

Takayuki Abe et al.

JOURNAL OF VIROLOGY (2014)

添加到收藏夹

Article Cell Biology

The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop

Xu Zhang et al.

CELL REPORTS (2014)

添加到收藏夹

Article Biochemistry & Molecular Biology

GLUT12 functions as a basal and insulin-independent glucose transporter in the heart

Amanda P. Waller et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

Cyclic [G(2′,5′) pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

Pu Gao et al.

CELL (2013)

添加到收藏夹

Article Immunology

Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization

Xin Li et al.

IMMUNITY (2013)

添加到收藏夹

Article Cell Biology

Alcohol-induced IL-1β in the brain is mediated by NLRP3/ASC inflammasome activation that amplifies neuroinflammation

Dora Lippai et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Structural mechanism of cytosolic DNA sensing by cGAS

Filiz Civril et al.

NATURE (2013)

添加到收藏夹

Article Cell Biology

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

Ryan C. Russell et al.

NATURE CELL BIOLOGY (2013)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

The roles of senescence and telomere shortening in cardiovascular disease

Frej Fyhrquist et al.

NATURE REVIEWS CARDIOLOGY (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

Lijun Sun et al.

SCIENCE (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

Extracellular M. tuberculosis DNA Targets Bacteria for Autophagy by Activating the Host DNA-Sensing Pathway

Robert O. Watson et al.

CELL (2012)

添加到收藏夹

Article Medicine, General & Internal

Associations Between Aldosterone Antagonist Therapy and Risks of Mortality and Readmission Among Patients With Heart Failure and Reduced Ejection Fraction

Adrian F. Hernandez et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2012)

添加到收藏夹

Article Biochemistry & Molecular Biology

Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system

Chang Shu et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2012)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Elevated peripheral blood mononuclear cell count is an independent predictor of left ventricular remodeling in patents with acute myocardial infarction

Satoshi Aoki et al.

JOURNAL OF CARDIOLOGY (2011)

添加到收藏夹

Article Virology

Activation of Plasmacytoid Dendritic Cells by Kaposi's Sarcoma-Associated Herpesvirus

John A. West et al.

JOURNAL OF VIROLOGY (2011)

添加到收藏夹

Article Multidisciplinary Sciences

The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse

Eleonora Mezzaroma et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

添加到收藏夹

Article Endocrinology & Metabolism

Adipose Tissue Endothelial Cells From Obese Human Subjects: Differences Among Depots in Angiogenic, Metabolic, and Inflammatory Gene Expression and Cellular Senescence

Aurelie Villaret et al.

DIABETES (2010)

添加到收藏夹

Article Medicine, General & Internal

Effects of high-dose versus low-dose losartan on clinical outcomes in patients with heart failure (HEAAL study): a randomised, double-blind trial

Marvin A. Konstam et al.

LANCET (2009)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Impact of oxypurinol in patients with symptomatic heart failure

Joshua M. Hare et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2008)

添加到收藏夹

Article Multidisciplinary Sciences

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

Hiroki Ishikawa et al.

NATURE (2008)

添加到收藏夹

Article Immunology

Recognition of cytosolic DNA activates an IRF3-dependent innate immune response

DB Stetson et al.

IMMUNITY (2006)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Targeted anticytokine therapy in patients with chronic heart failure - Results of the Randomized Etanercept Worldwide evALuation (RENEWAL)

DL Mann et al.

CIRCULATION (2004)

添加到收藏夹

Article Medicine, General & Internal

Effect of carvedilol on survival in severe chronic heart failure.

M Packer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2001)

添加到收藏夹

Review Medicine, General & Internal

Myocarditis

AM Feldman et al.

NEW ENGLAND JOURNAL OF MEDICINE (2000)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.