期刊
FOOD FRONTIERS
卷 4, 期 1, 页码 289-296出版社
WILEY
DOI: 10.1002/fft2.194
关键词
cytotoxicity; flavonoids; heterocyclic amine; hydroxyl substitution; myricetin
The aim of this study was to evaluate the intervention effect of different structures of flavonoids on the cytotoxicity of heterocyclic amines. The results showed that the cytotoxicity of heterocyclic amines significantly increased in the presence of myricetin and rutin.
The aim of the present work was to evaluate different structures of flavonoids interfering with the cytotoxicity of heterocyclic amines (HCA). Eight flavonoids with similar structure including myricetin, rutin, fisetin, quercetin, myricetrin, quercetrin, kaempferol, and galangin were coincubated with 2-amino-4-methylimidazo[4,5-f]quinolone (IQ) respectively to determine the cytotoxicity. The results revealed that IQ at low doses showed no cytotoxicity; however, in the presence of myricetin and rutin, the cytotoxicity significantly elevated. It seems that C-3 ', C-4 ', C-5 ', and C-5 hydroxyl substituents on the flavonoid skeleton of B ring play important role in the increasing cytotoxicity induced by IQ in HepG2 cells. Interestingly, the data obtained from the present study revealed an unexpected adverse effect of the supposed beneficial food ingredient myricetin, which appears to be able to increase the cytotoxicity of the procarcinogen HCA.
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