☆ 4.6 Review

Adipose tissue macrophages: implications for obesity-associated cancer

MILITARY MEDICAL RESEARCH (2023)

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Summary: In this study, Wang et al. used whole-genome sequencing to comprehensively analyze common and rare variants associated with lung cancer risk in individuals with East Asian ancestry. Their findings suggest that rare promoter variants in the BRCA2 gene are associated with an increased risk of lung cancer.

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The effect of short-chain fatty acids on M2 macrophages polarization in vitro and in vivo

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Summary: Short-chain fatty acids can inhibit M2 polarization of alveolar macrophages through GPR43 activation and/or HDAC inhibition, and they can also help alleviate airway inflammation in an asthma model.

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Single-cell and spatially resolved analysis uncovers cell heterogeneity of breast cancer

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Summary: This study combines single-nucleus RNA sequencing and spatial transcriptomics to identify cell populations and their spatial distribution in breast cancer tissues. Malignant cells are clustered into distinct subpopulations with diverse features and functions, and their mapping in tissue regions shows differential enrichment of stromal cell types.

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Summary: Obesity plays a significant role in the development and progression of breast cancer through complex metabolic and immune dysregulation. Chronic low-grade inflammation, particularly in white adipose tissue, contributes to immune dysfunction that promotes breast cancer. Understanding the interaction between obesity and breast cancer is crucial for developing effective interventions to mitigate the negative effects of obesity on breast cancer. Dietary interventions have shown promise in offsetting the impact of obesity on breast cancer. The rising rates of obesity worldwide make it urgent to develop safe and equitable interventions to address the burden of obesity on breast cancer.

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Lipid-associated macrophages in the tumor-adipose microenvironment facilitate breast cancer progression

Zhou Liu et al.

Summary: The study reveals the presence of a special macrophage subpopulation called lipid-associated macrophages (LAMs) in the tumor-adipose microenvironment (TAME), which is associated with poor survival in breast cancer patients. LAMs exhibit typical functional features of M2-like macrophages, such as lipid accumulation and enhanced phagocytosis, and are mainly distributed in the tumor-adipose junctional regions.

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Peripheral leptin signaling persists in innate immune cells during diet-induced obesity

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Plasticity of Epididymal Adipose Tissue in Response to Diet-Induced Obesity at Single-Nucleus Resolution

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Shuyun Liu et al.

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IL-33-induced metabolic reprogramming controls the differentiation of alternatively activated macrophages and the resolution of inflammation

Maria Faas et al.

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3D microscopy and deep learning reveal the heterogeneity of crown-like structure microenvironments in intact adipose tissue

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Aging adipose: Depot location dictates age-associated expansion and dysfunction

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ANNUAL REVIEW OF IMMUNOLOGY, VOL 39 (2021)

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Single-cell sequencing of human white adipose tissue identifies new cell states in health and obesity

Andrew D. Hildreth et al.

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Using Spheroids as Building Blocks Towards 3D Bioprinting of Tumor Microenvironment

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Maria Casanova-Acebes et al.

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Diet-regulated production of PDGFcc by macrophages controls energy storage

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Role of Tim4 in the regulation of ABCA1+ adipose tissue macrophages and post-prandial cholesterol levels

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IGF1 receptor inhibition amplifies the effects of cancer drugs by autophagy and immune-dependent mechanisms-

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Branched-chain ketoacids secreted by glioblastoma cells via MCT1 modulate macrophage phenotype

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EMBO REPORTS (2017)

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Article Oncology

Obesity and Adverse Breast Cancer Risk and Outcome: Mechanistic Insights and Strategies for Intervention

Manuel Picon-Ruiz et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2017)

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Article Hematology

Leukocyte Overexpression of Intracellular NAMPT Attenuates Atherosclerosis by Regulating PPARγ-Dependent Monocyte Differentiation and Function

Beatriz Bermudez et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2017)

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Article Endocrinology & Metabolism

Gut microbiota-derived lipopolysaccharide uptake and trafficking to adipose tissue: implications for inflammation and obesity

L. G. Hersoug et al.

OBESITY REVIEWS (2016)

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Article Gastroenterology & Hepatology

Radiation Therapy Induces Macrophages to Suppress T-Cell Responses Against Pancreatic Tumors in Mice

Lena Seifert et al.

GASTROENTEROLOGY (2016)

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Review Immunology

Macrophages in Tissue Repair, Regeneration, and Fibrosis

Thomas A. Wynn et al.

IMMUNITY (2016)

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The long road to leptin

Jeffrey Friedman

JOURNAL OF CLINICAL INVESTIGATION (2016)

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Review Oncology

Obesity and Cancer Mechanisms: Tumor Microenvironment and Inflammation

Neil M. Iyengar et al.

JOURNAL OF CLINICAL ONCOLOGY (2016)

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Article Genetics & Heredity

Circulating adipocyte-derived extracellular vesicles are novel markers of metabolic stress

Akiko Eguchi et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2016)

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Review Immunology

The development and maintenance of resident macrophages

Elisa Gomez Perdiguero et al.

NATURE IMMUNOLOGY (2016)

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Article Biochemistry & Molecular Biology

The adaptor protein insulin receptor substrate 2 inhibits alternative macrophage activation and allergic lung inflammation

Preeta Dasgupta et al.

SCIENCE SIGNALING (2016)

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Review Biochemistry & Molecular Biology

Leotin Regulation of Immune Responses

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TRENDS IN MOLECULAR MEDICINE (2016)

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Review Nutrition & Dietetics

The Intestinal Microbiota in Metabolic Disease

Anni Woting et al.

NUTRIENTS (2016)

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Article Cell Biology

Macrophage Ontogeny Underlies Differences in Tumor-Specific Education in Brain Malignancies

Robert L. Bowman et al.

CELL REPORTS (2016)

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Article Biochemistry & Molecular Biology

The adaptor protein insulin receptor substrate 2 inhibits alternative macrophage activation and allergic lung inflammation

Preeta Dasgupta et al.

SCIENCE SIGNALING (2016)

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Article Oncology

Murine mesothelioma induces locally-proliferating IL-10(+) TNF-alpha(+) CD206(-)CX3CR1(+) M3 macrophages that can be selectively depleted by chemotherapy or immunotherapy

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ONCOIMMUNOLOGY (2016)

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Article Multidisciplinary Sciences

The innate immune receptor Dectin-2 mediates the phagocytosis of cancer cells by Kupffer cells for the suppression of liver metastasis

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

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Article Cell Biology

Leptin Deficiency Shifts Mast Cells toward Anti-Inflammatory Actions and Protects Mice from Obesity and Diabetes by Polarizing M2 Macrophages

Yi Zhou et al.

CELL METABOLISM (2015)

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Review Physiology

OBESITY AND DIABETES: THE INCREASED RISK OF CANCER AND CANCER-RELATED MORTALITY

Emily Jane Gallagher et al.

PHYSIOLOGICAL REVIEWS (2015)

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Review Biotechnology & Applied Microbiology

Current Concept and Update of the Macrophage Plasticity Concept: Intracellular Mechanisms of Reprogramming and M3 Macrophage Switch Phenotype

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BIOMED RESEARCH INTERNATIONAL (2015)

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Review Endocrinology & Metabolism

Insulin and GH-IGF-I axis: endocrine pacer or endocrine disruptor?

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ACTA DIABETOLOGICA (2015)

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Article Hematology

Extracellular nicotinamide phosphoribosyltransferase (NAMPT) promotes M2 macrophage polarization in chronic lymphocytic leukemia

Valentina Audrito et al.

BLOOD (2015)

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Article Immunology

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

Abhishek K. Jha et al.

IMMUNITY (2015)

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Article Oncology

Inhibition of CSF-1 Receptor Improves the Antitumor Efficacy of Adoptive Cell Transfer Immunotherapy

Stephen Mok et al.

CANCER RESEARCH (2014)

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Macrophages eliminate circulating tumor cells after monoclonal antibody therapy

Nuray Gul et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

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Article Immunology

CCL2 Shapes Macrophage Polarization by GM-CSF and M-CSF: Identification of CCL2/CCR2-Dependent Gene Expression Profile

Elena Sierra-Filardi et al.

JOURNAL OF IMMUNOLOGY (2014)

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Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

Oscar R. Colegio et al.

NATURE (2014)

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Article Immunology

Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages

Stanley Ching-Cheng Huang et al.

NATURE IMMUNOLOGY (2014)

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Caloric restriction mimetics: towards a molecular definition

Frank Madeo et al.

NATURE REVIEWS DRUG DISCOVERY (2014)

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Obesity and cancer-mechanisms underlying tumour progression and recurrence

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NATURE REVIEWS ENDOCRINOLOGY (2014)

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Glutamine deprivation stimulates mTOR-JNK-dependent chemokine secretion

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NATURE COMMUNICATIONS (2014)

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Lipopolysaccharide Causes an Increase in Intestinal Tight Junction Permeability in Vitro and in Vivo by Inducing Enterocyte Membrane Expression and Localization of TLR-4 and CD14

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AMERICAN JOURNAL OF PATHOLOGY (2013)

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Article Oncology

Obesity Promotes Breast Cancer by CCL2-Mediated Macrophage Recruitment and Angiogenesis

Lisa M. Arendt et al.

CANCER RESEARCH (2013)

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Article Oncology

CSF1R Signaling Blockade Stanches Tumor-Infiltrating Myeloid Cells and Improves the Efficacy of Radiotherapy in Prostate Cancer

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CANCER RESEARCH (2013)

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Article Cell Biology

Obesity Activates a Program of Lysosomal-Dependent Lipid Metabolism in Adipose Tissue Macrophages Independently of Classic Activation

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CELL METABOLISM (2013)

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Review Cell Biology

Fibrosis and Adipose Tissue Dysfunction

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CELL METABOLISM (2013)

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Molecular Pathways: Adipose Inflammation as a Mediator of Obesity-Associated Cancer

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CLINICAL CANCER RESEARCH (2013)

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Review Endocrinology & Metabolism

Common mechanisms of dysfunctional adipose tissue and obesity-related cancers

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DIABETES-METABOLISM RESEARCH AND REVIEWS (2013)

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Richness of human gut microbiome correlates with metabolic markers

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Macrophage biology in development, homeostasis and disease

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Succinate is an inflammatory signal that induces IL-1β through HIF-1α

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NATURE (2013)

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Article Cell Biology

miR-126 and miR-126*repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis

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NATURE CELL BIOLOGY (2013)

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Review Immunology

Tissue-resident macrophages

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NATURE IMMUNOLOGY (2013)

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Review Immunology

Indoleamine 2,3 dioxygenase and metabolic control of immune responses

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TRENDS IN IMMUNOLOGY (2013)

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CSF1R inhibition delays cervical and mammary tumor growth in murine models by attenuating the turnover of tumor-associated macrophages and enhancing infiltration by CD8+ T cells

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ONCOIMMUNOLOGY (2013)

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Article Pediatrics

Circulating branched-chain amino acid concentrations are associated with obesity and future insulin resistance in children and adolescents

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PEDIATRIC OBESITY (2013)

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Review Oncology

Interleukin-6 signaling pathway in targeted therapy for cancer

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CANCER TREATMENT REVIEWS (2012)

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Histone deacetylase 3 is an epigenomic brake in macrophage alternative activation

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Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

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NATURE MEDICINE (2011)

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Dynamic, M2-Like Remodeling Phenotypes of CD11c+Adipose Tissue Macrophages During High-Fat Diet-Induced Obesity in Mice

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DIABETES (2010)

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Review Immunology

Alternative Activation of Macrophages: Mechanism and Functions

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IMMUNITY (2010)

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Article Biochemistry & Molecular Biology

Adiponectin Promotes Macrophage Polarization toward an Anti-inflammatory Phenotype

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JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

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Article Biochemistry & Molecular Biology

Adipose Tissue Branched Chain Amino Acid (BCAA) Metabolism Modulates Circulating BCAA Levels

Mark A. Herman et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

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Review Immunology

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

Subhra K. Biswas et al.

NATURE IMMUNOLOGY (2010)

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The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection

Takashi Satoh et al.

NATURE IMMUNOLOGY (2010)

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Article Genetics & Heredity

Myeloid Cell-Restricted Insulin Receptor Deficiency Protects Against Obesity-Induced Inflammation and Systemic Insulin Resistance

Jan Mauer et al.

PLOS GENETICS (2010)

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Article Biochemistry & Molecular Biology

Leptin enhances CC-chemokine ligand expression in cultured murine macrophage

Norikazu Kiguchi et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)

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Review Oncology

Obesity and Cancer: The Role of Dysfunctional Adipose Tissue

Rob C. M. van Kruijsdijk et al.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2009)

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Article Endocrinology & Metabolism

Adipose Tissue Exosome-Like Vesicles Mediate Activation of Macrophage-Induced Insulin Resistance

Zhong-bin Deng et al.

DIABETES (2009)

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Article Endocrinology & Metabolism

Receptors for Tumor Necrosis Factor-α Play a Protective Role against Obesity and Alter Adipose Tissue Macrophage Status

Nathalie Pamir et al.

ENDOCRINOLOGY (2009)

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Article Biochemistry & Molecular Biology

CCL2 and Interleukin-6 Promote Survival of Human CD11b+ Peripheral Blood Mononuclear Cells and Induce M2-type Macrophage Polarization

Hernan Roca et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

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Article Endocrinology & Metabolism

Forkhead Transcription Factors (FoxOs) Promote Apoptosis of Insulin-Resistant Macrophages During Cholesterol-Induced Endoplasmic Reticulum Stress

Takafumi Senokuchi et al.

DIABETES (2008)

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Article Biochemistry & Molecular Biology

Leptin induces macrophage lipid body formation by a phosphatidylinositol 3-kinase- and mammalian target of rapamycin-dependent mechanism

Clarissa M. Maya-Monteiro et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

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Review Immunology

Exploring the full spectrum of macrophage activation

David M. Mosser et al.

NATURE REVIEWS IMMUNOLOGY (2008)

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Article Multidisciplinary Sciences

Identification of Tim4 as a phosphatidylserine receptor

Masanori Miyanishi et al.

NATURE (2007)

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Article Multidisciplinary Sciences

Macrophage-specific PPARγ controls alternative activation and improves insulin resistance

Justin I. Odegaard et al.

NATURE (2007)

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Review Gastroenterology & Hepatology

Obesity, inflammation, and insulin resistance

Steven E. Shoelson et al.

GASTROENTEROLOGY (2007)

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Article Hematology

Role of the Toll-like receptor 4/NF-kappa B pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages

Takayoshi Suganami et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2007)

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Article Biochemistry & Molecular Biology

Resistin increases lipid accumulation and CD36 expression in human macrophages

Weibin Xu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)

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Review Immunology

Adipocytokines: mediators linking adipose tissue, inflammation and immunity

Herbert Tilg et al.

NATURE REVIEWS IMMUNOLOGY (2006)

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Article Cell Biology

Oxidative metabolism and PGC-1β attenuate macrophage-mediated inflammation

Divya Vats et al.

CELL METABOLISM (2006)

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Article Biochemistry & Molecular Biology

Human resistin stimulates the pro-inflammatory cytokines TNF-α and IL-12 in macrophages by NF-κB-dependent pathway

N Silswal et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)

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Review Immunology

The chemokine system in diverse forms of macrophage activation and polarization

A Mantovani et al.

TRENDS IN IMMUNOLOGY (2004)

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Article Multidisciplinary Sciences

The hormone resistin links obesity to diabetes

CM Steppan et al.

NATURE (2001)

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