☆ 4.7 Review

Beyond neutralization: Fc-dependent antibody effector functions in SARS-CoV-2 infection

NATURE REVIEWS IMMUNOLOGY (2023)

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Article Biochemistry & Molecular Biology

Protection from SARS-CoV-2 Delta one year after mRNA-1273 vaccination in rhesus macaques coincides with anamnestic antibody response in the lung

Matthew Gagne et al.

Summary: mRNA-1273 vaccine efficacy against SARS-CoV-2 Delta decreases over time, and protection may be dependent on anamnestic antibody responses. The vaccine provides durable but delayed protection in the lungs, while a boost may be needed for rapid and sustained protection in the upper and lower airways.

CELL (2022)

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Strong humoral immune responses against SARS-CoV-2 Spike after BNT162b2 mRNA vaccination with a 16-week interval between doses

Alexandra Tauzin et al.

Summary: The study found that extending the interval between doses to 16 weeks significantly increased humoral responses in non-infected individuals, reaching similar levels as previously infected individuals. Compared to a shorter interval, a longer interval between vaccine doses resulted in stronger immune responses.

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Article Microbiology

Neutralization and durability of 2 or 3 doses of the BNT162b2 vaccine against Omicron SARS-CoV-2

Hongjie Xia et al.

Summary: Two doses of the BNT162b2 mRNA vaccine demonstrate high efficacy against SARS-CoV-2 and also provide neutralization against Omicron SARS-CoV-2. The study shows that the neutralization response improves with the third dose, but decreases slightly after four months.

CELL HOST & MICROBE (2022)

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Review Biochemistry & Molecular Biology

Antibody glycosylation in COVID-19

Tamas Pongracz et al.

Summary: Antibody glycosylation plays a critical role in COVID-19 infections, affecting the effectiveness and safety of immune responses. This review summarizes recent research on antibody glycosylation in COVID-19, evaluating research methods and the dynamics, effector functions, clinical utility, and regulation of glycosylation. Future research could explore other antibody classes, non-canonical antibody receptors, and the regulation of antibody glycosylation.

GLYCOCONJUGATE JOURNAL (2022)

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Article Immunology

mRNA-1273 vaccine-induced antibodies maintain Fc effector functions across SARS-CoV-2 variants of concern

Paulina Kaplonek et al.

Summary: SARS-CoV-2 mRNA vaccines provide protection against COVID-19, but concerns have arisen due to the emergence of variants that may reduce the efficacy of existing vaccines. This study investigated the binding and functional capacity of antibodies from recovered individuals and those induced by the Moderna mRNA1273 COVID-19 vaccine against SARS-CoV-2 variants of concern. While neutralizing responses to the variants decreased in both groups, the Fc-mediated responses differed. Antibodies from recovered individuals showed compromised interactions with Fc receptors, while vaccine-induced antibodies maintained their ability to interact with Fc receptors and mediate antibody effector functions. These findings suggest that mRNA vaccines may offer resilience in the humoral immune response and continue to provide protection against SARS-CoV-2 variants independent of neutralization.

IMMUNITY (2022)

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Letter Medicine, General & Internal

Immunogenicity of Extended mRNA SARS-CoV-2 Vaccine Dosing Intervals

Brian Grunau et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2022)

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Article Multidisciplinary Sciences

Germinal centre-driven maturation of B cell response to mRNA vaccination

Wooseob Kim et al.

Summary: SARS-CoV-2 mRNA vaccination induces a persistent germinal center reaction in humans, resulting in affinity-matured long-term antibody responses that potently neutralize the virus.

NATURE (2022)

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Article Medicine, General & Internal

Protection against SARS-CoV-2 after Covid-19 Vaccination and Previous Infection

Victoria Hall et al.

Summary: This study investigated the duration and effectiveness of immunity among healthcare workers in the United Kingdom. It found that two doses of the BNT162b2 vaccine provided high short-term protection against SARS-CoV-2 infection, but this protection significantly decreased after six months. However, infection-acquired immunity boosted by vaccination remained high, even more than one year after infection.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Article Medicine, General & Internal

Duration of Protection against Mild and Severe Disease by Covid-19 Vaccines

Nick Andrews et al.

Summary: A study conducted in England showed that vaccines against SARS-CoV-2 provide high protection against hospitalization and death from Covid-19 at 20 weeks or more after vaccination. However, the effectiveness of the vaccines decreases over time, especially in individuals aged 65 and older and those with underlying risk factors.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Article Multidisciplinary Sciences

Immune correlates analysis of the mRNA-1273 COVID-19 vaccine efficacy clinical trial

Peter B. Gilbert et al.

Summary: In the COVE phase 3 clinical trial, neutralizing and binding antibodies were measured in vaccine recipients to determine their correlation with COVID-19 risk and vaccine efficacy. The results showed that these immune markers were inversely associated with COVID-19 risk and directly associated with vaccine efficacy. Postvaccination neutralization titers of 10, 100, and 1000 correlated with estimated vaccine efficacies of 78%, 91%, and 96% respectively.

SCIENCE (2022)

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Article Cell Biology

Early non-neutralizing, afucosylated antibody responses are associated with COVID-19 severity

Saborni Chakraborty et al.

Summary: A damaging inflammatory response in severe COVID-19 is associated with early non-neutralizing, afucosylated IgG antibodies specific to SARS-CoV-2. Human IgG-Fc-gamma receptor interactions regulate inflammation in the lung, and antibodies elicited by mRNA SARS-CoV-2 vaccines have reduced inflammatory potential.

SCIENCE TRANSLATIONAL MEDICINE (2022)

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Article Multidisciplinary Sciences

Phagocytosis by an HIV antibody is associated with reduced viremia irrespective of enhanced complement lysis

David A. Spencer et al.

Summary: Antibodies are increasingly used to treat and prevent viral infections. In this study, the researchers investigated the role of antibody-mediated effector and complement activity in protecting against SHIV in rhesus macaques. They found that enhancing complement function did not improve the protective efficacy of the antibody, suggesting that effector functions of the unmodified antibody contribute to its effectiveness.

NATURE COMMUNICATIONS (2022)

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Article Microbiology

A SARS-CoV-2 variant elicits an antibody response with a shifted immunodominance hierarchy

Allison Greaney et al.

Summary: SARS-CoV-2 variants can elicit polyclonal antibodies with different immunodominance hierarchies. The antibodies elicited by infection with B.1.351 variant are more focused on the class 3 epitope, which is mutated in the Delta variant. Prior infection and vaccination histories may partially determine individuals' susceptibilities to viral mutants in new variants.

PLOS PATHOGENS (2022)

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Article Immunology

Spike-Dependent Opsonization Indicates Both Dose-Dependent Inhibition of Phagocytosis and That Non-Neutralizing Antibodies Can Confer Protection to SARS-CoV-2

Wael Bahnan et al.

Summary: The concentration of Spike-specific antibodies can enhance or reduce Spike-bead phagocytosis by monocytes, independent of antibody neutralization potential. The levels of anti-Spike antibodies correlate with the outcome in an experimental SARS-CoV-2 infection model, suggesting that non-neutralizing antibodies could confer protection to SARS-CoV-2 infection by mediating phagocytosis.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Infectious Diseases

Neutralising antibody titres as predictors of protection against SARS-CoV-2 variants and the impact of boosting: a meta-analysis

Deborah Cromer et al.

Summary: By analyzing data on in-vitro neutralization and clinical protection, the study found that neutralizing activity against the ancestral SARS-CoV-2 is highly correlated with neutralization of variants of concern, and can still predict the vaccine's protection against these variants. Simulation results suggest that booster vaccination for previously infected individuals can provide higher levels of protection compared to primary vaccination. Although the protection may decrease within the first year after vaccination, the current vaccines can still offer robust protection in the medium term.

LANCET MICROBE (2022)

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Article Multidisciplinary Sciences

FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation

Caroline Junqueira et al.

Summary: This study suggests that SARS-CoV-2 infection in monocytes and macrophages, mediated by antibody uptake, triggers inflammatory cell death and systemic inflammation, which prevents the production of infectious virus but contributes to COVID-19 pathogenesis.

NATURE (2022)

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Article Cell Biology

Omicron variant Spike-specific antibody binding and Fc activity are preserved in recipients of mRNA or inactivated COVID-19 vaccines

Yannic C. Bartsch et al.

Summary: Despite evading neutralizing antibodies, the Omicron variant does not increase death rates in highly vaccinated populations, suggesting the presence of immune mechanisms beyond antibody-mediated virus neutralization. Vaccine-induced Spike protein-specific antibodies continue to drive Fc effector functions, indicating the potential of extraneutralizing antibodies in disease control.

SCIENCE TRANSLATIONAL MEDICINE (2022)

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Review Immunology

Sialylation as an Important Regulator of Antibody Function

Ravi Vattepu et al.

Summary: Antibodies play a critical role in linking the adaptive immune response to the innate immune system. Human antibodies are categorized into different classes and undergo post-translational modification by sugars. The structure of glycans on antibodies, especially sialic acid, significantly influences their functions.

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Immunoglobulin G1 Fc glycosylation as an early hallmark of severe COVID-19

Tamas Pongracz et al.

Summary: Low galactosylation, sialylation, and high bisection of anti-S IgG1 were associated with disease severity and inflammatory markers, suggesting the need for further studies to understand the contributions of anti-S IgG1 glycosylation to COVID-19 pathogenesis and its potential as a biomarker.

EBIOMEDICINE (2022)

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Review Microbiology

A Review of SARS-CoV-2 Disease (COVID-19): Pandemic in Our Time

Nasruddeen Al-Awwal et al.

Summary: This article summarizes the origin, characteristics, symptoms, prevention and treatment methods of COVID-19, as well as the methods for detecting SARS-CoV-2 and the symptoms after COVID-19.

PATHOGENS (2022)

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Article Cell Biology

Nucleocapsid-specific antibody function is associated with therapeutic benefits from COVID-19 convalescent plasma therapy

Jonathan D. Herman et al.

Summary: The study shows that convalescent plasma from COVID-19 patients can reduce inflammation and enhance immune response, providing significant clinical benefits for patients with low antibody function. These findings have important implications for the development of new antibody therapeutics targeting hyperinflammation in COVID-19.

CELL REPORTS MEDICINE (2022)

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Article Immunology

Signaling Through FcγRIIA and the C5a-C5aR Pathway Mediate Platelet Hyperactivation in COVID-19

Sokratis A. Apostolidis et al.

Summary: Patients with severe COVID-19 exhibit higher levels of platelet activation, which is associated with poor clinical outcomes and thrombotic events. Plasma from COVID-19 patients activates platelets from healthy donors and is correlated with kidney and liver injury. Blocking certain signaling pathways reverses this platelet hyperactivity.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Immunology

The germinal centre B cell response to SARS-CoV-2

Brian J. Laidlaw et al.

Summary: The GC response is crucial in establishing durable and broad immunity against SARS-CoV-2, with emerging evidence suggesting new approaches to modulate GC response and long-term immune responses induced by vaccines. Importantly, GC B cell responses persist for at least 6 months in some individuals following SARS-CoV-2 vaccination.

NATURE REVIEWS IMMUNOLOGY (2022)

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Review Urology & Nephrology

Immunity, endothelial injury and complement-induced coagulopathy in COVID-19

Luca Perico et al.

Summary: This review provides insights into the pathogenic mechanisms and clinical manifestations of COVID-19, highlighting the critical role of the immunological hyper-response induced by SARS-CoV-2 infection. The authors emphasize the importance of early diagnosis and intervention in controlling disease progression.

NATURE REVIEWS NEPHROLOGY (2021)

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Article Hematology

Circulating Markers of Neutrophil Extracellular Traps Are of Prognostic Value in Patients With COVID-19

Henry Ng et al.

Summary: Elevated levels of NET markers in patients with moderate to severe COVID-19 were found to be associated with disease severity, respiratory support requirement, and short-term mortality. These markers declined to healthy individual levels four months post-infection. The study suggests a potential role of NETs in COVID-19 disease progression and as targets for novel therapeutic interventions.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2021)

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Article Immunology

Antibody potency, effector function, and combinations in protection and therapy for SARS-CoV-2 infection in vivo

Alexandra Schafer et al.

Summary: The study shows that combined use of hu-mAbs is effective for prevention and therapy of SARS-CoV-2 infection, but in vivo protection is influenced by intact effector function.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

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Article Biochemistry & Molecular Biology

Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses

Jordan R. Barrett et al.

Summary: The study demonstrates that a booster dose of ChAdOx1 nCoV-19 is safer and better tolerated than priming doses. The booster dose significantly enhances anti-spike neutralizing antibody titers and other functional antibody responses. These data support the two-dose vaccine regime currently being evaluated in phase 3 clinical trials.

NATURE MEDICINE (2021)

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Article Multidisciplinary Sciences

Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection

Jennifer M. Dan et al.

Summary: Different components of immune memory to SARS-CoV-2 exhibit distinct kinetics, with antibodies and spike-specific memory B cells remaining relatively stable over 6 months, while CD4(+) T cells and CD8(+) T cells declining with a half-life of 3 to 5 months after infection.

SCIENCE (2021)

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Article Multidisciplinary Sciences

Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity

Mads Delbo Larsen et al.

Summary: This study reveals that afucosylated IgG antibodies are specifically formed against enveloped viruses, but not generally against other antigens. These antibodies enhance Fc gamma RIIIa responses, but also exacerbate cytokine storms and immune-mediated pathologies.

SCIENCE (2021)

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Article Biochemistry & Molecular Biology

Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity

Wilfredo F. Garcia-Beltran et al.

Summary: New variants of SARS-CoV-2 show high resistance to vaccine neutralization, with some able to escape vaccine responses with just a few mutations, highlighting the importance of developing broadly protective measures against variants.

CELL (2021)

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Article Biochemistry & Molecular Biology

Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection

Emma S. Winkler et al.

Summary: This study found that neutralizing human monoclonal antibodies in SARS-CoV-2-infected animals require Fc effector functions for optimal protection, reducing inflammation, improving respiratory mechanics, and being associated with diminished immune signaling and tissue repair.

CELL (2021)

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Article Microbiology

Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single supersite

Gabriele Cerutti et al.

Summary: Structural analysis revealed that seven potent NTD-directed neutralizing antibodies target a common surface on NTD, forming a single supersite different from the recognition pattern of RBD-directed antibodies.

CELL HOST & MICROBE (2021)

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Review Hematology

Platelet FcγRIIA in immunity and thrombosis: Adaptive immunothrombosis

Pravin Patel et al.

Summary: In the past decade, there has been a greater recognition of the role of platelets in host defense, specifically in immunity and thrombosis. Platelets are the first responders in the blood to both microbial and non-microbial antigens. They play a dual role in physiologic immunity and pathology, such as microvascular thrombosis.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2021)

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Article Multidisciplinary Sciences

Antibody resistance of SARS-CoV-2 variants B.1.351 and B.1.1.7

Pengfei Wang et al.

Summary: The COVID-19 pandemic has had global repercussions, with promising vaccines and monoclonal antibody therapies. However, newly detected variants of SARS-CoV-2 present challenges to these treatment options.

NATURE (2021)

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Article Biochemistry & Molecular Biology

Humoral signatures of protective and pathological SARS-CoV-2 infection in children

Yannic C. Bartsch et al.

Summary: The study reveals that the development of multisystem inflammatory syndrome in children (MIS-C) is associated with elevated levels of pathogen-specific IgG antibodies, which is different from children infected with SARS-CoV-2 who do not develop MIS-C. Using systems serology, it was found that children have a functional immune response to SARS-CoV-2, while adults may have different immune responses leading to varying disease severity.

NATURE MEDICINE (2021)

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Article Multidisciplinary Sciences

mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern

Rishi R. Goel et al.

Summary: This study found that immune memory to SARS-CoV-2 and its variants remains robust for at least 6 months after mRNA vaccination, with antibodies declining but still detectable in most individuals. mRNA vaccines also induced functional memory B cells and antigen-specific T cells, with recall responses primarily increasing antibody levels in individuals with preexisting immunity.

SCIENCE (2021)

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Article Multidisciplinary Sciences

Functional convalescent plasma antibodies and pre-infusion titers shape the early severe COVID-19 immune response

Jonathan D. Herman et al.

Summary: The study provides insights into the significant impact of convalescent plasma on modulating humoral responses by focusing on spike/nucleocapsid in recipients.

NATURE COMMUNICATIONS (2021)

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Article Immunology

Distinct Features and Functions of Systemic and Mucosal Humoral Immunity Among SARS-CoV-2 Convalescent Individuals

Savannah E. Butler et al.

Summary: Understanding humoral immune responses to SARS-CoV-2 infection is crucial for vaccine development and antibody-based interventions. Antibody responses in convalescent individuals varied depending on disease severity, with systemic and mucosal responses showing different characteristics. Neutralization and antibody-mediated effector functions in serum correlated with IgG response magnitude, while nasal neutralization was associated with IgA response, highlighting the importance of assessing mucosal immunity in larger natural infection cohorts.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Cell Biology

Anti-SARS-CoV-2 antibodies elicited by COVID-19 mRNA vaccine exhibit a unique glycosylation pattern

Inbal Farkash et al.

Summary: mRNA-based COVID-19 vaccines induce strong anti-SARS-CoV-2 antibody responses with unique and dynamic Fc compositions. The vaccine-induced antibodies exhibit differences in Fab and Fc-mediated functions between age groups and natural infection-generated antibodies. These findings suggest heterogeneity in Fc responses to SARS-CoV-2 infection and vaccination may support long-lasting protection differently.

CELL REPORTS (2021)

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Article Cell Biology

Stabilized coronavirus spike stem elicits a broadly protective antibody

Ching-Lin Hsieh et al.

Summary: This study developed stabilized stem (SS) antigens by removing the S1 subunit from the Middle East respiratory syndrome (MERS)-CoV spike (S) glycoprotein using structure-guided protein engineering. Vaccination with MERS SS elicited cross-reactive b-CoV antibody responses and protected mice against lethal MERS-CoV challenge. The discovery of a panel of cross-reactive monoclonal antibodies, among which IgG22 showed high affinity binding to both MERS-CoV and severe acute respiratory syndrome (SARS)-CoV-2 S proteins, indicates the potential for cross-reactive CoV antibodies.

CELL REPORTS (2021)

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Article Cell Biology

Landscape of human antibody recognition of the SARS-CoV-2 receptor binding domain

Adam K. Wheatley et al.

Summary: Potent neutralizing monoclonal antibodies are effective in treating COVID-19 by targeting specific sites on the viral spike protein. Research has identified antibodies that can improve SARS-CoV-2 infection and highlighted certain antibodies that remain effective against current VOCs. These findings suggest potential future therapeutics for combating SARS-CoV-2.

CELL REPORTS (2021)

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Article Biochemistry & Molecular Biology

Covalent Stabilization of Antibody Recruitment Enhances Immune Recognition of Cancer Targets

Eden Kapcan et al.

Summary: Antibody recruiting molecules (ARMs) function by binding to specific antibodies and cancer cell surface proteins to activate immune cells for cancer cell elimination. Covalent ARM (cARM) chemical tools have been developed to enhance therapeutic efficacy by increasing the stability of ARM:antibody complexes.

BIOCHEMISTRY (2021)

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Article Biochemistry & Molecular Biology

N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2

Matthew McCallum et al.

Summary: The study identifies 41 human monoclonal antibodies that recognize the N-terminal domain of the SARS-CoV-2 spike protein and exhibit strong neutralizing activity. These antibodies inhibit cell-to-cell fusion, activate effector functions, and protect animals from virus challenge, highlighting the importance of NTD-specific neutralizing antibodies for protective immunity and vaccine development. Several SARS-CoV-2 variants with mutations in the NTD supersite suggest ongoing selective pressure on the virus.

CELL (2021)

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Article Multidisciplinary Sciences

COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets

Toni M. Delorey et al.

Summary: This study using single-cell and spatial atlases revealed the impact of COVID-19 infection on lung, kidney, liver, and heart tissues, showing structural remodeling and viral RNA enrichment. Differences in lung inflammatory responses and transcriptional alterations in heart tissue of COVID-19 patients were also identified, along with cell types and genes associated with disease severity.

NATURE (2021)

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Article Biochemistry & Molecular Biology

Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection

David S. Khoury et al.

Summary: The level of neutralizing antibodies is closely related to immune protection against COVID-19, playing a crucial role in protecting against detected infection and severe infection. Studies have shown that neutralizing titers will decline over time after vaccination, leading to decreased protection against SARS-CoV-2 infection.

NATURE MEDICINE (2021)

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Letter Medicine, General & Internal

SARS-CoV-2 Antibody Response in Persons with Past Natural Infection

Gabriele Anichini et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Medicine, General & Internal

Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination

Andreas Greinacher et al.

Summary: After vaccination with ChAdOx1 nCov-19, rare immune thrombotic thrombocytopenia can occur due to platelet-activating antibodies against PF4, resulting in various thrombotic events. Most patients in this case series were women, with fatal outcomes such as cerebral venous thrombosis and intracranial hemorrhage. Additional studies are needed to further investigate and understand this phenomenon.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Cell Biology

High titers and low fucosylation of early human anti-SARS-CoV-2 IgG promote inflammation by alveolar macrophages

Willianne Hoepel et al.

Summary: Patients diagnosed with COVID-19 tend to become critically ill around the activation of the adaptive immune response. Evidence shows that antibodies in serum may worsen the disease during seroconversion. High anti-spike IgG levels in critically ill patients with severe COVID-19 induce excessive inflammatory responses and may lead to pulmonary complications such as microvascular thrombosis.

SCIENCE TRANSLATIONAL MEDICINE (2021)

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Article Microbiology

COVID-19 Severity Is Associated with Differential Antibody Fc-Mediated Innate Immune Functions

Opeyemi S. Adeniji et al.

Summary: The study suggests that qualitative differences in SARS-CoV-2-specific antibody-mediated innate immune functions may contribute to COVID-19 severity, with higher ADCD associated with higher inflammation and higher ADCP associated with lower inflammation. Understanding these qualitative features of antibodies could be crucial for developing effective and safe COVID-19 therapeutics and vaccines.

MBIO (2021)

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Article Microbiology

Markers of Polyfunctional SARS-CoV-2 Antibodies in Convalescent Plasma

Harini Natarajan et al.

Summary: This study analyzed convalescent plasma samples and found a diverse range of antiviral activity among recovered individuals. In addition to viral neutralization, convalescent plasma samples contained antibodies with various Fc-dependent functions, providing diversified resistance against SARS-CoV-2. Some eligible donors exhibited high activity in their plasma samples, which could be accurately identified as polyfunctional with even single Fc Array features.

MBIO (2021)

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Article Multidisciplinary Sciences

Cross-reactive serum and memory B-cell responses to spike protein in SARS-CoV-2 and endemic coronavirus infection

Ge Song et al.

Summary: This study examines the impact of pre-existing immunity to seasonal endemic coronaviruses on antibody responses to SARS-CoV-2, finding weak evidence of pre-existing cross-reactive serum antibodies in pre-pandemic donors, but evidence of pre-existing cross-reactive memory B cells activated during SARS-CoV-2 infection. Monoclonal antibodies show varying degrees of cross-reactivity with betacoronaviruses, and one neutralizing antibody specific to the S2 subunit of the S protein is identified, suggesting that pre-existing immunity to endemic coronaviruses should be considered in evaluating antibody responses to SARS-CoV-2.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

A SARS-CoV-2 antibody curbs viral nucleocapsid protein-induced complement hyperactivation

Sisi Kang et al.

Summary: This study isolated and analyzed 32 N protein-specific monoclonal antibodies from a COVID-19 convalescent patient, shedding light on the response to the N protein. The complex structure of the mAb with the highest binding affinity revealed changes in epitopes and regulation of the antigen, affecting the N protein-induced complement hyperactivation.

NATURE COMMUNICATIONS (2021)

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Article Biochemistry & Molecular Biology

Evaluation of COVID-19 vaccination strategies with a delayed second dose

Seyed M. Moghadas et al.

Summary: The study found that delaying the second dose of Moderna vaccine by at least 9 weeks could maximize vaccination effectiveness, while the Pfizer-BioNTech vaccine could also benefit from a delayed second dose strategy. However, for the Pfizer-BioNTech vaccine, delaying the second dose did not significantly reduce infections unless the efficacy of the first dose did not wane over time.

PLOS BIOLOGY (2021)

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Article Immunology

Complement Overactivation and Consumption Predicts In-Hospital Mortality in SARS-CoV-2 Infection

Gyorgy Sinkovits et al.

Summary: Uncontrolled complement activation is associated with advanced disease severity of COVID-19, with patients more likely to die when accompanied by overactivation and consumption of C3. These findings support the potential use of complement inhibitory drugs in the treatment of COVID-19.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Immunology

Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection

Lina Ma et al.

Summary: Complement activation is elevated in patients with COVID-19 and is associated with severe illness, endothelial injury, and hypercoagulability, serving as a distinctive feature of COVID-19 and providing specific targets for risk prognostication and drug discovery.

SCIENCE IMMUNOLOGY (2021)

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Article Hematology

Aberrant glycosylation of anti-SARS-CoV-2 spike IgG is a prothrombotic stimulus for platelets

Alexander P. Bye et al.

Summary: Critically ill patients with COVID-19 may experience thrombosis due to excessive immune response, with immune complexes containing SARS-CoV-2 spike protein and anti-spike immunoglobulin G exacerbating platelet-mediated thrombosis in vitro when Fc domain glycosylation state is modified to mimic that in severe COVID-19 cases. Activation is dependent on Fc gamma RIIA, and small molecules such as R406, ibrutinib, and cangrelor may counteract pathogenic platelet activation.

BLOOD (2021)

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Article Biochemistry & Molecular Biology

SARS-CoV-2 mRNA vaccination induces functionally diverse antibodies to NTD, RBD, and S2

Fatima Amanat et al.

Summary: After receiving the SARS-CoV-2 spike mRNA vaccine, individuals showed robust polyclonal antibody responses, with a majority of vaccine-induced antibodies lacking neutralizing activity. However, vaccine-induced RBD binding antibodies may offer substantial protection against viral variants carrying single E484K RBD mutations.

CELL (2021)

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Article Microbiology

A single dose of the SARS-CoV-2 vaccine BNT162b2 elicits Fc-mediated antibody effector functions and T cell responses

Alexandra Tauzin et al.

Summary: A single dose of the BNT162b2 mRNA vaccine can be up to 90% effective, with boosted humoral and T cell responses in previously infected individuals. Therefore, spacing doses may help vaccinate more people in conditions of limited vaccine supply.

CELL HOST & MICROBE (2021)

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Article Immunology

Live imaging of SARS-CoV-2 infection in mice reveals that neutralizing antibodies require Fc function for optimal efficacy

Irfan Ullah et al.

Summary: Neutralizing antibodies are effective in treating COVID-19, but the mechanism of immune protection is not fully understood. Real-time imaging revealed that highly potent NAbs can prevent and resolve established infections when administered within three days. Both Fab and Fc effector functions of NAbs are essential for optimal efficacy against SARS-CoV-2.

IMMUNITY (2021)

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Article Immunology

Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations

Frauke Muecksch et al.

Summary: This study examined the development of antibodies following infection with the coronavirus, finding that evolved antibodies had increased affinity and neutralization potency, altered mutational pathways for viral resistance, and restricted neutralization escape options. These findings suggest that increasing antibody diversity through prolonged or repeated antigen exposure may improve protection against diversifying populations of the virus and other pandemic threat coronaviruses.

IMMUNITY (2021)

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Article Immunology

Fc Galactosylation Promotes Hexamerization of Human IgG1, Leading to Enhanced Classical Complement Activation

Thijs L. J. van Osch et al.

Summary: This study demonstrates that galactose incorporation in IgG1-Fc enhances C1q binding, C4, C3 deposition and complement-dependent cellular cytotoxicity. Sialylation of IgG1-Fc slightly enhances C1q binding, but has little effect on downstream complement activation. Additionally, the data suggest that IgG1-Fc galactosylation enhances IgG1 hexamerization potential and complement activation.

JOURNAL OF IMMUNOLOGY (2021)

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Article Multidisciplinary Sciences

Fc-engineered antibody therapeutics with improved anti-SARS-CoV-2 efficacy

Rachel Yamin et al.

Summary: Monoclonal antibodies with optimized Fc domains show superior potency in preventing and treating COVID-19 in animal disease models, reducing the dose required for protection against SARS-CoV-2 challenge and for treating pre-infected animals. Selective engagement of activating Fc receptors results in improved efficacy, highlighting the importance of Fc receptor pathways in driving antibody-mediated antiviral immunity. These findings have implications for the development of Fc-engineered monoclonal antibodies with optimal Fc-effector function against COVID-19.

NATURE (2021)

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Article Multidisciplinary Sciences

Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization

Delphine Planas et al.

Summary: The SARS-CoV-2 B.1.617 Delta variant, first identified in India in 2020, has become dominant in some regions and is spreading to many countries. This variant shows resistance to certain monoclonal antibodies and antibodies in convalescent sera, as well as reduced neutralization by some COVID-19 vaccines. Administration of two doses of the vaccine is needed for a neutralizing response against the Delta variant.

NATURE (2021)

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Article Multidisciplinary Sciences

Antibody epitopes in vaccine-induced immune thrombotic thrombocytopaenia

Angela Huynh et al.

Summary: Alanine-scanning mutagenesis is used to identify the PF4 epitope that is recognized by anti-PF4 antibodies in patients with vaccine-induced immune thrombotic thrombocytopaenia, revealing that the epitope corresponds to the heparin-binding site on PF4. VITT anti-PF4 antibodies show stronger binding response compared to HIT anti-PF4 antibodies, potentially contributing to platelet activation and thrombosis by mimicking the effect of heparin binding on PF4. The findings suggest a potential mechanism for VITT development related to immune complexes formation and platelet activation via Fc gamma receptor IIa.

NATURE (2021)

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Article Multidisciplinary Sciences

SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses

Jackson S. Turner et al.

Summary: SARS-CoV-2 mRNA vaccines induce a persistent germinal centre B cell response in humans, leading to the generation of robust humoral immunity, especially more significant in individuals previously infected with the virus.

NATURE (2021)

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Article Multidisciplinary Sciences

Immunogenicity of Ad26.COV2.S vaccine against SARS-CoV-2 variants in humans

Galit Alter et al.

Summary: The Ad26.COV2.S vaccine has shown clinical efficacy against symptomatic COVID-19, including the B.1.351 variant, but there is uncertainty regarding its immunogenicity against SARS-CoV-2 variants. The study found that neutralizing antibody responses were reduced against the B.1.351 and P.1 variants, while non-neutralizing antibody responses and T cell responses were largely preserved against SARS-CoV-2 variants.

NATURE (2021)

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Article Biochemistry & Molecular Biology

Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

Philippe Begin et al.

Summary: Convalescent plasma did not reduce the risk of intubation or death at 30 days in hospitalized patients with COVID-19. Transfusion of convalescent plasma with unfavorable antibody profiles could be associated with worse clinical outcomes compared to standard care.

NATURE MEDICINE (2021)

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Review Microbiology

SARS-CoV-2 variants, spike mutations and immune escape

William T. Harvey et al.

Summary: The evolution of SARS-CoV-2 has been characterized by the emergence of mutations and variants that impact virus characteristics. Manufacturers are preparing for possible updates to vaccines in response to changes in the virus population, and it is crucial to monitor genetic and antigenic changes alongside experiments to understand the impacts of mutations.

NATURE REVIEWS MICROBIOLOGY (2021)

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Article Medicine, General & Internal

Prevention and Attenuation of Covid-19 with the BNT162b2 and mRNA-1273 Vaccines

Mark G. Thompson et al.

Summary: The study demonstrated that COVID-19 mRNA vaccines were highly effective in preventing SARS-CoV-2 infection in real-world conditions, while also attenuating the viral RNA load, febrile symptoms, and illness duration among vaccinated individuals who had breakthrough infections.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Multidisciplinary Sciences

The Fc-mediated effector functions of a potent SARS-CoV-2 neutralizing antibody, SC31, isolated from an early convalescent COVID-19 patient, are essential for the optimal therapeutic efficacy of the antibody

Conrad E. Z. Chan et al.

Summary: SC31 is a potent SARS-CoV-2 neutralizing antibody with therapeutic potential for COVID-19, acting through promoting immune responses and neutralizing the virus. It demonstrates good efficacy in animal models, including reducing viral loads, attenuating inflammatory responses, and protecting tissue damage.

PLOS ONE (2021)

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Article Multidisciplinary Sciences

IgA potentiates NETosis in response to viral infection

Hannah D. Stacey et al.

Summary: IgA plays a key role in protecting against viral infections by potentiating NETosis through neutrophils, which release neutrophil extracellular traps (NETs) to trap and inactivate viruses.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Multidisciplinary Sciences

Durability of mRNA-1273 vaccine-induced antibodies against SARS-CoV-2 variants

Amarendra Pegu et al.

Summary: The study assessed the impact of SARS-CoV-2 variants on antibody responses induced by the mRNA vaccine over 7 months, showing that most individuals maintained binding and functional antibodies against variants, with B.1.351 having the lowest antibody recognition.

SCIENCE (2021)

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Article Multidisciplinary Sciences

Immune correlates of protection by mRNA-1273 vaccine against SARS-CoV-2 in nonhuman primates

Kizzmekia S. Corbett et al.

Summary: In nonhuman primates (NHPs), vaccination with mRNA-1273 induces dose-dependent antibody responses, leading to a significant reduction in viral replication post SARS-CoV-2 challenge. Replication of the virus correlates strongly with antibody levels and neutralizing activity, with lower levels required in the lower airway than in the upper airway. Passive transfer of mRNA-1273-induced IgG is sufficient to provide protection, indicating that humoral immune responses induced by mRNA-1273 vaccine are effective against SARS-CoV-2 in NHPs.

SCIENCE (2021)

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Article Multidisciplinary Sciences

Broad betacoronavirus neutralization by a stem helix-specific human antibody

Dora Pinto et al.

Summary: The study identified five monoclonal antibodies from COVID-19 convalescent individuals that cross-react with multiple betacoronavirus spike glycoproteins, with one antibody (S2P6) showing broad neutralization of viruses from three different subgenera. This antibody reduced viral burden in hamsters challenged with SARS-CoV-2 by inhibiting membrane fusion, providing a framework for the design of pan-betacoronavirus vaccines for broad protection.

SCIENCE (2021)

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Review Microbiology

Animal Models for COVID-19: Hamsters, Mouse, Ferret, Mink, Tree Shrew, and Non-human Primates

Shuyu Shou et al.

Summary: Selecting appropriate animal models for SARS-CoV-2 research is crucial for antiviral drug development and therapeutic effect evaluation.

FRONTIERS IN MICROBIOLOGY (2021)

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Article Immunology

Lectin Pathway Mediates Complement Activation by SARS-CoV-2 Proteins

Youssif M. Ali et al.

Summary: Early and persistent complement activation is crucial in the pathogenesis of COVID-19, leading to a series of pathological events that trigger severe inflammatory responses to SARS-CoV-2. Research targeting MASP-2 suggests that the LP pathway of the complement system could offer a therapeutic window for treating severe COVID-19.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Multidisciplinary Sciences

Emerging SARS-CoV-2 variants of concern evade humoral immune responses from infection and vaccination

Tom G. Caniels et al.

Summary: New SARS-CoV-2 variants pose a threat to human immunity, with most individuals showing significantly reduced neutralization against three variants, especially B.1.351. Hospitalized patients and vaccine recipients maintained sufficient neutralizing titers, while a substantial portion of non-hospitalized patients exhibited no neutralization against B.1.351.

SCIENCE ADVANCES (2021)

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Review Immunology

Neutrophils and Influenza: A Thin Line between Helpful and Harmful

Sneha T. George et al.

Summary: Influenza viruses are a major threat to global public health each year, causing millions of infections and hundreds of thousands of deaths. Neutrophils, as the first innate cells to be recruited to infection sites in humans, play a key role in combating viruses through various effector functions.

VACCINES (2021)

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Review Immunology

Antigen Presentation of mRNA-Based and Virus-Vectored SARS-CoV-2 Vaccines

Ger T. Rijkers et al.

Summary: Infection with SARS-CoV-2 leads to the pandemic disease COVID-19, but effective vaccines such as mRNA and viral vector vaccines have been developed to control the spread. These vaccines can induce immune-related side effects like allergic reactions and thrombosis events, especially in rare cases.

VACCINES (2021)

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Article Cell Biology

Fab and Fc contribute to maximal protection against SARS-CoV-2 following NVX-CoV2373 subunit vaccine with Matrix-M vaccination

Matthew J. Gorman et al.

Summary: Newly approved vaccines have shown significant efficacy in limiting disease associated with SARS-CoV-2, single doses may prevent disease through combined Fc/Fab functions, but two doses may be crucial to prevent further transmission of the virus and emerging variants.

CELL REPORTS MEDICINE (2021)

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Article Biochemical Research Methods

A new flow cytometry assay to measure antibody- dependent cellular cytotoxicity against SARS-CoV-2 Spike-expressing cells

Guillaume Beaudoin-Bussieres et al.

Summary: Antibodies can engage specific receptors on effector cells and have functions beyond viral neutralization, such as antibody-dependent cellular cytotoxicity (ADCC), which plays an important role in protection against SARS-CoV-2 infections. By using a cell line expressing GFP-tagged SARS-CoV-2 spike, ADCC activity mediated by anti-SARS-CoV-2 Spike monoclonal antibodies or plasma from previously infected or vaccinated individuals can be measured in an optimized manner. Detailed information on the protocol can be found in Anand et al. (2021b).

STAR PROTOCOLS (2021)

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Article Biochemistry & Molecular Biology

Antibody-dependent cellular cytotoxicity response to SARS-CoV-2 in COVID-19 patients

Yuanling Yu et al.

Summary: ADCC responses are antibody-regulated immune responses mediated through the Fc fragment, and it is unclear if they contribute to COVID-19 disease development. Interestingly, patients with severe COVID-19 had higher ADCC activities, with recovered patients showing higher levels than deceased patients. This highlights ADCC as a major trait of COVID-19 patients with potential implications for neutralization levels against the virus.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Article Cell Biology

Longitudinal analysis of humoral immunity against SARS-CoV-2 Spike in convalescent individuals up to 8 months post-symptom onset

Sai Priya Anand et al.

Summary: Recent research on convalescent individuals of COVID-19 has shown a decline in antibody levels in plasma, while specific memory B cells remain present. IgM antibodies against Spike and RBD decay rapidly, whereas IgG decline is less significant. Understanding these immune memory responses is crucial for secondary infection prevention and vaccine efficacy.

CELL REPORTS MEDICINE (2021)

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Article Cell Biology

Broad auto-reactive IgM responses are common in critically ill patients, including those with COVID-19

Andrew Kam Ho Wong et al.

Summary: In critically ill COVID-19 patients, plasma contains broadly auto-reactive IgM that preferentially recognize primary lung cells, potentially leading to autoimmune reactions and contributing to disease severity. Identifying high-affinity auto-reactive IgM targeting specific autoantigens may provide a potential target for therapeutic interventions.

CELL REPORTS MEDICINE (2021)

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Article Cell Biology

Cross-reactive coronavirus antibodies with diverse epitope specificities and Fc effector functions

Andrea R. Shiakolas et al.

Summary: Research identifies antibodies from a recovered SARS-CoV donor sample that cross-react with the spike proteins of highly pathogenic SARS-CoV and SARS-CoV-2, as well as other coronaviruses. These antibodies mediate phagocytosis in vitro and reduce hemorrhagic pathology in murine lungs in vivo.

CELL REPORTS MEDICINE (2021)

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Article Immunology

Proinflammatory IgG Fc structures in patients with severe COVID-19

Saborni Chakraborty et al.

Summary: COVID-19 is often characterized by a hyperinflammatory syndrome, and disease severity is associated with specific antibody structures that enhance inflammatory responses.

NATURE IMMUNOLOGY (2021)

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Article Multidisciplinary Sciences

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

Daniel Wrapp et al.

SCIENCE (2020)

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Article Multidisciplinary Sciences

Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases

Lucija Klaric et al.

SCIENCE ADVANCES (2020)

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Article Biochemistry & Molecular Biology

Proteomic and Metabolomic Characterization of COVID-19 Patient Sera

Bo Shen et al.

CELL (2020)

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Article Multidisciplinary Sciences

DNA vaccine protection against SARS-CoV-2 in rhesus macaques

Jingyou Yu et al.

SCIENCE (2020)

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Article Critical Care Medicine

Tropism, replication competence, and innate immune responses of the coronavirus SARS-CoV-2 in human respiratory tract and conjunctiva: an analysis in ex-vivo and in-vitro cultures

Kenrie P. Y. Hui et al.

LANCET RESPIRATORY MEDICINE (2020)

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Article Multidisciplinary Sciences

Pathogenesis and transmission of SARS-CoV-2 in golden hamsters

Sin Fun Sia et al.

NATURE (2020)

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Article Biochemistry & Molecular Biology

Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19

Mingfeng Liao et al.

NATURE MEDICINE (2020)

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Article Biochemistry & Molecular Biology

Antibody responses to SARS-CoV-2 in patients with COVID-19

Quan-Xin Long et al.

NATURE MEDICINE (2020)

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Article Medicine, General & Internal

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

Maximilian Ackermann et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Hematology

Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome

Elizabeth A. Middleton et al.

BLOOD (2020)

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Article Immunology

Distinct Early Serological Signatures Track with SARS-CoV-2 Survival

Caroline Atyeo et al.

IMMUNITY (2020)

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Review Medicine, Research & Experimental

The complement system in COVID-19: friend and foe?

Anuja Java et al.

JCI INSIGHT (2020)

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Review Hematology

Thrombosis inCOVID-19

Thomas C. Hanff et al.

AMERICAN JOURNAL OF HEMATOLOGY (2020)

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Article Hematology

Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition

Jia Yu et al.

BLOOD (2020)

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Article Biochemistry & Molecular Biology

Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology

Luca Piccoli et al.

CELL (2020)

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Article Multidisciplinary Sciences

Association of COVID-19 inflammation with activation of the C5a-C5aR1 axis

Julien Carvelli et al.

NATURE (2020)

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Article Multidisciplinary Sciences

Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques

Noe B. Mercado et al.

NATURE (2020)

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Article Multidisciplinary Sciences

A perspective on potential antibody-dependent enhancement of SARS-CoV-2

Ann M. Arvin et al.

NATURE (2020)

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Article Biochemistry & Molecular Biology

Immune complement and coagulation dysfunction in adverse outcomes of SARS-CoV-2 infection

Vijendra Ramlall et al.

NATURE MEDICINE (2020)

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Article Multidisciplinary Sciences

Fc-mediated effector function contributes to the in vivo antiviral effect of an HIV neutralizing antibody

Mangaiarkarasi Asokan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Medicine, Research & Experimental

Complement and tissue factor-enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis

Panagiotis Skendros et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

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Article Medicine, Research & Experimental

Kinetics of viral load and antibody response in relation to COVID-19 severity

Yanqun Wang et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

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Article Multidisciplinary Sciences

SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies

Christopher O. Barnes et al.

NATURE (2020)

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Review Multidisciplinary Sciences

Animal models for COVID-19

Cesar Munoz-Fontela et al.

NATURE (2020)

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Editorial Material Medicine, General & Internal

The Power of Antibody-Based Surveillance

Galit Alter et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Multidisciplinary Sciences

Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients

Jan C. Holter et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Biochemistry & Molecular Biology

Compromised Humoral Functional Evolution Tracks with SARS-CoV-2 Mortality

Tomer Zohar et al.

CELL (2020)

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Article Multidisciplinary Sciences

The emerging role of neutrophil extracellular traps in severe acute respiratory syndrome coronavirus 2 (COVID-19)

Angelica Arcanjo et al.

SCIENTIFIC REPORTS (2020)

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Review Immunology

Immunological considerations for COVID-19 vaccine strategies

Mangalakumari Jeyanathan et al.

NATURE REVIEWS IMMUNOLOGY (2020)

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Article Biochemistry & Molecular Biology

Disease severity dictates SARS-CoV-2-specific neutralizing antibody responses in COVID-19

Xiangyu Chen et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

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Article Immunology

Isolation, Sequence, Infectivity and Replication Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2

Arinjay Banerjee et al.

EMERGING INFECTIOUS DISEASES (2020)

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Article Medicine, General & Internal

Risk stratification of hospitalized COVID-19 patients through comparative studies of laboratory results with influenza

Yang Mei et al.

ECLINICALMEDICINE (2020)

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Article Biochemical Research Methods

A novel method for determining antibody-dependent cellular phagocytosis

Lynn Kamen et al.

JOURNAL OF IMMUNOLOGICAL METHODS (2019)

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Article Microbiology

An Asymmetric Opening of HIV-1 Envelope Mediates Antibody-Dependent Cellular Cytotoxicity

Nirmin Alsahafi et al.

CELL HOST & MICROBE (2019)

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Article Biochemical Research Methods

A high-throughput, bead-based, antigen-specific assay to assess the ability of antibodies to induce complement activation

Stephanie Fischinger et al.

JOURNAL OF IMMUNOLOGICAL METHODS (2019)

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Review Immunology

Mind the Gap: How Interspecies Variability in IgG and Its Receptors May Complicate Comparisons of Human and Non-human Primate Effector Function

Andrew R. Crowley et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Biochemistry & Molecular Biology

Size-Dependent Segregation Controls Macrophage Phagocytosis of Antibody-Opsonized Targets

Matthew H. Bakalar et al.

CELL (2018)

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Article Immunology

High Level of Neutrophil Extracellular Traps Correlates With Poor Prognosis of Severe Influenza A Infection

Liuluan Zhu et al.

JOURNAL OF INFECTIOUS DISEASES (2018)

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Review Biochemistry & Molecular Biology

Impact of HIV-1 Envelope Conformation on ADCC Responses

Jonathan Richard et al.

TRENDS IN MICROBIOLOGY (2018)

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Article Immunology

Blockade of the C5a-C5aR axis alleviates lung damage in hDPP4-transgenic mice infected with MERS-CoV

Yuting Jiang et al.

EMERGING MICROBES & INFECTIONS (2018)

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Article Immunology

Novel Concepts of Altered Immunoglobulin G Galactosylation in Autoimmune Disease

Gillian Dekkers et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Microbiology

A Role for Fc Function in Therapeutic Monoclonal Antibody-Mediated Protection against Ebola Virus

Bronwyn M. Gunn et al.

CELL HOST & MICROBE (2018)

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Article Cell Biology

Immunoglobulin G glycosylation in aging and diseases

Ivan Gudelja et al.

CELLULAR IMMUNOLOGY (2018)

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Article Microbiology

Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis

Lisa E. Gralinski et al.

MBIO (2018)

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Review Immunology

Beyond binding: antibody effector functions in infectious diseases

Lenette L. Lu et al.

NATURE REVIEWS IMMUNOLOGY (2018)

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Article Biochemical Research Methods

Multiplexed Fc array for evaluation of antigen-specific antibody effector profiles

Eric P. Brown et al.

JOURNAL OF IMMUNOLOGICAL METHODS (2017)

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Article Immunology

Antibody Distance from the Cell Membrane Regulates Antibody Effector Mechanisms

Kirstie L. S. Cleary et al.

JOURNAL OF IMMUNOLOGY (2017)

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Article Medicine, Research & Experimental

Affinity of human IgG subclasses to mouse Fc gamma receptors

Gillian Dekkers et al.

MABS (2017)

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Article Biochemistry & Molecular Biology

Host DNA released by NETosis promotes rhinovirus-induced type-2 allergic asthma exacerbation

Marie Toussaint et al.

NATURE MEDICINE (2017)

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Article Multidisciplinary Sciences

Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice

Wenqian He et al.

NATURE COMMUNICATIONS (2017)

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Article Immunology

Decoding the Human Immunoglobulin G-Glycan Repertoire Reveals a Spectrum of Fc-Receptor- and Complement-Mediated-Effector Activities

Gillian Dekkers et al.

FRONTIERS IN IMMUNOLOGY (2017)

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Article Biochemistry & Molecular Biology

Roles of antibodies to influenza A virus hemagglutinin, neuraminidase, and M2e in conferring cross protection

Yu-Jin Kim et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

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Article Immunology

Defining B cell immunodominance to viruses

Davide Angeletti et al.

NATURE IMMUNOLOGY (2017)

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Article Oncology

Neutrophil extracellular traps cause airway obstruction during respiratory syncytial virus disease

Bart Cortjens et al.

JOURNAL OF PATHOLOGY (2016)

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Article Immunology

Mitochondrial Pyruvate Import Promotes Long-Term Survival of Antibody-Secreting Plasma Cells

Wing Y. Lam et al.

IMMUNITY (2016)

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Article Medicine, Research & Experimental

Broadly neutralizing anti-influenza antibodies require Fc receptor engagement for in vivo protection

David J. DiLillo et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

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Article Multidisciplinary Sciences

Epitope specificity plays a critical role in regulating antibody-dependent cell-mediated cytotoxicity against influenza A virus

Wenqian He et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

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Article Microbiology

Polyfunctional HIV-Specific Antibody Responses Are Associated with Spontaneous HIV Control

Margaret E. Ackerman et al.

PLOS PATHOGENS (2016)

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Article Multidisciplinary Sciences

Enhancement of Immune Effector Functions by Modulating IgG's Intrinsic Affinity for Target Antigen

Yariv Mazor et al.

PLOS ONE (2016)

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Article Biochemistry & Molecular Biology

Anti-HA Glycoforms Drive B Cell Affinity Selection and Determine Influenza Vaccine Efficacy

Taia T. Wang et al.

CELL (2015)

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Article Biochemistry & Molecular Biology

Dissecting Polyclonal Vaccine-Induced Humoral Immunity against HIV Using Systems Serology

Amy W. Chung et al.

CELL (2015)

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Review Immunology

Mouse and human FcR effector functions

Pierre Bruhns et al.

IMMUNOLOGICAL REVIEWS (2015)

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Article Biology

Masking of antigenic epitopes by antibodies shapes the humoral immune response to influenza

Veronika I. Zarnitsyna et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2015)

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Article Multidisciplinary Sciences

A potent broad-spectrum protective human monoclonal antibody crosslinking two haemagglutinin monomers of influenza A virus

Ying Wu et al.

NATURE COMMUNICATIONS (2015)

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Review Immunology

Complement system part I - molecular mechanisms of activation and regulation

Nicolas S. Merle et al.

FRONTIERS IN IMMUNOLOGY (2015)

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Article Biochemistry & Molecular Biology

Antibody-dependent SARS coronavirus infection is mediated by antibodies against spike proteins

Sheng-Fan Wang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)

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Article Biochemistry & Molecular Biology

Peering into the Crystal Ball: Influenza Pandemics and Vaccine Efficacy

Matthew S. Miller et al.

CELL (2014)

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Article Cell Biology

Actin Cytoskeleton Reorganization by Syk Regulates Fcγ Receptor Responsiveness by Increasing Its Lateral Mobility and Clustering

Valentin Jaumouille et al.

DEVELOPMENTAL CELL (2014)

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Article Multidisciplinary Sciences

Clonal selection in the germinal centre by regulated proliferation and hypermutation

Alexander D. Gitlin et al.

NATURE (2014)

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Article Biochemistry & Molecular Biology

Broadly neutralizing hemagglutinin stalk-specific antibodies require FcγR interactions for protection against influenza virus in vivo

David J. DiLillo et al.

NATURE MEDICINE (2014)

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Article Virology

Phagocytic cells contribute to the antibody-mediated elimination of pulmonary-infected SARS coronavirus

Fumihiko Yasui et al.

VIROLOGY (2014)

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Article Biochemical Research Methods

High-Throughput IgG Fc N-Glycosylation Profiling by Mass Spectrometry of Glycopeptides

Maja Pucic Bakovic et al.

JOURNAL OF PROTEOME RESEARCH (2013)

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Article Virology

Enhanced Phagocytic Activity of HIV-Specific Antibodies Correlates with Natural Production of Immunoglobulins with Skewed Affinity for FcγR2a and FcγR2b

Margaret E. Ackerman et al.

JOURNAL OF VIROLOGY (2013)

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Review Immunology

Neutrophil recruitment and function in health and inflammation

Elzbieta Kolaczkowska et al.

NATURE REVIEWS IMMUNOLOGY (2013)

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Review Hematology

Properties of mouse and human IgG receptors and their contribution to disease models

Pierre Bruhns

BLOOD (2012)

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Article Virology

Poorly Neutralizing Cross-Reactive Antibodies against the Fusion Loop of West Nile Virus Envelope Protein Protect In Vivo via Fcγ Receptor and Complement-Dependent Effector Mechanisms

Matthew R. Vogt et al.

JOURNAL OF VIROLOGY (2011)

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Article Virology

A Panel of IgG1 b12 Variants with Selectively Diminished or Enhanced Affinity for Fcγ Receptors To Define the Role of Effector Functions in Protection against HIV

Brian Moldt et al.

JOURNAL OF VIROLOGY (2011)

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Review Virology

The Human Antibody Response to Dengue Virus Infection

Wahala M. P. B. Wahala et al.

VIRUSES-BASEL (2011)

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Article Hematology

Specificity and affinity of human Fcγ receptors and their polymorphic variants for human IgG subclasses

Pierre Bruhns et al.

BLOOD (2009)

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Review Immunology

Fc gamma receptors as regulators of immune responses

Falk Nimmerjahn et al.

NATURE REVIEWS IMMUNOLOGY (2008)

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Article Medicine, General & Internal

Duration of humoral immunity to common viral and vaccine antigens

Ian J. Amanna et al.

NEW ENGLAND JOURNAL OF MEDICINE (2007)

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Article Biochemistry & Molecular Biology

Monomeric and polymeric IgA show a similar association with the myeloid FcαRI/CD89

Beatrijs D. Oortwijn et al.

MOLECULAR IMMUNOLOGY (2007)

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Article Biochemical Research Methods

A simplified method for the rapid fluorometric assessment of antibody-dependent cell-mediated cytotoxicity

VR Gómez-Román et al.

JOURNAL OF IMMUNOLOGICAL METHODS (2006)

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Review Immunology

Of mice and not men: Differences between mouse and human immunology

J Mestas et al.

JOURNAL OF IMMUNOLOGY (2004)

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Article Biochemistry & Molecular Biology

Structural analysis of human IgG-Fc glycoforms reveals a correlation between glycosylation and structural integrity

S Krapp et al.

JOURNAL OF MOLECULAR BIOLOGY (2003)

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Article Immunology

Mac-1 (CD11b/CD18) as accessory molecule, for FcαR (CD89) binding of IgA

AB van Spriel et al.

JOURNAL OF IMMUNOLOGY (2002)

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Article Biochemistry & Molecular Biology

Recognition of IgG by Fcγ receptor -: The role of Fc glycosylation and the binding of peptide inhibitors

S Radaev et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

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