4.7 Article

Multicenter Case-Control Study of COVID-19-Associated Mucormycosis Outbreak, India

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Ophthalmology

A fungal epidemic amidst a viral pandemic: Risk factors for development of COVID-19 associated rhino-orbital-cerebral mucormycosis in India

Varshitha Hemanth Vasanthapuram et al.

Summary: This study aimed to investigate the risk factors for the development of COVID-19 associated rhino-orbital-cerebral mucormycosis (ROCM) during the COVID-19 pandemic in India. The study found that male gender, active COVID-19 infection, moderate to severe COVID-19, uncontrolled diabetes, and steroid administration during COVID-19 treatment were risk factors for developing ROCM. Vaccination showed a protective effect against ROCM.

ORBIT-THE INTERNATIONAL JOURNAL ON ORBITAL DISORDERS-OCULOPLASTIC AND LACRIMAL SURGERY (2023)

Article Public, Environmental & Occupational Health

Evaluation of hospital environment for presence of Mucorales during COVID-19-associated mucormycosis outbreak in India - a multi-centre study

M. Biswal et al.

Summary: During the COVID-19 outbreak in India, contamination of air-conditioning vents and hospital air with Mucorales was found. Regular surveillance and improvement of hospital environment are necessary to prevent healthcare-associated mucormycosis outbreaks, particularly among immunocompromised patients.

JOURNAL OF HOSPITAL INFECTION (2022)

Article Infectious Diseases

Risk factors for Coronavirus disease-associated mucormycosis

Umang Arora et al.

Summary: This study aimed to identify risk factors for Coronavirus-disease associated mucormycosis (CAM) and found that diabetes, systemic steroid use, prolonged use of cloth and surgical masks, repeated nasopharyngeal swab testing, and lack of zinc therapy were associated with an increased risk of CAM. Mechanical ventilation or hospitalization did not affect the risk of CAM.

JOURNAL OF INFECTION (2022)

Review Mycology

Pulmonary Artery Pseudoaneurysm in COVID-19-Associated Pulmonary Mucormycosis: Case Series and Systematic Review of the Literature

Himanshu Pruthi et al.

Summary: Literature on COVID-19-associated pulmonary mucormycosis (CAPM) is limited, with pulmonary artery pseudoaneurysm (PAP) being a rare complication of the disease. This study reports five cases of CAPM with PAP, showcasing the importance of early diagnosis and multimodality management in improving outcomes for these patients, who face a high mortality rate.

MYCOPATHOLOGIA (2022)

Article Dermatology

Serum iron indices in COVID-19-associated mucormycosis: A case-control study

Mohan H. Kumar et al.

Summary: This study compared the serum iron indices in COVID-19 patients with and without COVID-19-associated mucormycosis (CAM), finding that CAM cases had lower TIBC levels than COVID-19 controls, suggesting a potential association with dysregulated iron metabolism in the pathogenesis of CAM.

MYCOSES (2022)

Article Dermatology

Results from a national survey on COVID-19-associated mucormycosis in Germany: 13 patients from six tertiary hospitals

Danila Seidel et al.

Summary: COVID-19-associated mucormycosis is rare in Germany, mostly reported in patients with comorbidities and impaired immune system who have severe COVID-19 and are treated in the ICU, with a high mortality rate. Compared to mainly rhino-orbito-cerebral CAM in patients with mild COVID-19 in India, the risk for CAM is higher in hospitalized COVID-19 patients.

MYCOSES (2022)

Article Immunology

Risk factors and outcomes of COVID associated mucormycosis in kidney transplant recipients

Shyam B. Bansal et al.

Summary: COVID-19 associated mucormycosis (CAM) is a common fungal infection in kidney transplant recipients (KTRs) in India, with most patients having pre-existing diabetes mellitus. The majority of cases present with rhino-orbital-cerebral mucormycosis (ROCM) and are treated with surgical debridement and a combination of antifungal drugs. The overall prognosis is favorable, although mortality can occur.

TRANSPLANT INFECTIOUS DISEASE (2022)

Article Medicine, General & Internal

Estimation of Ferritin and D-Dimer levels in COVID-19 Patients with Mucormycosis-A Pilot Study

Susanna Theophilus Yesupatham et al.

Summary: Serum ferritin and plasma D-dimer levels were significantly elevated in COVID-19 patients with mucormycosis. The occurrence of mucormycosis in COVID-19 patients without pre-existing co-morbidities may be attributed to the use of steroid therapy for COVID-19 infection. Therefore, serum ferritin and plasma D-dimer levels may play a significant role in predicting the risk of developing mucormycosis among COVID-19 infected patients.

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH (2022)

Review Infectious Diseases

The emergence of COVID-19 associated mucormycosis: a review of cases from 18 countries

Martin Hoenigl et al.

Summary: Reports of COVID-19-associated mucormycosis, particularly among patients with uncontrolled diabetes, have been increasing since early 2021. Most patients with COVID-19-associated mucormycosis have uncontrolled diabetes and receive systemic corticosteroid treatment, and rhino-orbital cerebral mucormycosis is the most common disease. COVID-19-associated mucormycosis is associated with high mortality and a significant proportion of survivors experience life-changing morbidities.

LANCET MICROBE (2022)

Review Infectious Diseases

Definition, diagnosis, and management of COVID-19-associated pulmonary mucormycosis: Delphi consensus statement from the Fungal Infection Study Forum and Academy of Pulmonary Sciences, India

Valliappan Muthu et al.

Summary: This article presents a consensus statement for the diagnosis and management of COVID-19-associated pulmonary mucormycosis (CAPM) using a modified Delphi method. The experts reached consensus on key statements related to CAPM, including its classification, diagnosis, and recommended treatments. However, further research is needed in this field.

LANCET INFECTIOUS DISEASES (2022)

Article Microbiology

Are Unique Regional Factors the Missing Link in India's COVID-19-Associated Mucormycosis Crisis?

Jessy Skaria et al.

Summary: The exact cause of the disproportionate increase in COVID-19-associated mucormycosis cases in India is still unknown. Researchers believe it is mainly due to the conjunction of the COVID-19 pandemic, corticosteroid treatment, and the large number of people with diabetes in India. However, environmental factors specific to India, such as the burning of Mucorales-rich biomass, may have also played a significant role in the country's CAM epidemic.
Letter Critical Care Medicine

Corticosteroids for Non-severe COVID-19: Primum Non Nocere

Valliappan Muthu et al.

INDIAN JOURNAL OF CRITICAL CARE MEDICINE (2022)

Article Infectious Diseases

Risk factors for COVID-19 associated mucormycosis in India: A case control study

Atul K. Patel et al.

Summary: This study identified new-onset diabetes, pre-existing diabetes, corticosteroid therapy, and home isolation as risk factors for COVID-19-associated mucormycosis.

MEDICAL MYCOLOGY (2022)

Article Mycology

Serum glucose-regulated protein 78 (GRP78) levels in COVID-19-associated mucormycosis: results of a case-control study

Valliappan Muthu et al.

Summary: This study compared the serum levels of glucose-regulated protein 78 (GRP78) in subjects with COVID-19-associated mucormycosis (CAM) and COVID-19 controls without mucormycosis. The results showed that the serum levels of GRP78 were significantly higher in CAM subjects than in COVID-19 controls. The study suggests that GRP78 may play a role in the pathogenesis of CAM.

MYCOPATHOLOGIA (2022)

Article Dermatology

Could cattle dung burning have contributed to the epidemic of COVID-19-associated mucormycosis in India? Results of an experimental aero-mycological study

Soundappan Kathirvel et al.

Summary: This study investigated the relationship between burning cattle dung and COVID-19-associated mucormycosis in India. The results showed that there was no significant increase in the proportion of Mucorales in the air during or after burning cattle dung, suggesting that burning cattle dung does not contribute to the occurrence of mucormycosis.

MYCOSES (2022)

Article Multidisciplinary Sciences

Hyperglycemia and steroid use increase the risk of rhino-orbito-cerebral mucormycosis regardless of COVID-19 hospitalization: Case-control study, India

Manickam Ponnaiah et al.

Summary: This study investigated the risk factors for post-COVID ROCM and found that factors such as hyperglycemia, diabetes mellitus, and steroid use were associated with an increased risk of developing the disease.

PLOS ONE (2022)

Review Microbiology

COVID-19-associated fungal infections

Martin Hoenigl et al.

Summary: Invasive fungal infections associated with COVID-19 are an important complication, primarily caused by Aspergillus, Mucorales, and Candida species. This review examines the incidence of these fungal infections in different income countries, evaluating their epidemiology, clinical risk factors, and pathogenesis for future research and clinical guidance. Hoenigl and colleagues provide an overview of the epidemiology, immunology, and clinical risk factors of COVID-19-associated fungal infections.

NATURE MICROBIOLOGY (2022)

Article Microbiology

Mucormycosis in COVID-19 Patients: A Case-Control Study

Awadh Kishor Pandit et al.

Summary: During the second wave of COVID-19 in India, there was a sudden surge in cases of both the COVID-19 delta variant and mucormycosis, a fungal infection, making the infection even more deadly. This study found that older age, elevated baseline serum creatinine, elevated D-dimer, and diabetes mellitus were associated with the occurrence of mucormycosis in COVID-19 patients. The study also observed intracranial involvement in some mucormycosis patients.

MICROORGANISMS (2022)

Article Immunology

Evaluation of environmental Mucorales contamination in and around the residence of COVID-19-associated mucormycosis patients

Anup K. Ghosh et al.

Summary: This study found that there is Mucorales contamination in the residential environment of CAM patients in India, which is closely related to the patients' condition. The results suggest that universal masking at home and environmental decontamination during the patients' convalescence period can reduce the risk of exposure for susceptible patients.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

Article Ophthalmology

Uncontrolled diabetes mellitus exacerbated by COVID-19-induced inflammation is the risk factor for COVID-19-associated rhino-orbito-cerebral mucormycosis: A matched pair case-control study

Shubashree Karat et al.

Summary: This study describes the epidemiology and risk factors for developing COVID-19-associated rhino-orbito-cerebral mucormycosis (ROCM) in India. The research reveals that uncontrolled diabetes mellitus is the main independent risk factor for COVID-19-associated ROCM. Middle-aged males with undetected diabetes from resource-constrained settings are particularly at risk.

INDIAN JOURNAL OF OPHTHALMOLOGY (2022)

Article Medicine, General & Internal

Role of Zinc and Clinicopathological Factors for COVID-19-Associated Mucormycosis (CAM) in a Rural Hospital of Central India: A Case-Control Study

Sunil Kumar et al.

Summary: COVID-19 has been a challenging disease for healthcare professionals worldwide. However, the emergence of opportunistic fungal infections during the pandemic has created havoc and led to high morbidity and mortality. This study suggests that apart from diabetes mellitus and immunosuppression, zinc may be a hidden culprit behind the sudden surge of COVID-19-associated mucormycosis worldwide.

CUREUS JOURNAL OF MEDICAL SCIENCE (2022)

Article Surgery

Are Low Serum Vitamin D Levels a Risk Factor for Advent of COVID-19 Associated Rhinocerebral Mucormycosis: A Preliminary Case Control Study

Harsha Popli et al.

Summary: This study suggests that low serum vitamin D level may be a risk factor for the development of Rhinocerebral mucormycosis in COVID-19 afflicted patients. Vitamin D supplements could potentially be provided to these patients to achieve normal serum levels.

INDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY (2022)

Review Infectious Diseases

Definition, diagnosis, and management of COVID-19-associated pulmonary mucormycosis: Delphi consensus statement from the Fungal Infection Study Forum and Academy of Pulmonary Sciences, India

Valliappan Muthu et al.

Summary: A consensus statement for the diagnosis and management of COVID-19-associated pulmonary mucormycosis (CAPM) was formulated using a modified Delphi method. Recommendations were proposed for defining, diagnosing, and managing CAPM, but further research is needed to fully understand this underdiagnosed entity.

LANCET INFECTIOUS DISEASES (2022)

Article Endocrinology & Metabolism

Absence of Case of Mucormycosis (March 2020-May 2021) under strict protocol driven management care in a COVID-19 specific tertiary care intensive care unit

Bindu Mulakavalupil et al.

Summary: Strict adherence to protocol of low dose steroids and strict glycemic control helped in reducing or eliminating the risk and incidence of mucormycosis in a tertiary care dedicated covid-19 hospital.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2021)

Review Infectious Diseases

Has the mortality from pulmonary mucormycosis changed over time? A systematic review and meta-analysis

Valliappan Muthu et al.

Summary: The study aimed to assess the mortality and trend of pulmonary mucormycosis (PM) in immunocompromised patients. Results showed that mortality of PM has improved over time, with combined medical-surgical therapy associated with lower mortality risk than medical treatment alone. Risk of death was higher in disseminated disease compared to isolated PM, while diabetes mellitus was not associated with higher mortality risk.

CLINICAL MICROBIOLOGY AND INFECTION (2021)

Review Mycology

Epidemiology and Pathophysiology of COVID-19-Associated Mucormycosis: India Versus the Rest of the World

Valliappan Muthu et al.

Summary: The COVID-19 pandemic has led to a concerning resurgence of mucormycosis, with a high number of cases reported from India. Diabetes mellitus was the most common underlying risk factor for COVID-19-associated mucormycosis in India, where the fatality rate of reported cases was relatively lower compared to globally reported cases.

MYCOPATHOLOGIA (2021)

Article Dermatology

Is there an association between zinc and COVID-19-associated mucormycosis? Results of an experimental and clinical study

Valliappan Muthu et al.

Summary: An increase in growth was observed in Rhizopus arrhizus isolates in zinc-enriched media, but the study did not conclusively support the hypothesis that zinc supplementation contributed to the pathogenesis of mucormycosis. More data, both in vitro and in vivo, may help clarify the role of zinc in the pathogenesis of CAM.

MYCOSES (2021)

Article Dermatology

ECMM/ISHAM recommendations for clinical management of COVID-19 associated mucormycosis in low- and middle-income countries

Shivaprakash M. Rudramurthy et al.

Summary: Globally, the incidence of COVID-19-associated mucormycosis (CAM) is rising, with a significant surge in India. The need to address misconceptions in managing and treating this infection is crucial, with a focus on early suspicion, diagnosis confirmation, glycemic control, surgical debridement, and antifungal therapy. Limited availability of amphotericin B formulations during the epidemic has led to discussions on alternative antifungal therapies.

MYCOSES (2021)

Article Immunology

Multicenter Epidemiologic Study of Coronavirus Disease-Associated Mucormycosis, India

Atul Patel et al.

Summary: This study found an increase in mucormycosis cases in India during the COVID-19 pandemic, mainly due to inappropriate glucocorticoid use, resulting in a higher mortality rate among mucormycosis patients.

EMERGING INFECTIOUS DISEASES (2021)

Article Ophthalmology

Epidemiology, clinical profile, management, and outcome of COVID-19-associated rhino-orbital-cerebral mucormycosis in 2826 patients in India - Collaborative OPAI-IJO Study on Mucormycosis in COVID-19 (COSMIC), Report 1

Mrittika Sen et al.

Summary: This study retrospectively reviewed the characteristics, treatment, and outcomes of COVID-19-associated ROCM patients during India's second wave of COVID-19 pandemic. The study found that corticosteroids and diabetes mellitus are important predisposing factors for ROCM development, and a high index of clinical suspicion and early treatment are essential for successful outcomes.

INDIAN JOURNAL OF OPHTHALMOLOGY (2021)

Review Mycology

Coronavirus Disease (Covid-19) Associated Mucormycosis (CAM): Case Report and Systematic Review of Literature

Deepak Garg et al.

Summary: The study discussed a case of probable pulmonary mucormycosis in a COVID-19 patient, highlighting the severity of the disease and the importance of aggressive management for better outcomes. A systematic review revealed that diabetes mellitus was the most common risk factor, and the concurrent use of glucocorticoids may also increase the risk of mucormycosis.

MYCOPATHOLOGIA (2021)

Editorial Material Medicine, General & Internal

A living WHO guideline on drugs for covid-19

Francois Lamontagne et al.

BMJ-BRITISH MEDICAL JOURNAL (2020)

Review Infectious Diseases

Contemporary management and clinical outcomes of mucormycosis: A systematic review and meta-analysis of case reports

Wirawan Jeong et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2019)