The Role of Fecal Microbiota Transplantation in the Treatment of Neurodegenerative Diseases: A Review

Neurodegenerative diseases are highly prevalent but poorly understood, and with few treatment options despite decades of intense research, attention has recently shifted toward other mediators of neurological disease that may present future targets for therapeutic research. One such mediator is the gut microbiome, which communicates with the brain through the gut-brain axis and has been implicated in various neurological disorders. Alterations in the gut microbiome have been associated with numerous neurological and other diseases, and restoration of the dysbiotic gut has been shown to improve disease conditions. One method of restoring a dysbiotic gut is via fecal microbiota transplantation (FMT), recolonizing the diseased gut with normal microbiome. Fecal microbiota transplantation is a treatment method traditionally used for Clostridium difficile infections, but it has recently been used in neurodegenerative disease research as a potential treatment method. This review aims to present a summary of neurodegenerative research that has used FMT, whether as a treatment or to investigate how the microbiome influences pathogenesis.

Automated summary

Neurodegenerative diseases are prevalent and poorly understood, and attention has recently shifted toward investigating the gut microbiome as a potential target for therapeutic research. Alterations in the gut microbiome have been associated with various neurological disorders, and the restoration of a dysbiotic gut through fecal microbiota transplantation (FMT) has shown promise in improving disease conditions. This review aims to summarize neurodegenerative research that has used FMT and its implications for understanding pathogenesis.