Impacts of Oral Florfenicol Medication and Residues on the Kidney and Liver of Nile Tilapia Oreochromis niloticus (L.)

Article Environmental Sciences

The effects of extended feeding of florfenicol coated medicated diets on the safety, serum biomarkers and blood cells morphology of Nile tilapia Oreochromis niloticus (L.)

Avishek Bardhan et al.

Summary: This study assessed the safety of oral florfenicol (FFC) at therapeutic dose in Oreochromis niloticus juveniles, and found that the effects of FFC on fish were reversible.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2022)

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Review Fisheries

Usage pattern of chemicals, biologicals and veterinary medicinal products in Indian aquaculture

Prasanna K. Patil et al.

Summary: The use of chemicals, biologicals, and veterinary medicinal products is essential for healthy and sustainable fish production. A nationwide survey revealed that farmers rely on various inputs such as disinfectants, nutritional supplements, and environmental modifiers to improve soil and water quality, enhance growth, and ensure biosecurity. The survey also indicated that education and farming experience significantly influence the usage pattern of aquaculture inputs.

REVIEWS IN AQUACULTURE (2022)

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Article Microbiology

Dysbiosis and Restoration Dynamics of the Gut Microbiome Following Therapeutic Exposure to Florfenicol in Snubnose Pompano (Trachinotus blochii) to Aid in Sustainable Aquaculture Production Strategies

T. G. Sumithra et al.

Summary: This study provides the first report on the impact of florfenicol (FFC) on the gut microbiome of snubnose pompano, highlighting the risks and restoration dynamics. The results show transient dysbiosis events and reductions in bacterial load and diversity. The gut microbiome fully recovers within 10-15 days of antibiotic withdrawal, indicating the need for proper management measures. The study also demonstrates the inhibitory potential of FFC against marine pathogens and ampicillin-resistant microbes, and identifies microbial signatures of stress in fish and potential probiotic microbes.

FRONTIERS IN MICROBIOLOGY (2022)

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Article Fisheries

Histopathological aberrations and oxidative stress responses in Nile tilapia Oreochromis niloticus as influenced by dietary florfenicol and its metabolites

Avishek Bardhan et al.

Summary: This study investigated the effects of dietary administration of florfenicol on kidney and liver tissues in Oreochromis niloticus juveniles. The results showed pathological changes in the kidney and liver, but the therapeutic dose of florfenicol was well tolerated by O. niloticus.

AQUACULTURE (2022)

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Article Environmental Sciences

Biological Responses of Nile tilapia Oreochromis niloticus as Influenced by Dietary Florfenicol

Avishek Bardhan et al.

Summary: In this study, the effects of florfenicol (FFC) on Oreochromis niloticus juveniles were investigated. The results showed that FFC caused a reduction in feed intake, survival, and biomass, as well as abnormalities in hematological, erythrocytic, and serum biochemical indices. However, most of the measured parameters and histopathological changes recovered within 3 weeks after the suspension of FFC dosing, indicating that the therapeutic dose of FFC is reversible and safe for O. niloticus.

TOXICS (2022)

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Review Fisheries

A global analysis on the systemic effects of antibiotics in cultured fish and their potential human health risk: a review

Samwel Mchele Limbu et al.

Summary: The use of antibiotics in aquaculture can improve fish health by killing pathogenic bacteria, but also causes side effects and potential risks to human health. Antibiotics can compromise fish immunity, leading to cellular damage, while also impacting fish growth and survival rates.

REVIEWS IN AQUACULTURE (2021)

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Article Ecology

Mixture toxicity effects of chloramphenicol, thiamphenicol, florfenicol in Daphnia magna under different temperatures

Yuxuan Zhang et al.

Summary: The acute toxicities of chloramphenicol, thiamphenicol, florfenicol, and their mixtures on Daphnia magna vary under different temperatures, with toxicity significantly increasing at 25 degrees Celsius. The phenicol antibiotic mixtures generally exhibit a dual synergism-antagonism effect, and the Combination Index equation appears to be more suitable for predicting their toxicity values compared to other models. Overall, phenicol antibiotic mixtures with temperature variation may pose greater hazards and risks to aquatic organisms and the environment.

ECOTOXICOLOGY (2021)

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Article Environmental Sciences

Florfenicol causes excessive lipid peroxidation and apoptosis induced renal injury in broilers

Xiao Wang et al.

Summary: The study revealed that FFC has certain nephrotoxicity to broilers, with dose-dependent and reversible effects on kidney function. The main manifestations include disorderly kidney tissue structure and atrophy of glomeruli. Additionally, FFC can lead to significant changes in certain indicators in serum and kidney, and promote renal cell apoptosis by regulating the expression of related factors.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

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Article Multidisciplinary Sciences

An Integrated biomarker approach for explaining the potency of exogenous glucose on transportation induced stress in Labeo rohita fingerlings

Abhilipsa Biswal et al.

Summary: This study found that 0.2% exogenous glucose as a water additive exhibited the lowest stress response in L. rohita fingerlings during simulated transportation, suggesting it may help mitigate transportation-induced stress. Upregulation of liver HSP70 mRNA expression was identified as an important marker of stress response.

SCIENTIFIC REPORTS (2021)

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Article Biochemistry & Molecular Biology

Acute toxicity of organophosphate pesticide profenofos, pyrethroid pesticide. cyhalothrin and biopesticide azadirachtin and their sublethal effects on growth and oxidative stress enzymes in benthic oligochaete worm, Tubifex tubifex

Arnab Chatterjee et al.

Summary: The study aimed to evaluate the acute toxicity of profenofos, lambda cyhalothrin, and azadirachtin on Tubifex tubifex, as well as their sublethal effects on growth rate and oxidative stress biomarkers. The pesticides caused behavioral abnormalities, decreased growth rate, and altered oxidative stress enzymes in the worms. Profenofos, lambda cyhalothrin, and azadirachtin induced significant effects on survivability, behavior, growth rate, and oxidative stress enzymes in T. tubifex.

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY (2021)

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Review Urology & Nephrology

Nitric oxide signalling in kidney regulation and cardiometabolic health

Mattias Carlstrom

Summary: Nitric oxide plays crucial roles in regulating kidney, cardiovascular, and metabolic functions. Reduced bioactivity of NO due to oxidative stress is considered important. Understanding NO biology and developing novel approaches to restoring NO homeostasis offer potential therapeutic applications for kidney, cardiovascular, and metabolic disorders.

NATURE REVIEWS NEPHROLOGY (2021)

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Article Fisheries

Effects of water temperature on tissue depletion of florfenicol and its metabolite florfenicol amine in crucian carp (Carassius auratus gibelio) following multiple oral doses

Fan Yang et al.

AQUACULTURE (2020)

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Article Multidisciplinary Sciences

Evaluation of health and environmental risks for juvenile tilapia (Oreochromis niloticus) exposed to florfenicol

Leticia Sayuri Shiroma et al.

HELIYON (2020)

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Article Fisheries

Effects of including triticale on growth performance, digestive enzyme activity, and growth-related genes of Nile tilapia (Oreochromis niloticus)

Mahmoud A. O. Dawood et al.

AQUACULTURE (2020)

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Article Multidisciplinary Sciences

Structural, biological and pharmaceutical importance of antibiotic agent chloramphenicol

A. Sathya et al.

HELIYON (2020)

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Article Environmental Sciences

Histopathological effects in gills and liver of Sparus aurata following acute and chronic exposures to erythromycin and oxytetracycline

Sara Rodrigues et al.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2019)

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Article Pathology

Renal Papillary Rarefaction: An Artifact Mimicking Papillary Necrosis

John Curtis Seely et al.

TOXICOLOGIC PATHOLOGY (2019)

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Article Fisheries

Erythromycin and florfenicol treatment of rainbow trout Oncorhynchus mykiss (Walbaum) experimentally infected with Flavobacterium psychrophilum

Maureen Jarau et al.

JOURNAL OF FISH DISEASES (2019)

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Article Infectious Diseases

A Case of Hypokalemia Possibly Induced by Nafcillin

Fernando Casado et al.

ANTIBIOTICS-BASEL (2018)

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Article Fisheries

Depletion study and estimation of withdrawal periods for florfenicol and florfenicol amine in pacu (Piaractus mesopotamicus)

Tamires Valim Marques et al.

AQUACULTURE RESEARCH (2018)

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Article Marine & Freshwater Biology

Role of Glutathione in Functioning of the System of Antioxidant Protection in Fish (Review)

I. V. Sukhovskaya et al.

INLAND WATER BIOLOGY (2017)

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Article Environmental Sciences

Effects of florfenicol on the antioxidant status, detoxification system and biomolecule damage in the swimming crab (Portunus trituberculatus)

Xianyun Ren et al.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2017)

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Article Fisheries

Pharmacokinetics of florfenicol and behaviour of its metabolite florfenicol amine in orange-spotted grouper (Epinephelus coioides) after oral administration

J-B Feng et al.

JOURNAL OF FISH DISEASES (2016)

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Article Immunology

Florfenicol induces more severe hemotoxicity and immunotoxicity than equal doses of chloramphenicol and thiamphenicol in Kunming mice

Dongfang Hu et al.

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY (2016)

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Article Fisheries

Assessment of Detoxifying Markers for Florfenicol in Rainbow Trout Liver

Antonia Concetta Elia et al.

JOURNAL OF AQUATIC ANIMAL HEALTH (2016)

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Article Veterinary Sciences

Biochemical, haematological and oxidative stress responses of common carp (Cyprinus carpio L.) after sub-chronic exposure to copper

M. Sevcikova et al.

VETERINARNI MEDICINA (2016)

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Article Microbiology

Florfenicol As a Modulator Enhancing Antimicrobial Activity: Example Using Combination with Thiamphenicol against Pasteurella multocida

Chia-Fong Wei et al.

Frontiers in Microbiology (2016)

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Article Pathology

Nonlesions, Misdiagnoses, Missed Diagnoses, and Other Interpretive Challenges in Fish Histopathology Studies: A Guide for Investigators, Authors, Reviewers, and Readers

Jeffrey C. Wolf et al.

TOXICOLOGIC PATHOLOGY (2015)

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Article Environmental Sciences

The impact of endocrine-disrupting chemicals on oxidative stress and innate immune response in zebrafish embryos

Hai Xu et al.

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY (2013)

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Review Food Science & Technology

Glutathione defense mechanism in liver injury: Insights from animal models

Y. Chen et al.

FOOD AND CHEMICAL TOXICOLOGY (2013)

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Article Fisheries

The Safety of Aquaflor (50% Florfenicol) Administered in Feed to Fingerling Yellow Perch

James D. Bowker et al.

NORTH AMERICAN JOURNAL OF AQUACULTURE (2013)

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Article Pathology

Safety of Florfenicol Administered in Feed to Tilapia (Oreochromis sp.)

Mark P. Gaikowski et al.

TOXICOLOGIC PATHOLOGY (2013)

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Article Biotechnology & Applied Microbiology

The Improvement of The Endogenous Antioxidant Property of Stone Fish (Actinopyga lecanora) Tissue Using Enzymatic Proteolysis

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BIOMED RESEARCH INTERNATIONAL (2013)

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Article Agriculture, Dairy & Animal Science

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ANIMAL FEED SCIENCE AND TECHNOLOGY (2012)

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Article Fisheries

Safety of Aquaflor-Medicated Feed to Sunshine Bass

David L. Straus et al.

NORTH AMERICAN JOURNAL OF AQUACULTURE (2012)

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Article Fisheries

Efficacy of Florfenicol for Control of Mortality Caused by Flavobacterium columnare Infection in Channel Catfish

Patricia S. Gaunt et al.

JOURNAL OF AQUATIC ANIMAL HEALTH (2010)

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Article Pharmacology & Pharmacy

Lipid peroxidation and antioxidant status in kidney and liver of rats treated with sulfasalazine

Victoria Linares et al.

TOXICOLOGY (2009)

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Article Fisheries

Interactive effects of ammonia and oxygen on growth and physiological status of juvenile Atlantic cod (Gadus morhua)

Mette Remen et al.

AQUACULTURE (2008)

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Article Pathology

Safety of aquaflor (florfenicol, 50% type A medicated article), administered in feed to channel catfish, Ictalurus punctatus

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TOXICOLOGIC PATHOLOGY (2003)

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Article Urology & Nephrology

Attenuation of tubular apoptosis by blockade of the renin-angiotensin system in diabetic Ren-2 rats

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KIDNEY INTERNATIONAL (2002)

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Impacts of Oral Florfenicol Medication and Residues on the Kidney and Liver of Nile Tilapia Oreochromis niloticus (L.)

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