CD8+ T cell depletion does not induce an expansion of viral reservoir in HIV model

Cytotoxic CD8(+) T cells reduce the average lifespan of productively infected cells during acute simian immunodeficiency virus infection (a primate model of human immunodeficiency virus infection). However, they are ineffective at preventing the establishment of a persistent reservoir of latently infected cells under long-term antiretroviral therapy.

Automated summary

Cytotoxic CD8(+) T cells can decrease the lifespan of infected cells during acute simian immunodeficiency virus infection, but they are unable to prevent the establishment of a persistent reservoir of latently infected cells under long-term antiretroviral therapy.