期刊
CLINICAL ORAL INVESTIGATIONS
卷 27, 期 6, 页码 2813-2821出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00784-023-04867-w
关键词
Gingival crevicular fluid; Periodontitis; Prolactin; Rheumatoid arthritis; Synovial fluid
This study aimed to investigate the levels of prolactin (PRL) in gingival crevicular fluid (GCF), synovial fluid, and serum in patients with moderately active rheumatoid arthritis (RA) with and without periodontitis (P). The study found that patients with periodontitis had higher levels of PRL in GCF and serum, and non-surgical periodontal treatment could reduce these levels.
ObjectivesWe aimed to investigate prolactin (PRL) levels in gingival crevicular fluid (GCF), synovial fluid, and serum in patients suffering from moderately active rheumatoid arthritis (RA) with and without periodontitis (P). Further, to evaluate the effect of non-surgical periodontal treatment on these levels compared to controls.Materials and methodsEighty subjects were divided into 4 groups: group 1: 20 patients with RA + P, group 2: 20 periodontitis patients (systemically healthy), group 3: RA patients (periodontally healthy), and group 4: healthy controls. Patients with periodontitis received scaling and root planning (SRP). PRL was measured using enzyme-linked immunosorbent assay.ResultsAt baseline, in GCF of RA + P group showed the highest mean PRL levels, followed by P group whereas groups 3 and 4 showed a statistically less values than the first 2 groups. Serum values showed non-significant difference between the first three groups, although higher than healthy controls. SRP reduced GCF and serum levels of PRL in both P groups as well as synovial fluid PRL in group 1. SRP caused no change in DAS scores while reduced ESR values were observed in group 1 after treatment.ConclusionsLocal GCF and synovial levels of PRL seem to be linked to the disease process of both periodontitis and rheumatoid arthritis than serum levels. SRP reduced these local levels.Trial registrationClinicaltrials.gov. Identifier: NCT04279691.
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